Introduction: There have been few well controlled altitude and hypoxic training studies to date. This thesis investigated the effects of altitude and (sham controlled) intermittent hypoxic training (IHT) on exercise capacity, and the associated physiological adaptations. Methods: Chapter 3 investigated how living and training at 2320 m or at sea level affected total haemoglobin mass (tHb) and race performance in highly trained swimmers. Chapter 4 investigated how IHT or normoxic training affected cardiopulmonary variables and the incremental exercise limit of tolerance (T-Lim), in highly trained runners. Chapter 5 investigated how single-legged IHT or normoxic training affected phosphorus-31 nuclear magnetic resonance spectroscopy assessed muscle energetics. Results: In Chapter 3, tHb increased significantly more after altitude (+0.6 ± 0.4 g•kg-1, or +4.4 ± 3.2%) than after sea level (+0.03 ± 0.1 g•kg-1, or +0.3 ± 1.0%), but the changes in swimming performances were not different between groups, and there were no correlations between tHb and performance changes. In Chapter 4, submaximal heart rate in normoxia decreased significantly more after IHT than after normoxic training (-5 ± 5 vs. -1 ± 5 b∙min-1), and submaximal "V" ̇O2 in hypoxia significantly decreased, only after IHT. T-Lim in hypoxia significantly increased post-IHT, but there were no between group differences. In Chapter 5, the phosphocreatine recovery time constant was speeded significantly more in the IHT compared to the normoxic trained leg, when tested in hypoxia (-25 ± 8% vs. -13 ± 6%), but not in normoxia (-16 ± 15% vs. -9 ± 10%). Conclusions: Altitude training likely increases tHb, but this is not necessarily associated with improved athletic performance. IHT may induce other non-haematological adaptations; potentially an enhanced skeletal muscle oxidative capacity, but evidence for exercise capacity gains is lacking. The precise underlying causes for these adaptations require further investigation, as does any translation to athletic performance.

Music that is categorized as part of the Indianist movement in American music (ca. 1890-1925) typically evokes Native American culture, ritual, story, or song through compositional gestures. It may also incorporate Native American tunes. Amy Beach (1867-1944) is considered to have composed five Indianist works, but her Theme and Variations for Flute and String Quartet, op. 80 has not been included as one of them. This thesis rethinks categorization of the piece, seeking the "Indian" in it through examination of its gestures, instrumentation, and relationship to contemporary Indianist compositions.

Les femmes diabétiques de type 2 présentent un risque cardiovasculaire (CV) plus élevé que les hommes diabétiques de type 2, mais peu d’études s’intéressent au sexe féminin dans ce contexte. L’objectif de ce doctorat était i) d’étudier les altérations CV induites par le prédiabète/diabète de type 2 dans le sexe féminin ; ii) de proposer une approche thérapeutique par le Resvératrol (RSV) chez des rates diabétiques de type 2 ; et iii) d’étudier l’effet du sexe sur les modifications physiologiques induites lors d’un prédiabète et sur la tolérance myocardique à un épisode d’ischémie-reperfusion (IR). Nous avons utilisé le rat prédiabétique induit par un régime riche en graisse et en sucre (HFS), et le rat Goto-Kakizaki (GK) diabétique de type 2. Nous avons réalisé des expériences d’imagerie, de spectroscopie par résonance magnétique in vivo et ex vivo et des analyses biochimiques. Nous avons mis en évidence un épaississement et une augmentation de la perfusion myocardiques chez les femelles HFS, ainsi qu’une forte sensibilité myocardique à un épisode d’IR, impliquant un stress oxydant exacerbé. Le RSV a induit chez les femelles GK une cardioprotection en augmentant les composés riches en énergie et les protéines de la voie du monoxyde d’azote lors d’un épisode d’IR. Enfin, il n’y a pas de dimorphisme sexuel dans la tolérance myocardique à un épisode d’IR lors d’un prédiabète, bien que le régime HFS ait induit des modifications physiologiques différentes selon le sexe. En conclusion, nous avons montré que les dysfonctions endothéliale et mitochondriale jouent un rôle important dans les complications CV associées au diabète de type 2 dans le sexe féminin. / Type 2 diabetic women have a higher cardiovascular (CV) risk than type 2 diabetic men, but few studies focus on the female sex in this context. The objective of this PhD was i) to study CV alterations induced by prediabetes/type 2 diabetes in female; ii) to propose a therapeutic approach by Resveratrol (RSV) in type 2 diabetic female; and iii) to study the effect of sex on the prediabetes-induced physiological modifications and on the myocardial tolerance to ischemia-reperfusion (IR) injury. We used the prediabetic rat induced by a high-fat high-sucrose diet (HFS), and the type 2 diabetic Goto-Kakizaki rat (GK). We performed in vivo and ex vivo cardiovascular magnetic resonance imaging and spectroscopy experiments and biochemical analyses. We highlighted myocardial thickening and increased perfusion in female HFS, as well as high myocardial sensitivity to IR involving exacerbated oxidative stress. RSV treatment of female GK induced cardioprotection by increasing the high-energy compounds and the proteins of the nitric oxide pathway during IR injury. Finally, there was no sexual dimorphism in myocardial tolerance to IR injury in prediabetes, although the HFS diet induced sex-specific physiological changes. In conclusion, we have shown that endothelial and mitochondrial dysfunctions play an important role in CV complications associated to type 2 diabetes in the female sex.

<p>Lipids and sodium (²³Na) are two essential components of the human body. They play a role in almost all biological systems. However, an increase in their levels is associated with metabolic diseases. The elevation of their contents can cause similar health disorders. Examples of prevalent disorders that share an increase of musculoskeletal lipids and ²³Na are hypertension and diabetes. However, the relationship between in vivo lipid and sodium levels in pathophysiology has not been studied enough and therefore is still unclear. Additionally, the available quantification methods to facilitate such a study may not be practical. They are either invasive, not sensitive enough, or require an impractical measurement time.</p> <p>Therefore, in this work, our aims were to develop practical in vivo methods to quantify the absolute sodium concentration as well as the concentration of each lipid component individually, and to study the correlation between them within the skeletal muscles.</p> <p>Since lipids and ²³Na have different nuclear magnetic resonance properties, their quantification by magnetic resonance (MR) techniques face different challenges. Thus, we optimized different MR spectroscopic imaging (MRSI) techniques for lipids and ²³Na. </p> <p>Our proposed proton MRSI was able to provide eight lipid fat fraction (FF) maps representing each musculoskeletal lipid component (fatty acid) detected by our MRSI technique, and demonstrated a superior sensitivity compared to the conventional MR imaging methods.</p> <p>For ²³Na, our developed ²³Na-MRSI was able to measure and map the absolute ²³Na concentration with values agreeing with those reported previously in biopsy studies, and with a high repeatability (CV < 6 %) within significantly shorter acquisition time compared to other available techniques.</p> <p> Finally, the ²³Na concentration and the fat fractions of each lipid component within healthy skeletal muscles were measured and correlated using our developed MRSI methods. Our findings suggest a positive regional relationship between ²³Na and lipids and negative correlation between ²³Na and BMI under healthy conditions.</p>

One aspect of the current revaluation of Victorian thought and literature is the examination of the crisis of religious faith, in which the proponents of doubt and denial took different directions: they became openly cynical and pessimistic; they turned from religion to an aesthetic substitute; or they concluded that since mankind could look only to itself for aid, the primary duties of the individual were to find a tenable creed for himself and to try to alleviate the lot of others. The movement from the agony of doubt to a serene, or at least calm, humanitarianism is the subject of this study. The discussion is limited to four novelists in whose work religious doubt and humanitarianism are overt and relatively consistent and in whose novels the intellectual thought of the day is translated into a form appealing to the middle-class reader. Their success is attested by contemporary criticism and by accounts of the sales of their books; although their work has had no permanent popularity, they were among the most discussed authors of their time.

No description available.

This study examines the major works of Judith Sargent Murray, Hannah Webster Foster, and Susanna Haswell Rowson, three major writers of the 1790s whose writing responds to the ideologies of the early American Republic. I suggest that Murray, Foster, and Rowson write conduct fiction which responds to the changing attitudes toward women and education after the American Revolution. Using fiction, these authors comment on the republican woman, the need for women’s education, and the necessity for women to gather in communities for support. Despite the prevailing notion that reading too many novels would corrupt young women, Judith Sargent Murray’s novella, The Story of Margaretta (1786), Hannah Webster Foster’s novels, The Coquette (1797) and The Boarding School (1798), and Susanna Rowson’s novels, Charlotte Temple (1794) and Reuben and Rachel; or, Tales of Old Times (1798), were some of the most popular books in the late eighteenth century. If these novels were not meant to be read by young women, who were the authors’ primary audience, why were they so popular? This project situates these questions in the political environment the authors were writing in to show that a relationship exists between what women were reading and how authors of conduct fiction helped facilitate the changing roles of women in the early Republic

In the production of paper, the quality of the pulp is an important factor both for the productivity and for the final quality. Reliable real-time measurements of pulp quality are therefore needed. One way is to use acoustic or vibration sensors that give information-rich signals and place the sensors at suitable locations in a pulp production line. However, these sensors are not selective for the pulp properties of interest. Therefore, advanced signal processing and multivariate calibration are essential tools. The current work has been focused on the development of calibration routes for extraction of information from acoustic sensors and on signal processing algorithms for enhancing the information-selectivity for a specific pulp property or class of properties. Multivariate analysis methods like Principal Components Analysis (PCA), Partial Least Squares (PLS) and Orthogonal Signal Correction (OSC) have been used for visualization and calibration. Signal processing methods like Fast Fourier Transform (FFT), Fast Wavelet Transform (FWT) and Continuous Wavelet Transform (CWT) have been used in the development of novel signal processing algorithms for extraction of information from vibrationacoustic sensors. It is shown that use of OSC combined with PLS for prediction of Canadian Standard Freeness (CSF) using FFT-spectra produced from vibration data on a Thermo Mechanical Pulping (TMP) process gives lower prediction errors and a more parsimonious model than PLS alone. The combination of FFT and PLS was also used for monitoring of beating of kraft pulp and for screen monitoring. When using regular FFT-spectra on process acoustic data the obtained information tend to overlap. To circumvent this two new signal processing methods were developed: Wavelet Transform Multi Resolution Spectra (WT-MRS) and Continuous Wavelet Transform Fibre Length Extraction (CWT-FLE). Applying WT-MRS gave PLS-models that were more parsimonious with lower prediction error for CSF than using regular FFT-Spectra. For a Medium Consistency (MC) pulp stream WT-MRS gave predictions errors comparable to the reference methods for CSF and Brightness. The CWT-FLE method was validated against a commercial fibre length analyzer and good agreement was obtained. The CWT-FLE-curves could therefore be used instead of other fibre distribution curves for process control. Further, the CWT-FLE curves were used for PLS modelling of tensile strength and optical parameters with good results. In addition to the mentioned results a comprehensive overview of technologies used with acoustic sensors and related applications has been performed. / Vid framställning av pappersprodukter är kvaliteten på massan en viktig faktor för produktiviteten och kvalitén på slutresultatet. Det är därför viktigt att ha tillgång till tillförlitliga mätningar av massakvalitet i realtid. En möjlighet är att använda akustik- eller vibrationssensorer i lämpliga positioner vid enhetsoperationer i massaprocessen. Selektiviteten hos dessa mätningar är emellertid relativt låg i synnerhet om mätningarna är passiva. Därför krävs avancerad signalbehandling och multivariat kalibrering. Det nu presenterade arbetet har varit fokuserat på kalibreringsmetoder för extraktion av information ur akustiska mätningar samt på algoritmer för signalbehandling som kan ge förbättrad informationsselektivitet. Multivariata metoder som Principal Component Analysis (PCA), Partial Least Squares (PLS) and Orthogonal Signal Correction (OSC) har använts för visualisering och kalibrering. Signalbehandlingsmetoderna Fast Fourier Transform (FFT), Fast Wavelet Transform (FWT) och Continuous Wavelet Transform (CWT) har använts i utvecklingen av nydanande metoder för signalbehandling anpassade till att extrahera information ur signaler från vibrations/akustiska sensorer. En kombination av OSC och PLS applicerade på FFT-spektra från raffineringen i en Termo Mechnaical Pulping (TMP) process ger lägre prediktionsfel för Canadian Standard Freeness (CSF) än enbart PLS. Kombinationen av FFT och PLS har vidare använts för monitorering av malning av sulfatmassa och monitorering av silning. Ordinära FFT-spektra av t.ex. vibrationssignaler är delvis överlappande. För att komma runt detta har två signalbehandlingsmetoder utvecklats, Wavelet Transform Multi Resolution Spectra (WT-MRS) baserat på kombinationen av FWT och FFT samt Continuous Wavelet Transform Fibre Length Extraction (CWT-FLE) baserat på CWT. Tillämpning av WT-MRS gav enklare PLS-modeller med lägre prediktionsfel för CSF jämfört med att använda normala FFT-spektra. I en annan tillämpning på en massaström med relativt hög koncentration (Medium Consistency, MC) kunde prediktioner för CSF samt ljushet erhållas med prediktionsfel jämförbart med referensmetodernas fel. Metoden CWT-FLE validerades mot en kommersiell fiberlängdsmätare med god överensstämmelse. CWT-FLE-kurvorna skulle därför kunna användas i stället för andra fiberdistributionskurvor för processtyrning. Vidare användes CWT-FLE kurvor för PLS modellering av dragstyrka samt optiska egenskaper med goda resultat. Utöver de nämnda resultaten har en omfattande litteratursammanställning gjorts över området och relaterade applikationer. / QC 20100629

Using a sociolinguistic and post-colonial approach, I analyze Irish dramas that speak about language and its connection to national identity. In order to provide a systematic and wide-ranging study, I have selected plays written at approximately fifty-year intervals and performed before Irish audiences contemporary to their writing. The writers selected represent various aspects of Irish society--religiously, economically, and geographically--and arguably may be considered the outstanding theatrical Irish voices of their respective generations. Examining works by Alicia LeFanu, Dion Boucicault, W.B. Yeats, and Brian Friel, I argue that the way each of these playwrights deals with language and identity demonstrates successful resistance to the destruction of Irish identity by the dominant language power. The work of J. A. Laponce and Ronald Wardhaugh informs my language dominance theory. Briefly, when one language pushes aside another language, the cultural identity begins to shift. The literature of a nation provides evidence of the shifting perception. Drama, because of its performance qualities, provides the most complex and complete literary evidence. The effect of the performed text upon the audience validates a cultural reception beyond what would be possible with isolated readers. Following a theoretical introduction, I analyze the plays in chronological order. Alicia LeFanu's The Sons of Erin; or, Modern Sentiment (1812) gently pleads for equal treatment in a united Britain. Dion Boucicault's three Irish plays, especially The Colleen Bawn (1860) but also Arrah-na-Pogue (1864) and The Shaughraun (1875), satirically conceal rebellious nationalist tendencies under the cloak of melodrama. W. B. Yeats's The Countess Cathleen (1899) reveals his romantic hope for healing the national identity through the powers of language. However, The Only Jealousy of Emer (1919) and The Death of Cuchulain (1939) reveal an increasing distrust of language to mythically heal Ireland. Brian Friel's Translations (1980), supported by The Communication Cord (1982) and Making History (1988), demonstrates a post-colonial move to manipulate history in order to tell the Irish side of a British story, constructing in the process an Irish identity that is postnational.

In this dissertation, I examine antagonistic relationships between women writers in the first half of the eighteenth century, focusing on the works of Delarivier Manley, Martha Fowke Sansom, Eliza Haywood, and Laetitia Pilkington. Professional rivalry among women writers represents an under-studied but vital element of the history of print culture in the early eighteenth century. I argue that the shared burden of negotiating the complicated literary marketplace did not, as critics have at times suggested, inspire women who wrote for print publication to feel for one another a sisterly benevolence. Rather, fine gradations in social class, questions of genre status and individual talent, and -- perhaps most importantly -- clashing literary ambitions spurred early eighteenth-century women writers into vicious rivalries recorded in print and driven by print culture. Women documented their literary battles in poems, in prefaces, and in autobiographical texts replete with self-justification and with attacks on former friends or disappointing patronesses. This dissertation recognizes rivalry as a crucial mode of interaction between eighteenth-century literary women and analyzes the ways in which these professional women writers labored to defend themselves not just against patriarchal pressures but against one another. In doing so, it contributes to the construction of a more complete literary history of the first half of the eighteenth century by exploring how early eighteenth-century women writers imagined their own professional lives, how they imagined the professional lives of other women, and how they therefore believed themselves influenced (or claimed themselves influenced) by the support or detraction of other women. The first two chapters of this dissertation focus on Delarivier Manley's career and writings, while the second two address the entangled writing lives of Eliza Haywood and Martha Fowke Sansom. The concluding chapter briefly examines Laetitia Pilkington's Memoirs. I investigate the way these women employed the practice of life-writing as a means of self-construction, self-promotion, and public appeal. / text