• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 564
  • 102
  • 25
  • 22
  • 22
  • 18
  • 15
  • 6
  • 5
  • 5
  • 5
  • 5
  • 4
  • 3
  • 1
  • Tagged with
  • 685
  • 333
  • 285
  • 192
  • 98
  • 69
  • 62
  • 60
  • 58
  • 56
  • 51
  • 46
  • 45
  • 44
  • 40
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Mastopatia fibrótica : revisão clínica, de imagem e patológica de 31 casos

Pereira, Maria Aparecida de Queiroz Freitas 06 December 2007 (has links)
Tese (doutorado)—Universidade de Brasília, Faculdade de Ciências da Saúde, 2007. / Submitted by wesley oliveira leite (leite.wesley@yahoo.com.br) on 2009-10-09T17:49:13Z No. of bitstreams: 2 Dissert_MariaAparecidaQFPereira_pag49_ate_final.pdf: 3465494 bytes, checksum: f87b689918c674f2a5698447f88e099f (MD5) Dissert_MariaAparecidaQFPereira_inicio_ate_pag48.pdf: 2111803 bytes, checksum: 31bedcbe1b4c691aa0c49b7d6a1774b8 (MD5) / Approved for entry into archive by Gomes Neide(nagomes2005@gmail.com) on 2010-07-20T12:34:05Z (GMT) No. of bitstreams: 2 Dissert_MariaAparecidaQFPereira_pag49_ate_final.pdf: 3465494 bytes, checksum: f87b689918c674f2a5698447f88e099f (MD5) Dissert_MariaAparecidaQFPereira_inicio_ate_pag48.pdf: 2111803 bytes, checksum: 31bedcbe1b4c691aa0c49b7d6a1774b8 (MD5) / Made available in DSpace on 2010-07-20T12:34:05Z (GMT). No. of bitstreams: 2 Dissert_MariaAparecidaQFPereira_pag49_ate_final.pdf: 3465494 bytes, checksum: f87b689918c674f2a5698447f88e099f (MD5) Dissert_MariaAparecidaQFPereira_inicio_ate_pag48.pdf: 2111803 bytes, checksum: 31bedcbe1b4c691aa0c49b7d6a1774b8 (MD5) Previous issue date: 2007-12-06 / Introdução: a mastopatia diabética ou mastopatia fibrótica é uma lesão benigna, pouco freqüente, normalmente associada a diabetes mellitus tipo 1 de longa duração e que clínica e radiologicamente pode simular um carcinoma. Objetivos: investigar os casos dos pacientes com diagnóstico histológico de mastopatia diabética/mastopatia fibrótica/mastopatia linfocítica com diabetes mellitus tipo 1 e tipo 2, outras doenças auto-imunes e não diabéticas. Métodos: foram analisados 31 pacientes da Unidade de Mastologia do Hospital de Base do DF e da clínica privada pessoal, a partir dos laudos histológicos das mesmas, no período de 1994 a 2007. Resultados: todos os pacientes eram do sexo feminino. A média de idade foi de 46,6 anos. O motivo mais freqüente de consulta foi de tumor em 22 pacientes (71%). Onze pacientes (35,5%) tinham mais de 12 meses de evolução e seis (19,3%) foram achados de exame. Seis pacientes (19,3%) tinham lesões não palpáveis; 15 pacientes (48,4%) tinham lesão entre 10 e 30 mm; e duas (6,4%) tinham lesão superior a 50 mm. Dez pacientes (32,2%) com ausência de patologias. Nove pacientes (29%) eram diabéticas, sendo que seis delas (19,3%) eram portadoras de diabetes tipo 2 e três (9,7%) eram portadoras de diabetes tipo 1. Três (9,7%) eram intolerantes à glicose. Sete pacientes (22,6%) tinham mastopatia fibrótica e câncer. Dessas, seis (19,3%) apresentavam câncer de mama e uma (3,2%) de tireóide. Das seis pacientes (19,3%) que tinham câncer de mama, quatro (12,9%) apresentavam alterações do metabolismo da glicose e duas (6,4%), somente câncer de mama. Duas (6,4%) eram hipotiroideas. Onze pacientes (35,5%) tiveram hipótese diagnóstica de câncer e sete (22,6%) de nódulo a esclarecer. Somente uma paciente (3,2%) teve o diagnóstico inicial correto de mastopatia diabética feito pelo mastologista com base na história clínica de diabetes mellitus de longa duração e achados clinícos. Em 20 pacientes (64,5%) houve algum grau de suspeição de malignidade. A mamografia foi compatível com mamas densas em seis pacientes (19,3%); com lesão benigna em oito (25,8%); com lesão suspeita em sete (22,6%); e em uma (3,2%) foram observadas microcalcificações suspeitas. Em 13 pacientes (41,9%) os exames de ultra-som (US) foram compatíveis com lesão benigna e em nove (29%) com lesão suspeita. Dez pacientes (32,2%) fizeram ressonância magnética (RM) com contraste, sendo três (9,7%) para diagnóstico e sete (22,6%) para seguimento de recorrência. Em sete pacientes (22,6%) o material da punção aspirativa por agulha fina (PAAF) foi insuficiente. Doze pacientes (38,7%) foram submetidas à biópsia por agulha de grosso calibre. Trinta pacientes (96,8%) foram submetidas à biópsia cirúrgica. A média do tempo de diagnóstico da mastopatia foi de 56,3 meses. Das 12 pacientes (38,7%) que tinham distúrbio do metabolismo da glicose, cinco (41,7%) tiveram o diagnóstico de diabetes mellitus após a biópsia, e nas demais a média do tempo do diagnóstico foi de 165,6 meses. Oito pacientes (25,8%) apresentaram recidiva. Foram avaliados a presença e o tipo do infiltrado lobular linfocítico, fibroblastos epitelióides, linfócitos intra-epiteliais e feito estudo imunohistoquímico para CD-20CY, CD-45RO, CD-68 e actina. Em 27 pacientes (87,1%) foi possível fazer revisão de lâminas para avaliar o infiltrado lobular linfocítico, fibroblastos epitelióides e linfócitos intra-epiteliais. Infiltrado lobular linfocítico: em 17 pacientes (63%) o resultado foi +; em sete (25,9%) foi ++; e em três (11,1%) foi +++. Fibroblastos epitelióides: em 13 pacientes (48,1%) o resultado foi +; em 11 (40,7%) foi ++; e em três (11,1%) foi +++. Linfócitos intra-epiteliais: em 13 pacientes (48,1%) estavam presentes. Em 26 pacientes (83,9%) foi feito estudo imunohistoquímico para CD-20CY e actina. CD-20CY: em 20 pacientes (76,9%) o resultado foi +; em cinco (19,2%) foi ++; e em uma (3,8%) foi +++. Actina: em duas pacientes (7,6%) o resultado foi +; em 19 (73,1%) foi ++; em cinco (19,2%) foi +++. Em 28 pacientes (90,3%) foi feito estudo para CD-45RO e em 22 (71%) para CD-68. CD-45RO: em 19 pacientes (67,9%) o resultado foi ++; e em nove (32,1%) foi +++. CD-68: em 16 pacientes (72,7%) o resultado foi +; em cinco (22,7%) foi ++; e em uma (4,5%) foi +++. Conclusões: a mastopatia fibrótica pode ocorrer tanto em pacientes diabéticas e com outras doenças auto-imunes quanto em pessoas com ausência de patologias. Encontramos oito recorrências (25,8%) e regressão da lesão em uma paciente (3,2%). Somente existe associação entre a dimensão da lesão e o motivo da consulta (p=0,0066) e há uma predominância dos linfócitos T sobre os B (p < 0,001). _____________________________________________________________________________________ ABSTRACT / Introduction: diabetic mastopathy or fibrous mastopathy is a benign lesion, infrequent, normally associated to long term type 1 diabetes mellitus. It may simulate a carcinoma on radiological and clinical examination. Objectives: to study the cases of patients with type 1 and 2 diabetes mellitus, other auto-immune diseases and non-diabetic individuals presenting with histological findings of diabetic mastopathy, lymphocytic mastopathy or fibrous mastopathy. Methods: the cases of 31 patients from the Mastology Unit at the Hospital de Base do DF and a private clinic were analyzed based on their histological findings, between 1994 and 2007. Results: all patients were female. The average age was 46.6 years. The most frequent reason for the appointment was tumor, in 22 patients (71%). Eleven patients (35.5%) had more than 12 months of tumor evolution and in six (19.3%) the lesion was found on examination. Six patients (19.3%) had non-palpable lesions; 15 (48.4%) had lesions ranging in size from 10 to 30 mm; and two (6.4%) had lesions larger than 50 mm. Ten patients (32.2%) didn’t show any other pathology. Nine patients (29%) were diabetics and among those, six (19.3%) had type 2 diabetes, three (9.7%) had type 1 diabetes. Three (9.7%) were glucose intolerant. Seven patients (22.6%) had cancer and fibrous mastopathy. Among those, six (19.3%) had mammarian cancer and one (3.2%) had thyroid cancer. Among these six patients with mammarian cancer, four (12.9%) showed glucose metabolism alterations. Two patients (6.4%) showed hypothyroidism. Eleven patients (35.5%) had a suspected cancer diagnosis and seven (22.6%) were diagnosed with nodule to be analyzed. Only one patient (3.2%) had a correct initial diagnosis of diabetic mastopathy, which was made based on the clinical history of long term diabetes mellitus and clinical findings. Twenty patients (64.5%) were suspected of having malignant tumors. The mammography was compatible with dense breasts in 6 patients (19.3%); for eight patients (25.8%) it was compatible with benign lesion; it showed a suspected lesion in seven of the patients (22.6%), and in one patient (3.2%) were observed suspicious microcalcifications. The ultrasound (US) exam was compatible with benign lesion in 13 patients (32.2%), and in nine patients (29%) it showed a suspicious lesion. Magnetic resonance imaging (MRI) was performed with contrast in 10 patients (32.2%), in seven of these patients (22.6%) it was for evaluation of relapse and in three (9.7%) it was performed for diagnosis purpose. In seven patients (22.6%), the sample collected by fine needle aspiration punction (FNAP) was insufficient. Twelve patients (38.7%) were submitted to core needle biopsy. Thirty patients (96.8%) underwent surgical biopsy. The average time for diagnosis of mastopathy was 56.3 months. Among 12 of the patients (38.7%) having glucose metabolism disorder, five (41.7%) were diagnosed after biopsy as having diabetes mellitus. For the rest of them the average time for diagnosis was 165.6 months. Eight patients (25.85) relapsed. The presence and the type of lobular lymphocytic infiltration, epithelioid fibroblasts and intraepithelial lymphocytes were evaluated and an Immunohistochemical analysis for CD-20CY, CD-45RO, CD-68 and Actin was performed. It was possible to re-examine the slides from 27 patients (87.1%) to evaluate the lobular lymphocytic infiltrated, epithelioid fibroblasts and intraepithelial lymphocytes. The lobular lymphocytic infiltrated: in 17 patients (63%) the result was +; in 7(25.9%) it was ++; and in three patients (11.1%) it was +++. Epithelioid fibroblasts: in 13 patients (48.1%) the result was +; in 11 (40.7%) it was ++; and in three patients (11.1%) it was +++. Intraepithelial lymphocytes: they were present in 13 patients (48.1%). An Immunohistochemical study was carried out in 26 patients (83.9%) for CD-20CY and actin. CD-20CY: in 20 patients (76.9%) the result was +; in five (19.2%) it was ++; and in one (3.8%) it was +++. Actin: in two patients (7.6%) the result was +; in 19 (73.1%) it was ++; and in five patients (19.2%) it was +++. A study for CD-45RO was carried out in 28 patients (90.3%), and in 22 patients (71%) for CD-68. CD-45RO: in 19 patients (67.9%) the result was ++; and in nine patients (32.1%) it was +++. CD-68: in 16 patients (72.7%) the result was +; in five (22.7%) it was ++; and in one patient (4.5%) it was +++. Conclusions: fibrous mastopathy may occur in diabetic patients and in patients with other auto-immune diseases as well as in individuals showing no other pathologies. In our findings, eight patients (25.8%) relapsed, and one (3.2%) showed regression of the lesion. There is only association between the dimension of the lesion and the reason for the appointment (p=0.0066), and there is also a prevalence of T-lymphocyte over B (p<0.001).
22

Carcinoma in situ de la mama: correlación radiológica anatomopatológica de lesiones localizadas con guía estereotaxica.

Acuña Chumpitaz, Santos January 2004 (has links)
El Objetivo del estudio fue establecer las características radiológicas y anatomopatológicas del Carcinoma in situ de la mama en pacientes evaluadas con mamografía a quienes se les realizo localización con aguja con guía estereotaxica y luego biopsia quirúrgica durante el Periodo Enero 2001 a Diciembre del 2003. En este intervalo se realizaron 706 LCA en el Servicio de Radiología del HNGAI en mujeres con sospecha de cáncer de mama por mamografía que presentaron lesiones no palpables, de los cuales 10.6%(75) correspondieron a Cáncer y 32%(24) fueron CIS de mama, siendo la edad promedio de presensación 55.16 años, correspondiendo principalmente a categoría BIRADS 4. En 95.8% se encontraron microcalcificaciones, solas 70.8% y asociadas a otros hallazgos como Distorsión asimétrica focal con menor frecuencia. Las microcalcificaciones estuvieron agrupadas en menos de 20por cm2 principalmente. La Variedad histológica mas frecuente encontrada las de tipo Mixto no Comedocarcinomas. No se encontró diferencias en cuanto al grado nuclear de los carcinomas. El Índice Pronostico de Van Nuys fue alto en 33.3%. En conclusión la incidencia de Carcinoma in situ de la mama en pacientes sometidas a LPA fue semejante a lo encontrado en estudios internacionales, presentándose como microcalcificaciones solas principalmente, agrupadas en numero menor de 20 por cm2 y correspondieron con mayor frecuencia al a la variedad histológica Mixta, de tipo no comedor carcinoma. / Tesis de segunda especialidad
23

Factores de riesgo y conocimiento sobre prevención del cáncer de mama en mujeres usuarias del C.S. Materno Infantil "Tablada de Lurín" Villa María del Triunfo 2006

Ricse Asencios, Jannet Jakeline January 2007 (has links)
En el estudio titulado “Factores de riesgo y conocimiento sobre prevención del cáncer de mama en mujeres usuarias del C.S. Materno Infantil “Tablada de Lurín” en el distrito de Villa Maria del Triunfo” ha sido realizado en la ciudad de Lima en el 2006, debido a que el cáncer de mama es considerado actualmente la neoplasia más frecuente en la mujer y la principal causa de muerte en mujeres por encima de los 40 años. Por ende es importante que todo el equipo multidisciplinario de salud trabaje con la población, enfatizando la prevención de la enfermedad con la finalidad de que los factores de riesgo disminuyan y el nivel de conocimientos aumente. El objetivo fue Determinar los factores de riesgo y conocimientos sobre medidas preventivas del cáncer de mama en usuarias del C.M.I. Tablada de Lurín en el distrito de Villa Maria del Triunfo – 2006, con el propósito de fomentar y propiciar la implementación de programas, talleres u otros preventivo promociónales que contribuyan a mejorar la calidad de vida de las personas. El diseño Metodológico estuvo enfocado un estudio cuantitativo de nivel descriptivo de corte transversal. La muestra estuvo constituida por 76 mujeres usuarias del C.M.I.T.L. entre 35 a 64 años de edad, con un promedio de 43.0 años, una desviación estándar de 8.8 y una mediana de 42.0, donde se obtuvo que, el 48.7% (37) representa al mayor grupo de mujeres que presento más de 9 factores de riesgo para el cáncer de mama, el 36.8% (28) presento alguna enfermedad benigna como factor de riesgo no modificable, un 53.9% (41) percepción de estrés como factor de riesgo modificable. En cuanto a la variable en estudio de conocimientos el 50% (38) tiene un conocimiento medio sobre las medidas preventivas del cáncer de mama. / --- In the study titled "Factors of risk and knowledge has more than enough prevention of the cancer of he/she suckles in women users of C.S. Infantile maternal "Tablada of Lurin" in the district of Villa María of the Victory" has been carried out in the city of Lima in the 2006, because the cancer of she suckles you/he/she is considered the neoplasia at the moment but I/you/he/she frequents in the woman and the main cause of death in women above the 40 years. For ende it is important that the whole multidisciplinary team of health works with the population, emphasizing the prevention of the illness with the purpose that the factors of risk diminish and the level of knowledge increases. The objective was to Determine the factors of risk and knowledge on preventive measures of the cancer of he/she suckles in users of C.M.I. Tablada of Lurin in the district of Villa María of the Victory. 2006, with the purpose of to foment and to propitiate the implementation of programs, shops or other preventive promociónales that contribute to improve the quality of people's life. The Methodological design was focused a quantitative study of descriptive level of traverse court. The sample was constituted by 76 women users of C.M.I.T.L. among 35 to 64 years of age, with a 43.0 year-old average, a standard deviation of 8.8 and a medium of 42.0, where it was obtained that, 48.7% represents (37) to the biggest group of women that I present more than 9 factors of risk for the cancer of he/she suckles, 36.8% presents (28) some benign illness as factor of non modifiable risk, 53.9% estres perception (41) like factor of modifiable risk. As for the variable in study of knowledge 50% has (38) a knowledge half envelope the preventive measures of the cancer of he/she suckles.
24

Correlación cito-histológica en tumores de mama

Acurio Zárate, David January 2004 (has links)
El cáncer de mama es la neoplasia más frecuente en la mujer, que cada día se incrementa y afecta cada vez mas a grupos etarios menores y de ahí l a importancia de un método diagnostico rápido sencillo que permita al cirujano seleccionar mejor a sus pacientes, evitar las cirugías innecesarias disminuyendo los gastos que estas conlleven y las horas hombre perdidas y determinar el estudio del cáncer y permitir administrar un tratamiento adecuado de estos pacientes , siendo uno de los beneficios principales de la técnica de aspiración es que sin anestesia se puede llegar a un diagnostico rápido y económico de lesiones mamarias en pacientes ambulatorios siendo importante evaluar cuidadosamente estos beneficios con los posibles riesgos. El “blanco” mas evidente para aspirados , son las lesiones palpables que se abordan con gran facilidad mediante la técnica en la que se emplea aguja fina y permite la obtención de material fino permitiéndole al patólogo la visualización de las estructuras celulares que permitan un adecuado diagnostico de malignidad. En nuestro Hospital se esta realizando este tipo de procedimiento utilizando la técnica con aguja fina y un porta jeringas o manija la cual esta siendo realizada por Anatomos Patólogos entrenados en el procedimiento, abarcando glándulas tiroides y tumores de partes blandas, en contraposición con los Ginecólogos Oncólogos que realizan las aspiraciones en patología mamaria utilizando agujas de 18, y 21 , sin porta jeringa o manija. Como antecedentes se tiene trabajos realizados en este Hospital en patología tiroidea utilizando la técnica de aspiración con aguja fina y manija, los resultados están dentro de los reportados a nivel internacional de falsos positivos, falsos negativos, la efectividad y sensibilidad del proceso, este trabajo permitirá evaluar la sensibilidad y especificidad utilizando la técnica utilizada por Los ginecólogos Oncólogos de esta Institución. / Tesis de segunda especialidad
25

Correlación entre características mamográficas y resultados anatomopatológicos de lesiones no palpables de pacientes con cáncer de mama : Lima-Perú

Arguedas Meza, Juan Carlos January 2012 (has links)
OBJETIVO: El objetivo principal del presente estudio es describir las características radiológicas de las lesiones no palpables de mama y determinar su relación con el estudio anatomopatológico en el Hospital Nacional Edgardo Rebagliati Martins. METODOLOGÍA: El tipo de estudio fue observacional-analítico, retrospectivo de corte transversal, cuyo número de muestra fue constituido por las historias clínicas de 159 pacientes con lesiones clínicamente no palpables detectadas por mamografía y confirmadas por biopsia quirúrgica. Se elaboro una ficha de recolección en la que se incluían las características poblacionales, mamográficas y de anatomía patológica de las pacientes. Posteriormente, se creo una base de datos sobre la cual se realizo el análisis aplicando la prueba de Chi-cuadrado y Odds Ratio, según fuera conveniente. RESULTADOS: La cantidad de pacientes estudiadas fue de 159 cuya media de edad fue de 58 +/- 7.9 años. Se hallo que 93.1% de los casos correspondían a la categoría BIRADS 4. 27% de las pacientes fueron diagnosticadas con cáncer de mama. En cuanto a las lesiones la ubicación lateral mas frecuente fue la mama izquierda (56%) sobre el cuadrante superior externo (36.5%). La lesión que se hallaba con mas frecuencia fue la microcalcificación, en 89.9% de los casos, cuya distribución se concentraba entre las de tipo lineal y grupal con 37.1% de los casos en cada una, 50% eran de tipo amorfa, 45.5% se presentaban en numero de menos de 10 por cm2. Las masas correspondían al 23.9% de los casos, la forma oval es la que mas predominaba con 34.2 % de los casos y el tamaño menor a 1 cm. con 63.2% de los casos. La distorsión de la arquitectura tenia una frecuencia del 15.1%. Se encontró una diferencia estadísticamente significativa para la prueba de Chi–cuadrado entre los casos de Efecto de masa y Cáncer de mama (p= 0.17), se calculo la asociación para estas variables con un valor de OR = 2.5 IC (<1.2; 5.5>), lo cual indica que las pacientes con evidencia mamográfica de masa tienen 2.5 veces mas riesgo de desarrollar Cáncer de mama que las que no lo presentan. CONCLUSIÓN: Se encontraron diferencias estadísticamente significativas entre los casos de efecto de masa y cáncer de mama; se calculo que existe un riesgo doblemente mayor de padecer cáncer de mama en aquellas pacientes que presentan masas en la mamografía. -- PALABRAS CLAVE: Lesiones no palpables de mama, mamografía, biopsia guiada por arpón, cáncer de mama. / - OBJECTIVE: The main objective of this study is to describe the radiological characteristics of nonpalpable breast lesions and determine their relationship to the pathology at the National Hospital Edgardo Rebagliati Martins. METHODOLOGY: The type of study was observational, analytical, retrospective cross-sectional sample whose number was established by the medical records of 159 patients with clinically non-palpable lesions detected by mammography and confirmed by surgical biopsy. A card in the collection that included population characteristics, mammography and pathology of the patients. Subsequently, I create a database on which the analysis performed using the chi-square and Odds Ratio, as appropriate. RESULTS: The number of patients studied was 159 whose average age was 58 + / - 7.9 years. It was found that 93.1% of the cases were BIRADS category 4. 27% of patients were diagnosed with breast cancer. As for the injuries the most frequent side location was the left breast (56%) on the upper outer quadrant (36.5%). The injury was most often was microcalcification in 89.9% of cases, the distribution was more concentrated among lineal and group with 37.1% of cases in each, 50% were amorphous type, 45.5% were number presented in less than 10 cm2. The masses corresponding to 23.9% of cases, the oval shape is the most prevalent that with 34.2% of cases and smaller than 1 cm. with 63.2% of cases. The architectural distortion had a frequency of 15.1%. We found a statistically significant difference for the chi-square between the cases of mass effect and breast cancer (p = 0.17), the association was calculated for these variables with a value of OR = 2.5 CI (<1.2, 5.5 >), indicating that patients with mammographic evidence of mass 2.5 times higher risk of developing breast cancer than those not present. CONCLUSION: Statistically significant differences were found between cases of mass effect and breast cancer was calculated that there is a double major risk of breast cancer in those patients with masses on the mammogram. -- KEY WORD: Nonpalpable breast lesions, mammography, harpoon guided biopsy, breast cancer. / Tesis
26

Correlación cito-histológica en tumores de mama

Acurio Zárate, David January 2004 (has links)
No description available.
27

Factores de riesgo y conocimiento sobre prevención del cáncer de mama en mujeres usuarias del C.S. Materno Infantil "Tablada de Lurín" Villa María del Triunfo 2006

Ricse Asencios, Jannet Jakeline January 2007 (has links)
En el estudio titulado “Factores de riesgo y conocimiento sobre prevención del cáncer de mama en mujeres usuarias del C.S. Materno Infantil “Tablada de Lurín” en el distrito de Villa Maria del Triunfo” ha sido realizado en la ciudad de Lima en el 2006, debido a que el cáncer de mama es considerado actualmente la neoplasia más frecuente en la mujer y la principal causa de muerte en mujeres por encima de los 40 años. Por ende es importante que todo el equipo multidisciplinario de salud trabaje con la población, enfatizando la prevención de la enfermedad con la finalidad de que los factores de riesgo disminuyan y el nivel de conocimientos aumente. El objetivo fue Determinar los factores de riesgo y conocimientos sobre medidas preventivas del cáncer de mama en usuarias del C.M.I. Tablada de Lurín en el distrito de Villa Maria del Triunfo – 2006, con el propósito de fomentar y propiciar la implementación de programas, talleres u otros preventivo promociónales que contribuyan a mejorar la calidad de vida de las personas. El diseño Metodológico estuvo enfocado un estudio cuantitativo de nivel descriptivo de corte transversal. La muestra estuvo constituida por 76 mujeres usuarias del C.M.I.T.L. entre 35 a 64 años de edad, con un promedio de 43.0 años, una desviación estándar de 8.8 y una mediana de 42.0, donde se obtuvo que, el 48.7% (37) representa al mayor grupo de mujeres que presento más de 9 factores de riesgo para el cáncer de mama, el 36.8% (28) presento alguna enfermedad benigna como factor de riesgo no modificable, un 53.9% (41) percepción de estrés como factor de riesgo modificable. En cuanto a la variable en estudio de conocimientos el 50% (38) tiene un conocimiento medio sobre las medidas preventivas del cáncer de mama. / In the study titled "Factors of risk and knowledge has more than enough prevention of the cancer of he/she suckles in women users of C.S. Infantile maternal "Tablada of Lurin" in the district of Villa María of the Victory" has been carried out in the city of Lima in the 2006, because the cancer of she suckles you/he/she is considered the neoplasia at the moment but I/you/he/she frequents in the woman and the main cause of death in women above the 40 years. For ende it is important that the whole multidisciplinary team of health works with the population, emphasizing the prevention of the illness with the purpose that the factors of risk diminish and the level of knowledge increases. The objective was to Determine the factors of risk and knowledge on preventive measures of the cancer of he/she suckles in users of C.M.I. Tablada of Lurin in the district of Villa María of the Victory. 2006, with the purpose of to foment and to propitiate the implementation of programs, shops or other preventive promociónales that contribute to improve the quality of people's life. The Methodological design was focused a quantitative study of descriptive level of traverse court. The sample was constituted by 76 women users of C.M.I.T.L. among 35 to 64 years of age, with a 43.0 year-old average, a standard deviation of 8.8 and a medium of 42.0, where it was obtained that, 48.7% represents (37) to the biggest group of women that I present more than 9 factors of risk for the cancer of he/she suckles, 36.8% presents (28) some benign illness as factor of non modifiable risk, 53.9% estres perception (41) like factor of modifiable risk. As for the variable in study of knowledge 50% has (38) a knowledge half envelope the preventive measures of the cancer of he/she suckles.
28

Hallazgos radiológicos según clasificación BI-RADS en la primera mamografía de tamizaje en pacientes atendidas en el Servicio de Mamografía de la Unidad Básica de Atención Primaria UBAP Zárate - EsSalud 2016

Andia Condori, Noelia Corina January 2018 (has links)
Publicación a texto completo no autorizada por el autor / Determina los hallazgos radiológicos según clasificación BI-RADS en la primera mamografía de tamizaje en pacientes atendidas en el servicio de mamografía del UBAP Zárate – EsSalud, de enero a setiembre del 2016. Realiza una investigación de tipo observacional y descriptiva. Es retrospectivo y de acuerdo al periodo y secuencia del estudio es transversal. Se utiliza como instrumento la hoja de recolección de datos para la recopilación de información proveniente de las fichas de factores de riesgo e informes mamográficos que cumplieron los criterios de selección. En el instrumento se registraron los datos ginecológicos y hallazgos radiológicos de las mamografías. Se estudiaron 183 fichas de factores de riesgo e informes mamográficos de pacientes que en su mayoría fueron adultas mayores de 50 años, con una edad media de 56. Presentaron menarquía entre los 12 y 15 años y el 71% se encontraba en la menopausia. Los hallazgos radiológicos con mayor frecuencia fueron las calcificaciones con el 56%, seguido de los nódulos representado por el 37%, la asimetría focal con el 6% y la distorsión de arquitectura presentó sólo el 1%. La categoría con mayor frecuencia fue el BI-RADS 2 con del 47%, seguido del BIRADS 1 con el 43%, el BI-RADS 3 presentó el 10% y para el BI-RADS 4 y BIRADS 5 el 0% de casos. Los nódulos y las calcificaciones en su mayoría fueron clasificados como BI-RADS 2, mientras que la distorsión de arquitectura y la asimetría focal en la totalidad pertenecieron a la categoría BI-RADS 3. Concluye que las calcificaciones pertenecientes a la clasificación BI-RADS 2 es el hallazgo radiológico con mayor frecuencia, en la primera mamografía de tamizaje en pacientes atendidas en el servicio de mamografía del UBAP Zárate – EsSalud durante los meses de enero a setiembre del 2016. / Tesis
29

Caracterização dos efeitos antitumorais de compostos derivados do ácido anacárdico em linhagens celulares de adenocarcinoma de mama / Characterization of the antitumoral effects of anacardic acid derivatives in breast cancer cell lines

Sampaio, Erika Pereira 31 March 2015 (has links)
Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2015. / Submitted by Marília Freitas (marilia@bce.unb.br) on 2015-11-04T13:43:12Z No. of bitstreams: 1 2015_ErikaPereiraSampaio.pdf: 2604363 bytes, checksum: 330c5f79fff86de8706b10db7f0c723e (MD5) / Approved for entry into archive by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br) on 2016-01-13T12:38:03Z (GMT) No. of bitstreams: 1 2015_ErikaPereiraSampaio.pdf: 2604363 bytes, checksum: 330c5f79fff86de8706b10db7f0c723e (MD5) / Made available in DSpace on 2016-01-13T12:38:03Z (GMT). No. of bitstreams: 1 2015_ErikaPereiraSampaio.pdf: 2604363 bytes, checksum: 330c5f79fff86de8706b10db7f0c723e (MD5) / O câncer de mama é o tipo de câncer que mais acomete mulheres em todo o mundo. Muitas drogas tem sido estudadas como potenciais terapias para este tipo de câncer, incluindo agonistas de PPARγ e anti-inflamatórios não-esteróides. A partir do ácido anacárdico, um lipídeo fenólico do líquido da casca da castanha de caju com características anti-inflamatórias, foram sintetizados diferentes agonistas parciais de PPARγ. O objetivo deste trabalho foi investigar o efeito de novos derivados do ácido anacárdico, previamente descritos como agonistas parciais de PPARγ, na viabilidade, proliferação, ciclo celular e migração de células tumorais de mama. Células MDA-MB-231 e MCF-7, células mononucleares do sangue periférico e células epiteliais de mama MCF-10 foram tratadas com os compostos derivados de ácido anacárdico e comparados com o controle (células sem tratamento). Ensaios para avaliar viabilidade (MTT), proliferação (ensaio clonogênico e CFSE), ciclo celular (PI), migração (wound healing) e apoptose (anexina/PI) foram realizados em células MDA-MB-231. Além disso, também investigamos a ocorrência de alteração na produção de ROS e NO, na biogênese de corpúsculos lipídicos e na expressão de 5LO, NFkB e PPARγ nesta linhagem celular após estímulo com os compostos LDT11, LDT13, LDT380 e LDT383. Após o tratamento com o composto LDT13, foi observada uma redução significativa na viabilidade de MCF-7 e MDA-MB-231, assim como diminuição na proliferação, enquanto a viabilidade de MCF-10 não foi afetada. O tratamento com os compostos LDT11, LDT13, LDT380 e LDT383 reduziram a viabilidade, aumentaram a apoptose, reduziram a proliferação e migração de MDA-MB-231 e promoveram alterações no ciclo celular. Os compostos LDT13 e LDT383 aumentaram a expressão de PPARγ, enquanto LDT11 e LDT380 não o fizeram. O composto LDT13 aumentou a produção de ROS e NO, reduziu a expressão de 5LO, e promoveu a translocação de NFκB para o núcleo em algumas células. Nossos dados sugerem que o composto LDT13 pode ser um candidato para testes clínicos e um agente terapêutico promissor para o tratamento de câncer de mama. / Breast cancer is the type of cancer that affects more women in the world. Many drugs have been studied as potential therapies for this type of cancer, including PPARγ agonists and nonsteroidal anti -inflammatory drugs. From the anacardic acid, an phenolic lipid of the cashew nutshell liquid with anti-inflammatory properties, were synthesized different partial agonists of PPARγ. The aim of this study was to investigate the effects of new anacardic acid derivatives, which were previously described as PPARγ partial agonists, on breast cancer cell lines viability, proliferation, cell cycle and migration. MDA-MB-231 and MCF-7 breast cancer cell-lines and nontumorigenic PBMCs and MCF-10 human mammary epithelial cells were treated with anacardic acid derivatives and compared with negative control (without treatment). Assays to evaluate viability (MTT), proliferation (CFSE and clonogenic assay), cell cycle (PI), migration (wound healing) and apoptosis (annexin v/ PI) were performed in MDA-MB-231. Moreover, we analyzed de occurrence of alterations in the production of ROS and NO, lipid bodies biogenesis, and 5LO, NFkB and PPARγ expression after treatment with LDT11, LDT13, LDT380 and LDT383. After treatment with the compound LDT13, we observed a significant reduction in MCF-7 and MDA-MB-231 viability, as well as a decrease in proliferation and cell cycle alterations, while MCF-10 viability was not affected. The treatment with the drugs LDT11, LDT13, LDT380 and LDT383 reduced viability, increased apoptosis, reduced proliferation and migration of MDA-MB-231 cells and promoted cell cycle alterations. LDT13 and LDT383 increased the expression of PPARγ, while LDT11 and LDT380 did not. LDT13 increased the production of ROS and NO, reduced the expression of 5LO, and promoted the translocation of NFκB in some cells. Our data suggest that new anacardic acid derivative LDT13 may be a strong candidate for breast cancer clinical trials and a promising therapeutic agent.
30

Relação do Color Doppler e Power Doppler com densidade micro vascular intra tumoral corada com o anticorpo CD34 no câncer de mama /

Komatsu, Moisés Yoshifumi. January 2004 (has links)
Orientador: José Ricardo P. Rodrigues / Resumo: O aumento progressivo nas últimas décadas na incidência do câncer de mama é um fato que assola a humanidade, entretanto, as taxas de mortalidade tendem ao decréscimo em virtude da detecção precoce através de métodos de rastreio não invasivos, e do conhecimento cada vez maior do comportamento biológico do tumor. A maior adesão aos meios de rastreamento existentes hoje, deve-se não apenas ao medo que o câncer provoca nas mulheres, mas também ao fato dos exames utilizados para este rastreio não serem invasivos. Infelizmente, ainda não existem métodos capazes de dar indícios do comportamento biológico do tumor de forma instantânea, sem que haja a necessidade de submeter as pacientes portadoras de tumores malignos da mama a procedimentos cirúrgicos. Desde o início da última década do século XX, tem-se estudado a angiogênese do tumor através da ultra-sonografia, utilizando-se dos recursos de Color Doppler e Power Doppler. Neste trabalho, realizado no Hospital Santa Marcelina de Itaquaquecetuba, em conjunto com a Disciplina de Mastologia da Faculdade de Medicina de Botucatu - UNESP, foram estudadas trinta e cinco pacientes com tumores malignos da mama, onde os parâmetros hemodinâmicos (Índice de Resistência, Índice de Pulsatibilidade e a Velocidade Máxima no Pico Sistólico) através do Color Doppler... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Although a progressive increase in the incidence of breast cancer is a fact that plagues mankind, mortality rates tend to decrease given precocious detection using non-invasive tracking methods and an ever-growing knowledge of tumoral biological behaviour. The current large adhesion to tracking methods is explained not only by the fear cancer raises in women but also to the use of non-invasive exams. Unfortunately, there are no methods capable of giving instantaneous indication of tumoral biological behaviour without submitting patients with malignant tumors to surgical procedure. Since the early nineties and now at the dawn of the 21st Century, the angiogenesis of the tumor is being studied with the help of Color Doppler and Power Doppler ultrasonography. In this research - carried out at Santa Marcelina Hospital in Itaquaquecetuba in cooperation with the Department of Mastology of the Botucatu Medical School, São Paulo State University, thirty five patientes with mammary malignat tumors were... (Complete abstract click electronic access below) / Mestre

Page generated in 0.4399 seconds