Rapid urbanization is taking place in Low-and middle-income countries (LMICs). Often there is not sufficient data monitoring the quick urban change. This study explores the use of machine learning classification within remote sensing to foster sustainable urban practices in a secondary city in an LMIC. The aim is to extract spatially detailed land cover data and investigate its temporal evolution from 2018 to 2021. Furthermore, targeted interviews with residents were conducted to gain an in-situ understanding of the land cover changes. The research reveals a trend of increased impervious surface in Sekondi-Takoradi, especially around the urban outskirts. Some patterns of densification can also be identified, predominantly in urban areas with a mix of impervious surfaces and vegetation. These findings reveal similar land cover change patterns as previous remote sensing studies, a decrease in vegetation, and an increase in impervious surfaces.  The used method can be applied at a larger scale to monitor the urbanization of secondary cities in LMICs, a field that often is neglected. These insights can contribute to achieving the UN's 11th Sustainable Development Sustainable Cities and Communities.

This investigation is carried out with the desire to create a framework for digital learning tools in the region of Guanajuato, Mexico aimed towards primary schools in rural parts of the area. The framework is meant to be an aid in the implementation of technological equipments, especially tablets, and shed light on the most important aspects to take into consideration when designing and creating applications for those. In order to gather data, interviews and user tests were carried out with primary school students as well as with principals and teachers of primary schools in the mentioned area. The results show that clear feedback, intuitive graphics and appropriate levels of difficulty is of importance, as well as adaptability to users. No preference was noted regarding motions or amount of text. Norman’s design principles were additionally confirmed to be one of the vital parts to take into consideration. The challenges that come into the picture when implementing digital tools into classrooms seem to circulate around socio-economic aspects and insufficient resources such as wifi, power supply and personnel. However, these challenges may be worth taking upon, as implementing EdTech can benefit both students and teachers in many aspects and establish learning more in line with the trends in society where technology is on a constant rise. / Denna utredning genomförs med strävan att skapa ett ramverk för digitala lärverktyg i regionen Guanajuato, Mexico riktat mot grundskolor på landsbygden i området. Ramverket är tänkt att vara ett hjälpmedel vid implementering av teknisk utrustning, särskilt surfplattor, och belysa de viktigaste aspekterna att ta hänsyn till när man designar och skapar applikationer för dessa. För att samla in data har intervjuer och användartest genomförts med såväl grundskoleelever som med rektorer och lärare på grundskolor inom nämnda området. Resultaten visar att tydlig feedback, intuitiv grafik och svårighetsgrad är av betydelse, liksom anpassning till användaren. Ingen preferens noterades beträffande rörelser eller mängden text. Normans designprinciper bekräftades dessutom att vara en av de viktiga delarna att ta hänsyn till. De utmaningar som kommer in i bilden när man implementerar digitala verktyg i klassrummet verkar cirkulera kring socioekonomiska aspekter och otillräckliga resurser såsom wifi, strömförsörjning och personal. Men dessa utmaningar kan vara värda att ta sig an eftersom en inkorporering av EdTech kan gynna både elever och lärare i många aspekter och etablera lärande mer i linje med trenderna i samhället där tekniken är på ständig uppgång.

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[pt] Esta pesquisa versa sobre o maior entre os nascidos de mulheres, com base no texto de Mt 11,2-15. Partindo desse princípio, a pesquisa aborda sobre João, o Batista, no testemunho dado por Jesus aos discípulos que estavam à sua volta. É bem verdade que a vida de João, o Batista, é um enigma a ser desvendado, tendo em vista as poucas informações oferecidas a respeito de sua vida, com exceção daquelas que são encontradas em textos do Novo Testamento (Evangelhos e Atos dos Apóstolos) e em textos extrabíblicos. Ao pesquisar essa perícope, encontramos um paralelo em Lc 7,18-28, com suas semelhanças e diferenças, sobre as quais faremos menção aqui em nosso estudo e abordagem. Nesse sentido, esse trabalho faz uma análise do texto base aqui pesquisado, recorrendo ao contexto histórico de Mateus, passando pela comunidade mateana, onde o Evangelho foi desenvolvido e o testemunho de Jesus foi identificado a João, o Batista. Em outro momento, faremos um status quaestionis a respeito do tema João, o Batista, o maior entre os nascidos de mulheres em Mt 11,2-15 com as contribuições necessárias de alguns autores. Por fim, faremos uma exegese da perícope de Mt 11,2-15, seguindo os critérios do Método Histórico-Crítico e da Análise Retórica Bíblica, para alcançarmos o sentido próprio do texto direcionando para a compreensão do tema: João, o Batista, o maior entre os nascidos de mulheres: Uma análise exegética de Mt 11,2-15. / [en] This research deals with the greatest among women born based on the text of Mt 11,2-15. Based on this principle, the research addresses John the Baptist s testimony given by Jesus to the disciples around him. It is quite true that the life of John the Baptist is a riddle to be unraveled, given the little information offered about his life, except for that found in New Testament texts (Gospels and Acts of the Apostles). and in extrabiblical texts. In researching this pericope, we find a parallel in Luke 7,18-28, with its similarities and differences, which we will mention here in our study and approach. In this sense, this work makes an analysis of the base text researched here, using the historical context of Matthew, passing through the Matean community, where the Gospel was developed, and the testimony of Jesus was identified to John the Baptist. In another moment, we will make a status quaestionis on the theme John the Baptist, the greatest among the born of women in Mt 11,2-15 with the necessary contributions of some authors. Finally, we will make an exegesis of the pericope of Mt 11,2-15, following the criteria of the Historical-Critical Method and Biblical Rhetorical Analysis, in order to reach the proper meaning of the text, directing to the understanding of the theme: “John the Baptist, the greatest among women born: An exegetical analysis of Mt 11,2-15.

京都大学 / 新制・課程博士 / 博士(理学) / 甲第24078号 / 理博第4845号 / 新制||理||1693(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)准教授 小山 時隆, 教授 田村 実, 教授 山内 淳 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

Yes / CC-1065, the duocarmycins and yatakemycin are members of a family of ultrapotent antitumour antibiotics that have been the subject of extensive investigations due to their mode of action and potential in the design of new anticancer therapeutics. The natural products and their analogues exert their effects through a sequence selective alkylation of duplex DNA in the minor groove at the N3 of adenine. An understanding of their structure and its effect on biological activity has been derived through chemical synthesis and has also generated new potential lead compounds. These studies form the first section of the review. The desire to progress these compounds to clinic has also led to studies of bioconjugation and prodrug formation and this is discussed in the second section of the review. The combination of synthesis with key biological experiments is a powerful tool to define the requirements for the development of natural products as potential therapeutic agents. The studies described herein form an excellent paradigm for the study and development of other natural products. / EPSRC, Yorkshire Cancer Research, Big C Cancer Research, UCB Pharma

This dissertation examines the skill of adaptable playing essential for collaborative pianists by looking closely at the sonata's many challenges for ensemble playing, using musical examples from the sonata to study balance between instruments, tone and articulation, choice of voicing, and use of pedal to ensure a successful performance.

This thesis presents a brief history of the sonata form until the time of Beethoven. It also discusses Beethoven's use of the sonata form, and how it applies to his op. 111 piano sonata.