Submitted by Maicon Juliano Schmidt (maicons) on 2015-06-01T14:54:42Z No. of bitstreams: 1 Helena Beatriz Rower.pdf: 1700201 bytes, checksum: e1cfc9673a0cf09e95b5175f18b6ad50 (MD5) / Made available in DSpace on 2015-06-01T14:54:42Z (GMT). No. of bitstreams: 1 Helena Beatriz Rower.pdf: 1700201 bytes, checksum: e1cfc9673a0cf09e95b5175f18b6ad50 (MD5) Previous issue date: 2013-01-31 / Nenhuma / Objetivo: Verificar a associação entre autopercepção de nervosismo/stress, distúrbios psiquiátricos menores (DPM) e consumo adequado de frutas, verduras e legumes (FVL). Método: Este é um estudo transversal de base populacional com uma amostra representativa de 1100 adultos, com idade igual ou superior a 18 anos, residentes na zona urbana de um município de médio porte do sul do Brasil. O consumo adequado de frutas e legumes foi avaliado através de duas perguntas: uma sobre a quantidade de frutas ou suco natural de frutas consumido ao dia, e outra, a respeito do número de colheres de sopa de verduras/legumes consumidos ao dia. Considerou-se como consumo adequado a ingestão de três ou mais frutas ao dia concomitante com cinco ou mais colheres de sopa de verduras/legumes ao dia. As exposições principais variáveis foram autopercepção de nervosismo/stress e DPM. Para fornecer uma estimativa das razões de prevalências (RP) brutas e ajustadas, utilizou-se a regressão de Poisson. Potenciais fatores de confusão eram variáveis demográficas, socioeconômicas e comportamentais. Resultados: Ao analisar a amostra total, observaram-se associações significativas entre o desfecho com a autopercepção de nervosismo/stress e DPM. Após o controle de fatores de confusão, adultos relatando ausência de nervosismo/stress possuíam uma prevalência de consumo adequado duas vezes maior do que aqueles com resposta positiva (RP=1,99; IC95% 1,17-3,37; p=0,010). Similarmente, participantes com ausência de DPM possuíam uma prevalência de consumo adequado FVL 52% mais elevada quando comparados àqueles que relataram presença de DPM (RP=1,52; IC95% 1,10-2,10; p=0,016). Quando estratificada para o sexo, este efeito se manteve e aumentou nas mulheres, perdendo efeito e significância estatística entre os homens. Conclusão: Os resultados sugerem que a saúde mental pode ter papel importante para o consumo adequado de FVL, especialmente entre as mulheres. / Objective: To assess the association between mental health with adequate fruits and vegetables consumption. Method: This is a population based cross-sectional with a representative sample of 1,100 adult subjects living in the urban area of a medium size city in Souther Brazil. The adequate fruits and vegetables ́ intake was evaluated through two questions: one asking the quantity of fruit or fresh natural juice ingested on a daily basis; the other asking the number of soup spoons of vegetables consumed in a day. It was considered as an adequate intake the ingestion of three or more portions of fruit and of five or more soup spoons of vegetables. The main exposures were self-reported nervousness/stress and minor psychiatric disorders (MPD). In order to provide an estimation of the unadjusted and adjusted prevalence ratios (PR) Poisson regression was used. Potential confounding factors were demographic, socioeconomic and behavioral. Results: When the full sample was analyzed, a significant association between the nervousness/stress self-awareness and minor psychiatric disturbances was found. After controlling for the confounding factors, adults reporting absence were 2 times more likely to have the appropriate daily fruits and vegetables intake than those reporting presence of stressfull/nervous estates (PR=1,99; CI95% 1,17-3,37; p=0,010). In the same way, subjects not reporting mental disorders had a prevalence of adequate intake FVL 52% higher compared to those who had MPD (PR=1,52; CI95% 1,10-2,10; p=0,016). When stratified by gender, this effect was kept and increased in women. However, it lost its effect and statistical significance among men. Conclusion: The results suggests that the mental health may have an important role in the adequate intake of fruits and vegetables, especially among women.

Les ambassades des cités d’Asie Mineure constituent un poste d’observation commode pour qui veut apprécier les évolutions politiques et institutionnelles qui travaillèrent les communautés grecques de l’irruption des légions en Orient à la fin du Haut-Empire. Cette enquête portant sur un temps long permet notamment de cerner les évolutions dans les raisons qui poussaient les cités à en référer aux autorités romaines. Si l’institution du principat constitua une rupture indéniable en personnalisant les relations entretenues par les communautés de l’Orient grec avec une Rome conçue jusque-là par elles comme une puissance collective, il n’en reste pas moins que plusieurs éléments de permanence prouvent que la mue des ambassades civiques d’actes éminemment diplomatiques en faits purement administratifs n’était pas totalement réalisée à la fin du IIe siècle apr. J.-C. Les pratiques ambassadoriales ont quant à elles fortement évolué, car elles étaient tributaires des mutations institutionnelles, diplomatiques mais aussi sociales du monde romain. Toutefois, on a pu entrevoir à travers plusieurs phénomènes de contournement par les communautés grecques des normes diplomatiques romaines l’aspiration persistante des entités civiques à manifester une forme de vie extérieure, et donc un semblant d’autonomie à l’égard de Rome. Malgré l’apparition, notamment au sein des élites civiques, d’un discours dépréciatif condamnant l’envoi intempestif de délégations, dépêcher pour de bonnes raisons une ambassade à Rome permettait de donner à voir, non plus la liberté absolue de l’entité émettrice, mais le dialogue qu’elle était capable d’instaurer avec les maître du monde antique. / Asia Minor cities embassies are a good vantage point to assess political and institutional evolutions that went through Greek communities from the arrival of legions in the East to the end of the Early Empire. This investigation focuses on a long time scale that allows us to see evolutions in the reasons why cities would refer to Roman authorities. Principate institution was a break away in the relationships between oriental Greek communities and Rome, that they considered until then as a joint power. However, many continuities show that civic missions haven't quite shifted from being diplomatic acts to purely administrative facts at the end of the 2nd century. Ambassadorial practices have evolved a lot, being linked to institutional, diplomatic and social mutations of the Roman world. However, the several workarounds of Roman diplomatic rules can be seen as a persistent will for Greek communities to express their autonomy towards Rome. Despite the outbreak, especially among civic elites, of critical views towards inopportune delegations, sending a mission to Rome for good reasons would allow to show, not the complete freedom of the sending entity, but the dialog that it was able to establish with the masters of the antique world.

S’interrogeant sur l’existence d’une culture matérielle propre à la Cappadoce, X. de Planhol soulevait déjà, dans les années 1980, la contradiction entre les résultats des études cappadociennes et les sources. De fait, archéologiquement et historiquement, la Cappadoce rupestre s’inscrit dans la continuité des autres provinces anatoliennes. Dépendant d’empires plus puissants, elle ne semble pas développer des traditions architecturales et culturelles propres, si ce n’est de posséder des monuments creusés dans la roche. A contrario à l’époque médiévale, certains auteurs arabes et byzantins reconnaissent aux Cappadociens un mode de vie troglodytique qui les individualise, de facto, de leurs voisins anatoliens. Ces assertions sont d’ailleurs confirmées par le développement de la pratique rupestre à l’époque byzantine dans la zone. Afin de comprendre ce décalage, deux approches ont été menées parallèlement. La première, historique, a pour objet d’étudier les représentations littéraires de la Cappadoce et des Cappadociens entre le Ve av. J.-C. et le Xe ap. J-C. La seconde approche, archéologique, a pour but de comprendre les processus de réalisation des monuments rupestres entre le IIIe siècle av. J.-C. et le Xe siècle ap. J.-C. À elles deux, elles mettent en lumière la lente construction culturelle qui, tant dans les sources que dans la praxis, aboutit à la fin du Xe siècle à l’existence d’un fait rupestre. / In the 1980s, questioning the existence of an own material cultures in Cappadocia, X. de Planhol already raised the contradictions between results of Cappadocian studies and sources. In fact, the current region of Cappadocia seems to be “provincial”. Dependent on more powerful Empires, this region doesn’t seem to develop its own architectural traditions and its own material cultures. It has just carved monuments. But in some medieval sources, Cappadocians are described like Troglodyte and de facto are distinguished from their Anatolian neighbors. To understand this shift, two methodological approaches were conducted. The first one is historical and has the purpose to study literary representations of Cappadocia and Cappadocians between the Vth century BC and the Xth century AD. The second approach is archaeological and should allow understanding process of making a carved monument between the IIIrd century BC and the Xth century AD. Both highlight the slow cultural construction that results in recognition of a “carving fact” in the Xth century AD.

Submitted by Aline Batista (alinehb.ufpel@gmail.com) on 2018-03-29T13:18:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Carlos_Alberto_dos_Santos_Treichel.pdf: 4138762 bytes, checksum: 1071a774bc33b0f53d5548686e5fdafb (MD5) / Made available in DSpace on 2018-04-03T18:38:32Z (GMT). No. of bitstreams: 2 Dissertacao_Carlos_Alberto_dos_Santos_Treichel.pdf: 4138762 bytes, checksum: 1071a774bc33b0f53d5548686e5fdafb (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-02-06 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / A partir dos movimentos de reforma psiquiátrica e do estabelecimento dos serviços comunitários de saúde mental, a família que antes se mantinha como observadora do processo do cuidado é olhada em uma nova perspectiva, passando a ser incorporada no processo terapêutico e contribuindo com a reabilitação psicossocial do indivíduo. Nesse sentido, dentro do contexto de cuidado comunitário, a família passa a ser considerada como um objeto de estudo deste campo de atuação. Diversos estudos têm enfatizado sua abordagem como necessária e documentado diferentes repercussões desse cenário entre esses sujeitos, dentre as quais àquelas relacionadas a aspectos psicossomáticos como a manifestação de transtornos psiquiátricos menores. Levando em conta que identificar quais características influem na ocorrência desses transtornos possa ser um passo importante para o estabelecimento de práticas que previnam ou interfiram nesse desfecho este estudo buscou identificar a prevalência e os fatores associados à manifestação de transtornos psiquiátricos menores entre 537 cuidadores familiares de pessoas em sofrimento psíquico atendidas em 16 Centros de Atenção Psicossocial (CAPS) localizados na 21ª região de saúde do estado do Rio Grande do Sul. Para análise, munindo-se de um modelo teórico hierarquizado, utilizou-se regressão de Poisson com o cálculo das razões de prevalência ajustadas. A prevalência de Transtornos Psiquiátricos Menores encontrada na população estudada foi de 42,1%. Os fatores associados à esses transtornos foram: sexo feminino (RP: 1,54); vínculo próximo com o usuário, em especial pais/mães (RP: 2,00); baixa escolaridade, apresentando risco de RP: 1,85 no estrato mais baixo; possuir problemas de saúde (RP: 1,24); referir problemas de nervos (RP: 3,02); baixo desempenho de avaliação da qualidade de vida nos âmbitos físico (RP:1,84) e de meio ambiente (RP:1,95); insatisfação com as relações familiares (RP: 1,56); falta de apoio familiar (RP: 1,25) e sentimento de sobrecarga, para qual foi encontrado um risco de RP: 2,61 entre os indivíduos com maior nível de sobrecarga. Levando em conta que na análise multivariada os aspectos que efetivamente exerceram influência sobre o desfecho na amostra estudada estão relacionados às condições situacionais e de apoio e organização familiar, sugere-se a implementação por parte dos serviços de medidas que favoreçam a melhoria no suporte social e inclusão de todos os membros do grupo familiar de seus usuários nos processos de cuidado. / With the psychiatric reform movements and the establishment of community mental health services, the family that before were considered as an observator of the health care process is seen in a new perspective, becoming incorporated into the therapeutic process and contributing to patient rehabilitation. In this sense, in the context of communitary health care, the family is considered as an object of study in this field. Several studies have emphasized their approach as a need and have documented different repercussions of this scenario among the relatives. These repercussions include those related to psychosomatics aspects as the manifestation of minor psychiatric disorders. Taking into account that identifying characteristics that contribute to occurrence of these disorders may be an important step towards establishing practices that prevent or interfere in this outcome, this study sought to identify the prevalence and the associated factors with the manifestation of minor psychiatric disorders among 537 family caregivers of In psychic suffering attended at 16 Psychosocial Care Centers (CAPS) located in the 21st health region of the state of Rio Grande do Sul. Using a hierarchical theoretical model, Poisson regression was used to track the Prevalence ratio. The prevalence of Minor Psychiatric Disorders found in the study was 42.1%. The associated factors with these disorders were: female gender (PR: 1.54); strong bond with the user, especially fathers / mothers (PR: 2.00); low educational level, especially in the lowest stratum (PR: 1.85); Have health problems (PR: 1.24); Refer problems of nerves (PR: 3.02); low performance of evaluation in the quality of life in the physical aspect (RP: 1.84) and environment aspect (PR: 1.95); dissatisfaction with family relationships (PR: 1.56); lack of family support (PR: 1.25) and feelings of burden, especially when intense (PR: 2,61). Taking into account that in the multivariate analysis the aspects that effectively influenced the outcome in the studied sample are related to situational conditions, family support and organization, it is suggested the implementation by the services of measures that favor the improvement in social support and inclusion of all members of the family group of its users in the processes of care.

Made available in DSpace on 2014-12-17T15:41:46Z (GMT). No. of bitstreams: 1 RinaLSMpdf.pdf: 3452236 bytes, checksum: 7d7e19e1df71d1563d94e1dd5d766bbb (MD5) Previous issue date: 2009-02-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The aim of this study was to quantify the presence of major and minor elements in the sediments of the Jundia?-Potengi estuary, bordering the municipalities of Maca?ba, Natal and S?o Gon?alo do Amarante in the state of Rio Grande do Norte, Brazil, considering the evidence of anthropic activity along this estuary, resulting in pollution by treated and untreated wastewaters as well as those produced by industry and shrimp farming. The assessment of the environmental status of this estuary was based on physical-chemical parameters, such as granulometry, organic matter and the major (Al, Fe, Mn and P) and minor (Cd, Cr, Cu, Ni, Pb and Zn) elements found in sediment samples. Two collections were made at 12 georeferenced points along the channel of the estuary at different times. Granulometric analysis was carried out and the percentage of organic matter was determined. The sediments were microwave digested using acid digestion and quantitative analyses of the elements Al, Fe, Cd, Cr, Cu, Mn, Ni, P, Pb and Zn were performed by inductively coupled plasma optical emission spectrometry. Sediment analysis followed the methodology proposed by US EPA 3051A for total elements analysis. The small correlation between the organic matter and the elements studied here suggests that they are of geochemical rather than anthropic origin. The analytical results obtained from the bottom sediment samples in the study area show that the concentration of elements was below the reference values for standard shales (Turekian & Wedepohl, 1961) at the vast majority of points analyzed, ruling out a possible contamination by metals / Este trabalho teve como objetivo avaliar, por meio da quantifica??o, a presen?a dos elementos maiores e menores nos sedimentos do Estu?rio Jundia?-Potengi localizado as margens dos munic?pios de Maca?ba, Natal e S?o Gon?alo do Amarante no Estado do Rio Grande do Norte, considerando as evid?ncias de atividades antr?picas ao longo deste estu?rio, no qual se destacam a polui??o por efluentes dom?sticos, tratados e sem tratamento, efluentes industriais e de carciniculturas. A avalia??o do estado ambiental desse estu?rio foi feito atrav?s da determina??o dos par?metros f?sicoqu?micos, como granulometria, mat?ria org?nica e elementos maiores, Al, Fe, Mn e P, e elementos menores, Cd, Cr, Cu, Ni, Pb e Zn em amostras de sedimento deste estu?rio. As coletas foram feitas em 12 pontos, georefer?nciados, na calha, ao longo desse estu?rio, e em duas coletas com per?odos distintos. Foram feitas as determina??es das porcentagens de mat?ria org?nica e a an?lise granulom?trica. A digest?o dos sedimentos foi feita com um aparelho de microondas por digest?o ?cida e as an?lises quantitativas dos elementos Al, Fe, Cd, Cr, Cu, Mn, Ni, P, Pb e Zn por espectrometria de emiss?o ?tica com plasma acoplado indutivamente Para a an?lise dos sedimentos tomou-se como refer?ncia a metodologia proposta pela US EPA 3051A para a an?lise dos elementos. A pequena correla??o da mat?ria org?nica com os elementos estudados neste trabalho sugere que estes n?o sejam de origem antr?pica e sim de suporte geoqu?mico. Os resultados anal?ticos apresentados pelas amostras de sedimentos de fundo para a ?rea estudada mostraram que a concentra??o dos elementos ficou abaixo dos valores de refer?ncia do folhelho padr?o de Turekian & Wedepohl (1961) na grande maioria dos pontos analisados, descaracterizando uma poss?vel contamina??o por metais

INTRODUÇÃO: Xerostomia é um sintoma comum relacionado a diversas doenças e faz parte da complexa exocrinopatia que afeta glândulas salivares na síndrome de Sjögren (SS). Sintomas similares são encontrados em outras doenças crônicas auto-imunes, incluindo o lúpus eritematoso (LE). O principal achado histopatológico na SS é a infiltração linfocitária que destrói o epitélio ductal levando à atrofia glandular. No LE, alterações das glândulas salivares são raramente relatadas, e tem sido comumente associadas com a SS pela maioria dos autores. OBJETIVOS: Analisar e comparar as alterações histopatológicas e de imunofluorescência direta (IFD) das glândulas salivares menores de doentes com xerostomia e diagnóstico de LE ou SS. MÉTODO: No período de março de 2007 a março de 2009, 56 doentes (29 com diagnóstico de LE e 27 com SS) acompanhados na Divisão de Dermatologia e/ou de Reumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), foram avaliados. Todos os doentes apresentavam em comum a queixa de xerostomia e foram submetidos a biopsia das glândulas salivares labiais. Os espécimes foram submetidos a estudo histopatológico e de IFD. Todos os doentes foram também avaliados quanto ao uso de medicações, dados clínico-demográficos, comorbidades e duração dos sintomas. RESULTADOS: Dos 56 doentes examinados, 54 eram mulheres e apresentavam idades de 16 a 77 anos. Nas glândulas salivares de doentes com SS, observou-se, principalmente, sialadenite linfocítica moderada a intensa, com expressiva agressão ductal, fibrose e atrofia glandular. A intensidade da agressão tecidual correlacionou-se com a duração da SS. Nos doentes com LE, evidenciou-se sialadenite crônica leve na maioria dos casos acompanhada de espessamento e hialinização da membrana basal ductal e infiltrado linfocitário perivascular. A presença deste infiltrado correlacionou-se com a duração do LE. O exame de IFD revelou que 11 (41%) dos 27 doentes com SS apresentaram depósitos de IgA intercelulares no epitélio ductal. Os doentes com SS que demonstraram destruição glandular maciça (52%,n=14), apresentaram IFD negativa. Dezoito (62%) dos 29 doentes com LE apresentaram depósitos homogêneos de IgG na membrana basal dos ductos glandulares. CONCLUSÃO: As alterações histopatológicas e de IFD nas glândulas salivares de doentes com SS e LE são distintas. Na SS observa-se fundamentalmente infiltração linfocitária com agressão ductal e deposição de IgA, enquanto que no LE, a alteração principal é a hialinização da membrana basal ductal e deposição de IgG. Esses dados indicam que o envolvimento das glândulas salivares no LE é uma alteração específica da doença sialadenite lúpica, refletindo uma apresentação multissistêmica da mesma, sendo, portanto, inadequada a classificação dessas alterações como SS associada ao LE. / Background: Xerostomia is a symptom that can be triggered by chronic diseases such as Sjögren\'s syndrome (SS) and lupus erythematosus (LE). Many authors accredit most cases of salivary hypofunction in LE to secondary SS. Others believe that salivary changes in patients with LE might reflect a multisystem presentation of the disease. The present study compared histopathological and direct immunofluorescence (DIF) alterations in salivary glands of patients with xerostomia and diagnosis of LE or SS. Methods: From march of 2007 to march of 2009, in Hospital das Clínicas of São Paulo University, fifty-six salivary gland biopsies from patients with xerostomia and diagnosed with LE or SS were submitted to histopathological and DIF exams. Other clinical information was evaluated such as comorbidities and use of medication. Additionally, the patients were enquired about disease and dry mouth symptom duration. Results: From the 56 patients, 54 were women. Patients ages ranged from 16 to 77 years old. Twenty-seven had SS and 29 had LE. In SS, there was moderate to intensive sialadenitis, with infiltration and destruction of excretory salivary ducts. In LE, mild to moderate sialadenitis with thickening and hyalinization of the ductal basement membrane and perivascular lymphocytic infiltration were observed. DIF revealed that 41% (n=11) of SS patients presented intercellular ductal IgA deposits, whereas 62% (n=18) of LE patients demonstrated deposits of IgG in the ductal basement membrane. In 14 cases of SS, an intense glandular fibrosis was observed in histopathology and these cases were negative for all immunoglobulins in DIF. Conclusions: Taken together, the most important of our results indicate that alterations in minor salivary glands of patients with LE and SS are distinct both in their histopathological and immunofluorescence aspects. This reveals different mechanisms of xerostomia in these conditions. Salivary gland alterations in LE patients may be a specific manifestation of the LE process (lupus sialadenitis), reflecting its multisystemic presentation, instead of an association of secondary SS and LE.

O Quarteto de cordas em sol menor de Claude Debussy é uma obra marcada por importantes dicotomias. Composta em 1893, ela se encontra permeada de elementos harmônicos e formais ligados à tradição tonal e ao final do século XIX, particularmente ao compositor César Franck. Ao mesmo tempo, a peça utiliza procedimentos que são observados apenas em obras maduras do compositor, nas quais o tonalismo se encontra pouco presente, e análises que dependam exclusivamente de elementos tonais mostramse pouco eficientes para o Quarteto. Essa relação entre tradição e inovação é investigada nesta pesquisa, que traz como enfoque duas características diretamente relacionadas: a maneira como Debussy utiliza elementos repetidos nesta peça, assunto pesquisado por Sylveline Bourion, e aspectos relativos à forma cinética, elemento descrito por Richard Parks. Uma comparação entre o primeiro movimento do Quarteto e o primeiro movimento da Sonata para flauta, viola e harpa, peça do final da carreira de Debussy, é oportuna para que sejam observados elementos formais semelhantes aplicados em contextos diferentes. / Claude Debussy\'s String quartet in G minor is a work characterized by important dichotomies. Written in 1893, the piece is permeated by harmonic and formal elements attached to the tonal tradition and to the end of the 19th century, and specially to the composer César Franck. At the same time, the Quartet uses procedures observed only in Debussy\'s mature works, in which the presence of tonalism is weak, and analyses that rely exclusively on tonal elements are proven to have little efficiency regarding this piece. The relation between tradition and innovation is examined in this research, which focuses on two related characteristics: the way in which Debussy uses repeated elements in this piece, a matter also examined by Sylveline Bourion, and aspects related to the kinetic form described by Richard Parks. A comparison between the Quartet\'s first movement and the first movement from the Sonata for flute, viola and harp, composed at the end of Debussy\'s career, is useful for observing similar formal elements applied in different contexts.

This diploma thesis extends the bachelor thesis research that analysed whether and what characteristic features appear in ordinary language of native speaker who come from Jiratice. The goal of this thesis is linguistic analysis of official, unofficial personal names, minorplace and local names in Jiratice or in its nearby vicinity. These names are collected from written sources and from interviews with witnesses. The collected material is organized into a dictionary that analyses primarily the motivation of each name. The complex of names is also classified according to various criteria. The aim of the diploma thesis is to contribute partially to the Czech onymic research.

Domestic Minor Sex Trafficking is a crime happening right in our own backyards. Social Workers are seeing this vulnerable population fall through the fingers of social services and into the clutches of traffickers at alarming rates. This research project analyzed San Bernardino and Riverside County Foster Family Agency Social Workers' Awareness of Domestic Minor Sex Trafficking. This project was a quantitative exploratory research design. A paper survey was distributed to Foster Family Agency Social Workers within San Bernardino and Riverside County, California using a snowball sampling. A bivariate analysis was conducted to evaluate the relationship that social work experience in the field and the amount of DMST trainings attended have on social work awareness of DMST. The results of this research show that high number of DMST trainings result in a lower level of DMST awareness. Data also showed no significant relationship between how participants scored on the Awareness of Domestic Minor Sex Trafficking survey and years of social work experience. The results of this research can be used as a baseline to study Foster Family Agency Social Worker awareness with San Bernardino and Riverside County, California and how to best implement effective DMST trainings; as federal and state laws are predicted to make Domestic Minor Sex Trafficking training mandatory within social service fields.

1 9 ABSTRACT Jurkaninová, M.: Vinca minor L. alkaloids and their biological activity I. Diploma thesis, Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany, Hradec Králové, 2019 The aim of this thesis was the isolation of alkaloids from selected fraction 3 (joined fractions (15 - 36), which was a sub-fraction of the fraction VM 323 - 327. It was obtained from the previous processing of an alkaloidal extract from the Vinca minor L at the Department of Pharmaceutical Botany as a part of elaboration of diploma thesis of Aneta Vítavcová.[78] The fraction VM 323-327 was separated by column chromatography on silica gel and a totally, of 7 subfractions were obtained. Subsequent repeated processing of the selected sub-fraction 3 (15 - 36) by preparative TLC on silica gel resulted in the isolation of (-)-vinoxine and its racemate (±)-vinoxine. Identification of their structure was determined based on MS, NMR and optical rotation. The inhibitory activity against acetylcholinesterase, butyrylcholiesterase and prolyl oligopeptidase were determined for the isolated substances. Inhibitory activity against selected enzymes was measured by spectrophotometric methods. Isolated alkaloids were required to be inactive against AChE and POP (IC50 >1000 μM), against to BChE showed a...