Today media centers are often cluttered with multiple devices each controlled by their own remote control. It is often hard and/or painful to manage and utilize these devices, especially for inexperienced users. Simstream wants to build an innovative smart-TV that as much as possible centralizes functions and controls.  Operating the system should be intuitive and simple, yet experienced users should have access to more advanced operations. This requires acquiring several inputs as well as integrating the communication devices that are necessary to control the attached external devices. Whenever possible, we want to efficiently process every input while minimizing latencies.  As a result, we want all the frequent operation to be as quick and lightweight as possible in order to provide a high quality user experience even under high system loads. This project takes advantage of the widespread availability of touchscreen mobile devices in order to provide an innovative means of control over the television, with remote control mobile applications running on an user’s familiar device. A remote controller will also be sold together with the television, and this remote controller will also have a touchscreen, and will propose the same capabilities as the remote control mobile applications. Finally, this platform will be open to third-party applications, and as a result this thesis project developed a software development kit which is designed to be easy and familiar enough for developers to adopt it and create applications with it. Applications will be developed together with an interface displayed on the remote controllers, in order to tailor the remote control interface to what is currently displayed on the television screen / Idag är mediecentrer ofta belamrade med många enheter som är kontrollerade av sina egna fjärrkontroller. Det är ofta svårt och / eller smärtsamt att använda dessa enheterna, särskilt för oerfarna användare. Simstream vill bygga en innovativ smart TV som centraliserar funktioner och kontroller så mycket som möjligt. Att använda systemet ska vara intuitivt och enkelt, men mer erfarna användare ska också ha tillgång till mer avancerade funktioner. Detta kräver att förvärva flera indata samt att integrera kommunikationsenheterna som är nödvändiga för att kontrollera de anslutna externa enheter. När det är möjligt vill vi behandla varje indata på ett effektivt sätt oh samtidigt minimera latenser. Det här betyder att en operation som utförs ofta skall vara så snabb och så lätt som möjligt, för att förbättra användarupplevelse även när systemet är hårt belastad. Detta projekt drar fördel av den vidsprädda tillgången till pekskärma mobila enheter för att tillföra användaren en innovativ kontroll över sin TV, direkt från sin bekanta enhet. Slutligen kommer denna plattformen att vara öppen för tredjepartsutvecklare, och som ett resultat har detta examensarbete utvecklat ett software development kit som är gjort för att vara enkelt och välbekant nog för att utvecklare ska kunna använda det och skapa applikationer med det.

Beside designing the graphical interface of mobile applications, mobile phones and their built-in sensors enable various possibilities to engage with digital content in a physical, device-based manner that move beyond the screen content. So-called mobile device-based interactions are characterized by device movements and positions as well as user actions in real space. So far, there is only little guidance available for novice designers and developers to ideate and design new solutions for specic individual or collaborative use cases. Hence, the potential for designing mobile-based interactions is seldom fully exploited. To address this issue, we propose a design kit for mobile device-based interaction techniques following a morphological approach. Overall, the kit comprises seven dimensions with several elements that can be easily combined with each other to form an interaction technique by selecting at least one entry of each dimension. The design kit can be used to support designers in exploring novel mobile interaction techniques to specic interaction problems in the ideation phase of the design process but also in the analysis of existing device-based interaction solutions.

Tissue-resident stem cells are present in many adult organs, where they are important for organ homeostasis and repair in response to injury. However, the signals that activate these cells and the mechanisms governing how these cells self-renew or differentiate are highly context dependent and incompletely understood, particularly in non-hematopoietic tissues. In the skin, melanocyte stem cells (McSCs) are responsible for replenishing mature pigmented melanocytes. In mammals, these cells reside in the hair follicle bulge and bulb niches where they are activated during homeostatic hair follicle turnover and following melanocyte destruction, as occurs in vitiligo and other skin hypopigmentation disorders. Recently, we identified adult McSCs in the zebrafish. To elucidate mechanisms governing McSC self-renewal and differentiation fates we analyzed individual transcriptomes from thousands of melanocyte lineage cells during the regeneration process. We identified transcriptional signatures for McSCs, deciphered transcriptional changes and intermediate cell states during regeneration, and analyzed cell-cell signaling changes to discover mechanisms governing melanocyte regeneration. We identified KIT signaling via the RAS/MAPK pathway as a regulator of McSC direct differentiation. Analysis of the scRNAseq dataset also revealed a population of mitfa/aox5 co-expressing cells that divides following melanocyte destruction, likely corresponding to cells that undergo self-renewal. Our findings show how different subpopulations of mitfa-positive cells underlie regeneration and differentiation of at least one subpopulation requires reactivation of developmental KIT signaling to properly reconstitute the melanocyte stripe.

På uppdrag av EQpack var projektets mål att utveckla ett koncept för en hyllvagn tänkt att användas i fabriksgolv av montörer. Hyllvagnen ska bära på kit-boxar med komponenter och ta upp mindre golvyta än befintliga hyllvagnar för kit-boxar. EQpacks idé var att till skillnad från konventionella hyllvagnar, i vilka kit-boxar placeras horisontellt till varandra och förs vidare med rullband, i stället ha hyllvagnar där kit-boxar kan placeras vertikalt i relation till varandra. Någon form av mekanism ska möjliggöra styckvis nedförsel av kit-boxar åt montören, i vilken form detta sker var föremål för utveckling i projektet. Utvecklingen av hyllvagnen skedde i fyra faser; analys och avgränsning, faktainsamling, genomförande samt utvärdering. Som förstudie har bland annat befintliga vagnar i en fabrik observerats vid arbete samt har samtal förts med de olika användarna om deras synpunkter. Under samtal med handledare sattes förväntningar, krav och avgränsningar. Genomförandet bestod av att ta fram diverse idéer och testa deras funktionsduglighet m.h.a bland annat lego. De olika koncepten analyserades och jämfördes med puhg matris. Med valda legomodellen som grund gjordes en CAD-modell med standardiserade komponenter som förslag på hur det skulle kunna konstrueras. Modellen uppmättes ta upp ca en fjärdedel av golvytan som en konventionell vagn tar. / The aim of the project was to develop a concept for a shelf trolley for EQpack, intended to be used on factory floors by assemblers. The shelf trolley must be able to carry kit boxes with components and take up less floorspace than existing shelf trolleys for kit boxes. EQpack's idea was to, unlike conventional shelf trolleys, in which kit boxes are placed next to each other horizontally and transported by conveyor belts, instead have shelf trolleys where kit boxes can be placed vertically in relation to each other. Some form of mechanism must enable piecemeal lowering of kit boxes for the assembler. How this is done was subject for development in the project. The development of the shelf trolley took place in four phases; analysis and boundaries, fact-gathering, exicution and evaluation. As a preliminary study, existing trolleys in a factory have been observed at work and discussions have been held with the various users about their views. Through discussion with supervisors the expectations, requirements and boundaries were set. The execution consisted of development of various ideas and testing their functionality with Lego. The different concepts were analyzed and compared with a puhg matrix. With the chosen Lego model as a basis, a CAD model was made with standardized components as suggestions for how a final product could be constructed. The final model was measured to take up about a quarter of the floorspace that the conventional trolley occupies.

Tesis por compendio / [ES] El melanoma es el tipo de cáncer de piel más mortífero y peligroso, ya que tumores de pequeño tamaño pueden generar metástasis. Hasta la fecha, se ha tratado de clasificar desde el punto de vista clínico, epidemiológico y molecular, empleándose actualmente el nivel de exposición solar y la localización del tumor como criterios principales para dividir en distintos grupos a los pacientes de melanoma. En 1998, David Whiteman y colaboradores propusieron un "modelo de vías divergentes" para el desarrollo del melanoma. Este presentaba dos vías: una vinculada a la proliferación melanocítica (nevogénica) y otra relacionada con la exposición solar crónica (CSD). Corroborado desde el punto de vista clínico y epidemiológico, todavía no se ha aportado una caracterización molecular en profundidad. A nivel general se habían identificado genes cuyas mutaciones eran relevantes para el desarrollo del melanoma, como por ejemplo KIT. Sin embargo, todavía se había de estudiar con más detalle la distribución de estas mutaciones entre los distintos subgrupos de melanoma, así como su posible valor pronóstico. En esta tesis se han empleado técnicas de secuenciación - masiva y tradicional - para caracterizar los perfiles mutacionales de las poblaciones del modelo de vías divergentes. Encontramos diferencias tanto en el número de mutaciones como en los genes afectados. También hemos visto cómo los melanomas con mutaciones en KIT parecen desarrollarse por una vía independiente de la etiopatogenia conocida, careciendo el estatus mutacional de este gen de valor pronóstico para la supervivencia de los pacientes. / [CA] El melanoma és el tipus de càncer de pell més mortífer i perillós, ja que fins els tumors de menor mida poden acabar generant metàstasi. Al llarg dels anys, s'ha tractat de classificar des del punt de vista clínic, epidemiològic i molecular. Les classificacions actuals utilitzen el nivell d'exposició solar i la localització tumoral per dividir en diferents grups als pacients de melanoma. Al 1998, David Whiteman i col·laboradors proposaren un model de desenvolupament del melanoma que anomenaren "model de vies divergents". Aquest presentava dos vies per la melanomagènesi: una vinculada a la proliferació melanocítica (nevogènica) i l'altra relacionada amb l'exposició solar crònica (CSD). Malgrat aquest model fou corroborat des del punt de vista clínic i epidemiològic, encara no s'ha aportat una caracterització molecular en profunditat. A nivell general s'havien identificat gens les mutacions dels quals eren rellevants per al desenvolupament del melanoma, com el gen KIT. Però, encara s'havia d'estudiar amb més cura la distribució d'estes mutacions entre els distints subgrups de melanoma, així com el seu possible valor pronòstic. En aquesta tesi s'han emprat tècniques de seqüenciació -massiva i tradicional- per caracteritzar els perfils mutacionals de les dues poblacions proposades pel model de vies divergents, trobant diferències tant al nombre de mutacions com als gens afectats. També hem vist com els melanomes mutats en KIT semblen desenvolupar-se per una via independent de l'etiopatogènia coneguda, mancant l'estatus mutacional d'aquest gen de valor pronòstic per la supervivència dels pacients. / [EN] Melanoma is the deadliest and most dangerous type of skin cancer, given that a small tumor can spread and result in metastasis. Over the years, classifications have been made either from a clinical, epidemiological or molecular point of view. Current classifications use the degree of solar exposure and tumoral location to divide into different melanoma groups. In 1998, David Whiteman and collaborators proposed the divergent pathway model for melanoma development. This presented two pathways to melanomagenesis: one related to melanocytic proliferation (nevogenic) and the other related to chronic sun exposure (CSD). Despite corroborations of this model from the clinic and epidemiology, it is yet to be molecularly characterized in depth. At a general level, different genes had been identified with relevant mutations for the development of melanoma, as is the gene KIT. However, there was a lack of knowledge on how these mutations were distributed among different melanoma subgroups, as well as the potential prognostic value. In this thesis we have implemented sequencing techniques - both massive and traditional - to characterize the mutational profile of the two populations proposed by the divergent pathways model. We found differences both in the number of mutations and in the genes carrying the mutations. We have also seen how melanomas harboring KIT mutations seem to develop in a way which is independent from the known etiology, and how the mutational status of this gene lacks prognostic value on the outcome of the patients. / Millán Esteban, D. (2022). Next-Generation Sequencing in the Identification of Biomarkers in Cutaneous Melanoma According to the Etiopathogenic Development Pathway and their Potential Clinical Relevance [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/182977 / Compendio

Web services provide organizations with a powerful infrastructure by which information and products may be distributed, but the task of supporting Web service systems can be difficult due to the complex nature of environment configuration and operation. Tools are needed to monitor and analyze such Enterprise environments so that appropriate engineering, quality control, or business activities can be pursued. This investigation resulted in the development of a software development kit, the WSLogA Framework, which is inspired by the vision of Cruz et al. (2003, 2004). The WSLogA Framework provides distributed Enterprise systems with a platform for comprehensive information capture and environment management. Five component groups are intended for employment to enable integrated workflows addressing monitoring and response activities, but these components may also be used individually to facilitate the phased integration of the WSLogA Framework into existing environments. The WSLogA Framework's design is portable across technology platforms (e.g., Java and .NET) and a variety of technologies may be substituted for the provided implementations to address unique system architectures. The WSLogA Framework supersedes existing logging and monitoring solutions in terms of both capability and intent. Applications based on the WSLogA Framework have an internal, real-time view of their operation and may adjust their environment based on the information provided by events related to their or system activities. The WSLogA Framework is intended as a software development kit around which system functionality may be organized and implemented, which makes the WSLogA Framework an architectural peer or complement to traditional application frameworks such as Spring's Web module. WSLogA Framework based systems should be envisioned as information appliance elements rather than traditionally scoped applications or services.

A wide variety of information or 'metadata' is required when undertaking dendrochronological sampling. Traditionally, researchers record observations and measurements on field notebooks and/or paper recording forms, and use digital cameras and hand-held GPS devices to capture images and record locations. In the lab, field notes are often manually entered into spreadsheets or personal databases, which are then sometimes linked to images and GPS waypoints. This process is both time consuming and prone to human and instrument error. Specialised hardware technology exists to marry these data sources, but costs can be prohibitive for small scale operations (>$2000 USD). Such systems often include proprietary software that is tailored to very specific needs and might require a high level of expertise to use. We report on the successful testing and deployment of a dendrochronological field data collection system utilising affordable off-the-shelf devices ($100-300 USD). The method builds upon established open source software that has been widely used in developing countries for public health projects as well as to assist in disaster recovery operations. It includes customisable forms for digital data entry in the field, and a marrying of accurate GPS location with geotagged photographs (with possible extensions to other measuring devices via Bluetooth) into structured data fields that are easy to learn and operate. Digital data collection is less prone to human error and efficiently captures a range of important metadata. In our experience, the hardware proved field worthy in terms of size, ruggedness, and dependability (e.g., battery life). The system integrates directly with the Tellervo software to both create forms and populate the database, providing end users with the ability to tailor the solution to their particular field data collection needs.

This study compared seven dental unit water line (DUWL) treatments and three in-office bacteria test kits. Sodium hypochlorite (NaOCl) 1:10 in tap water weekly; 3 drops of NaOCl in 1 liter of water; Dentapure® DP 40; ICX™ tablet; Sterilex® Ultra powder; Lines™; and Selective Micro® Dental-Clean. Traditional culture technique was compared to HPC Dental Sampler; Aquasafe™ Dental Unit Water Line Test Kit; and Bacteria in Water Test Kit. Eight dental units in the Virginia Commonwealth University Graduate Endodontic Clinic were randomly assigned treatment regimens. Samples were taken weekly initially and after flushing for 1 minute. In conclusion NaOCl hypochlorite 1:10 in tap water once weekly, Sterilex® Ultra, Lines™, and Selective Micro® Dental-Clean were effective at all sample times while ICX™, 3 drops of NaOCl, and Dentapure® DP 40 were only effective after 1 minute flushing. There was no significant difference between the in-office test kits and traditional culture.

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Studiens syfte är att utifrån ett genusperspektiv studera hur trumlektioner genomförs i musik- och kulturskola. Forskningsfrågor är: Vilka förutsättningar för lärande ges killar respektive tjejer i trumundervisning? Hur arbetar trumlärare med det sociala samspelet, val av undervisningsmaterial, kravställningar och förväntningar på sina elever, sett utifrån ett genusperspektiv? För att undersöka detta har tre kvalitativa intervjuer och sex deltagande videoobservationer genomförts. Tidigare studier visar bland annat att musiklärare förväntar sig en feminin och maskulin stil av sina elever, att det är svårt som tjej att positionera sig på ett sätt som utmanar den lokala genusregimen samtidigt som det är svårt att vara traditionellt feminin – måttfull och kontrollerad - när det ska spelas instrument som elbas och trumset. I föreliggande studies resultat visas trumlärarnas syn på trumundervisning men också hur de genomför sin undervisning och hur kill- och tjejelever hanteras i undervisningen. Där framkommer att lärarna i stor utsträckning anpassar undervisningen efter elevernas personligheter och individuella förutsättningar och inte efter könstillhörighet, men att trumlärarna uttrycker vissa fördomar som kan peka på att de förväntar sig att se en feminin och maskulin stil hos sina elever. Diskussion förs om problematiken i att instrument och yrken är genuskodade, vilket kan påverka elevernas förutsättningar för lärande, och om lärares eventuella fördomar samt att vi lärare måste anpassa oss efter eleverna och inte tvärtom. / The purpose of this study is to, from a gender perspectice, explore how the drum kit lessons in three music and culture schools are performed. To investigate this, three qualitative interviews and six participant video observations have been implemented. Previous studies show that music teachers expect a feminine and masculine style of their students, that it is difficult as a girl to position themselves in a way that challenges the local gender regime while it is difficult to be traditionally feminine - moderate and controlled – when playing instruments such as electric bass and drum kit. In the present studies results, drum teachers’ views on drum teaching are shown but also how they conduct their teaching, and how boy- and girl students are handled in teaching. It emerges that teachers largely adapt teaching to students’ personalities and individual circumstances and not to gender, but the drum teachers express certain prejudices which may indicate that they expect to see a feminine and masculine style of their students. There is a discussion about the problems of instruments and professions being gender-coded, which can affect students’ learning conditions, and teacher prejudices and that teachers have to adapt to the students and not vice versa.