No description available.

Painting decorations of the Sedlec Antiphonary manuscript (Prague, NK ČR, XIII A 6) serve as significant evidence for art painting development in Central Europe during the cultural changes, when Late Romanesque style evolved into Gothic. The aim of the thesis is to submit profound art-historical analysis of the Sedlec Antiphonary manuscript, which is stored in National Library of the Czech Republic in Prague, call number XIII A 6. The main method of this work is the careful study of painting decorations in the manuscript, in terms of both analysing their layout in general and typology of the single ornament motifs. Among other methods are formal analysis, comparison based on typology and iconography analysis. Similarities of the manuscript and works of the same time of origin, such as Mater verborum manuscript (Prague, KNM, X A 11) or Wolfenbüttel sketch-book , are also taken into consideration. Due to this comparison could be proved that the author of the Sedlec Antiphonary was probably influenced by Byzantine, Venetian and German painting styles. The Sedlec Antiphonary represents an important and practically key work in the context of painting development in the 13th century. Keywords book painting, miniature, initial letter, Women at the Sepulcher, 13th century

1. The effect of urotensin II (U-II) on spontaneous transmitter release was examined in the frog to see if the biological activity of this vasoactive peptide extended to neural tissues. 2. In normal Ringer solution, frog and human U-II (fU-II and hU-II, respectively) caused concentration-dependent, reversible increases in miniature endplate potential (MEPP) frequency, with hU-II about 22 times more potent than fU-II. hU-II caused a dose-dependent increase in MEPP amplitude, whereas fU-II caused an increase, followed by a decrease with higher concentrations. 3. Increasing extracellular Ca 2+ three-fold had no effect on the MEPP frequency increase to 25 μM hU-II. Pretreatment with thapsigargin to deplete endoplasmic reticulum Ca 2+ caused a 61% reduction in the MEPP frequency increase to 25 μM hU-II. 4. Pretreatment with the phospholipase C inhibitor U-73122 caused a 93% reduction in the MEPP frequency increase to 25 μM hU-II and a 15% reduction in the increase in MEPP amplitude. Pretreating with antibodies against the inositol 1,4,5-trisphosphate (IP 3) type 1 receptor using liposomal techniques reduced the MEPP frequency increase by 83% but had no effect on MEPP amplitude. 5. Pretreating with protein kinase C inhibitors (bisindolylmaleimide I and III) had no effect on the response to 25 μM hU-II, but pretreating with protein kinase A inhibitors (H-89 and KT5720) reduced the MEPP frequency increase by 88% and completely abolished the increase in MEPP amplitude. 6. Our results show that hU-II is a potent stimulator of spontaneous transmitter release in the frog and that the effect is mediated by IP 3 and cyclic AMP/protein kinase A.

Cloud Manufacturing är en teknologi som sedan begreppets introduktion 2010 genomgått en omfattande utveckling och transformation. Under de tio år som passerat har forskning skett i Sverige och internationellt på hur det ska kunna realiseras. Detta projekt syftar till att undersöka det nuvarande forskningsläget och med grund i den forskning som skett analysera miniatyrtillverkningsindustrins möjligheter att ta till sig de senaste årens landvinningar inom Cloud Manufacturing med inriktning på offentliga moln, och om möjligt, dra slutsatser kring vad vi kan lära oss av detta exempel när det kommer till implementering i andra industrier. Projektet resulterade i att med de förutsättningar som enligt litteraturen krävs för att implementera Cloud Manufacturing finns det flera svårigheter med att implementera ett offentligt tillverkningsmoln i miniatyrtillverkningsindustrin. Dessa svårigheter inkluderade den nuvarande nivån av implementering av teknologier som stödjer implementationen av Cloud Manufacturing och hur implementationen ska finansieras. Industrin skulle dock kunna ta till sig innovationen i framtiden om förutsättningarna förändras. Det finns även en risk att dessa uppdagade svårigheter delas med andra tillverkande industrier som har många mindre företag. / Cloud Manufacturing is a new technology that has since the terms conception in 2010 gone through significant developments. During the ten years that have passed there have been much research on the subject in both Sweden and abroad. The purpose of this project is to shed some light on the current developments within Cloud Manufacturing , and with a basis in recent research analyse the possibilities of the miniature making industry to apply the progress within cloud manufacturing, and, if possible, see what could be learned from this example when it comes to the application of the technology within other industries. The project results in the conclusion that with the requirements for implementing cloud manufacturing established in the recent literature there are several difficulties with implementing Cloud Manufacturing within the miniature making industry. These identified include the current level of adaptation of technologies supporting the implementation of Cloud Manufacturing and the conditions for financing the implementation. The industry could have the possibility of implementing the technology in the future if conditions change. It also concludes that there is a possibility that these difficulties are shared with other producing industries with many small to medium enterprises.

No description available.

Star trackers are essential instruments commonly used on satellites. They provide precise measurement of the orientation of a satellite and are part of the attitude control system. For cubesats star trackers need to be small, consume low power and preferably cheap to manufacture. In this thesis work the electronics for a miniature star tracker has been developed. A star detection algorithm has been implemented in hardware logic, tested and verified. A platform for continued work is presented and future improvements of the current implementation are discussed. / Stjärnkameror är vanligt förekommande instrument på satelliter. De tillhandahåller information om satellitens orientering med mycket hög precision och är en viktig del i satellitens reglersystem. För kubsatelliter måste dessa vara små, strömsnåla och helst billiga att tillverka. I detta examensarbete har elektroniken för en sådan stjärnkamera utvecklats. En algoritm som detekterar stjärnor har implementerats i hårdvara, testats och verifierats. En hårdvaruplattform som fortsatt arbete kan utgå ifrån har skapats och förslag på förbättringar diskuteras.

The subcellular mechanism and site of action of linopirdine or DuP 996 (3,3‐bis(4‐pyridinylmethyl)‐1‐phenylindolin‐2‐one) was investigated at the frog neuromuscular junction, using miniature endplate potential (m.e.p.p.) counts and a new method for obtaining unbiased estimates of n (number of functional release sites), p (probability of release), and varsp (spatial variance in p). DuP 996 produced an increase in m (no. of quanta released), which was due to an increase in n and p. The increase in m was concentration‐dependent over a range of 0.1–100 μm and completely reversible with 15 min of wash. There was a saturation in the increase in p, but not in the increase in m and n, for [DuP 996] >10 μm. By contrast, there was no major change in varsp. Block of presynaptic Na+‐ and Ca2+‐channels with 3 μm tetrodotoxin and 1.8 mm Co2+prevented the m.e.p.p. frequency increase to DuP 996, and this effect was completely reversed by washing. Application of the neuronal Ca2+‐channel blocker, ω‐conotoxin GVIA (1 μm) brought about a rapid and profound decrease in the m.e.p.p. frequency increase produced by DuP 996. The effect of the toxin was not reversed by prolonged washing. Block of voltage‐gated K+‐channels with 100 μm 4‐aminopyridine (4‐AP) resulted in only a small (28%) increase in m. The combination of 4‐AP (100 μm) and DuP 996 (10 μm) produced an increase in m (189%) which was much greater than the sum of the responses to each agent alone. This increase in m was due solely to an increase in n, as p and varsp were unchanged. For [DuP 996] up to 100 μm, there was no apparent change in the mean size, amplitude distribution, or time course of m.e.p.ps, signifying that it had no anticholinesterase activity. It is concluded that DuP 996 increases the release of quantal transmitter but not the postsynaptic response to the quanta. This appears to involve an effect at the nerve terminal membrane, most likely an increase in Ca2+‐conductance, and not an action to block K+‐conductance or to release Ca2+from intraterminal organelles. 1994 British Pharmacological Society

The main aim of this thesis was to understand the mechanism behind the classical transition scenario inside the boundary layer over an airfoil and eventually attempting to control this transition utilizing passive devices for transition delay. The initial objective of analyzing the transition phenomenon based on TS wave disturbance growth was conducted at 90 Hz using LDV and CTA measurement techniques at two different angles of attack. This was combined with the studies performed on two other frequencies of 100 and 110 Hz, in order to witness its impact on the neutral stability curve behavior. The challenges faced in the next phase of the thesis while trying to control the transition location, was to understand and encompass the effect of adverse pressure gradient before setting up the passive control devices, which in this case was miniature vortex generators. Consequently, several attempts were made to optimize the parameters of the miniature vortex generators depending upon the streak strength and stability. Finally, for 90 Hz a configuration of miniature vortex generators have been found to successfully stabilize the TS wave disturbances below a certain forcing amplitude, which also led to transition delay.

No description available.

No description available.