Die sich in den letzten Jahren abzeichnende Verteilung von Anwendungssystemen auf viele Rechner in Netzwerken, die sich in der Praxis unter dem Begriff Client/Server-Computing etabliert hat, brachte zwangsläufig eine Lücke im Management dieser Systeme mit sich. Es wurde schnell deutlich, daß die Verteilung der Systeme wesentlich kompliziertere Techniken benötigt, um sie zu administrieren, als man dies von zentralistischen Systemen her kannte. Anstrengungen von Standardisierungsgremien und Herstellervereinigungen führten zwar zu einer gewissen Administrierbarkeit, diese beschränkt sich aber derzeit noch weitgehend auf die beteiligten Knoten und auf die Netzkomponenten. Anwendungen, für die ja letztendlich die Rechner eingesetzt werden, sind bisher nur rudimentär in die heute vorliegenden und in der Praxis eingesetzten Managementstandards integriert. Die Anzahl der zu managenden Objekte innerhalb der Anwendungen wird aber immer größer und die Komplexität der Beziehungen unter den Objekten steigt immer mehr an. Diese Komplexität erfordert fehlertolerante Mechanismen in den Managementsystemen, über die Anwendungen administriert werden. Dieser Beitrag befaßt sich mit Mechanismen zum transaktionsgesicherten Management, wobei das Anwendungsmanagement im Vordergrund steht. Transaktionskonzepte, die vorwiegend im Datenbankbereich entwickelt wurden, werden auf die Verwendbarkeit im Management verteilter Anwendungen hin untersucht. Es wird ein neues Protokoll (Management-Transaktions-Protokoll, kurz MTAProtokoll) als Erweiterung zu SNMP vorgestellt, das die Abwicklung von verteilten Transaktionen auf Managementobjekte ermöglicht.

Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-25T10:17:54Z No. of bitstreams: 2 Tese - Omar Zina - 2013.pdf: 1884367 bytes, checksum: ac70615bb4bc9a680a17fead9dac004b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-25T12:28:09Z (GMT) No. of bitstreams: 2 Tese - Omar Zina - 2013.pdf: 1884367 bytes, checksum: ac70615bb4bc9a680a17fead9dac004b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Made available in DSpace on 2014-11-25T12:28:09Z (GMT). No. of bitstreams: 2 Tese - Omar Zina - 2013.pdf: 1884367 bytes, checksum: ac70615bb4bc9a680a17fead9dac004b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2013-09-13 / The aim of this study was to determine the solution-powder ration and to evaluate the setting time, solubility, dimensional change, pH and radiopacity of White structural and non-structural Portland cement, ProRoot MTA® and MTA BIO® associated to 2% glycolic solution of Aloe vera. Five samples of each material were used for each test according to American National Standards Institute/American Dental Association specification 57. Statistical analyses were carried out using ANOVA and Tukey’s test at 5% level of significance. When sample distribution was non-normal, nonparametric analysis of variance were performed with Kruskal-Wallis test (α=0.05). The results revealed no statistical difference in the water-powder ratio among the tested materials. ProRoot MTA® had the longest setting time (116.50 ± 4.08) (P<0.05). White structural and nonstructural Portland cements did not have means values on the radiopacity test (109.76 ± 10.40 and 118.75 ± 15.44, respectively) in accordance with ANSI/ADA, being significantly different from the MTA-based cements (P<0.05), and demonstrated higher mean solubility values (2.30 ± 0.36 and 2.81 ± 0.40, respectively) (P<0.05). The values for dimensional change of all tested materials were considered acceptable by ANSI/ADA. There were no significant differences between the mean pH values recorded for the materials (p>0.05). It was alkaline from the beginning to the end of the tests. MTA BIO presented lower setting time and lower solubility. The cements did not showed a higher solubility than 3%. All the assessed cements showed acceptable values of dimensional variation and high pH during the test time. MTA BIO and ProRoot MTA had adequate radiopacity values. / Esse estudo teve como objetivo determinar propriedades físico-químicas dos cimentos Portland branco estrutural e não estrutural, ProRoot MTA® e MTA BIO® associados à solução glicólica de Aloe vera a 2%. Após o estabelecimento da proporção pó/líquido para cada cimento, foram analisadas as propriedaes físicoquímicas: tempo de endurecimento, alteração dimensional, pH e radiopacidade. Cinco amostras de cada cimento foram usadas para cada teste, seguindo a especificação n. 57 da American National Standards Institute/American Dental Association (ANSI/ADA). A análise estatística foi realizada usando ANOVA e o teste de Tukey em nível de significância de 5%. Quando a distribuição das amostras foi não normal, a análise de variância não paramétrica foi realizada com o teste de Kruskal-Wallis (α=0,05). Os resultados não mostraram diferenças estatisticamente significantes (p>0,05) entre os cimentos em relação à proporção pó/líquido, que variou de 3,14 a 3,52 gramas. O ProRoot MTA® apresentou o tempo de endurecimento mais longo (116,50 min) e o MTA BIO® o menor (66,75 min) (p<0,05). Os cimentos Portland brancos estrutural e não estrutural apresentaram valores médios de solubilidade mais elevados (2,30 e 2,81%, respectivamente) (p<0,05). Todos os cimentos testados apresentaram valores de alteração dimensional semelhantes entre si (1,00%). O pH dos cimentos manteve-se elevado do início ao final do experimento, não havendo diferenças significantes entre os valores médios obtidos (cimento Portland branco estrutural, 11,96; cimento Portland branco não estrutural, 11,80; MTA BIO® 12,07; ProRoot MTA® 11,77) (p>0,05). Os cimentos Portland branco estrutural e não estrutural não apresentaram valores médios em conformidade com ANSI/ADA no teste de radiopacidade (109,76 e 118,75 mmAl, respectivamente), significantemente diferentes dos cimentos MTA BIO® (156,83 mmAl) e ProRoot MTA® (157,95 mmAl) (p<0,05), que apresentaram valores de densidade radiográfica acima do degrau 3 do penetrômetro de alumínio. O MTA BIO® evidenciou menor tempo de endurecimento e menor percentual de solubilidade. Nenhum cimento apresentou solubilidade maior que 3%. Todos os xiv cimentos analisados mostraram valores aceitáveis de alteração dimensional e pH elevado durante todo o período de teste. O MTA BIO® e o ProRoot MTA® apresentaram valores de radiopacidade adequados..

The thesis aims for relationship between military-caused disturbance intensity and species richness, conservation value and composition of arthropods communities in the Brdy Mts. In the Brdy abandoned military area (MTA), a highly heterogeneous habitat mosaic developed by the long-term influence of military disturbances on two shooting areas of Jordán and Tok. The habitats range from strongly disturbed sites with sparse vegetation, through heterogeneous growths of Erica and Vaccinium in moderately disturbed sites, to sparse woodlands in the least disturbed sites. Based on the shooting areas history reconstruction, 24 study plots of 4 categories of different disturbance intensity were selected in both shooting areas together. Standardized sampling of seven groups of arthropods was performed in summer 2017 by pitfall traps, yellow pan traps, and light traps. More intensive disturbances positively influenced species richness of Aculeates and conservation value of spiders and beetles, but negatively affected species richness of moths. Simultaneously, the intensity of disturbances affected community composition of spiders, moths, beetles, Aculeates and Orthopteroids. Endangered species mostly affiliated to the more intensively disturbed plots. This results should be helpful in understanding of influence...

Die sich in den letzten Jahren abzeichnende Verteilung von Anwendungssystemen auf viele Rechner in Netzwerken, die sich in der Praxis unter dem Begriff Client/Server-Computing etabliert hat, brachte zwangsläufig eine Lücke im Management dieser Systeme mit sich. Es wurde schnell deutlich, daß die Verteilung der Systeme wesentlich kompliziertere Techniken benötigt, um sie zu administrieren, als man dies von zentralistischen Systemen her kannte. Anstrengungen von Standardisierungsgremien und Herstellervereinigungen führten zwar zu einer gewissen Administrierbarkeit, diese beschränkt sich aber derzeit noch weitgehend auf die beteiligten Knoten und auf die Netzkomponenten. Anwendungen, für die ja letztendlich die Rechner eingesetzt werden, sind bisher nur rudimentär in die heute vorliegenden und in der Praxis eingesetzten Managementstandards integriert. Die Anzahl der zu managenden Objekte innerhalb der Anwendungen wird aber immer größer und die Komplexität der Beziehungen unter den Objekten steigt immer mehr an. Diese Komplexität erfordert fehlertolerante Mechanismen in den Managementsystemen, über die Anwendungen administriert werden. Dieser Beitrag befaßt sich mit Mechanismen zum transaktionsgesicherten Management, wobei das Anwendungsmanagement im Vordergrund steht. Transaktionskonzepte, die vorwiegend im Datenbankbereich entwickelt wurden, werden auf die Verwendbarkeit im Management verteilter Anwendungen hin untersucht. Es wird ein neues Protokoll (Management-Transaktions-Protokoll, kurz MTAProtokoll) als Erweiterung zu SNMP vorgestellt, das die Abwicklung von verteilten Transaktionen auf Managementobjekte ermöglicht.:1 Einleitung und Motivation S. 4 2 Anwendungsmanagement S. 6 2.1 Begriffsbestimmung S. 6 2.2 Anwendungsmanagement im SNMP-Modell S. 7 3 Allgemeine Transaktionskonzepte S. 8 3.1 ACID-Transaktionen S. 8 3.2 Concurrency Control S. 9 3.3 Logging und Recovery S. 11 4 ACID-Eigenschaften von Managementtransaktionen S. 14 5 MTA-Protokoll S. 17 5.1 Modell S. 17 5.2 Dienste und Protokolle S. 18 5.3 Concurrency Control S. 21 5.4 Logging und Recovery S. 21 5.5 Prinzipieller Protokollablauf S. 22 5.6 Nachrichteneinheiten S. 27 5.7 Protokoll-Timer S. 28 5.8 MTA-Zustandsautomaten S. 29 5.9 Logginginformation S. 32 5.10 Fehlersituationen und Wiederanlauf S. 34 5.10.1 Ausfall eines Managers S. 34 5.10.2 Ausfall eines Objektservers S. 36 5.10.3 Ausfall einer MTA-Instanz S. 38 5.10.4 Knotenausfall und Kommunikationsunterbrechung S.40 5.11 Recovery-Algorithmus S. 42 5.12 SDL-Spezifikation S. 44 6 Verwandte Arbeiten S. 46 7 Zusammenfassung und Ausblick S. 47 8 Anhang S. 50 8.1 SDL-Diagramm für Monitorprozeß S. 50 8.2 SDL-Diagramme für MTA-Koordinatorprozeß S. 51 8.2.1 SDL-Diagramm für Zustand Wait S. 51 8.2.2 SDL-Diagramm für Zustand Initiated S.52 8.2.3 SDL-Diagramm für Zustand WaitResp S. 53 8.2.4 SDL-Diagramm für Zustand Active S. 54 8.2.5 SDL-Diagramm für Zustand Preparing S. 55 8.2.6 SDL-Diagramm für Zustand Committing S. 57 8.2.7 SDL-Diagramm für Rollback S. 58

<p>This thesis looks at two sides of the same coin: how to support the production and future development at a specialist medical technology department at Danderyd Hospital. The two sides are; a pilot study of a product management system (PDM) and an interview based study on the characteristics of the silent knowledge of the technicians. The department (National respiratory centre, NRC) is facing retirement of several key employees.</p><p>The technical study shows that the success of an implementation is largely dependent on the users’ prior knowledge and use of a 3D Computer aided design system (CAD).The system itself is shown to fulfill the Lifecycle requirement of tracking the products (mostly tracheostomy tubes) but without a CAD centered workflow, some substantial education and preferably some new recruits, an implementation of the PDM system will fail. The author recommends development of the current “low-tech” system of MS Excel and Access rather than redistribute the dependency from technician towards a complex, commercial software and its vendor.</p><p>The analysis of the technicians’ silent knowledge with the newly developed method, epithet for silent knowledge (ETK), shows that the longer employment time:</p><ul><li>the more differentiated technicians become in describing their work,</li><li>practical knowledge are regarded higher and</li><li>the social and collective problem solving factors of the work becomes more important.</li></ul><p>Typically, it is shown that a new employee should preferably enjoy problem solving, being pragmatic and social as well as having some prior education or work experience in a CAD and/or a PDM system.</p>

Los cuerpos nucleares de Cajal (CBs) son estructuras nucleares implicadas en la biogénesis de ribonucleoproteínas nucleares y nucleolares de pequeño tamaño (snRNPs y snoRNPs) requeridas para el procesamiento nuclear de pre-mRNAs y pre-rRNAs, respectivamente. El CB concentra la proteína coilina, un marcador molecular de esta estructura, snRNPs, el factor de supervivencia de las neuronas motoras (SNM) y las proteínas que comparte con el nucleolo Nopp140 y fibrilarina. Los CB son estructuras dependientes de transcripción, pero los mecanismos de ensamblaje molecular de estos cuerpos nucleares son poco conocidos.En este estudio se utilizan métodos de inmunofluorescencia, expresión ectópica de proteínas del CB y métodos bioquímicos para analizar la importancia de dos modificaciones postraduccionales, la metilación de la coilina y la conjugación con SUMO1 del factor SMN para el ensamblaje molecular de los CBs. Se ha utilizado la línea celular MCF7 como un modelo de hipometilación endógena debido al déficit del gen MTAP. La hipometilación de la coilina conduce al desensamblaje de los CBs y a la relocalización nucleolar de la coilina no metilada. Este efecto revierte en células transfectadas que expresan el gen MTAPwt, indicando que el grado de metilación de la coilina marca su destino nuclear.Respecto a la importancia de la sumoilación en el ensamblaje de los CBs, hemos demostrado la existencia de un subtipo de CBs que concentran SUMO1 y la conjugasa de SUMO Ubc9. En neuronas, hemos detectado la presencia de SUMO durante la fase de reformación de CBs, en la respuesta al estrés. Los experimentos de inmunoprecipitación confirman la interacción de SUMO-1 con el factor SMN y demuestran que la lisina K119, portadora de una secuencia consenso de sumoilación, es esencial para la regulación del número de CBs. / Cajal bodies (CBs) are nuclear structures involved in the biogenesis of small nuclear and nucleolar ribonucleoproteins (snRNPs and snoRNPs) required for nuclear processing of pre-mRNAs and pre-rRNAs, respectively. CBs concentrate the protein coilin, a molecular marker of this structure, snRNPs, the survival of motor neurons factor (SMN) and proteins shared with the nucleolus Nopp140 and fibrillarin. CBs are transcription-dependent structures, but the mechanisms of molecular assembly of these structures are poorly understood.In this study we used inmunofluorescence, ectopic expresion of CB proteins and biochemical methods to analyze the importance of two posttranslational modifications, methylation of coilin and conjugation of SMN with SUMO1, for the molecular assembly of CBs. The cell line MCF7 has been used as a model of endogenous hypomethylation due to the lack of MTAP gene. Coilin hypomethylation leads to the disassembly of CBs and nucleolar relocation of unmethylated coilin. This effect reverses in transfected cells expressing the gene MTAPwt, indicating that the degree of methylation of coilin directs its nuclear destination.On the importance of sumoylation in the assembly of CBs, we have demonstrated the existence of a subset of CBs which concentrate SUMO1 and the SUMO1 conjugase Ubc9. In neurons, we detected the presence of SUMO1 during the reformation of CBs in response to stress. Immunoprecipitation experiments confirm the molecular interaction of SUMO1 with SMN and demonstrate that lysine 119, carrying the SMN sumoylation consensus sequence, is essential for regulating the number of CBs.

Microtubule targeting agents (MTAs) are chemotherapeutics commonly used in the treatment of breast, ovarian, lung, and lymphoma cancers. There are two main classes of MTAs based upon their effects on microtubule stability. The two classes are the destabilizing agents, which include the drug vincristine, and the stabilizing agents, which include paclitaxel and epothilone B. These drugs are highly effective antineoplastics, but their use is often accompanied by several side effects, one of which is peripheral neuropathy. Peripheral neuropathy can be characterized by burning pain, tingling, loss of proprioception, or numbness in the hands and feet. In some patients, the MTA-induced peripheral neuropathy is debilitating and dose-limiting; however, there are no effective prevention strategies or treatment options for peripheral neuropathy as the mechanisms mediating this side effect are unknown. The goal of this work was to investigate MTA-induced effects on neuronal activity and morphology in order to elucidate the underlying mechanisms involved in the development of MTA-induced peripheral neuropathy. As an indicator of sensory neuronal activity, the basal and stimulated release of the putative nociceptive peptide, calcitonin gene-related peptide (CGRP), was measured from sensory neurons in culture after exposure to the MTAs paclitaxel, epothilone B, and vincristine. Neurite length and branching were also measured in sensory neuronal cultures after treatment with these MTAs. The results described in this thesis demonstrate that MTAs alter the stimulated release of CGRP from sensory neurons in differential ways depending on the MTA agent employed, the CGRP evoking-stimulus used, the concentration of the MTA agent, the duration of exposure to the MTA agent, and the presence of NGF. It was also observed that MTA agents decrease neurite length and branching, independent of the concentration of NGF in the culture media. Thus, this thesis describes MTA-induced alterations of sensory neuronal sensitivity and neurite morphology and begins to elucidate the underlying mechanisms involved in MTA-induced alterations of sensory neurons. These findings will undoubtedly be used to help elucidate the mechanisms underlying MTA-induced peripheral neuropathy.

Indiana University-Purdue University Indianapolis (IUPUI) / Brasseler USA (Savannah, GA) developed and introduced a bioceramic putty called EndoSequence Root Repair Material (ERRM) that can be used as a retrofilling material for surgical endodontics. The material is said to have many of the same chemical, physical, and biological properties as mineral trioxide aggregate (MTA), but with superior handling characteristics. The material is composed of calcium silicates, monobasic calcium phosphate, zirconium oxide, tantalum oxide, proprietary fillers, and thickening agents. ERRM is said by the manufacturer to bond to adjacent dentin, have no shrinkage, be highly biocompatible, hydrophilic, radiopaque, and antibacterial due to a high pH during setting. Investigations on the sealing properties of this material have not yet been conducted. The purpose of this study was to compare the microbial leakage of Enterococcus faecalis in teeth with root-end fillings using ProRoot MTA and Brasseler’s ERRM in a dual-chamber bacterial leakage model as described by Torabinejad and colleagues. The aim of this investigation was to compare the bacterial microleakage of these two root-end filling materials exists. Sixty-two human, single-rooted, mandibular premolars in which extraction was indicated were accessed and instrumented in an orthograde fashion with hand and rotary files. Root resection of the apical 3 mm was then completed and root-end retropreparations were created for placement of root-end filling material. Twenty-seven of these premolars had root-end fillings using ProRoot MTA and 27 had root-end fillings using ERRM. Two teeth were used as a positive control group with no root-end filling, and two other teeth were used as a negative control group and were sealed and coated with dentin bonding agent. The teeth were then evaluated for microleakage using a dual-chamber bacterial microleakage model for 40 days as described by Torabinejad and colleagues. Microleakage was determined by the presence of turbidity in the lower chamber of the apparatus and was assessed each day. Fresh samples of E. faecalis were used every three days to inoculate the apparatus and serve as a bacterial challenge for the materials. Results were recorded every day for 30 days. The outcome of interest (bacterial turbidity) and time-to-leakage (in days) were determined for each of the samples. Survival analysis was used to compare the two groups with a Kaplan-Meier plot to visualize the results and a nonparametric log-rank test for the group comparison. The microleakage of ERRM was not statistically different (p > 0.05) than leakage of ProRoot MTA when subjected to E. faecalis over the 40 day observation period. Both groups had a small number of early failures (within 4 days) and no leakage was observed for the remaining 40 days of the study. Therefore, the null hypothesis was rejected. The results of this research support the use of either of these two materials when compared with the controls. The microleakage of Brasseler’s EndoSequence Root Repair Material was at least as good as ProRoot Mineral Trioxide Aggregate when tested with E. faecalis.

This thesis looks at two sides of the same coin: how to support the production and future development at a specialist medical technology department at Danderyd Hospital. The two sides are; a pilot study of a product management system (PDM) and an interview based study on the characteristics of the silent knowledge of the technicians. The department (National respiratory centre, NRC) is facing retirement of several key employees. The technical study shows that the success of an implementation is largely dependent on the users’ prior knowledge and use of a 3D Computer aided design system (CAD).The system itself is shown to fulfill the Lifecycle requirement of tracking the products (mostly tracheostomy tubes) but without a CAD centered workflow, some substantial education and preferably some new recruits, an implementation of the PDM system will fail. The author recommends development of the current “low-tech” system of MS Excel and Access rather than redistribute the dependency from technician towards a complex, commercial software and its vendor. The analysis of the technicians’ silent knowledge with the newly developed method, epithet for silent knowledge (ETK), shows that the longer employment time: the more differentiated technicians become in describing their work, practical knowledge are regarded higher and the social and collective problem solving factors of the work becomes more important. Typically, it is shown that a new employee should preferably enjoy problem solving, being pragmatic and social as well as having some prior education or work experience in a CAD and/or a PDM system.

Tesis por compendio / [ES] ¿Cómo es la atribución en un entorno de omnicanal? Se puede determinar una distinción importante en contraste con la atribución en un entorno multicanal. Además de proporcionar el proceso de análisis de marketing, una especificación del proceso estándar intersectorial para la minería de datos (CRISP¿DM), se utiliza un enfoque de método mixto secuencial para analizar la cuestión principal de la investigación. En el primer paso de esta investigación se analizan las características y los requisitos de atribución eficiente en un entorno omnicanal. A partir de entrevistas semiestructuradas con expertos y de un proceso de investigación bibliográfica holística estructurada, se identifica claramente la falta de un enfoque de atribución omnicanal. Los enfoques de atribución existentes se identifican mediante la realización de un proceso estructurado de revisión de la literatura. Estos enfoques identificados se evalúan aplicando los resultados de las entrevistas semiestructuradas con expertos, es decir, los requisitos y características de una atribución omnicanal eficiente. Ninguno de los enfoques de atribución identificados cumple con la mayoría de los requisitos de omnicanal analizados. Al tener la brecha de investigación ¿ la falta de un enfoque de atribución de omnicanales ¿ claramente identificada, se desarrolla un enfoque de atribución de omnicanales en la segunda parte de esta investigación presentada. Utilizando la metodología MAP, la principal laguna de investigación se llena proporcionando el Holistic Customer Journey (HCJ): una base de datos lista para el omni¿canal y un enfoque de atribución de omni¿canal correspondiente. Entre otras cosas, el enfoque de atribución desarrollado consiste en una clasificación de aprendizaje automático. Esta investigación presentada es la primera en utilizar información de casi 240.000.000 de conjuntos de datos de interacción, que contienen información entre dispositivos y entre plataformas. Todas las fuentes de datos subyacentes son proporcionadas por una de las plataformas inmobiliarias más grandes de Alemania. / [CA] Com és l'atribució en un entorn de omnicanal? Es pot determinar una distinció important en contrast amb l'atribució en un entorn multicanal. A més de proporcionar el procés d'anàlisi de màrqueting, una especificació del procés estàndard intersectorial per a la mineria de dades (CRISP¿DM), s'utilitza un enfocament de mètode mixt seqüencial per analitzar la qüestió principal de la investigació. En el primer pas d'aquesta investigació s'analitzen les característiques i els requisits d'atribució eficient en un entorn omnicanal. A partir d'entrevistes semiestructurades amb experts i d'un procés de recerca bibliogràfica holística estructurada, s'identifica clarament la falta d'un enfocament d'atribució omnicanal. Els enfocaments d'atribució existents s'identifiquen mitjançant la realització d'un procés estructurat de revisió de la literatura. Aquests enfocaments identificats s'avaluen aplicant els resultats de les entrevistes semiestructurades amb experts, és a dir, els requisits i característiques d'una atribució omnicanal eficient. Cap dels enfocaments d'atribució identificats compleix amb la majoria dels requisits de omnicanal analitzats. En tenir la bretxa de recerca ¿ la manca d'un enfocament d'atribució de omnicanales ¿ clarament identificada, es desenvolupa un enfocament d'atribució de omnicanales a la segona part d'aquesta investigació presentada. Utilitzant la metodologia MAP, la principal llacuna de recerca s'omple proporcionant el Holistic Customer Journey (HCJ): una base de dades a punt per al omni¿canal i un enfocament d'atribució de omni¿canal corresponent. Entre altres coses, l'enfocament d'atribució desenvolupat consisteix en una classificació d'aprenentatge automàtic. Aquesta investigació presentada és la primera a utilitzar informació de gairebé 240.000.000 de conjunts de dades d'interacció, que contenen informació entre dispositius i entre plataformes. Totes les fonts de dades subjacents són proporcionades per una de les plataformes immobiliàries més grans d'Alemanya. / [EN] What does attribution in an omni¿channel environment look like? A major distinction can be determined in contrast to attribution in a multi¿channel environment. Besides providing the Marketing Analytics Process, a specification of the Cross¿industry standard process for data mining (CRISP¿DM), a sequential mixed method approach is utilized to analyze the main research question. Within the first step of this presented research characteristics, and requirements of efficient attribution in an omni¿channel environment are analyzed. Based on semi¿structured expert interviews and a holistic structured literature research process, the lack of an omni¿channel attribution approach is clearly identified. Existing attribution approaches are identified by conducting the structured literature review process. Those identified approaches are evaluated by applying the results of the semi¿structured expert interviews - the requirements and characteristics of efficient omni¿channel attribution. None of the identified attribution approaches fulfill a majority of the analyzed omni¿channel requirements. By having the research gap - the lack of an omni¿channel attribution approach - clearly identifed, an omni¿channel attribution approach is developed in the second part of this presented research. Utilizing the MAP methodology, the main research gap is filled by providing the Holistic Customer Journey (HCJ): an omni¿channel ready data foundation and a corresponding omni¿channel attribution approach. Among other things the developed attribution approach consists of a machine learning classification. This presented research is the first to utilize information from almost 240.000.000 interaction data sets, containing crossdevice and cross¿platform information. All underlying data sources are provided by one of Germany's largest real¿estate platforms. / Nass, O. (2019). Optimizing Online Marketing Efficiency By Analyzing the Mutual Influence of Online Marketing Channels with Respect to Different Devices [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/122296 / Compendio