This diploma thesis deals with the creation of engineering design of holder of projector lens. The thesis is created in cooperation with department of development in Varroc Lighting Systems, s.r.o. Initial part provides a brief description of the development of lighting technology used in car´s headlamps. The following part describes solutions currently used in clamping the lens in holder. The main part of the thesis focuses on the design of holder of projector lens itself. Projector lenses testing provide critical values of cohesive failure of the lens material, which cannot be exceed during the process of lens fitting and its subsequent clamping. In the final part the engineering design is verified and optimized using finite element analysis.

This dissertation proposes, studies and experimentally demonstrates novel liquid crystal (LC) optics to solve challenging problems in RF and photonic signal processing, freespace and fiber optic communications and microscopic imaging. These include free-space optical scanners for military and optical wireless applications, variable fiber-optic attenuators for optical communications, photonic control techniques for phased array antennas and radar, and 3-D microscopic imaging. At the heart of the applications demonstrated in this thesis are LC devices that are non-pixelated and can be controlled either electrically or optically. Instead of the typical pixel-by-pixel control as is custom in LC devices, the phase profile across the aperture of these novel LC devices is varied through the use of high impedance layers. Due to the presence of the high impedance layer, there forms a voltage gradient across the aperture of such a device which results in a phase gradient across the LC layer which in turn is accumulated by the optical beam traversing through this LC device. The geometry of the electrical contacts that are used to apply the external voltage will define the nature of the phase gradient present across the optical beam. In order to steer a laser beam in one angular dimension, straight line electrical contacts are used to form a one dimensional phase gradient while an annular electrical contact results in a circularly symmetric phase profile across the optical beam making it suitable for focusing the optical beam. The geometry of the electrical contacts alone is not sufficient to form the linear and the quadratic phase profiles that are required to either deflect or focus an optical beam. Clever use of the phase response of a typical nematic liquid crystal (NLC) is made such that the linear response region is used for the angular beam deflection while the high voltage quadratic response region is used for focusing the beam. Employing an NLC deflector, a device that uses the linear angular deflection, laser beam steering is demonstrated in two orthogonal dimensions whereas an NLC lens is used to address the third dimension to complete a three dimensional (3-D) scanner. Such an NLC deflector was then used in a variable optical attenuator (VOA), whereby a laser beam coupled between two identical single mode fibers (SMF) was mis-aligned away from the output fiber causing the intensity of the output coupled light to decrease as a function of the angular deflection. Since the angular deflection is electrically controlled, hence the VOA operation is fairly simple and repeatable. An extension of this VOA for wavelength tunable operation is also shown in this dissertation. A LC spatial light modulator (SLM) that uses a photo-sensitive high impedance electrode whose impedance can be varied by controlling the light intensity incident on it, is used in a control system for a phased array antenna. Phase is controlled on the Write side of the SLM by controlling the intensity of the Write laser beam which then is accessed by the Read beam from the opposite side of this reflective SLM. Thus the phase of the Read beam is varied by controlling the intensity of the Write beam. A variable fiber-optic delay line is demonstrated in the thesis which uses wavelength sensitive and wavelength insensitive optics to get both analog as well as digital delays. It uses a chirped fiber Bragg grating (FBG), and a 1xN optical switch to achieve multiple time delays. The switch can be implemented using the 3-D optical scanner mentioned earlier. A technique is presented for ultra-low loss laser communication that uses a combination of strong and weak thin lens optics. As opposed to conventional laser communication systems, the Gaussian laser beam is prevented from diverging at the receiving station by using a weak thin lens that places the transmitted beam waist mid-way between a symmetrical transmitter-receiver link design thus saving prime optical power. LC device technology forms an excellent basis to realize such a large aperture weak lens. Using a 1-D array of LC deflectors, a broadband optical add-drop filter (OADF) is proposed for dense wavelength division multiplexing (DWDM) applications. By binary control of the drive signal to the individual LC deflectors in the array, any optical channel can be selectively dropped and added. For demonstration purposes, microelectromechanical systems (MEMS) digital micromirrors have been used to implement the OADF. Several key systems issues such as insertion loss, polarization dependent loss, wavelength resolution and response time are analyzed in detail for comparison with the LC deflector approach. A no-moving-parts axial scanning confocal microscope (ASCM) system is designed and demonstrated using a combination of a large diameter LC lens and a classical microscope objective lens. By electrically controlling the 5 mm diameter LC lens, the 633 nm wavelength focal spot is moved continuously over a 48 [micro]m range with measured 3-dB axial resolution of 3.1 [micro]m using a 0.65 numerical aperture (NA) micro-objective lens. The ASCM is successfully used to image an Indium Phosphide twin square optical waveguide sample with a 10.2 [micro]m waveguide pitch and 2.3 [micro]m height and width. Using fine analog electrical control of the LC lens, a super-fine sub-wavelength axial resolution of 270 nm is demonstrated. The proposed ASCM can be useful in various precision three dimensional imaging and profiling applications.

Automotive radars have gained considerable interest in recent years for applications of road safety for vulnerable road users. The use of multipleinput and multiple-output (MIMO) technology in automotive radar has helped in realising a virtual aperture greater than the physical aperture of the antenna which has reduced the size of the overall radar module. But increasing the number of MIMO channels for greater angular resolution can introduce increased computational complexity, processing time and latency. A new type of radar using the multiple input multiple steered output (MIMSO) radar can alleviate these concerns by replacing the angle-FFT with beamforming by means of a lens. A double-layer lens with a beamforming layer and a radiating layer with a radiating aperture on the 2-D footprint of the lens is proposed as an antenna system for this new radar technique. This work focuses on the radiating aperture which has been realised as a travelling wave planar slotted array in gap waveguide technology due to its benefit of low losses and ease of manufacturing. A ridged gap waveguide is chosen for the reduction of the waveguide size and to avoid the appearance of grating lobes in the visible range for large scan angles. The planar slotted array is synthesised in the travelling wave configuration and reflection cancelling notches are used in the ridge to cancel the reflections from the slots. The aperture is chosen to be of a circular shape for a compact design and to maximise aperture efficiency. The planar array is verified with a full-wave simulation with a bandwidth of 76 to 81 GHz and a realised gain of 27.7 dBi at the centre frequency. The array can be scanned up to ±50◦ with a scan loss of 2.4 dBi. / Fordonsradarer har fått stort intresse under de senaste åren för tillämpningar av trafiksäkerhet för utsatta trafikanter. Användningen av MIMO-teknik (multipleinput och multiple-output) i bilradar har hjälpt till att realisera en virtuell bländaröppning som är större än antennens fysiska bländaröppning, vilket har minskat storleken på den totala radarmodulen. Men att öka antalet MIMOkanaler för större vinkelupplösning kan introducera ökad beräkningskomplexitet, bearbetningstid och latens. En ny typ av radar som använder MIMSO-radarn (multiple input multiple steered output) kan lindra dessa problem genom att ersätta vinkel-FFT med strålformning med hjälp av en lins. En dubbelskiktslins med ett strålformande skikt och ett strålande skikt med en strålande bländare på linsens 2D-fotavtryck föreslås som ett antennsystem för denna nya radarteknik. Detta arbete fokuserar på strålningsöppningen som har realiserats som en plan slitsad array i gap-vågledarteknologi på grund av dess fördel med låga förluster och enkel tillverkning. En vågledare med räfflade gap väljs för att minska vågledarstorleken och för att undvika uppkomsten av gitterlober i det synliga området för stora avsökningsvinklar. Den plana uppsättningen syntetiseras i den vandringsvågkonfigurationen och reflektionsupphävande skåror används i åsen för att eliminera reflektionerna från slitsarna. Bländaren är vald för att ha en cirkulär form för en kompakt design och för att maximera bländareffektiviteten. Planar arrayen verifieras med en helvågssimulering med en bandbredd på 76 till 81 GHz och en realiserad vinst på 27, 7 dBi vid mittfrekvensen. Arrayen kan skannas upp till ±50◦ med en skanningsförlust på 2, 4 dBi.

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Die komplexe Analysen großer Datensätze stellt in der Informationsvisualisierung eine zunehmende Herausforderung dar. Mit Hilfe von Magic Lenses wird die teilweise unübersichtliche Visualisierung dieser Datensätze lokal manipuliert und vereinfacht. Dabei spielen besonders der Umfang an Filterfunktionen und wie sie verändert werden können eine Rolle. Die Vorteile eines Multitouchdisplays im Vergleich zu herkömmlicher Maus- oder Keyboardinteraktion kommen dabei zum Einsatz. Es treten jedoch stetig Probleme bei der Adaption bisheriger Menüdesigns auf. Da Magic Lenses über Menüs parametrisiert werden sollen, stellt sich die Frage welche Menü- und Interaktionsarten besser dazu geeignet sind. In dieser Arbeit wird ein Multitouch-basiertes Kontextmenü für Magic Lenses evaluiert. Es befindet sich direkt am Linsenrand und ist kompakt jedoch neuartig. Es wird die Konkurrenzfähigkeit zu einem speziell für die Studie entworfenen und implementierten klassischen, globalen Menü getestet. Dieses ist für Nutzer vertrauter, aber distanziert sich von der Linse. Die Ergebnisse werden anschließend unter quantitativen und qualitativen Punkten zusammengefasst und ausgewertet. Es zeigt sich, dass klassische Menüs mit Touchinteraktion performanter waren. Das Multitouch-basierte Kontextmenü war allerdings bei den Probanden beliebter und wurde für die Arbeit mit Linsen bevorzugt. / The complex analysis of huge data sets is an increasing challenge in information visualization. With the help of emph{Magic Lenses} the somtimes confusing visualization of those data sets is being locally manipulated and simplified. Especially the amount of filter functions and how they can be altered matter. The advantages of multitouch displays in comparison to conventional mouse and keyboard interaction are used. However, there occur continual problems with the adaption of existing menu designs. Since emph{Magic Lenses} have to be parameterized with those menus the question arises which kind of menu and interaction are more fitting. In this work we evaluate a multitouch based context menu for emph{Magic Lenses}. It is located directly at the lens and compact but new to users. We test its competitiveness to a classical global menu specifically designed and implemented for this study. Users are more familiar with it but it is distanced from the lens. Finally, the results are summarized and analyzed under quantitative and qualitative points. It turns out that classical menus with touch interaction performed best. The multitouch-based context menu though was more popular with probands and was preferred for the work with lenses.

O objetivo do estudo foi analisar a cápsula e o epitéilo subcapsular cristaliniano (ESC) de pacientes submetidos à capsulotomia curvilínea contínua (CCC) utilizando o corante azul de tripano (AT) a 0,1%, através de microscopia óptica (MO), da técnica TUNEL, de imunohistoquímica e de microscopia eletrônica transmissão (MET). Realizamos um estudo prospectivo, controlado e randomizado utilizando 30 amostras de cápsulas e ESC obtidos de pacientes após CCC durante cirurgia de facectomia. Essas amostras foram divididas em dois grupos (15 espécimes cada) um utilizando o AT (grupo experimental) no ato cirúrgico e o outro sem o uso do corante (grupo controle). As cápsulas e o ESC destes grupos foram fixados e processados para análises estruturais posteriores com técnicas de MO de rotina, técnica TUNEL para detecção de morte celular por apoptose, imunohistoquímica para analisar a expressão da beclina-1 (um marcador de morte celular por autofagia), além de análise ultraestrutural por meio da MET. Foram realizadas análises morfométricas das imagens de microscopia após captura e digitalização, utilizando o programa Image Pró Plus (Cybernetics®, USA). Foram encontrados resultados positivos para a expressão de morte celular por apoptose e por autofagia no grupo submetido ao uso do AT, enquanto que no grupo controle os resultados foram negativos. As análises através da MET do ESC mostraram alterações em células coradas com o AT, incluindo ruptura mitocondrial, dilatação das cisternas do retículo endoplasmático, aumento da elétrondensidade citoplasmática e nuclear, e alteração no perfil nuclear. Os resultados estatísticos obtidos pelo teste de Mann-Whitney a partir da morfometria obtida de micrografias, demonstraram diferenças morfológicas significativas entre os grupos estudados, tanto nas dimensões dos maiores eixos nucleares, quanto na relação perímetro/área do núcleo celular (p=0,03). Em relação à espessura da cápsula, do epitélio subcapsular e do conjunto dessas estruturas obtidas a partir da MO de rotina não houve diferença estatisticamente significativa entre os grupos (p= 0,1). O AT provoca no ESC toxicidade celular com sinais indicativos de morte celular. Observamos nos aspectos morfológicos e moleculares morte celular tanto pelo mecanismo de apoptose quanto de autofagia. A partir destes achados podemos sugerir que a ação do AT, talvez possa ajudar a prevenir ou reduzir a opacificação da cápsula posterior do cristalino no período pós-operatório das facectomias / The purpose of this study was to evaluate the effect of trypan blue (TB) 0.1% staining on lens epithelial cells (LECs) and capsules of patients undergoing capsulorhexis using routine optical microscopy (OM), TUNEL technique, immunohistochemistry and transmission electron microscopy (TEM). In a prospective controlled and randomized study we evaluated 30 samples of capsules with LECs obtained after capsulorhexis during cataract surgery. Samples were randomly assigned to one of two groups (15 specimens each), one submitted to TB (experimental group) during the surgery and the other without the dye (control group). The capsule and the LECs of both groups were fixed and processed for later structural analysis with routine optical microscopy, immunohistochemistry for beclin-1 expression (a marker of cell death by autophagy), and the TUNEL technique to detect apoptosis, in addition to ultra-structural analysis by TEM. Morphometrical analysis were performed by using the Image Pro Plus software (Cybernetics®, USA). In the TB-stained group we have found positive results for the expression of cell death by autophagy and apoptosis while in the control group the results were negative. Analysis of LEC by TEM showed abnormalities in TB-stained cells including mitochondrial disruption, dilation of the endoplasmic reticulum cisterns, increased cytoplasmic and nuclear electron density and abnormalities in the nuclear profile. Statistical analysis using the Mann-Whitney test on morphometric data from micrographies showed significant morphologic differences between the two groups, both regarding longest nuclear axis difference and the ratio between the total nuclear perimeter and the cell area (p=0.03). No statistically significant difference was observed in capsule thickness, the LEC and the grouping of these two structures obtained from routine OM (p=0.1). Trypan blue is toxic to LECs, and cause abnormalities indicative of cell death. We observed molecular and morphologic aspects of cell death both by the mechanism of apoptosis and autophagy. Our findings lend support to the hypothesis that staining with 0.1% TB can help prevent or reduce the incidence of posterior capsule opacification following cataract surgery

<p>A previously designed lens system is constructed and characterized for possible application to engine diagnostics and 3D reconstructions of combusting flows. Since optical engines cannot be operated at the same conditions as a production engine, optical access to a production engine, with minimum changes in the engine geometry is necessary for developing a better understanding of the in-cylinder processes. The application of a probe designed to fit in the pressure transducer port of a diesel engine was demonstrated in this work. Measurement of various optical parameters established the ability of the lens system to have a good resolution over the entire stroke length of the cylinder. The temperature analysis of the probe and lens system confirmed its ability to withstand the high-temperature conditions in the engine cylinder head. The lens system design was coupled with imaging fibers to transmit images from the image plane of the probe to a high-speed camera located at a safe distance from the combusting environment. Due to the robust design of the probe and its compatibility with an imaging fiber, the probe was identified to be a good alternative as an inexpensive lens system for tomography in challenging environments. To validate its use, 3D reconstruction of a sewing pin using a range of views was demonstrated. Parameters affecting the reconstructions were identified and optimized to obtain high-quality reconstructions. </p>

Transforming growth factor beta (TGF-β) has been implicated in anterior subcapsular cataract (ASC) development. In the first section of this thesis, an in-vitro rat lens model was used to determine the role of matrix metalloproteinases during TGF-β-induced ASC. In the second part, an in-vivo TGF-β transgenic and Smad3 knockout model was used to examine the role of Smad3 signaling pathway in TGF-β-induced ASC development. Lastly, an in-vitro rat lens epithelial explant culture model was used to investigate the potential role of heat shock proteins (Hsps) in TGF-β-induced epithelial-mesenchymal transition (EMT). Optical, morphological and molecular changes were analyzed in theses studies. Results from cultured rat lenses show a significant increase of back vertex distance variability (decrease of sharpness and focus) during ASC development. Inhibition of MMPs eliminated the TGF-β-induced plaque formation. Similarly, the overexpression of TGF-β1 in transgenic mouse lenses leads to ASC formation and a decrease in lens optical quality in comparison to wild-type lenses, while TGF-β1/Smad3-/- (null) lenses show diminished TGF-β-induced effects. The plaques formed in the TGF-β1/Smad3-/- lenses are substantially smaller than in the TGF-β1/Smad3+/+ lenses. The morphological and molecular changes of TGF-β2/FGF-2 treated rat lens epithelial explants are similar to those found in the TGF-β2 treated rat lenses and transgenic TGF-β1 mouse lenses. Heat shock treatment prior to TGF-β treatment significantly reduced the effects of EMT in rat LECs. In conclusion, MMP inhibition prevented TGF-β-induced ASC formation whereas heat shock treatment and the absence of Smad3 protein expression only reduced the severity of TGF-β-induced effects.

Transforming growth factor beta (TGF-β) has been implicated in anterior subcapsular cataract (ASC) development. In the first section of this thesis, an in-vitro rat lens model was used to determine the role of matrix metalloproteinases during TGF-β-induced ASC. In the second part, an in-vivo TGF-β transgenic and Smad3 knockout model was used to examine the role of Smad3 signaling pathway in TGF-β-induced ASC development. Lastly, an in-vitro rat lens epithelial explant culture model was used to investigate the potential role of heat shock proteins (Hsps) in TGF-β-induced epithelial-mesenchymal transition (EMT). Optical, morphological and molecular changes were analyzed in theses studies. Results from cultured rat lenses show a significant increase of back vertex distance variability (decrease of sharpness and focus) during ASC development. Inhibition of MMPs eliminated the TGF-β-induced plaque formation. Similarly, the overexpression of TGF-β1 in transgenic mouse lenses leads to ASC formation and a decrease in lens optical quality in comparison to wild-type lenses, while TGF-β1/Smad3-/- (null) lenses show diminished TGF-β-induced effects. The plaques formed in the TGF-β1/Smad3-/- lenses are substantially smaller than in the TGF-β1/Smad3+/+ lenses. The morphological and molecular changes of TGF-β2/FGF-2 treated rat lens epithelial explants are similar to those found in the TGF-β2 treated rat lenses and transgenic TGF-β1 mouse lenses. Heat shock treatment prior to TGF-β treatment significantly reduced the effects of EMT in rat LECs. In conclusion, MMP inhibition prevented TGF-β-induced ASC formation whereas heat shock treatment and the absence of Smad3 protein expression only reduced the severity of TGF-β-induced effects.

Titel: “En experimentell studie om användningen av ekonomisk information vid kreditbedömning” Inledning: I de flesta företag uppstår det någon gång ett behov av att öka företagets kapital. Ett sätt för företag att öka sitt kapital är att söka kredit hos en bank. Det ställs höga krav på bankerna att de har bra underlag för att bevilja företag en kredit. Kreditbedömaren måste samla in en mängd olika informationskällor för att de ska ha möjlighet att göra en korrekt bedömning. Revisionsberättelsen är en av de informationskällor som kreditbedömare kan använda i sin kreditbedömning. Den 15 december 2016 infördes nya standarder gällande revisionsberättelsen. De nya standarderna innebär förändringar i revisionsberättelsens utseende och innehåll vilket kan ha påverkat användarnas arbete. Även tidigare erfarenhet verkar enligt tidigare studier ha en avgörande betydelse vid kreditbedömningar. Syfte: Studiens syfte är att undersöka och förstå huruvida olika informationskällor används olika i en kreditbedömning beroende på om beslutsfattaren besitter erfarenhet eller inte. Slutligen kommer studien även se till om detaljeringsgraden i revisionsberättelsen påverkar dess informationsvärde för de som ska bedöma en kredit. Metod: Genom en experimentell studiedesign har två delstudier upprättats. Den första består av en kvasiexperimentell enkät som skickats ut till både erfarna och oerfarna. I enkäten har den nya alternativt gamla revisionsberättelsen medföljt. Enkäten testar dels om bedömningen av olika informationskällor får olika utfall beroende på om respondenten har erfarenhet eller inte samt om respondenten tagit del av den nya eller gamla revisionsberättelsen. Delstudie två består av semistrukturerade intervjuer med både erfarna kreditbedömare och oerfarna studenter och innehar en deduktiv ansats. Slutsats: Det finns inga bevis på att erfarenheten påverkar om en kredit beviljas eller inte. Inte heller enskilda ekonomiska informationskällor påverkar ett beslut om kredit. Att förändra innehållet i starkt institutionaliserade dokument påverkar inte bedömningen eller beslutet vilket gjort att den nya revisionsberättelsen inte kan ses som en bidragande hjälp för personer som arbetar med kreditbedömning av företag. / Background: In most companies, there is sometimes a need to increase the company’s capital. One way for companies to increase their capital is to do a credit application in a bank. The creditor at the bank has to collect a lots of information to make it possible to do a correct assessment. One part of the information that can be used in a credit assessment is the audit report. In 15 December 2016 new standards from IAASB were introduced for the audit report. The new standards imply changes in the audit report's appearance and content, which may have affected users' daily work. Also previous experience seems, according to previous studies, to be important in credit assessments. Purpose: The purpose of the study is to investigate and to understand whether different financial information sources are used differently in a credit assessment depending on whether the decision maker has experience or not. Finally, the study will also ensure that the degree of detail in the audit report affect the information value. Method: The study has an experimental study design where two substudies have been established. The first one consists of a experimental survey sent to both experienced and inexperienced. In the survey, the new alternative to the old audit report has been included. The survey tests whether the assessment of different sources of information has different outcomes depending on whether the respondent has experience or not. It also tests whether the respondent has taken part in the new or old audit report. The second studie consists of semistructured interviews with both experienced creditors and inexperienced students and has a deductible approach. Conclusions: There is no evidence that the experience affects whether a credit is granted or not. Neither individual parts of the annual report affect the outcome of the credit. Changing the content of highly institutionalized documents does not affect the assessment or decision, which has meant that the new audit report can not be seen as a contributing help for individuals who work with creditors to companies. Keywords: The use of information in credit assessment, Credit assessment, Experience, The new audit report, The Brunswiks Lens Model.