Le locus des chaînes lourdes d’immunoglobulines (IgH) subit trois processus de remaniements géniques durant la lymphopoïèse B. Ces événements induisent des cassures de l’ADN potentiellement oncogéniques, d’où la nécessité d’une régulation extrêmement stricte. Ceci est dû aux deux principaux éléments cis-régulateurs du locus IgH. L’enhancer 5’Eµ régule les recombinaisons VHDJH qui établissent un répertoire antigénique fonctionnel lors des phases précoces. La région régulatrice en 3’ (3’RR) est essentielle aux hypermutations somatiques (SHM) et à la recombinaison de classe (CSR) aux stades tardifs, modifiant respectivement, l’affinité et les fonctions effectrices de l’Ig. La plupart des lymphomes B matures portent les stigmates de translocations d’oncogènes au locus IgH. Le but de ma thèse a été de mieux comprendre les interactions transcriptionelles entre les enhancers Eµ et 3’RR et évaluer si le ciblage de cette dernière pourrait se révéler une approche thérapeutique potentielle. Nous avons démontré que la 3’RR est l’élément essentiel qui contrôle la transcription du locus IgH dans les lymphocytes B matures. Elle est dispensable lors des phases initiales (recombinaisons VHDJH), mais agit comme silencer sur l’expression des segments DJH. L’analyse de la lymphomagenèse dans trois modèles murins porteurs d’une insertion de Myc en trois points du locus IgH a montré des différences dans les cinétiques d’émergence des lymphomes, leurs phénotypes et index de prolifération. L’effet de la 3’RR sur l’oncogène est suffisant pour l’émergence de lymphomes B. Son absence ne semble pas être préjudiciable au développement de réactions inflammatoires/immunes. Son ciblage pourrait donc se révéler une approche thérapeutique intéressante pour diminuer son activité transcriptionelle sur l’oncogène transloqué. Un rôle potentiel des inhibiteurs des histones désacétylases est à l’étude. / The immunoglobulin heavy chain locus (IgH) undergoes several changes along B-cell differentiation. VHDJH recombinations during the early stages give the diversity of the antigenic repertoire. Somatic hypermutation (SHM) and class switch recombination (CSR) during late stages allow affinity maturation and the acquisition of new effectors functions. These rearrangements are highly regulated and are under the control of the IgH locus cis-regulatory elements. The 5’ Eµ enhancer is important for VHDJH recombination. The 3’ regulatory region (3’ RR) is essential for both CSR and SHM. These events induce breaks into the IgH locus, making it a hotspot for oncogenic translocations. The aim of my thesis was to understand the transcriptional interactions between Eμ and 3'RR enhancers and to evaluate whether the targeting of the latter could be of a potential therapeutic approach. We have demonstrated that 3'RR is essential to control IgH transcription in mature B cells. It is dispensable during the initial stages of developement (VHDJH recombinations). At the pro-B cell stage, it has a silencer effect rather than a transcriptional one on the DJH segments expression. The analysis of lymphomagenesis in three mice models carrying an insertion of Myc in different locations at the IgH locus showed significant differences in lymphoma kinetics, phenotypes and proliferation index. 3'RR alone, as a major transcriptional activator of the IgH locus, is capable of leading to B-cell lymphomas. Its absence is not detrimental for the development of classical inflammatory/immune reactions. Its targeting may be of a potentially interesting therapeutic approach to decrease its transcriptional activity on the translocated oncogene. A potential role for histone deacetylase inhibitors is under study.

[pt] Esta tese discorre sobre a relação entre design e indústrias maduras com ênfase em um agir projetual estratégico e orientado para contextos de mudança que incorporam obsolescência e inovação. A abordagem teórica está alinhada com as noções de acumulação criativa do conhecimento, rejuvenescimento e inovação endógena de indústrias no estágio de maturidade do ciclo de vida. Nesse sentido, defende-se que o design é capaz de gerar conhecimento novo para que essas indústrias possam se preparar para inovar sem desprezar o conhecimento existente endogenamente e questiona-se como isso é possível. Foi realizado levantamento bibliográfico sobre Design e Gestão, conciliando três matrizes de pensamento e cultura: de projeto, da gestão do processo de design e da gestão de empresa. Para a condução da pesquisa, também foram adotados os métodos Design Science Research, Material Driven Design e estudo de caso. No âmbito das indústrias maduras, a tese contribui ao caracterizar as atividades projetuais como design pendular; apontar desafios da Gestão do Design; consolidar e propor Capacidades Dinâmicas baseadas no conhecimento do Design, incluindo o transver como síntese; sugerir perspectivas para a relação entre design e a indústria-caso, especializada em materiais têxteis para piso residencial e, principalmente, propor uma abordagem de Design Estratégico com estrutura matricial que abrange bens de consumo, tecnologias e princípios culturais. Por fim, aborda-se neste texto o fato de reflexões sobre um design que enfatiza a sua intenção estratégica ao construir espaços de pesquisa, criação e crítica serem consideradas fundamentais para a transformação de ambientes industriais caracterizados por práticas consolidadas, possivelmente obsoletas. / [en] This study aims to analyze the relationship between design and Mature Industries, focusing on Strategic Design, oriented to changing contexts that incorporated obsolescence and innovation. The theoretical approach is aligned with the notions of creative accumulation of knowledge, dematurity and endogenous innovation for industries in the maturity stage of the Life Cycle. Considering these circumstances, the study discusses and questions how design is capable of generating novelties to prepare these industries for innovation without disregarding the existing endogenous knowledge. For such, bibliographic references in the areas of Design and Management, combining 3 lines of thinking and culture matrices were consulted, including design, design process management, and business management. Moreover, the Design Science Research and Material Driven Design methods, and a case study were also used during the research. Within the scope of Mature Industries, the thesis contributes by distinguishing design activities as pendulum design; by highlighting Design Management challenges; by strengthening and proposing Dynamic Capabilities based on design knowledge, which includes to see beyond as a synthesis; and, finally, by suggesting perspectives for the relationship between design and the industry case specialized in textiles for residential flooring and, mainly, by proposing a Strategic Design approach with a matrix structure that encompasses consumer goods, technologies and cultural principles. Reflections about Design that features its strategic intent in the development of spaces for research, creativity and criticism are considered essential to change industrial environments characterized by conventional practices, possibly obsolete.

Made available in DSpace on 2014-12-17T15:41:48Z (GMT). No. of bitstreams: 1 KyteriaSLF_DISSERT.pdf: 2575352 bytes, checksum: 9c601baf3a71a96816d5ae90fe0ecaea (MD5) Previous issue date: 2010-02-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Over exploitation of oil deposits on land onshore or offshore, there is simultaneous generation of waste water, known as produced water, which represents the largest waste stream in the production of crude oil. The relationship between the chemical composition of oil and water production and the conditions in which this process occurs or is favored are still poorly studied. The area chosen for the study has an important oil reserve and an important aquifer saturated with freshwater meteoric. The aim of this work is to study some chemical parameters in water produced for each reservoir zone of production in mature oil fields of A?u Formation, using the hydrochemical and statistical analysis to serve as a reference and be used as tools against the indicator ranges water producers in oil producing wells. Samples were collected from different wells in 6 different areas of production and were measured 50 parameters, which can be classified into three groups: anions, cations and physicochemical properties (considering only the parameters that generated values above detection limits in all samples). Through the characterization hydrochemistry observed an area of water and chlorinated sodium, chlorinated calcium or magnesium (mixed) in well water in different areas of A?u, by applying a statistical treatment, we obtained a discriminant function that distinguishes chemically production areas. Thus, it was possible to calculate the rate of correct classification of the function was 76.3%. To validate this model the accuracy rate was 86% / Ao longo da explora??o de petr?leo de jazidas em terra (onshore) ou no mar (offshore), existe gera??o concomitante de um efluente aquoso, denominado ?gua produzida, que representa a maior corrente de res?duo na produ??o do ?leo cru. A rela??o entre a composi??o qu?mica dos ?leos e das ?guas de produ??o, bem como as condi??es em que este processo ocorre ou ? favorecido ainda s?o pouco estudadas. A ?rea escolhida para o estudo possui uma importante reserva petrol?fera e um importante aqu?fero saturado em ?gua doce mete?rica. O objetivo desse trabalho ? estudar alguns par?metros qu?micos na ?gua produzida para cada zona-reservat?rio de produ??o em campos maduros de petr?leo da Forma??o A?u, utilizando a hidroqu?mica e a an?lise estat?stica para servir de refer?ncia e serem utilizados como ferramentas indicadoras frente a intervalos produtores de ?gua nos po?os produtores de petr?leo. Foram coletadas amostras de po?os distintos em 6 diferentes zonas de produ??o e foram medidos 50 par?metros, que podem ser classificados em tr?s grupos: ?nions, c?tions e propriedades f?sico-qu?micas (considerando-se apenas os par?metros que geraram valores acima dos limites de detec??o em todas as amostras). Atrav?s da caracteriza??o hidroqu?mica observou-se um dom?nio de ?guas cloretadas s?dicas e cloretadas c?lcicas ou magnesianas (mista) nas ?guas de po?os das diversas zonas na Forma??o A?u e, com a aplica??o de um tratamento estat?stico, obteve-se uma fun??o discriminante que distingue quimicamente as zonas de produ??o. Assim, foi poss?vel calcular a taxa de acerto de classifica??o da fun??o que foi de 76,3%. Para a valida??o desse modelo a taxa de acerto foi de 86%

Durante anos, o lixo da cidade de Guaratinguetá foi aterrado e o seu produto recalcitrante não passou por nenhum tratamento físico ou mesmo químico, percolando diretamente sob o aterro. Mesmo tendo sido desativado e transformado em Parque Ecológico, o material depositado no local ao longo dos anos, continuará a ser decomposto por microrganismos e continuará a ser produzido o lixiviado como fonte de poluição ambiental. Inicialmente, fez-se a caracterização do chorume \"in natura\", demonstrando-se como fonte de matéria orgânica recalcitrante, com massa molar característica de macromoléculas (5,58 kDa e polidispersidade de 1,16), DBO não determinável pela recalcitrância molecular e/ou pela ação tóxica e DQO característica de lixiviado estabilizado (1.013 mg L-1). A fração inorgânica total, dada pela quantidade de sólidos fixos, foi de 3.670 mg L-1, valor esse 3,6 vezes maior que a fração orgânica. O estudo de tratamento do chorume, por ozonização catalítica homogênea foi desenvolvido, principalmente, pelo uso seqüencial de dois arranjos ortogonais de Taguchi, sendo o primeiro, matriz L16, para estudo exploratório dos fatores mais importantes na redução percentual da DQO. Os fatores estudados foram vazão de ozônio, concentração dos íons Fe2+, Fe3+, Zn2+, Mn2+, Ni2+ e Cr3+, pH do meio reacional e presença/ausência de fonte de radiação UV (254 nm). Dentre os metais de transição, os íons Fe2+ e Fe3+ demonstraram-se como mais viáveis como catalisadores na geração de radicais livres hidroxilas devido à sua significância estatística (p = 0,005), e por terem maior tolerância ao descarte no meio ambiente (menor toxicidade) frente aos demais íons. Com a utilização do arranjo ortogonal L8 de Taguchi, foi possível atingir degradação máxima de DQO da ordem de 50 %. A melhor configuração dos fatores, visando aumentar o percentual de redução da DQO foi: vazão de ozônio igual a 5 L h-1 (589,9 mg h-1 O3), concentração de íon de íon ferroso igual a 10 mg L-1, concentração de íon férrico igual a 5 mg L-1 e pH 5. / During many years, the garbage of Guaratinguetá city was landfilled and its recalcitrant product was not submitted to any physical or chemical treatment, leaching directly through the area. After deactivating and transforming the landfill into an Ecological Park, the material deposited in the place by the past years, will continue being decomposed by microorganisms and will continue producing the leached one as a mean of environment pollution. Initially, the leachate \"in natura\" was characterized, demonstrating itself as a source of recalcitrant organic substance with a higher molecular size characteristic of 5,58 kDa and polidispersity of 1,16 and stabilized effluent (not determinable DBO due to molecular recalcitrance and/or toxicity and DQO of 1,013 mg L-1). The total inorganic fraction, given by the amount of total fixed solids was 3,670 mg L-1, which means 3,6 times bigger than the organic fraction. The study of leachate treatment by homogeneous catalytic ozonation was given, mainly, for the sequential use of two Taguchi\'s orthogonal arrangements, being the first, L16 design, for exploratory studies of the most important factors in the percentual reduction of DQO. The factors studied were the ozone outflow, the Fe2+, Fe3+, Zn2+, Mn2+, Ni2+ and Cr3+ ions concentration, the reaction medium pH and the presence/absence of UV radiation source UV (254 nm). Amongst the transition metals, Fe2+ and Fe3+ ions have demonstrated to be as more viable as free hydroxyl radicals catalyst due to its statistics significance (p = 0,005) and also because they have a greater tolerance to the environment discarding (less toxicity) compared to the other ions. The use of L8 Taguchi\'s orthogonal arrays gives the possibility to reach 50 % maximum COD depletion. The best factors configuration, using COD percentage reduction as experimental design response was: 5 L h-1 (589,9 mg h-1 O3) ozone outflow, 10 mg L-1 ferrous concentration, 5 mg L-1 ferric ion concentration and pH 5.

Base teórica: doenças linfoproliferativas crônicas de linhagem B (DLPC-B) são neoplasias clonais que afetam linfócitos B maduros. A tirosina quinase de Bruton (do inglês Bruton’s tyrosine kinase, BTK) é uma proteína essencial para o desenvolvimento, diferenciação e sinalização nos linfócitos B. Ki-67 é uma proteína nuclear associada à proliferação celular. A avaliação de proteínas envolvidas nas vias de sinalização oncogênicas pode levar ao aprimoramento do diagnóstico, tratamento e definição de prognóstico das DLPC-B. Objetivo: avaliar a expressão de BTK e Ki-67 em linfócitos de portadores de DLPC-B. Métodos: para avaliação de BTK foi realizado um estudo transversal; foi avaliada a expressão de BTK em amostras de pacientes saudáveis e de pacientes com diagnóstico de DLPC-B. Para avaliação de Ki-67 foi realizado um estudo transversal. As amostras foram marcadas com CD45 FITC e CD19 APC para identificação dos linfócitos B. Após a lise das hemácias, foi realizada marcação citoplasmática de BTK PE e/ou Ki-67 PerCP-Cy5.5. O percentual de expressão e a intensidade de fluorescência média (IFM) dos marcadores avaliados foram determinados nos linfócitos B. A análise estatística foi realizada com testes de correlação de Pearson e Spearman entre BTK ou Ki-67 e as demais variáveis clínicas e laboratoriais, e ANOVA seguido por teste post hoc de Bonferroni para comparações entre grupos. Foi considerado resultado significante quando P < 0,05. Resultados: não foram observadas diferenças na expressão de BTK e não houve associação entre a expressão de BTK e as variáveis clínicas avaliadas. A expressão de Ki-67 foi maior nos grupos linfoma do manto, linfoma de Burkitt e linfoma difuso de grandes células B em relação aos demais; após análise multivariada, a IFM de Ki-67 foi associada à IFM de CD38. Conclusão: no presente trabalho, a expressão de BTK em DLPC-B foi similar a de linfócitos B normais e a expressão de Ki-67 foi maior nas DLPC-B com curso clínico mais agressivo. / Background: mature B-cell neoplasms (MBCN) are clonal neoplasms that affect mature B-cell lymphocytes. Bruton’s tyrosine kinase (BTK) is an essential protein for the development, differentiation and signaling in B-cell lymphocytes. Ki-67 is a nuclear protein associated to cellular proliferation. Evaluation of proteins involved in oncogenic signaling pathways can lead to improvement in the diagnosis, treatment and prognosis definition in MBCN. Objective: to evaluate the expression of BTK and Ki-67 in lymphocytes of MBCN patients using flow cytometry. Methods: a cross-sectional study was conducted for BTK assessment; BTK expression was assessed on healthy patients samples and MBCN samples. For evaluation of Ki-67 a cross-sectional study was conducted. Samples were stained with CD45 FITC and CD19 APC for identification of B-cell lymphocytes. After lysis of red blood cells, cytoplasmic staining of BTK PE and/or Ki-67 PerCP-Cy5.5 was performed. Percentage of expression and mean fluorescence intensity (MFI) of the markers were determined in B-cell lymphocytes. Statistical analysis was performed with Pearson and Spearman correlation tests between BTK and Ki-67 and the other clinical and laboratory variables, and ANOVA followed by post-hoc Bonferroni test for comparisons between groups. Results were considered significant when P < 0.05. Results: no differences in BTK expression were identified and there was no association between BTK expression and clinical variables evaluated. Ki-67 expression was higher in mantle cell lymphoma, Burkitt lymphoma and diffuse large B-cell lymphoma cases; after multivariate analysis, MFI of Ki-67 was associated with MFI of CD38. Conclusions: in this study, BTK expression in B-cell neoplasms was similar to that of normal B-cell lymphocytes and Ki-67 expression was higher in MBCN with more aggressive clinical courses.

Os vegetais apresentam defesa natural contra os fatores externos, bióticos e abióticos, por meio da síntese de compostos fenólicos no metabolismo secundário, as quais variam com as fases fenológicas e com o clima. O aumento dos compostos fenólicos nas plantas está, diretamente, relacionado com a resistência à infecção por patógenos e à infestação de pragas. Entretanto, pouco se sabe sobre a variação dos teores dessa substância durante os estádios fenológicos do cafeeiro, em particular, nas fases de frutificação, e em razão das condições climáticas. Tais conhecimentos são fundamentais para a previsão dos riscos de ataques aos vegetais, uma vez que a defesa natural da planta deve mudar ao longo do ciclo. O experimento foi realizado em uma cultura de Coffea arabica L., cultivar Obatã IAC 1669-20, instalada no campo experimental do Departamento de Produção Vegetal, da Escola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo, Piracicaba/SP. Para a realização do experimento foi adotado o delineamento experimental inteiramente casualizado, utilizando quatro tratamentos (plantas com e sem frutos - folhas dreno e plantas com e sem frutos - folhas fonte) e cinco repetições constituídas por plantas individuais. Após a análise de variância dos resultados foi aplicado o teste t de Student ao nível de 5 % de significância para a comparação das médias entre os tratamentos. Os teores de fenóis totais (µg g-1) foram extraídos das folhas maduras (fonte) e novas (dreno) e analisados em relação à produção de café, fenologia e clima. As variáveis climáticas adotadas foram temperatura atmosférica (média, mínima e máxima; oC), radiação global (MJ m-2 dia-1) e insolação diária (h dia-1). Durante a condução do experimento foram realizadas avaliações de altura da planta (cm), diâmetro do caule (mm) e comprimento de ramos plagiotrópicos (cm) para determinar as respectivas taxas de crescimento vegetativo das plantas. As quantidades de fenóis totais determinadas nas plantas com produção (17.40 µg g-1 e 13.89 µg g-1 folhas dreno e fonte, respectivamente) e sem produção de café (18.65 µg g-1 e 12.76 µg g-1 folhas dreno e fonte, nessa ordem) não variaram. No entanto, a concentração de fenóis totais nas folhas novas (dreno) das plantas com e sem produção de café foi maior que a quantidade determinada nas folhas maduras (fonte), da ordem de 25 % e 46 %, respectivamente. A síntese de fenóis nas fases de expansão (16.35 µg g-1) e granação dos frutos (14.68 µg g-1) foi 31 % inferior em relação às quantidades determinadas na fase de maior produção dessas substâncias - fruto em maturação (21.24 µg g-1). A metabolização de fenóis totais depende, indiretamente, da temperatura (oC) e da radiação global (MJ m-2 dia-1), apresentando tendência inversa em relação a estas variáveis climáticas. A orientação do manejo fitossanitário deve levar em consideração as épocas em que há comprometimento da defesa natural da planta, em relação à produção de substâncias protetivas - os fenóis. / The vegetables show a natural defense against external factors, biotic and abiotic, by the synthesis of the phenolic compounds in the secondary metabolism, which varies with the maturity state and with the climate. The increase of phenolic compounds in the plants is directly related to the resistance to the infection thought pathogens and insect infestation. However, little is known about the variation in the content of this substance during the maturity state of the coffee tree, particularly in the fructification phases due to the climatic variations. Such knowledge is the base for the risks analyses of attacks to vegetables, since the natural defense of the plant shall change during the cycle. The experiment was carried out in a Coffea arabica L. crop, to cultivar Obatã IAC 1669-20, installed in the experimental field of the department of vegetal production of the Escola Superior de Agricultura "Luiz de Queiroz", University of São Paulo, Piracicaba/SP. For the accomplishment of the experiment it was adopted a totally randomized experimental design, using four treatments (plants with and without fruits - drain leaves and plants with and without fruits - source leaves) and five repetitions consisting of individual plants. After analysing the variance of the results it was applied Student t test at the level of 5 % of significance to compare the averages between the treatments. The total phenol grade (µg g-1) have been extracted from the mature (source) and new (drain) leaves and have been analyzed in relation to the coffee yield, phenology and climate. The climatic conditions adopted were atmospheric temperature (average, minimum and maximum; oC), global radiation (MJ m-2 day-1) and daily insolation (h day-1). During the conduction of the experiment it was analyzed the evaluations of the height (cm), diameter (mm) and length of the reproductive branches (cm) to determine the respective vegetative growth rates of the plants. The determined amounts of total phenols in the plants with production (17.40 µg g-1 and 13.89 µg g-1 drain and source leaves, respectively) and without coffee production (18.65 µg g-1 and 12.76 µg g-1 drain and source leaves, respectively) did not varied. However, the total phenol concentrations in new leaves of the plants with and without coffee production were greater than the amount determined in mature leaves around 25 % and 46 %, respectively. The secondary substance synthesis in the phases of expansion (16.35 µg g-1) and grain filling of the fruits (14.68 µg g-1) was 31% lower than the amounts determined in the phase of the greatest production of these substances - fruit in maturation (21.24 µg g-1). The total phenol metabolization depends indirectly on the temperature (oC) and on the global radiation (MJ m-2 day-1), presenting inverse trend in relation to these climatic variable. The orientation of the crop protection managing shall take into consideration the period when it has endangerment of the natural defense of the plant.

The aim of this study was to evaluate the effects of M. elsdenii (Me) dosing on dairy heifer performance. A secondary set of data (feed intake, heifers birth weights, age and Weight at insemination, and first lactation milk performance) of heifers (dosed and not dosed with Me) was obtained from the dairy herd of the Agricultural Research Council – Animal Production. Data were arranged in a complete randomised design and analysed as repeated measures. Milk, pre-weaning starter and metabolised energy intake did not differ between the control and the Me groups. Post-weaning starter feed intake was higher (p=0.03) for Me fed heifers than control heifers. The post-weaning metabolisable energy intake was also higher (p=0.03) for heifer fed Me than control heifers. The average daily weight gain of heifers dosed with Me was higher during the pre-weaning period (0.66 kg/day; p=0.04) and after weaning (1.12 kg/day; p=0.03) compared to control (0.60 and 0.65 kg/day, respectively). At 42 and 70 days old, the BW of Me-heifers was greater (75.8 ± 2.6 and 91.2 ± 4.6 kg) than control heifers (61.9 ± 2.6 and 77.2 ± 4.6 kg) (p<0.05). There was no difference (P>0.05) in BW at insemination, number of insemination and milk yield between the two groups of cows (p>0.05). Early feeding of Me to heifers in the present study positively affect heifer growth during and early after milk feeding period, confirming previous report. Animal weight at puberty and the subsequent milk production were not influenced by feeding Me. It is possible that Me did not survive long after weaning to continue to express its influence on animal performance. / Agriculture and  Animal Health / M. Sc. (Agriculture)

To meet the goal of atmospheric stabilization of carbon dioxide (CO2 ) levels a technological transformation should occur in the energy sector. One strategy to achieve this is carbon sequestration. Carbon dioxide can be captured from industrial sources and sequestered underground into depleted oil and gas reservoirs. CO2 injected into geological formations, such as mature oil reservoirs can be effectively trapped by hydrodynamical (structural), solution, residual (capillary) and mineral trapping methods. In this work, a case study was conducted using CMG-STARS software for CO2 sequestration in a mature oil field. History matching was done with the available production, bottom hole pressures and water cut data to compare the results obtained from the simulator with the field data. Next, previously developed optimization methods were modified and used for the case of study. The main object of the optimization was to determine the optimal location, number of injection wells, injection rate, injection depth and pressure of wells to maximize the total trapped amount of CO2 while enhancing the amount of oil recovered. A second round of simulations was carried out to study the factors that affect the total oil recovery and CO2 &not / storage amount. These include relative permeability end points effect, hysteresis effect, fracture spacing and additives of simultaneous injection of carbon dioxide with CO and H2S. Optimization runs were carried out on a mildly heterogeneous 3D model for variety of cases. When compared with the base case, the optimized case led to an increase of 20% in the amount of oil that is recovered / and more than 95% of the injected CO2 was trapped as solution gas on and as an immobile gas. Finally, an investigation of the economical feasibility was accomplished. NPV values for various cases were obtained, selected and studied yielding in a number of cases that are found to be applicable for the field of concern.

The distribution of Heterobasidion annosum in Scots pine stands in Nemenčinė Forest Enterprise, Mera and Magūnai forest districts were examined in this Master thesis. The object of the study: Scots pine stands that were established on formerly used agricultural land, former tank range areas and the stands growing in the cut areas of mature stands. Also, the Scots pine stands where after partly clear sanitation cuttings the birch groups were planted, in purpose to avoid the disturbances of Heterobasidion annosum. The aim of the study: to summaries the information about the distribution of Heterobasidion annosum in Lithuanian forests; to study the distribution of Heterobasidion annosum in Scots pine plantations established in agricultural lands and the cut areas of mature stands. The evaluation of the effectiveness of earlier used partly clear sanitation cuttings against Heterobasidion annosum in disturbed stands was also done. Methods: the distribution of Heterobasidion annosum in the forests of Nemenčinė Forest Enterprise, Mera forest district was evaluated visually. Each studied plot was evaluated according 4 grades. 6 assessment plots in Magūnai forest district were evaluated for the effectiveness of partly clear sanitation cuttings. The stand characteristics of the remained healthy pine and birch trees were measured using standard silvicultural mensuration methods, taking the measurements of each tree at breast height, in 2 cm precision. The results: The distribution of... [to full text]

Tyrimo objektas -vidutinio ir pagyvenusio amžiaus žmonių fizinis aktyvumas (FA) ir fizinis pajėgumas (FPj). Tyrimo problema - Lietuvoje kaip ir daugelyje pasaulio šalių visuomenė sparčiai senėja, tačiau problema yra ne senstanti visuomenė, o problemos su kuriomis susiduria pagyvenę žmonės. Dėl milžiniškos mokslo, technikos ir medicinos pažangos XX a., beveik visiškai pakeitusios žmonių gyvenimą, įsivyravo fiziškai pasyvus gyvenimo būdas. Viena iš pagrindinių problemų yra fizinio pasyvumo didėjimas senėjant, dėl ko susiduriama su širdies ir kraujagyslių ligomis bei mirtimi. Moksliniais tyrimais įrodyta, kad fizinis pasyvumas yra viena iš trijų pagrindinių mirtingumo priežasčių pasaulyje. Tyrimo tikslas – nustatyti pagyvenusio ir vidutinio amžiaus žmonių fizinio aktyvumo apimties sąsają su fizinio pajėgumo rezultatų atsako dėsningumais. Tyrimo autoriaus iškelti uždaviniai: 1. Nustatyti brandaus amžiaus žmonių fizinį aktyvumą. 2. Nustatyti ir palyginti pagyvenusio amžiaus fiziškai aktyvių ir vidutinio amžiaus fiziškai pasyvių žmonių fizinį pajėgumą. 3. Nustatyti sąsajas tarp fizinio aktyvumo ir fizinio pajėgumo. 4. Nustatyti prie kokio fizinio aktyvumo dažnumo pasiekiami geriausi fizinio pajėgumo rezultatai. Tyrimo hipotezė – neatsižvelgiant į suaugusių žmonių amžiaus brandumą, egzistuoja fizinio aktyvumo apimties ir fizinio pajėgumo (judesių koordinacijos, raumenų pajėgumo, širdies kraujagyslių sistemos) rezultatų atsako sąsajos. Išvados 1. Dauguma, t.y. 28 %... [toliau žr. visą tekstą] / Object of research – physical activity and physical potency of middle and mature aged people. Problem of research – society grow old rapidly in Lithuania as in many countries in the world. However the problem is not the senescent society, but the problems faced by mature aged people. Because of huge progress of science, technology and medicine in 20 century, what almost totally changed people life, passive lifestyle settled. One of the main problems is the growth of physical passivity while senescent, which results heart and vessel diseases and even death. It was confirmed by scientific research that physical passivity is one of three main reasons of mortality in the world The purpose of research – to identify the connection between middle and mature aged people physical activity extent and consistent pattern of reaction of physical potency results. The goals proposed by the author of research: 1. To assess the physical activity of mature aged people 2. To assess and compare physical potency of physically active and passive people 3. To identify the connection between physical activity and potency. 4. To assess what physical activity rate provides best results of physical potency. The hypothesis of research – not considering the maturity of adults’ age, there exist the connection between physical activity extent and reaction of results of physical potency (movement coordination, muscle potency, heart vessel system). Conclusion 1. Most that is 28 percents of... [to full text]