This study was intended to investigate the nature of child labour, continued causes and effects of child labour on development initiatives, establishing the magnitude of the problem and make recommendations for intervention. It was generally established that child labour is a hindrance to developmental programmes by negatively affecting the targeted next generations. The high rate of child labour was mainly attributed to poverty, HIV/AIDS, low incomes, culture, weak laws, invisible phenomenon, population growth, armed conflict, limited access to education opportunities, employment, gender, social attitudes and ignorance, irresponsible parenthood, agriculture and orphan hood. Solutions suggested to child labour included; stronger government intervention, training and awareness raising, further research and adopting a zero-tolerance for child labour. Facilitation of the Universal Primary Education Programme to be improved and stronger bye-laws should to be adopted. / Development Studies / M. A. (Development Studies)

The aim of this thesis was to develop user interface in LabVIEW to make typical measurements with spectral analyzer HP89410A There is introduced the theory of operation of an analogue heterodyne and a digital FFT spectral analyzer. It is explained the background of the Fast Fourier Transform. There are discussed the key settings in measuring with FTT analyzer, like window function, bandwidth, number of frequency points, or the averaging. Further is described the program, which was developed for measuring frequency characteristic by white noise and by stepped measurement. It was also made a module for measuring Signal to Noise Ratio and module for Total Harmonic Distortion. In the last part of this thesis are shown the results of processed exemplar measurements.

The doctoral thesis deals with spectrum sensing and subsequent use of the frequency spectrum by multicarrier communication system, which parameters are set on the basis of the optimization technique. Adaptation settings can be made with respect to several requirements as well as state and occupancy of individual communication channels. The system, which is characterized above is often referred as cognitive radio. Equipments operating on cognitive radio principles will be widely used in the near future, because of frequency spectrum limitation. One of the main contributions of the work is the novel usage of the Kolmogorov – Smirnov statistical test as an alternative detection of primary user signal presence. The new fitness function for Particle Swarm Optimization (PSO) has been introduced and the Error Vector Magnitude (EVM) parameter has been used in the adaptive greedy algorithm and PSO optimization. The dissertation thesis also incorporates information about the reliability of the frequency spectrum sensing in the modified greedy algorithm. The proposed methods are verified by the simulations and the frequency domain energy detection is implemented on the development board with FPGA.

In my doctoral thesis I have investigated earthquake swarms from two com- pletely different tectonic areas, West Bohemia/Vogtland and Southwest Iceland, with the aim of gaining a deeper insight into the nature of earthquake swarms in diverse tectonic environments. I analysed swarm-like activities from West Bo- hemia and Southwest Iceland from the perspective of statistical characteristics (magnitude-frequency distribution, interevent time distribution), seismic moment release, and space-time distribution of events. I found that the ratio of small to large events and the event rates are similar for all the activities in both areas, while the rate of the seismic moment release is significantly higher for the South- west Icelandic swarms. Seismic moment released step by step is characterised for the West Bohemia swarms, whereas seismic moment released in one dominant short-term phase is typical of Southwest Icelandic earthquake swarms. All the West Bohemian swarms took place in a bounded focal zone Nový Kostel that is fairly complex, consisting of several fault segments. The Southwest Icelandic swarms are distributed at much larger area along the Mid Atlantic Ridge up to its branching in the Hengill triple junction, the individual swarms clearly reflect a tectonic structure of respective focal areas. I have...

<p>With 2.1 million new cases, breast cancer is the most common cancer in women. Triple negative breast cancer (TNBC), which is 15-20% of these breast cancer cases is clinically negative for expression of estrogen and progesterone receptors (ER/PR) and human epidermal growth factor receptor 2 (HER2) receptors<a>.</a> It is characterized by its unique molecular profile, aggressive behavior, distinct patterns of metastasis, and lack of targeted therapies. TNBCs utilize glycolysis for growth, proliferation, invasiveness, chemotherapeutic resistance and hence has poor therapeutic response. There is an urgent need for novel/alternate therapeutic strategies beyond current standard of treatment for this subset of high-risk patients. Electrical pulse-based chemotherapy, known as electrochemotherapy (ECT) could be a viable option for TNBC therapy. ECT involves the local application of precisely controlled electrical pulses to reversibly permeabilize the cell membrane for enhanced uptake. ECT can increase the cytotoxicity of the chemotherapeutics up-to 1000 times, facilitating a potent local cytotoxic effect. </p> <p>The high cost and severe side-effects of conventional chemotherapeutics motivate the application of effective natural compounds. Combining electrical pulses with natural compounds will enhance the treatment efficacy. This dissertation focuses on curcumin, the yellow pigment of natural herb turmeric, that has been used for over 5000 years for its excellent anticancer properties. Previous studies have demonstrated the effectiveness of curcumin for treating multiple cancers, including TNBC, with limited side effects. The potency of curcumin can be enhanced further by combining it with ECT to provide an attractive and cost-effective alternative for TNBC treatment. </p> <p>Towards this we studied the effect of ECT with curcumin on MDA-MB-231 cell line, a human adenocarcinoma epithelial TNBC cell line. We performed various assays, including cell viability, colony forming, cell cycle, apoptosis, H₂O₂ reactive oxygen species (ROS), immunoblotting, real time quantitative PCR (qPCR), and cellular metabolites detection to study the impact of ECT with curcumin on MDA-MB-231 cells. In addition, to better understand the underlying mechanisms, we used high throughput, label-free quantitative proteomics. While several studies have attempted to define the mechanism of action of curcumin on cancer cells, little is known on the action mechanism of the curcumin delivered with electrical pulses. This work unravels the molecular mechanism behind the enhanced effects observed under the ECT-based curcumin therapy in TNBC cells, employing a high-throughput, quantitative, label-free mass spectroscopy-based proteomics approach. The proteomics approach provides information on the thousands of cellular proteins involved in the cellular process, allowing a comprehensive understanding of the electro-curcumin-therapy mechanism. Similar studies were also performed for ECT with cisplatin to compare the efficacy of the electro-curcumin-therapy to the standard stand-alone cisplatin-based therapy.</p> <p>Our results revealed a switch in the metabolism from glycolysis to mitochondrial metabolic pathways. This metabolic switch caused an excessive production of H₂O₂ ROS to inflict apoptotic cell death in MDA-MB-231 cells, demonstrating the potency of this ECT based curcumin therapy. These results encourage further studies to extend the application of ECT for clinical practice.</p>

The aim of this thesis is to interconnect human tactile perception with various physical properties of materials. Tactile perception necessitates contact and relative motion between the skin and the surfaces of interest. This implies that properties such as friction and surface roughness ought to be important physical properties for tactile sensing. In this work, a method to measure friction between human fingers and surfaces is presented. This method is believed to best represent friction in tactile perception. This study is focused on the tactile perception of printing papers. However, the methodology of finger friction measurements, as well as the methodology to link physical properties with human perception data, can be applied to almost whichever material or surfaces.   This thesis is based on three articles.   In Article I, one participant performed finger friction measurements, using a piezoelectric force sensor, on 21 printing papers of different paper grades and grammage (weight of the papers). Friction coefficients were calculated as the ratio of the frictional force and the normal force, shown to have a linear relationship. The values were recorded while stroking the index finger over the surface. The results show that measurements with the device can be used to discriminate a set of similar surfaces in terms of finger friction. When comparing the friction coefficients, the papers group according to paper surface treatment and an emerging trend is that the rougher (uncoated) papers have a lower friction coefficient than the smoother (coated) papers. In the latter case, this is interpreted in terms of a larger contact between the finger and paper surface.   In addition, a decrease in friction coefficient is noted for all papers on repeated stroking, where the coated papers display a larger decrease. XPS (X-ray Photoelectron Spectroscopy) reveals that skin lipids are transferred from the finger to the paper surface, acting as a lubricant and hence decrease friction. Nevertheless, there is evidence that mechanical changes of the surface cannot be completely ruled out.   The reproducibility of the finger friction measurements is elaborated in Article II, by using many participants on a selection of eight printing papers out of the 21. The trends in friction are the same; once again, the coated papers display the highest friction. There are notably large variations in the exact value of the friction coefficient, which are tentatively attributed to different skin hydration and stroking modes.   These same participants also took part in a tactile study of perceived paper coarseness (“strävhet” in Swedish). The results reveal that the participants can distinguish a set of printing papers in terms of perceived coarseness. Not unexpectedly, surface roughness appears to be an important property related to perceived coarseness, where group data display that perceived coarseness increases with increasing surface roughness. Interestingly, friction also appears to be a discriminatory property for some subjects. A few participants showed opposite trends, which is evidence for that what is considered coarse is subjective and that different participants “weigh” the importance of the properties differently. This is a good example of a challenge when measuring one-dimensional perceptions in psychophysics.   In Article III, a multidimensional approach was used to explore the tactile perception of printing papers. To do this, the participants scaled similarity among all possible pairs of the papers, and this similarity data are best presented by a three-dimensional space solution. This means that there are three underlying dimensions or properties that the participants use to discriminate the surface feel. Also, there is a distinct perceptual difference between the rougher (uncoated) and smoother (coated) papers. The surface roughness appears to be the dominant physical property when discriminating between a real rough paper and a smooth paper, whereas friction, thermal conductivity and grammage are more important when discriminating among the smooth coated papers.

Traditionally, source coding (data compression) and channel coding (error protection) are performed separately and sequentially, resulting in what we call a tandem (separate) coding system. In practical implementations, however, tandem coding might involve a large delay and a high coding/decoding complexity, since one needs to remove the redundancy in the source coding part and then insert certain redundancy in the channel coding part. On the other hand, joint source-channel coding (JSCC), which coordinates source and channel coding or combines them into a single step, may offer substantial improvements over the tandem coding approach. This thesis deals with the fundamental Shannon-theoretic limits for a variety of communication systems via JSCC. More specifically, we investigate the reliability function (which is the largest rate at which the coding probability of error vanishes exponentially with increasing blocklength) for JSCC for the following discrete-time communication systems: (i) discrete memoryless systems; (ii) discrete memoryless systems with perfect channel feedback; (iii) discrete memoryless systems with source side information; (iv) discrete systems with Markovian memory; (v) continuous-valued (particularly Gaussian) memoryless systems; (vi) discrete asymmetric 2-user source-channel systems. For the above systems, we establish upper and lower bounds for the JSCC reliability function and we analytically compute these bounds. The conditions for which the upper and lower bounds coincide are also provided. We show that the conditions are satisfied for a large class of source-channel systems, and hence exactly determine the reliability function. We next provide a systematic comparison between the JSCC reliability function and the tandem coding reliability function (the reliability function resulting from separate source and channel coding). We show that the JSCC reliability function is substantially larger than the tandem coding reliability function for most cases. In particular, the JSCC reliability function is close to twice as large as the tandem coding reliability function for many source-channel pairs. This exponent gain provides a theoretical underpinning and justification for JSCC design as opposed to the widely used tandem coding method, since JSCC will yield a faster exponential rate of decay for the system error probability and thus provides substantial reductions in complexity and coding/decoding delay for real-world communication systems. / Thesis (Ph.D, Mathematics & Statistics) -- Queen's University, 2008-05-13 22:31:56.425

Denna rapport täcker arbetsprocessen bakom att skapa en spektrumanalysator. Läsaren kommer att få läsa om den valda metoden men även alternativa metoder. Utöver detta kommer även de teoretiska delarna bakom varje moment att undersökas samt jämföras med potentiella alternativa lösningar. Projektet har utförts på uppdrag av KA Automation. Syftet med projektet var att skapa en basplattform för analys av ljudfrekvenser. Målet med detta var att kunna identifiera ljudegenskaper i form av frekvenserna hos exempelvis servomotorer i vattenpumpar. Tanken var att i ett senare utvecklingsskede kunna identifiera om och när nya frekvenser dykt upp i ljudprofilen vilket i sådana fall kan resultera i att motorn är i behov av service. Basplattformen är uppbyggd med hjälp av C# och ljudbehandlingsbiblioteket NAudio. Från resultatet kan slutsatsen dras att detta program kan analysera ljud och visa de olika frekvensernas styrka och därmed är en lämplig basplattform för vidareutveckling. / This report will cover the work process behind creating a spectrum analyzer. The reader will be able to read about the chosen method but also the alternative methods. Apart from this the theoretical parts behind every moment will also be covered and compared to potential alternative solutions. The project has been carried out on behalf of KA Automation. The purpose of the project was to create a base for analyzing sound frequencies. The goal was to be able to identify sound properties in the form of frequencies in servo motors in for example water pumps. The idea was to be able to in a later development stage be able to identify when new frequencies have entered the audio profile which might result in the motor to be in need of service. The base is created with the help of C# and the sound library NAudio. From the result one can conclude that this program can analyze sound and display the magnitude of its frequency components and is therefore a suitable base for future development.

Tactile perception is considered an important contributor to the overall consumer experience of a product. However, what physical properties that create the specifics of tactile perception, are still not completely understood. This thesis has researched how many dimensions that are required to differentiate the surfaces perceptually, and then tried to explain these dimensions in terms of physical properties, by interconnecting human perception measurements with various physical measurements. The tactile perception was assessed by multidimensional scaling or magnitude estimation, in which methods human participants assign numbers to how similar pairs of surfaces are perceived or to the relative quantity of a specified perceptual attribute, such as softness, smoothness, coarseness and coolness. The role of friction and surface texture in tactile perception was investigated in particular detail, because typically tactile exploration involves moving (at least) one finger over a textured surface. A tactile approach for measuring friction was developed by means of moving a finger over the surfaces, mounted on a force sensor. The contribution of finger friction to tactile perception was investigated for surfaces of printing papers and tissue papers, as well as for model surfaces with controlled topography. The overarching research goal of this thesis was to study, systematically, the role of texture in tactile perception of surfaces. The model surfaces displayed a sinusoidal texture with a characteristic wavelength and amplitude, fabricated by surface wrinkling and replica molding techniques. A library of surfaces was manufactured, ranging in wavelengths from 270 nm up to 100 µm and in amplitudes from 7 nm up to 6 µm. These surfaces were rigid and cleanable and could therefore be reused among the participants. To my knowledge, this is the first time in a psychophysical experiment, that the surface texture has been controlled over several orders of magnitude in length scale, without simultaneously changing other material properties of the stimuli. The finger friction coefficient was found to decrease with increasing aspect ratio (amplitude/wavelength) of the model surfaces and also with increasing average surface roughness of the printing papers. Analytical modeling of the finger’s interaction with the model surfaces shows how the friction coefficient increases with the real contact area, and that the friction mechanism is the same on both the nanoscale and microscale. The same interaction mechanism also explains the friction characteristics of tissue paper. Furthermore, it was found that the perceptions of smoothness, coarseness, coolness and dryness are satisfactorily related to the real contact area at the finger-surface interface.  It is shown that it is possible to discern perceptually among both printing papers and tissue papers, and this differentiation is based on either two or three underlying dimensions. Rough/smooth and thin/thick were the two main dimensions of surface feel found for the printing papers, whereas friction and wavelength were strongly related to the perceptual cues employed in scaling the model surfaces. These experimental results support the duplex theory of texture perception, which holds that both a “spatial sense”; used to discriminate the roughest textures from the others, and a “vibration sense”; used to discriminate among the smoother textures, are involved. The perception of what is considered rough and smooth depends on the experimental stimulus context. It is concluded that friction is important for human differentiation of surface textures below about 10 µm in surface roughness, and for larger surface textures, friction is less important or can even be neglected. The finger friction experiments also allowed the following conclusions to be drawn: (i) The interindividual variation in friction coefficients is too large to allow direct comparison; however, the trends in relative friction coefficients for a group of participants are the same. (ii) Lipids are transferred to the test surface of study, and this lowers the friction. (iii) Many of the studies point to a characteristic frequency during sliding of about 30 Hz, which is both characteristic of the resonance frequency of skin and the expected frequency associated with the fingerprints. (iv) The applied load in surface interrogation is in fact regulated in response to the friction force. The limits in tactile perception were indirectly researched by similarity scaling experiments on the model surfaces. Wrinkle wavelengths of 760 nm and 870 nm could be discriminated from untextured reference surfaces, whereas 270 nm could not. The amplitude of the wrinkles so discriminated was approximately 10 nm, suggesting that nanotechnology may well have a role to play in haptics and tactile perception. / Taktil perception bidrar starkt till den sammantagna upplevelsen av en produkt, men hur materials olika ytegenskaper påverkar och styr perceptionen är ännu inte helt klart. Den här avhandlingen undersöker hur många och vilka egenskaper som är viktiga när känslan mellan två ytor jämförs. Tillvägagångssättet är tvärvetenskapligt där fysikaliska mätningar kopplas ihop med perceptions mätningar där människor används som instrument. Två typer av perceptionsförsök har utförts, multidimensionell skalning där försökspersoner sätter siffror på hur lika två ytor känns, samt magnitud estimation där i stället intensiteten på specifika perceptuella storheter som t.ex. upplevt lenhet, upplevd mjukhet och upplevd strävhet bedömdes. Eftersom taktil perception innebär kontakt samt relativ rörelse mellan hud och ytor, har fokus i avhandlingen varit att undersöka hur friktion och ytans struktur (ytråhet) påverkar och bidrar till den taktila perceptionen. Förutom fysikaliska mätningar på friktion och ytstruktur har värmekonduktivitet, mjukhet samt olika standard mätningar inom pappersindustrin mätts. En metod för att mäta friktion mellan ett finger och olika ytor har utvecklats för att i möjligaste mån återspegla friktionskomponenten i upplevt taktil perception. Friktionskoefficienter beräknades och jämfördes mellan alla ytor. De stimuli som har studerats är tryckpapper och mjukpapper samt modellytor, gjorda för att systematiskt undersöka hur ytstruktur påverkar perceptionen. Tillverkningsmetoden för modellytorna valdes så att ytorna var tåliga och kunde tvättas och därmed återanvändas. Strukturen på ytorna bestod av ett vågformat mönster där våglängden varierade mellan 270 nm och 100 µm och amplituden mellan 7 nm och 6 µm. Enligt vår vetskap är det första gången som strukturer i de här skalorna har gjorts utan att samtidigt ändra andra material egenskaper. Friktionskoefficienten minskade med ökad kvot mellan amplituden och våglängden på modellytorna samt med ytråheten på tryckpappren. En analytisk modell tillämpades på kontakten mellan ett finger och ytorna som visade att friktionskoefficienten beror av den verkliga kontaktarean. För de mycket grövre mjukpappren uppmättes inga stora skillnader i friktion förmodligen för att kontakarean mellan de olika mjukpapprena var lika. Den faktiska kontakarean visade sig också vara viktig för perceptionen av lenhet, strävhet, torrhet och svalhet. Det visade sig vara en stor perceptuell skillnad mellan olika typer av tryckpapper och mjukpapper utifrån hur stimuli placerade sig på en taktil karta. För de tre materialen användes enbart två alternativt tre egenskaper hos materialet för att särskilja mellan alla olika par. För tryckpapper verkade en viktig dimension kunna beskrivas av alla de perceptuella och fysikaliska egenskaper som har med kontaktarean att göra, d.v.s. lenhet, svalhet, torrhet, ytråhet, värmekonduktivitet samt friktion. För att taktilt särskilja mellan olika ytor där bara strukturen är varierade, kunde friktion och våglängden relateras till spridningen i kartan. Båda studierna stödjer duplex theory of texture perception, där ett spatialt sinne används för att särskilja en av de grövre ytorna från en slät, och ett vibrationssinne för att särskilja mellan olika släta strukturer. Friktionen visade sig alltså vara en viktig fysikalisk egenskap för strukturer under åtminstone 10 µm i ytråhet. Från fingerfriktions mätningar kunde även följande slutsatser dras: (i) Stora skillnader i friktionskoefficient mellan olika personer uppmättes, men trenderna mellan olika individer var samma, vilket gör att relativa skillnader i friktion från en individ är representativa. (ii) Lipider (fingerfett) som överförs från fingret till ytan vid kontakt sänker friktionen. (iii) Frekvensinnehållet i friktionskraften varierar mellan olika ytor och den frekvenstopp som ses vid 30 Hz kan möjligtvis bero på fingrets struktur eller resonansfrekvensen på huden. (iv) Den pålagda kraften under en friktionsmätning visar sig omedvetet regleras av den friktionskraft som fingret möter under rörelse.  Hur små strukturer som kan diskrimineras har indirekt undersökts genom likhetsförsöket på modellytorna där försökspersoner skulle bedöma hur lika alla par av ytor kändes. Resultaten visade att ytorna med våglängder på 760 nm och 870 nm upplevdes olika jämfört med referens ytor utan något systematiskt mönster, medan ytan med 270 nm i våglängd inte kunde särskiljas. Amplituden på ytan som kunde diskrimineras var endast ca 10 nm, vilket indikerar att nanoteknologi mycket väl kan bidra inom haptiken och för att i framtiden kontrollera den taktila perceptionen. / <p>QC 20121026</p>

The dissertation thesis deals with the investigation of the coexistence of GSM–EDGE and UMTS systems with focus on the physical layer of the systems. The aim is to provide a set of recommendations for practical cooperation while the systems operate in both the separated and the common radio bands. A detailed description of signal processing of both the systems on the physical layer is presented. On the basis of this description, models of both systems were created and implemented in the MATLAB environment. The simulations are focused on the physical layer quality parameters, especially the bit error ratio evaluation for various ratios of useful signal power to noise power during the transmission over the radio channel. Simulation is also used to examine the quality of received useful signal while it is interfered by signals from the same and adjacent channels. The purpose is to determine the isolation between these adjacent channels, when the bit error ratio of the useful signal does not exceed a certain reference value. The simulation results are subsequently subjected to comparison with the results of the experimental measurements in laboratory conditions. Before the measurements are carried out, a study of possible interference types is performed. Consequently, the crucial parameters of the measuring equipment used are verified. From the results of simulations and measurements, the proposal of a minimum and recommended carrier separation between both the systems is presented in order to efficiently utilize the assigned frequency spectrum. Furthermore, for the cooperation in both the separated and the common radio bands, the necessary precautions are given for reaching the required isolation and thereby inter-system interference minimization.