Submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic, Durban University of Technology, 2014. / BACKGROUND Mechanical neck pain (MNP) has been described as any condition which changes joint mechanics and muscle structure / function. A review of the current literature shows that Muscle Energy Technique (MET) is an effective manual therapy for patients with acute or chronic MNP. The most useful contraction of MET however remains unknown. Some authors advocate the use of a two to seven second MET (Brous, 2005; Greenman, 2003 Mitchell, Moran, and Pruzzo, 1979) whilst other authors have recommended contraction durations of 30 to 60 seconds (Chaitow, 2006; Feland et al., 2001; Bandy and Irion, 1994). This study aimed to establish the most suitable contraction duration of MET in the treatment of chronic MNP by comparing a short duration MET to a long duration MET. OBJECTIVES Objectives included the comparison of a five-second (short duration) MET and a 45-second (long duration) MET in terms of subjective and objective findings in the treatment of chronic MNP. METHOD This randomized clinical trial, with 53 participants utilised a randomization table for group allocation. For the purpose of this study an average of the short contraction durations reported in the literature i.e. five seconds, was used for the short duration MET treatment and an average of the long contraction durations reported in the literature i.e. 45 seconds, was used for the long duration MET. Group A (n=26) received the five-second MET contraction and Group B (n=27) received the 45-second MET contraction treatment. Objective measures included the cervical range of motion (CROM Goniometer) and tenderness levels (algometer). The subjective measures were pain (Numerical Rating Scale-101) and MNP related disability (CMCC Neck Disability Index). Each participant received four treatments over a two week period, with all data collected prior to the first and third consultations and at the final follow up. Data were analysed using the SPSS version 20 (IBM), with a statistically significant p value set at <0.05. Repeated measures ANOVA testing determined the intergroup effects. To assess intergroup effects and effects of the intervention a time x treatment group interaction analysis was conducted. Profile plots assessed direction and trend of the effect of the treatment. RESULTS Intra-group analysis of both groups showed significant improvement in all of the range of motion measures (over time) except for Flexion, Right Lateral Flexion and Left Rotation in Group A and Flexion, Extension, Right Lateral Flexion and Left Lateral Flexion in Group B. The intra-group analysis also showed a significant improvement in the neck disability index scores and the tenderness measurements in both groups. The results of the inter-group analysis revealed that only Left Lateral Flexion showed a significant treatment effect (p=0.011) where increased scores were shown in Group A and not in Group B. There was no treatment effect for the neck disability index scores or the tenderness measurements. CONCLUSION It may be concluded that both treatment protocols were equally effective for all outcomes except for Left Lateral Flexion where the five-second MET seemed to show greater degree of improvement than the 45-second MET. The neck disability index scores and the pain levels of participants in both groups showed an improvement. No treatment was better than the other in terms of these two variables. This therefore seems to support the use of the shorter duration MET in clinical practice.

Submitted in partial compliance with the requirements for the Masters’ Degree in Technology: Chiropractic, Department of Chiropractic, Durban University of Technology, Durban, South Africa, 2014. / Background Spinal manipulative therapy (SMT) is a commonly used therapeutic modality. It has been shown that neuromuscular reflexes are elicited during spinal manipulation resulting in changes in the surrounding muscle tonicity and seen as changes in surface electromyography. Despite this little is known about the effect that SMT may have on muscle function. Increased maximum voluntary contraction (MVC) of the paraspinal muscles has been observed following lumbar SMT compared to a control and sham treatment; however its effect on muscle endurance has not been investigated. The aim of this study was to determine the effect of lumbar SMT compared to a placebo treatment on lumbar extensor muscle endurance in asymptomatic individuals. Method This study was a quantitative double blinded, pre-test and post-test placebo controlled experimental trial. Forty asymptomatic participants were randomly allocated to one of two treatment groups. One group received a single SMT applied to the L3 vertebrae and the other received the pre-load force of the SMT but no thrust. Subjective (a self-report of pain/discomfort while performing the Biering-Sorensen test) and objective [surface electromyography (sEMG), paraspinal muscle endurance time and lumbar spine range of motion] measurements were taken pre- and post-intervention. The latest version of SPSS version (IBM SPSS Inc.) was used to analyse the data. A p-value < 0.05 was considered statistically significant. Independent t-tests were used to compare means and two-way factor ANOVA (for repeated measures) was used to compare the change in the two time points between the two treatment groups (intervention and control). RESULTS There were no statistically significant differences between the intervention and placebo groups in terms of subjective reports of pain/discomfort and objective evidence of surface EMG readings, paraspinal muscle endurance time and lumbar spine range of motion.

Submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic, Department of Chiropractic, Durban University of Technology, Durban, South Africa, 2015. / Background: Spinal manipulative therapy (SMT) is a commonly used treatment for many musculoskeletal conditions although the exact mechanism explaining its effectiveness is not well understood. Several studies have investigated the effect of SMT on the paraspinal muscles where neuromuscular effects have been observed, however few studies have assessed whether these changes result in a change in the functioning of the paraspinal muscles. This study aimed to determine the effect of lower thoracic spinal manipulation compared to a placebo intervention on lumbar extensor muscle endurance in asymptomatic participants. Methodology: This was a quantitative, pre-test post-test, placebo controlled trial involving 40 male participants between the ages of 20 and 40 years. The participants were randomly allocated to either the lower thoracic spinal manipulation group or a placebo group. Manipulation was delivered using the Impulse Adjusting Instrument®. Objective measures included lumbar spinal range of motion, a paraspinal muscle endurance test, and surface electromyography readings. Subjective measures were the verbalisation of pain and/or discomfort during the paraspinal muscle endurance test. IBM® SPSS® statistics version 21 and STATA 11 were used to analyse the data. A p-value of <0.05 was considered statistically significant. Results: There were no statistically significant differences between the groups in terms of subjective and objective measurements. A trend of treatment effect was observed for paraspinal muscle endurance where the intervention group showed noticeable improvements in endurance scores. Conclusion: Further studies need to be conducted to determine if the trends observed would occur in a larger study population.

Bakgrund: Befolkningen blir allt äldre och ökad ålder medför funktionsnedsättningar som minskad muskelmassa och balans. Det påverkar gången negativt, men genom att träna funktionellt eller träna upp muskelstyrkan och balansen kan äldres gångförmåga förbättras. Syfte: Syftet med studien är att undersöka hur äldres gångförmåga, self-efficacy och eventuell oro inför att gå påverkas av två olika åttaveckors interventioner med träning inom kommunal verksamhet, samt hur följsamhet till träning påverkas av self-efficacy och eventuell oro. Metod: Studiedesignen är en experimentell design i form av pretest-posttest control group som är en form av RCT. Nitton deltagare ≥65 år rekryterades via konsekutivt urval. Testresultat från TUG, självvald gånghastighet och skattningar på oro och self-efficacy inför att gå samlades in. Resultat: Ingen signifikant skillnad (p&gt;0,05) förekom mellan eller inom grupperna med avseende på testvariablerna. Korrelationsanalyserna visade på ingen, låga och moderata korrelationer, både positiva och negativa men inga signifikanta korrelationer observerades. Slutsats: Resultatet i studien kan inte generaliseras till en större population, men kan vara till grund för ytterligare studier med ett större stickprov som randomiseras utifrån populationen. Ytterligare studier krävs med syfte att undersöka om enbart gångträning är effektivt för att utveckla gångförmågan. / Background:  Since the population is aging the decrease in muscle function and balance impairments leads to increased disable. Which has a negative impact on walking ability, though through functional training, by training muscle strength and balance can enhance walking ability in elderly. Aim: The purpose of the study is to investigate how elderly people walking ability, self-efficacy and any anxiety about going, influenced by two different eight-week interventions within municipal operations, and how adherence to exercise is influenced by self-efficacy and anxiety. Method: The study design is an experimental variant of the pretest-posttest control group design. Nineteen participants’ ≥65 years recruited consecutively through selection. Test results from TUG, self-selected walking speed, and estimates on anxiety and self-efficacy before going was collected. Result: No significant difference (p&gt;0, 05) occurred between or within groups for the test variables. The correlation analysis showed none, low, moderate correlation, both positive and negative but no significant correlations was observed. Conclusion: The results of the study can’t be generalized to a larger population, but can be the basis for further studies with a larger sample to be randomized on the basis of population.  More studies are needed to investigate if only walking exercise is effective for developing the walking ability.

Thesis (MASpor)--University of Stellenbosch, 2007. / ENGLISH ABSTRACT: The purpose of this study was to gain more information on respiratory muscle function of team sports. This was achieved by determining the relationship between anthropometry and respiratory muscle function and the relationship between respiratory muscle function and exercise performance. The degree of respiratory muscle fatigue after a speed endurance test on land and in water was also determined. A total of 62 subjects were tested. The group consisted of 14 netball players (age: 20.9 ± SD 2.0 years; height: 172.5 ± SD 6.1cm and weight: 66.6 ± SD 7.8 kg); 15 rugby players (age: 21.7 ± SD 2.2 years; height: 183.1 ± SD 7.3cm and weight: 92.5 ± SD 13.2 kg); 12 male swimmers (age: 18.9 ± SD 2.5 years; height: 183.3 ± SD 6.5cm and weight: 77.2 ± SD 8.6 kg); 8 female swimmers (age: 17.8 ± SD 1.6 years; height: 168.3 ± SD 5.4cm and weight: 63.9 ± SD 9.8 kg); 7 male control subjects (age: 21.4 ± SD 1.5 years; height: 179.7 ± SD 5.0cm and weight: 80.8 ± SD 10.8 kg) and 6 female control subjects (age: 21.5 ± SD 1.5 years; height: 166.9 ± SD 6.5cm and weight: 60.2 ± SD 6.7 kg). Testing included anthropometric measurements, lung function (FVC test), and respiratory muscle function (baseline MIP, MEP, MVV). Netball -, rugby players and the control subjects performed a speed endurance test on land and the swimmers performed a speed endurance test in the swimming pool. This test was followed by a second MIP measurement 60 and 120 seconds after the sprint endurance test. Respiratory muscle strength showed no correlations to anthropometry for men and women. For men, height, weight, sitting height, biiacromiale breath and waist girth accounted for 17% of the variance in MIP (P = 0.34). The variance in MEP was accounted for 15.6% by height, weight, sitting height, biacromiale breath and waist girth (P = 0.41). For women, weight, sitting height, arm span, biacromiale breath and chest girth accounted for 28.4% of the variance in MIP (P = 0.17), but MEP was accounted for only 22% by sitting height, arm length, arm span and body mass index as well as chest girth (P = 0.32). Respiratory muscle endurance showed correlations to certain anthropometry variables and had a significant regression equations for MVV in men: -312.51 + (2.83 x Arm span) – (0.38 x Sum of 8 skinfolds) and arm span and sum of eight skinfolds accounted for 47.3% of the variance in MVV. Women’s MVV also had a significant regression (P = 0.002): - 106.7 + (1.5 x Body mass) + (1.0 x Arm span) – (0.2 x Sum of 8skinfolds) and weight, arm span and sum of eight skinfolds accounted for 45% of the variance in MVV. Only MIP and MEP had significant correlations (r = 0.63, P < 0.01 and r = 0.66, P < 0.02 respectively) to the speed endurance test on land. Although significant, MVV and FVC showed no correlations to the speed endurance test. Both MIP and MEP had a correlation to the speed endurance test in the water (r = -0.55, P < 0.02 for both). FVC also had a correlation to the speed endurance test, although it was not significant (r = -0.51, P < 0.44). MVV had a poor correlation to the speed endurance test. Sixty seconds after the speed endurance test the land –based group’s (netball and rugby players grouped together) RM were 14.39% fatigued compared to the 9.04% of the water – based group (swimmers) and 41.02% of the control group. One hundred and twenty seconds after the sprint endurance test the land –based group’s RM were 8.43 fatigued compared to the 3.54% of the water –based group and the 24.64% of the control group. In conclusion, anthropometry plays a moderate role in RM endurance but even a smaller role in RM strength. The relationship between RM functions and the speed endurance test varied between the land – and water –based groups, but certain RM function can play a moderate role in the performance in this speed endurance test. All the groups experienced fatigue after the speed endurance test, but the degree was more in the control group followed by the land –based athletes compared to the water –based athletes. This indicates that stronger RM function can lead to less RM fatigue. / AFRIKAANSE OPSOMMING: Die doel van die studie was om die respiratoriese spier funksies van span sporte te bestudeer en is gedoen deur na die verband tussen respiratoriese spier funksies en antropometrie, die verband tussen respiratoriese spier funksies en oefen prestasie en die mate van respiratoriese spier uitputting na oefening te kyk. ‘n Totaal van 62 subjekte is getoets. Die groep het bestaan uit 14 netbal (ouderdom: 20.9 ± SD 2.0 jaar; lengte: 172.5 ± SD 6.1cm en gewig: 66.6 ± SD 7.8 kg); 15 rugbyspelers (ouderdom: 21.7 ± SD 2.2 jaar; lengte: 183.1 ± SD 7.3cm en gewig: 92.5 ± SD 13.2 kg); 12 mans swemmers (ouderdom: 18.9 ± SD 2.5 jaar; length: 183.3 ± SD 6.5cm and gewig: 77.2 ± SD 8.6 kg); 8 dames swemmers (ouderdom: 17.8 ± SD 1.6 jaar; lengte: 168.3 ± SD 5.4cm and gewig: 63.9 ± SD 9.8 kg); 7 mans kontrole subjekte (ouderdom: 21.4 ± SD 1.5 jaar; lengte: 179.7 ± SD 5.0cm and gewig: 80.8 ± SD 10.8 kg) and 6 dames kontrole subjekte (age: 21.5 ± SD 1.5 years; height: 166.9 ± SD 6.5cm and weight: 60.2 ± SD 6.7 kg). Toetsing het die volgende ingesluit: Antropometriese meetings, long funksies en respiratoriese spier funksies (basislyn maksimale inspirasie drukking (MID), maksimale ekspirasie drukking (MED), maksimale willekeuring ventilasie (MWV)). ‘n Spoed uithouvermoë toets op land is deur die netbal –, rugbyspelers en die kontrole subjekte en ‘n uitgevoer en ‘n spoed uithouvermoë toets in die water is deur die swemmers uitgevoer. Beide hierdie toetse is gevolg deur ‘n tweede en derde maksimale inspirasie drukking 60 en 120 sekondes na die toets. Geen korrelasies is gevind tussen antropometrie en respiratoriese spier sterkte vir beide mans en dames. In die geval van mans, het lengte, gewig, bolyf lengte, bi- akromiale breedte en die omtrek van die middel 17% uitgemaak van die variansie in MIP (P = 0.34). Die variasie van MEP is uitgemaak deur 15.6% van lengte, gewig, bolyf lengte, biakromiale lengte en die omtrek van die middel (P = 0.41). Vir dames het gewig, bolyf length, arm reikwydte, bi –akromiale breedte en bors omtrek ’n 28.4% rol gespeel in die variansie van MIP (P = 0.17), maar die variasie in MEP is voorspel met 22% deur bolyf length, arm length, arm reikwydte, liggaams massa indeks en bors omtrek (P = 0.32). Respiratoriese spier uithouvermoê het ‘n korrelasie getoon met sekere antropometriese veranderlikes en ‘n statisties beduidende vergelyking vir mans MWV: -312.51 + (2.83 x Arm reikwydte) – (0.38 x Som van 8 velvoue) waar arm reikwydte en som van ag velvoue was verantwoordelik vir 47.3% van die variansie in MWV. Die dames se MWV het ook ‘n statisties beduidende vergelyking getoon: MWV = -106.7 + (1.5 x gewig) + (1.0 x Arm reikwydte) – (0.2 x Som van 8 velvoue) waar gewig, arm reikwydte en die som van ag velvoue verantwoordelik was vir 45% van die variansie in MWV. Slegs MID en MED het statisties beduidende korrelasies ( onderskeidelik r = 0.63, P < 0.01 and r = 0.66, P < 0.02 ) getoon met die spoed uithouvermoë toets op land. Geen korrelasie is tussen MWV en die geforseerde vitale kapasiteit toetse gevind al was die verband statistiese beduidend. Beide MID en MED het ’n korrelasie met die spoed uithouvermoë toets in die water getoon (r = -0.55, P < 0.02 vir beide). Die geforseerde vitale kapasiteit toets het ook ’n korrelasie met die spoed uithouvermoë toets, tog was dit nie statisties beduidend nie (r = -0.51, P < 0.44). MWV het geen korrelasie getoon met die spoed uithouvermoë toets op land. Sestig sekondes na die spoed uithouvermoë toets is ’n 14.39 % respiratoriese spier uitputting in die land gebaseerde groep (netbal – en rugby spelers), 9.04% respiratoriese spier uitputting in die water gebaseerde groep (swemmers) en ’n 41.02% respiratoriese spier uitputting in die kontrole groep gevind. Na 120 sekondes was die respiratoriese spiere van die land gebaseerde groep steeds 8.43% uitgeput in vergelyking met die 3.54% van die water gebaseerde groep en die 24.64% van die kontrole groep. Dus speel antropometrie ‘n matige rol in respiratories spier uithouvermoë en selfs ‘n kleiner rol in respiratoriese spier sterkte. Die verband tussen respiratoriese spier funksies en die spoed uithouvermoë toets het gevarieer tussen die land – en die water gebaseerde groepe, maar respiratoriese spier funksies kan ‘n matige rol speel in die voorspelling van die prestasie in die spoed uithouvermoë toets. Die kontrole groep het meer respiratoriese spier uitputting ervaar na die spoed uithouvermoë toets, dus beteken dit dat geoefende en ongeoefend persone respiratoriese spier uitputting sal ervaar.

Exercise-induced muscle soreness is characterized by stiffness, tenderness and pain during active movements and weakness of the affected musculature the days after unusually or particularly heavy work. The most pronounced subjective symptoms do not arise immediately but rather between a couple of hours to some days after the exercise (a delayed-onset of muscle soreness), the intensity of pain is greatest about 48 hours after the work. A particular association exists between muscle soreness and eccentric contractions. Despite the fact that muscle soreness is a well known phenomenon in the sphere of sports as well as working life, the pathophysiological mechanisms underlying this are still not understood. In the present study a detailed analysis of human muscle fibre population structure after high tension work (eccentric exercise) that gave rise to muscle soreness, was carried out. The objective was to elucidate how fibres of different types are influenced by repeated muscle contractions reaching extreme tension levels using qualitative and quantitative light and electron microscopic techniques. It was hoped that such morphological analysis would provide a basis for discussion of possible causes for muscle soreness. The muscle function after the work was measured by isokinetic methods. To improve the basis for the ultrastructural analysis the fibre populations in untrained and en­durance trained human m. vastus lateralis of age-matched individuals were classified into different fibre type groups according to their ultrastructure. The selective glycogen depletion from Type 1 fibres seen after long term submaximal work, visualized electron microscopically with PA-TSC-SP staining, substantiated the usefulness of the appearance of the M-band to differentiate between fibre types. Stereological data showed that neither volume density of mitochondria nor of lipid droplets provide sufficient criteria to differentiate between fibre types. After an eccentric exercise regimen sore muscles (m. soleus or m. vastus lateralis) showed disturb­ances of the cross striated band pattern. Fibres with disorganized myofibrillar material made up 1/3, 1/2 and 1/10 of the analysed material, 1 hour, 3 and 6 days after exercise, respectively. The myofibril­lar lesions were preferably localized in the Z-band. This showed streaming, broadening and sometimes total disruption. The Type 2 fibres were most affected. The reduction of strength was greatest with the most rapid contractions. Strength remained de­creased the period when the structural damage was most pronounced. Eight weeks of eccentric muscle training reduced all the above negative effects. The results indicate that the Z-disc constitute the weak link in the myofibrillar contractile chain at high muscle tensions. It is suggested that the myofibrillar lesions are a direct result of mechanical tearing. Rupture of myofibrils is thought to result in formation of protein components and a con- sequental release of protein bound ions that via osmosis result in oedema and soreness. Training, using eccentric contractions over a long period of time leads to adaptations at the fibre level by a reorgani­zation of the contractile apparatus as well as an optimization of nervous coordination. / <p>S. 1-40: sammanfattning, s. 41-79: 5 uppsatser</p> / digitalisering@umu

The purpose of this study was to examine the self-concepts and body cathexis of both males and females engaged in an eleven week weight training course and to examine if differences in gender role would influence the relationship of strength to self-concept and body cathexis. Each group (weight trainers versus controls) was administered the Tennessee Self Concept Scale, Bem Sex-Role Inventory, Eysenck Personality Inventory, and the Body Cathexis Scale. Strength measures were obtained. Group by gender ANOVA and ANCOVA examined differences between and among the groups and genders. Gender role by gender ANOVA and ANCOVA examined differences between and among the androgynous and masculine typed males and females. Multiple regression analyses were performed to examine the relationship of strength to body cathexis and self-concept. Results indicated pre- and post differences between and among the groups and genders and the genders and the gender roles.

Tyrimo pagrindimas: sportininkų judėjimo gebėjimai vyksta dalyvaujant paskutiniai grandžiai pėdos lenkiamiesiems ir tiesiamiesiems raumenims (Нечаев, 2011). Didelio meistriškumo graikų-romėnų imtynininkų raumenų kraujotakos mobilizacijos ir atsigavimo ypatybės yra artimesnės ištvermės sporto šakų atstovams nei sprinto grupės sportininkų ypatybėms. (Ežerskis, 2009). Tikslas- išanalizuoti skirtingos adaptacijos fiziniams krūviams vyrų ir merginų pėdų lenkiamųjų raumenų funkcinius ypatumus. Hipotezė: pėdos lenkiamųjų raumenų ištvermė priklauso nuo maksimalios valingos jėgos dydžių, kuo didesnė jėga, tuo mažesnė ištvermė. Metodai: dinamometrija, literatūros šaltinių studija, statistinė analizė. Aptarimas ir Išvados: dvikovos sportininkių, ištvermės ir greitumo jėgos atstovų tarpusavyje kairės ir dešinės kojos jėga nesiskyrė yra proporcingų dydžių. Ištvermės sportininkų vyrų pėdos lenkiamųjų raumenų kojų jėga buvo ženkliai didesnė už dvikovos, sporto šakų, tačiau mažesnė nei greitumo jėgos atstovų. Dvikovos sporto šakų sportininkių ir ištvermės atstovų bei greitumo jėgos sportininkų MRI rodikliai skyrėsi neženkliai, tačiau jėga buvo mažesnė Nuo jėgos dydžio priklauso ištvermės trukmė. Esant didesnei jėgai ištvermės trukmė mažėja. Pagal santykio MVJ/MRI reikšmes visos priklauso stajerio tipui. Tyrimo uždaviniai: 1. Nustatyti dvikovos sporto šakų moterų ir vyrų, pėdos lenkiamųjų raumenų maksimalios valingos jėgos dydžius. 2. Nustatyti dvikovos sporto šakų moterų ir vyrų, pėdos... [toliau žr. visą tekstą] / Introduction: Atlete's movement depends on the activity of the foot flexor muscle strength and endurance. High craftsmanship Greco- Roman wrestlers muscle blood mobilization and recovery features are closer to endurance sports disciplines than sprint atlete properties. Aim: Analysis the different physical exertion adaptation of men and a girl's foot muscle flexion functional features. Hypothesis: foot flexor muscle endurance duel sport athletes are the same length as the representatives of the endurance strength but size was lager. Methods: dynamometry, literature study, a statistical analysis. Discussion and Conclusion: The duel athletes, endurance and speed power representatives each other left and right leg power is proportional not different sizes. Endurance representatives of men's foot flexor muscles leg strength was significantly higher than the duel sports, but less than the speed force representatives. Duel sport athletes and endurance representatives maximal muscle endurance characteristics differed slightly, but the force was smaller size of the force depends on endurance time. At higher power of endurance time decreases. According to the ratio of maximal voluntary contruction / maximal muscle endurance values all belong stajer type. Exploratory tasks : 1)set duel sports for men and women, foot flexion maximum voluntary muscle force figures. 2)Set duel sports for men and women, foot flexor muscle endurance for maximum muscle size. 3)Identify and analyze the duel... [to full text]

In the first part of the thesis Objectification of disorders of the fine motor skills of the upper extremities in the patients with hereditary neuropathies there are mentioned some brief informations about characteristics, classifications, clinical symptoms, deformities and testing of upper extremities, rehabilitation and treatment of CMT neuropathy. The practical part of this thesis is concerned with testing and evaluating of strength, fine motor skills and sensation of the upper extremities in the patients with CMT. For the measurement of the hand strenght the dynamometry and the functional muscle test are used. The Jebsen-Taylor test, the Nine-Hole Peg Test and the examination of static and dynamic handgrip rating are used. For the examination of the sensation the Nottingham Sensory Assessment is used. CMT neuropathy score and Overall Neuropathy Disability Scaleare are used for the classification of disability. The aim of this thesis is the comparison of the muscle strength and the function of the dominant and non-dominant hand. Partial aim of thesis is detection of the correlations between tests. According to the results CMT disease leads to the muscle strenght weakness and to worsening of the fine motor skills mainly of the dominant upper extremity. This may be the result of overwork weakness. For...

O ATP é a moeda corrente de energia no organismo, sendo indispensável para a manutenção da homeostase celular. A fosfocreatina é a fonte mais rápida de regeneração do ATP, através da ação da enzima creatina quinase (CK). O presente estudo tem como objetivo avaliar os efeitos da suplementação de curto prazo com creatina (Cr) sobre parâmetros da função muscular em ratos, além de alterações celulares e moleculares que auxiliem na compreensão de tais efeitos. A suplementação com Cr promoveu uma atenuação da fadiga em todos os músculos analisados. A expressão proteica do GH na hipófise dos animais suplementados encontrou-se reduzida, assim como a expressão gênica do IGF-I hepático. No músculo, O IGF-I teve sua expressão aumentada. Houve hipertrofia das fibras musculares tipo I e aumento na proporção de fibras tipo II no sóleo. O conteúdo muscular de espécies reativas de oxigênio mostrou-se reduzido no grupo Cr. Ensaios cell free apontam para uma ação direta da molécula de Cr sobre o radical superóxido. Assim, os efeitos observados podem se dever a uma ação antioxidante da Cr, que muito se assemelha à resposta observada quando animais são tratados com N-acetil-cisteína, um potente antioxidante. / The ATP is the energy unit of currency in the body and is indispensable for the maintenance of cellular homeostasis. Phosphocreatine is the fastest source for ATP regeneration, catalyzed by creatine kinase (CK). This study aims to evaluate the effects of short-term creatine (Cr) supplementation upon muscular functional parameters and cellular and molecular alterations that could explain such effects. Cr supplementation promoted an attenuation of muscle fatigue. GH protein expression was reduced in supplemented animals, as well as IGF-I mRNA in the liver, but not in muscle, where its expression was stimulated by Cr. Muscle fibers of soleus were hypertrophied and the type II fiber content was augmented. The muscular content of oxygen reactive species was lower in Cr group. Cell free experiments show a direct scavenger action of Cr on superoxide anion. Thus, the effects could result from a antioxidant properties of Cr. These effects was similar to that observed when N-Acetyl-Cysteine (a potent antioxidant) was administered to adult rats prior to intense contractile activity.