Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-07-15T17:11:17Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) PDF FINAL.pdf: 3656140 bytes, checksum: 3e0d3d7208e1250139b33b911f613e68 (MD5) / Made available in DSpace on 2016-07-15T17:11:17Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) PDF FINAL.pdf: 3656140 bytes, checksum: 3e0d3d7208e1250139b33b911f613e68 (MD5) Previous issue date: 2016-02-26 / O Brasil tem dificuldades na implementação de suas políticas, em parte, agravadas pela lógica federalista. O estudo trata das dificuldades de implantação da Política Estadual de Resíduos Sólidos (PERS) no Agreste Meridional de Pernambuco (AMP). A problemática foi abordada em uma perspectiva complexa, considerando os aspectos econômicos, sociais e ambientais, usados como indicadores de caracterização do Agreste Meridional de Pernambuco. Esta região foi escolhida por ser pioneira na implementação da política no interior. O objetivo geral deste estudo foi investigar as dificuldades de implementação da PERS nas Regiões de Desenvolvimento (RD) do AMP, considerando aspectos da interiorização no federalismo. Especificamente objetivou-se caracterizar, socioeconômica e ambientalmente, os municípios do AMP, identificar os municípios do AMP que implementaram o Plano de Gestão de Resíduos Sólidos (PGRS) e demais instrumentos, qualificando as dificuldades de implementação; identificar o destino final dos resíduos e implementação dos demais objetivos da PERS cumpridos, nos municípios do AMP, além de qualificar as dificuldades de implementação. Para isto foram analisados os objetivos e instrumentos da política, de dados amostrais de entrevistas com secretários ambientais de Garanhuns, Lajedo, Correntes e Bom Conselho, os PGRS e realizadas visitas aos aterros sanitários desses municípios, os dados relativos a caracterização do Agreste Meridional de Pernambuco, a existência dos PGRS e o destino final dos resíduos sólidos e dados amostrais quanto à implantação dos objetivos e instrumentos da política. Concluímos que a política não se mostrou prioritária para o Estado, que tem dificuldades no propósito de implementação da Política Nacional de Resíduos Sólidos, compartilhando responsabilidades e transferindo o ônus da implementação para os municípios, condicionando a transferência de recursos ao dispositivo fiscal, acarretando dificuldades econômicas, principalmente para os municípios mais pobres. Foi confirmada a hipótese de que a distância entre os municípios e a capital do estado, sob uma ótica operacional federalista, agrava as dificuldades técnicas, econômicas, fiscais e políticas da implementação da Política Nacional de Resíduos Sólidos no Agreste Meridional de Pernambuco. / Brazil has difficulty in implement its policies, in part exacerbated by the federalist logic. The study deals with the implementation difficulties of Solid Waste State Policy (PERS) in the Agreste Meridional of Pernambuco (AMP) aggravated by federalism. The issue was addressed in a complex perspective, considering the economic, social and environmental aspects used as the South Agreste characterization of indicators of Pernambuco. This region was chosen for being a pioneer in the implementation of policy on the inside. The aim of this study was to investigate the difficulties of implementation of PERS in the Development Region (RD) of the AMP, considering aspects of the internalization in federalism. Specifically aimed to characterize, socioeconomic and environmentally, municipalities of the AMP, to identify AMP municipalities that implemented the Solid Waste Management Policy (PGRS) and other instruments, describing the difficulties of implementation; identify the final destination of waste and implementation of the remaining PERS objectives met in the districts of AMP, in addition to qualifying the difficulties of implementation. Were analyzed the objectives and instruments of policy, through data from interview with environmental secretaries of Garanhuns, Lajedo, Correntes and Bom Conselho, the Solid Waste Management Plans and visits to landfills in these municipalities, data of the characterization the AMP region, the existence of the PGRS and the final destination of solid waste and sample data for the implementation of the objectives and instruments of policy. We conclude that the policy was not a priority for the State, which has difficulties in the way of implementation of the National Solid Waste Policy, sharing responsibilities and transferring the charge of implementation to municipalities, affecting the transfer of funds to the fiscal framework, causing economic difficulties especially for the poorest municipalities. The hypothesis that the distance between the municipalities and the State capital, under a federalist operational perspective, aggravates the technical, economic, fiscal difficulties, and policies of the implementation of the PNRS in the AMP.

Purpose: The aim of this thesis is to develop a better understanding on how businesses should communicate their sustainability strategy to their stakeholders. Businesses are facing the challenge of designing sustainability communications strategies that appeal to stakeholders of various interest and knowledge on the topic, and stakeholders whose objectives might even be contradictory to that of the company. In order to facilitate the communications process to encourage a better uptake of sustainability initiatives by corporations and the public, it is essential to find solutions to these communications challenges. Methodology: The study focuses on the food and drink value chain in Western Europe and is based on empirical evidence from a multiple case study methodology involving in-depth interviews with 25 senior managers and directors from food and drink manufacturing companies, retailers, and some of their stakeholders. Findings: A framework for corporate sustainability communications is developed, depicting five communications strategies. The framework also offers an insight how stakeholders can be categorised into the most appropriate communications strategy through the application of certain segmentation attributes. It is further illustrated how the application of strategic ambiguity can add value to the communications process in order to stimulate interest, initiatives and innovation from stakeholders. Theoretical and practical implications/originality: Previous research on corporate communications strategies, has seen limited empirical validation, is primarily focussed on consumers, and more importantly is lacking in advice regarding how to craft communications that not only appeal to a multitude of stakeholders, but that also encourage collaboration. The findings therefore add confirmation and extension to the previous research and, importantly, it provides a link between theories of strategic ambiguity and the corporate communications literature. The framework also offers practical value as it provides managers with a clear guidance on how to design effective corporate sustainability communications, ensuring diverse appeal and/or engagement for collaboration. Thus it provides a tool that has the potential of facilitating holistic sustainability progress in a value chain.

The European Foundation for Quality Management (EFQM) excellence model is used increasingly in the public sector in the Middle East. This thesis addresses a shortage of empirical research in this field and extends the, so called, dynamic capabilities perspective by investigating how the EFQM model can contribute to developing organisational capabilities. A research model was developed based on the theory of structuration and the dynamic capabilities perspective. A multiple case study design was used in three public sector organisations in the United Arab Emirates (UAE). The unit of analysis was the activity configuration involved in the deployment of the EFQM model. This research investigates how activity configurations changed over time, their effect on the organisational social structure and their outcomes in developing new capabilities. In-depth data were collected using interviews and archival sources. The thesis suggests that motives for using the EFQM model represent an important factor in defining the type of activities in its deployment and for its success. It was found that external and internal motives can both have positive impact. The findings showed that organisations experienced with the EFQM model tend to follow similar paths of deployment and achieve comparable results. An indicative model is proposed describing the three stages the organisation can go through in the deployment of the EFQM model. Firstly, the organisation develops the capability to understand the benefits of the model and to plan for its successful deployment. Secondly, the organisation focuses on developing operational capabilities, using the EFQM model. Thirdly, the organisation improves existing capabilities and develops new ones in a recurring cycle, referred to as the cycle of dynamic capabilities. This research contributes to the perspective of dynamic capabilities by investigating the sources of capabilities and how they are shaped through the deployment of the EFQM excellence model. The theoretical background and the research methodology used in this research extend the research application of the structuration theory by linking it with the dynamic capabilities perspective. Suggestions for further research include investigation of the learning cycle of dynamic capabilities through the lens of organisational learning. The research methodology can also be extended to consider strategy formation. An investigation of the EFQM model, which is the basis for assessment in the government award scheme, carries inevitable sources of limitations and bias. A significant proportion of the data collected and analysed was confidential in nature and presented challenges in relation to dissemination of the results.

Prostate cancer is the most commonly diagnosed cancer in men and nearly 30,000 patients will die this year due to complications arising from the disease. Prostate cancer patients are frequently treated with androgen deprivation therapies, but the duration of response is variable, and patients frequently progress to an incurable stage of the disease referred to as castration-resistant prostate cancer (CRPC). Second-generation AR antagonists such as enzalutamide and apalutamide are effective therapies that block androgen receptor (AR) transactivation and signaling in over 50% of CRPC patients. However, an estimated 30% of responders will develop resistance to these therapies within two years. There is another class of AR antagonists which are referred to as pan AR antagonists, that have shown to inhibit the activity of wild-type AR as well as several mutated versions of AR. Currently, there are several pan AR antagonists in preclinical development and approved for the treatment of CRPC in patients harboring pathogenic point mutations in AR. We chose four genetically distinct AR-positive prostate cancer preclinical models to generate enzalutamide, JNJ-pan-AR, or apalutamide resistant cell lines. We then performed transcriptomic and proteomic profiling on the AR antagonist sensitive and resistant cell lines to uncover molecular alterations that may be critical to the maintenance and/ or predictive biomarkers of the resistant phenotype. Global profiling uncovered significant variability in molecular alterations across the AR antagonist resistant cell lines as well as the prostate cancer preclinical models. However, we uncovered upregulation of AKR1C3 protein expression across all three AR antagonist resistant cell lines using the LNCaP and LNCaP/AR preclinical models. Further characterization of the functional significance of AKR1C3 upregulation demonstrated that AKR1C3 protein expression contributes to JNJ-pan-AR resistance. Similar findings have reported the correlation between AKR1C3 expression and changes in drug efficacy across several chemotherapeutic agents approved to CRPC treatment. Collectively the findings from this study support the rationale of AKR1C3 as a target for AR antagonist resistant prostate cancer disease progression.

No description available.

The master’s thesis deals with project design of a web application development as a tool for electronic administration of public contracts in a selected company. It analyzes the environment and feasibility of the company. The thesis contains a practical application of recommended methods for specific project design solution.

SSH je jeden z nejpoužívanějších protokolů pro vzdálený přístup v Internetu. SSH je flexibilní a rozšiřitelný protokol, který se skládá ze tří hlavních součástí: SSH transportního protokolu, který obstarává důvěrnost, integritu a autentizaci serveru, SSH autentizačního protokolu, který obstarává autentizaci uživatelů a SSH spojovacího protokolu, který obstarává multiplexování více kanálů různých typů (interaktivní sezení, přesměrování TCP/IP spojení, atd.) do jednoho spojení. OpenSSH je jedna z nejrozšířenějších implemetací SSH. OpenSSH obsahuje SSH server, SSH klienty, generátor SSH klíčů a autentizační agent, který usnadňuje autentizaci pomocí veřejných klíčů. FreeIPA a SSSD jsou projekty poskytující centrální správu identit pro Linuxové a Unixové systémy. Tyto projekty sice v době psaní této práce přímou podporu SSH neobsahovaly, ale do jisté míry je ve spojení s OpenSSH používat možné bylo.

No description available.

No / April 2008 saw the introduction of a new Public Law Outline (PLO) that aims to improve judicial case management of Public Law Children Act cases. The PLO is a response to concerns about the rising number of care proceedings, associated costs, and the difficulties of achieving case resolution given this volume. Based on an ethos that care proceedings should be avoided wherever possible, the new approach to case management, which places significant emphasis on pre-proceedings work and the effective engagement of parents, can be seen to reinforce the ‘no order principle’ enshrined in the Children Act (CA) 1989. Focusing specifically on relationships between parents and professionals, this paper provides a critical discussion of the potential of the PLO to further promote consensual practices with parents. Discussion traces the introduction of the concept of partnership within the CA 1989, provides a review of the evidence to-date of effective partnership working, before considering the prospects for the PLO with respect to parental engagement. A number of key contextual obstacles are highlighted that will inevitably undermine the aspirations of the new outline, and a more general observation is drawn about the limits of procedure in effecting change in complex social issues.

Human resources management is a key aspect in Public Administration. In fact, it is argued that people are indeed the most valuable resource to any organisation. However, it is imperative to note that having people within an organisation does not automatically translate into results. Success within an organisation stems from implementing best practice human resources management. Performance management is one of the aspects involved in streamlining human resources management in an organisation. The foundation of this research is therefore based on the realization that performance management is a key factor to achieving results in Uganda’s public sector. Similar to several other countries, Uganda’s public sector has gone through various transitions and reforms. The performance management system that stands in the current public sector is a result of the reforms in the public sector. In order to understand the environment in which public servants operate, this research starts by giving a background to the history of the public sector and the evolution of the public service through the public service reform programme. Attention is then drawn to the theoretical framework by way of identifying the standards required in any given performance management system. Based on these identified standards and the research objectives, an evaluation of the implementation of performance management in Uganda’s public sector is discussed with specific reference to the Ministry of public service. The final chapter of the research gives critical recommendations to improve public sector performance management in the Ministry of public service and the Ugandan Public service as a whole. The research findings indicate that performance management policies in Uganda’s public sector are founded on the right and basic principles of performance management. However, critical measures should be put in place to address the actual implementation of performance management in the public sector in order to improve results. / Public Administration / M.A. (Public Administration)