Thesis (LLM (Public Law))--University of Stellenbosch, 2010. / Bibliography / ENGLISH ABSTRACT:The objective of this thesis is to establish whether the notion of public nuisance has a legitimate purpose in post-apartheid South African. Public nuisance originated in English law in the 12th century as a tort-based crime called tort against land and was used to protect the Crown against infringements. This special remedy of the Crown was used in cases of unlawful obstruction of public highways and rivers, damage or injury causing an inconvenience to a class or all of her majesty‟s subjects and a selection of other crimes. The notion of public nuisance was adopted in South African law during the late 19th century. Between its inception and 1943, the notion of public nuisance was applied in line with its original aims, namely to protect and preserve the health, safety and morals of the public at large. Public nuisance regulated unreasonable interferences such as smoke, noise, violence, litter and blockage of roads which originated in a public space or land, as opposed to a private space or land. However, the public nuisance remedy was indirectly used, in a number of cases during the 1990s, by private individuals to apply for an interdict to evict occupiers of informal settlements. In so doing, these private individuals bypassed legislation regulating evictions and in the process disrupted or frustrated new housing developments, especially those provided for in land reform programmes. In fact, it was established that this indirect application of public nuisance is unconstitutional in terms of section 25(1) of the Constitution. Most of the public disturbances originally associated with the public nuisance doctrine are currently provided for in legislation. Since the remedy is now mainly provided for in legislation, the question is whether the doctrine of public nuisance as a Common Law remedy is still relevant in modern South African law. It was concluded, especially after an analysis of two cases during 2009 and 2010, that the notion of public nuisance only has a future in South African law if it is applied iv in the absence of statutory nuisance or any other legislation covering public nuisance offences and where it is not used as an alternative mechanism to evict occupiers. / AFRIKAANSE OPSOMMING: Die doel van die tesis is om vas te stel of publieke oorlas as gemeenregtelike remedie „n geldige doel in post-apartheid Suid-Afrika het. Die remedie bekend as publieke oorlas het ontstaan in 12de eeuse Engelse reg. Hierdie remedie het ontwikkel as „n delikteregtelike en kriminele remedie, met die doel om land wat aan die Kroon behoort te beskerm. Publieke oorlas het, onder andere, toepassing gevind waar daar onwettige obstruksie van publieke hoofweë en riviere was sowel as skade of nadeel wat vir die breë publiek ongerief sou veroorsaak. Ander misdade was ook gekenmerk as „n publieke oorlas. Publieke oorlas is teen die laat 19de eeu in die Suid-Afrikaanse regoorgeneem . Tussen die oorname van die remedie in die Suid-Afrikaanse reg en 1943 is die remedie van publieke oorlas toegepas in lyn met sy oorspronlike doelwitte, naamlik om optrede wat die gesondheid, veiligheid en moraliteit van die breë publiek in gedrang kon bring, te verhoed. Volgens sy oorspronklike doel reguleer publieke oorlas onredelike inmenging soos rook, geraas, geweld en obstruksie van paaie wat op publieke grond of „n publieke spasie ontstaan het. Die remedie van publieke oorlas is, in ‟n reeks sake gedurende die 1990‟s, deur privaat individue indirek gebruik om okkupeerders van informele nedersettings uit te sit. Sodoende het privaat individue die wetgewing wat spesiaal ontwerp is om uitsettings te reguleer vermy en in die proses nuwe behuisingsontwikkelinge ontwrig en gefrustreer, veral in gevalle waarvoor in grondhervormingsprogramme voorsiening gemaak word. Hierdie indirekte toepasing van publieke oorlas is ongrondwetlik omdat dit nie met artikel 25(1) van die Grondwet versoenbaar is nie. Die meerderheid van steurnisse wat gewoonlik met publieke oorlas geassosieer word, word tans deur wetgewing gereguleer. Aangesien die remedie nou hoofsaaklik in wetgewing vervat is, ontstaan die vraag of die leerstuk van publieke oorlas as „n gemeenregtelike remedie nog van enige nut is in die moderne Suid-Afrikaanse reg. vi Die slotsom, veral na die analise van twee sake in 2009 en 2010, was dat die publieke oorlas remedie slegs „n toekoms in Suid-Afrikaanse reg het, indien dit toegepas word in die afwesigheid van statutêre oorlas of enige ander wetgewing wat publieke oorlas oortredinge dek en waar dit nie as „n alternatiewe meganisme gebruik word om okkupeerders uit te sit nie. / National Research Fund

Com o aumento do tráfego aéreo no aeroporto de Ribeirão Preto - SP e o conhecimento de várias reclamações sobre o incômodo sonoro junto ao Ministério Público é apresentada uma análise, através de simulação computacional, de como ficou as curvas de ruído deste aeródromo. O objetivo deste estudo foi verificar como a população, que está no seu entorno, é afetada pela operação das aeronaves e qual o percentual a ser encontrado após a simulação realizada com o programa INM (Integrated Noise Model). A simulação indicou que o aumento das operações no Aeroporto Leite Lopes SBRP não ocasionou um impacto maior na população afetada dentro da área definida pela curva de 65 dB(A), ficando este valor dentro de parâmetros aceitáveis pelas normas adotadas. A velocidade e a direção dos ventos locais contribuem para o aumento do impacto ambiental, sugerindo a necessidade de alterar as rotas das aeronaves conforme ocorrerem estas mudanças meteorológicas. O estudo indicou a necessidade de alteração das rotas de pouso e decolagem. Orientar os pilotos através dos controladores de voo que pousos e decolagens sejam efetuados pela cabeceira da pista 36 (trinta e seis), prolongando o eixo de decolagem em mais 2 milhas náuticas ou 2 km. Para mitigar o efeito do impacto produzido pelas operações das aeronaves no aeroporto, se faz necessário a realização de novos estudos para que possamos orientar o planejamento urbano do entorno utilizando novas rotas de voos com novos levantamentos de campo e simulações. / With increasing air traffic at the airport of Ribeirão Preto - SP and the knowledge of numerous complaints about noise nuisance with the Public Ministry, it is presented an analysis through computer simulation of how would be the noise curves of this airfield. The objective of this study was to determine how the population, which is in its surroundings, is affected by the operation of aircraft and what percentage to be found after the simulation performed with the program INM (Integrated Noise Model).The simulation indicated that the increase in operations in Leite Lopes Airport - SBRP did not cause increases in the affected population within the area defined by the curve 65 dB(A), with this value within acceptable parameters by the standards adopted. The speed and direction of local winds contribute to the increased environmental impact, suggesting the need to change the routes of aircraft as these weather changes occur. The study indicated the need for change in takeoff and landing routes. Guide the pilots through the flight controllers that takeoffs and landings are made by the end of the runway 36 (thirty six), extending the shaft off at over 2 nautical miles or 2 km. To mitigate the effect of the impact produced by aircraft operations at the airport, it is necessary to carry out further research so we can guide the planning of urban environment using new flight routes with new field surveys and simulations.

Com o aumento do tráfego aéreo no aeroporto de Ribeirão Preto - SP e o conhecimento de várias reclamações sobre o incômodo sonoro junto ao Ministério Público é apresentada uma análise, através de simulação computacional, de como ficou as curvas de ruído deste aeródromo. O objetivo deste estudo foi verificar como a população, que está no seu entorno, é afetada pela operação das aeronaves e qual o percentual a ser encontrado após a simulação realizada com o programa INM (Integrated Noise Model). A simulação indicou que o aumento das operações no Aeroporto Leite Lopes SBRP não ocasionou um impacto maior na população afetada dentro da área definida pela curva de 65 dB(A), ficando este valor dentro de parâmetros aceitáveis pelas normas adotadas. A velocidade e a direção dos ventos locais contribuem para o aumento do impacto ambiental, sugerindo a necessidade de alterar as rotas das aeronaves conforme ocorrerem estas mudanças meteorológicas. O estudo indicou a necessidade de alteração das rotas de pouso e decolagem. Orientar os pilotos através dos controladores de voo que pousos e decolagens sejam efetuados pela cabeceira da pista 36 (trinta e seis), prolongando o eixo de decolagem em mais 2 milhas náuticas ou 2 km. Para mitigar o efeito do impacto produzido pelas operações das aeronaves no aeroporto, se faz necessário a realização de novos estudos para que possamos orientar o planejamento urbano do entorno utilizando novas rotas de voos com novos levantamentos de campo e simulações. / With increasing air traffic at the airport of Ribeirão Preto - SP and the knowledge of numerous complaints about noise nuisance with the Public Ministry, it is presented an analysis through computer simulation of how would be the noise curves of this airfield. The objective of this study was to determine how the population, which is in its surroundings, is affected by the operation of aircraft and what percentage to be found after the simulation performed with the program INM (Integrated Noise Model).The simulation indicated that the increase in operations in Leite Lopes Airport - SBRP did not cause increases in the affected population within the area defined by the curve 65 dB(A), with this value within acceptable parameters by the standards adopted. The speed and direction of local winds contribute to the increased environmental impact, suggesting the need to change the routes of aircraft as these weather changes occur. The study indicated the need for change in takeoff and landing routes. Guide the pilots through the flight controllers that takeoffs and landings are made by the end of the runway 36 (thirty six), extending the shaft off at over 2 nautical miles or 2 km. To mitigate the effect of the impact produced by aircraft operations at the airport, it is necessary to carry out further research so we can guide the planning of urban environment using new flight routes with new field surveys and simulations.

Les nuisances causées par les odeurs sont devenues un problème environnemental et de santé publique majeur au cours des dernières décennies, surtout dans les zones densément peuplées. Pour cette raison, les odeurs environnementales sont un sujet de préoccupation mondiale et qui reçoivent une attention de plus en plus importante au Brésil. Cependant, il manque aux autorités brésiliennes les instruments réglementaires pour prévenir ou atténuer ces impacts. Plus précisément, au niveau national, aucune législation n’établit des limites d’exposition aux odeurs (critères d’acceptabilité) basé sur les facteurs FIDOL (i.e., fréquence, intensité, durée, offensivité et localisation) qui déterminent l’ampleur de l’effet expérimenté par le récepteur, qui peut être un individu ou un groupe d’individus dans une communauté exposée à des odeurs environnementales. En outre, à l’exception de l’état du Paraná (au sud) et la ville de Uberlândia (au sud-est du pays), aucune méthodologie basée sur l’olfactométrie (i.e., mesure de la réponse d’un jury à un stimulus olfactif), n’est ni standardisée ni reconnue. Dans ce contexte, ce travail de thèse vise à contribuer au développement de politiques publiques de lutte contre les nuisances olfactives au Brésil. Une approche est présentée pour l’évaluation des émissions odorantes d’un site d’équarrissage (une activité à fort potentiel de pollution environnementale) et mettre en évidence la nécessité d’établir un cadre légal et réglementaire pour les odeurs au Brésil, notamment un système d’agrément environnemental avec des critères de conformité spécifiques à chaque secteur de l’industrie. Conscient du besoin de tenir compte des caractéristiques et attributs de la juridiction, comme l’activité économique et la superficie du territoire, l’applicabilité de l’olfactométrie de terrain (en utilisant des appareils portables) a été évaluée pour le relevé d’un contour de panache d’odeur dans l’environnement. De plus, une recherche bibliographique et documentaire a été menée afin de fournir des éléments qui pourront aider les autorités locales dans le développement de solutions adaptées en référence aux expériences et pratiques utilisées à l’échelle internationale. Différents critères de conformité sont discutés et recommandés, sur la base d’une approche réglementaire qui prévoit l’adoption des Meilleures Techniques Disponibles (MTD) et l’établissement de Normes de Distances Minimales (NDM), Normes Maximales d’Emission (NME), Normes Maximales d’Impact (NMI), Normes Maximales de Nuisance (NMN; VIEIRA, 2013). Il est prévu que cette recherche promeut des discussions sur la gestion et la réglementation des odeurs au Brésil (y compris les citoyens, le gouvernement, l’industrie et le milieu académique) et puisse aider à soutenir le développement des structures juridique et réglementaire en vigueur, afin d’assurer un niveau minimum de confort et de protection à la population exposée à ce type de pollution. / Annoying odours have become a major environmental and public health issue in recent decades, especially in densely populated areas. For this reason, environmental odours are a matter of global concern and have received increasing attention in Brazil. However, Brazilian authorities lack the regulatory instruments to prevent or mitigate such impacts. More specifically, at the national level, there is no legislation establishing odour exposure limits (acceptability criteria) based on the FIDOL factors (i.e., frequency, intensity, duration, offensiveness and location) that determine the magnitude of the effect experienced by the receptor, which may be an individual or a group of individuals in a community exposed to environmental odours. Moreover, except for the state of Paraná (in the southern) and the municipality of Uberlândia (in the southeast part of the country), no methodology based on olfactometry (i.e., the measured response of a jury to an olfactory stimulus) is neither standardised nor recognized. In this context, this doctoral thesis aims to contribute to the development of public policies for odour-nuisance control in Brazil. It presents an approach for the evaluation of odour emissions from a rendering plant (an activity with high potential for environmental pollution) and highlights the need to establish a legal and regulatory framework for odours in Brazil, including an environmental permitting system with industry-specific compliance criteria. In light of the necessity of considering jurisdiction-specific characteristics and features such as economy and land area, the applicability of field olfactometry (using portable equipment) was evaluated to outline the contours of an odour plume in the environment. Additionally, bibliographical and documentary research were conducted to provide information that may assist local authorities in developing tailored solutions by reference to experience and practices that have been employed internationally. Different odour compliance criteria are discussed and recommended, based on a regulatory approach that provides for the adoption of the Best Available Techniques (BAT) and the establishment of Minimum Distance Standards (MDS), Maximum Emission Standards (MES), Maximum Impact Standards (MIS) and Maximum Annoyance Standards (MAS; VIEIRA, 2013). It is expected that this research will foster discussions on odour management and regulation in Brazil (involving citizens, government bodies, industry and academia) and may help support the development of the legal and regulatory framework in force, to ensure a minimum level of comfort and protection for the population exposed to this type of pollution.

Le stress environnemental croissant perçu dans les zones résidentielles crée un sentiment d’insécurité et une perception négative de la qualité de vie, plaçant la nuisance olfactive au coeur des préoccupations des études environnementales. Dans ce contexte, les travaux de recherche présentés dans cette thèse de doctorat ont été initiés dans le but d’aboutir à une méthode permettant d’évaluer et de représenter les niveaux de gêne olfactive sur un territoire. En conséquence, l’intérêt s’est porté non seulement sur les caractéristiques de la source et des sujets récepteurs mais aussi sur leur environnement au moment de la perception de la nuisance odorante. Plus particulièrement, l’objectif de cette nouvelle approche est de permettre de mesurer et de prévoir l’impact olfactif d’une industrie existante ou future sur un territoire donné. L’idée est de représenter le niveau de gêne olfactive et ses conséquences sur le territoire, afin d’avoir une meilleure gestion du site industriel en termes de rejets, mais aussi de fournir une aide à la décision claire et objective aux acteurs impliqués. La démarche développée s’articule autour de deux concepts : la gêne olfactive et le préjudice économique de cette gêne sur le territoire. Ces deux concepts sont définis par un ensemble de critères hétérogènes organisés et agrégés afin d’aboutir à un outil géographique et environnemental opérationnel. L’outil a été validé autour d’un site industriel permettant de confronter l’approche méthodologique développée et le résultat des mesures sur place. Les résultats de l’application de cette méthode sont de qualité satisfaisante et ouvrent la porte à de nombreuses perspectives de recherche. / The increasing environmental stress felt in residential areas leads to an unsafety sensation and to a negative life-quality perception, setting odor annoyance at the heart of environmental issues. Within this context, the research work presented in this doctoral thesis was initiated in order to result in a method allowing to assess and to represent the odor annoyance levels on a given territory. As a consequence, the interest has focused not only on the characteristics of the source and of the exposed targets, but also on their environment during the perception of the olfactory nuisance. To be more precise, the aim of this new approach is to make us able to measure and to forecast the olfactory impact of an existing or a future industry plant on a given territory. The main idea is to represent the level of odor annoyance and its consequences on the territory, in order to reach a best level of industrial plant management in terms of wastes as well as to provide a clear and objective decision support tool for the involved actors. The developed method revolves around two main concepts: the odor annoyance and the economical prejudice of this annoyance on the targeted territory. These two concepts are defined by a group of heterogeneous criteria, organized and aggregated in order to obtain a geographical and environmental operational tool. This tool has been validated for an industrial plant, thus comparing the developed approach to on the spot measurements results. The results of the application of this method came out satisfying and open numerous paths of inquiry.

This thesis deals with the emergence of the airport as a new strategic actor in the air transport system which has undergone profound changes since its liberalisation and within which the airport turned out to be a major player. Considering the airport as an actor in the air transport system, even if it is affected by its environment in a large sense, this work proposes a contribution to current discussion about airport economics. This contribution refers to two levels : an analysis of the European airport business within which the airport emerges as a full player and an analysis of the link between airport strategy and the spatial and territorial context into which the airport is embedded. Based on the differentiation of airport strategies according to the airports' commitment to certain market segments, the analysis of the spatial and territorial context into which the airports are embedded showed its influence on the development of airports but confirmed also that the latter is not automatic but subject to the dynamics arising from the interactions between the different actors. The emergence of the airport as a new strategic player in the air transport system places the emphasis on the complex relation between airport and territory which is reflected in a number of issues connected with the airport activity

The state of California has one of the largest and most violent gang populations in the United States. Although there have been a variety of anti-gang measures and policies enacted by local and state governments, none have been more effective than the Civil Gang Injunction (CGI). This civil action prohibits certain street gangs, and their members, from participating in activities that would otherwise be considered lawful. In order to obtain an injunction a prosecutor must demonstrate to the court that the gang is engaged in ongoing criminal conduct and represents a public nuisance to a geographically defined area. When a neighborhood is under an injunction, not only is police presence in the area increased but officers are also given more freedom to investigate and apprehend gang members who are suspected to be in violation of the terms. As this thesis will argue, injunctions, when used correctly, have proven to be an effective weapon in diminishing the influence of territorial street gangs on community well-being. When used incorrectly, however, they often only provide a temporary fix to a long-lasting problem. They also have been known to contribute to an increase in crime in neighboring areas, an increased number of wrongful arrests, and in some cases they have promoted criminality amongst young people. To explore the efficacy of injunctions, this thesis will focus on three empirical studies that cover a period from 1993 to 2003, when the rates of gang-related violence were at an all-time high and injunctions became the primary tool for City and District Attorneys to combat the nuisance. Two of these studies argue that injunctions have a positive impact on violent crime statistics, whereas the third concludes that they do not. By comparing these conflicting pieces of quantitative evidence, this thesis aims to gauge the actual effect of injunctions on crime rates and weigh the perceived benefits of this measure against its unintended negative effects.

La prévision du bruit rayonné par une structure vibrante à partir de données vibratoires calculées ou mesurées intéresse de nombreux industriels qui, dés le stade de la conception, peuvent prévoir, analyser et éventuellement corriger les nuisances sonores engendrées par une machine. Grâce aux récents développements des moyens de calcul numériques, les travaux de recherche théoriques et expérimentaux dans le domaine de la vibro-acoustique ont fortement progressé. Ils ont conduit à des logiciels de calcul basés sur des méthodes d'éléments finis ou d'éléments finis de frontière qui nécessitent cependant des investissements importants : calculateurs puissants et utilisateurs avertis. Afin de réduire les temps de calcul, on applique le principe des sources équivalentes en remplaçant la structure par une sphère qui va générer le même rayonnement acoustique que la structure. Le champ de vitesse vibratoire à la surface de la structure étant supposé connu, il est utilisé pour déterminer le champ vibratoire à la surface de la sphère équivalente par minimisation (méthode de la sphère équivalente proprement dite) ou par projection (approche géométrique). Les deux méthodes sont validées sur des exemples numériques et expérimentaux lorsque la structure admet une géométrie simple et compacte. Différents paramètres qui permettent de caractériser le modèle (rayon et position de la sphère par exemple) ainsi que la précision et la stabilité des résultats en fonction du maillage vibratoire et des erreurs de mesure sont discutés.

Made available in DSpace on 2016-06-02T19:46:22Z (GMT). No. of bitstreams: 1 5017.pdf: 3901978 bytes, checksum: 341c26eb41e6c9a13550c8429a4ff3f9 (MD5) Previous issue date: 2013-02-26 / The Asperger nuisance is considered a global development nuisance with loss in many areas: social interaction, communication and interests and restrict activities. People with the nuisance, in general, do not present problems of cognitive and verbal fluency is evident. The searches about the academics abilities of reading and writing to this population are scarce in the scientific literature. A student joined this research with a previous Asperger diagnostic, he was in his last year on high school, 9 years and 11 months old. The present search identified the positive points and the academic deficits in reading and writing of the student; present strategies, programs and teaching reviews of individualized teaching were made. It was implemented five programming of teaching to the specific difficulties of the student, with the progression criterion from the repertory development of the student. It was: 1) Module of Application 2 of the Reading Program and dictation managed by the software Aprendendo a ler e escrever em pequenos passos; 2)Complemented activity of auditory discrimination; 3) Program to exchange phonemic voiced and unvoiced; 4) Vocalic meeting program and 5) Read texts. The experimental designs used were a multiple base line to the programs 1 and 5 and the design of pre and post test to the programs 3 and 4. The general goals about reading were: 1) Read with precision complex words from the portuguese language and texts; 2) Read with fluency; 3) Read with understanding. About the writing: 1) Write with precision under control dictation. The specific goals were relacted to: discriminate accurately between words dictated and words printed that presented phonemes deaf and sound; read and write with precision with meeting vowel; write with a right sequence of words of configuration vowel-word-consonant-vowel. The results showed satisfactory and achieved the goal presented. The research showed still the importance of elaboration of teaching strategies based in the verification of needs and students potential, beyond teaching and consistent evaluations, systematic and consistent. / O Transtorno de Asperger é classificado como um Transtorno Global do Desenvolvimento com prejuízos em várias áreas: interação social, comunicação e interesses e atividades restritos. Pessoas com o transtorno, em geral, não apresentam problemas de ordem cognitiva e a fluência verbal é evidente. As pesquisas sobre as habilidades acadêmicas de leitura e escrita para esta população são escassas na literatura científica. Participou desta pesquisa um estudante com diagnóstico prévio de Síndrome de Asperger, que cursava 3º ano do ensino fundamental, com 9 anos e 11 meses. A presente pesquisa identifica os pontos positivos e os déficits acadêmicos em leitura e escrita do participante; apresenta estratégias, programações e avaliações de ensino dessas habilidades, bem como os resultados conseguidos com as programações de ensino individualizado realizadas. Foram implementadas cinco programações de ensino para as dificuldades específicas do participante, com critério de progressão a partir do desenvolvimento dos repertórios do aluno. Foram: 1) Aplicação do Módulo 2 do Programa de leitura e ditado gerenciado pelo software Aprendendo a ler e escrever em pequenos passos; 2) Atividade complementar de discriminação auditiva; 3) Programa para trocas fonêmicas surdas e sonoras; 4) Programa de encontros vocálicos; e 5) Leitura de textos. Os delineamentos experimentais utilizados foram de linha de base múltipla para as programações 1 e 5 e delineamento de pré e pós-teste para as programações 3 e 4. Os objetivos gerais quanto à leitura consistiram em: 1) Ler com precisão palavras complexas da língua portuguesa e textos; 2) Ler com fluência; 3) Ler com compreensão. Quanto à escrita: 1) Escrever com precisão sob controle de ditado. Os objetivos específicos estavam relacionados a: discriminar com precisão entre palavras ditadas e palavras impressas que apresentavam fonemas surdos e sonoros; ler e escrever com precisão palavras com encontros vocálicos; escrever em sequência correta palavras de configuração vogal-letra-consoante e/ou consoante-letra-vogal. Os resultados mostraram-se satisfatórios e alcançaram os objetivos propostos. A pesquisa mostrou ainda a importância da elaboração de estratégias de ensino baseadas na verificação das necessidades e potencialidades dos alunos, além de ensino e avaliações coerentes, sistemáticos e consistentes.

The fundamental question of how cells maintain their characteristic size remains open. Cell size measurements made through microscopic time-lapse imaging of microfluidic single cell cultivations have posed serious challenges to classical cell growth models and are supporting the development of newer, nuanced models that explain empirical findings better. Yet current models are limited, either to specific types of cells and/or to cell growth under specific microenvironmental conditions. Together with the fact that tools for robust analysis of said time-lapse images are not widely available as yet, the above-mentioned point presents an opportunity to progress the cell growth and size homeostasis discourse through generative, probabilistic modeling and analysis of the utility of different statistical estimation and inference techniques in recovering the parameters of the same. In this thesis, I present a novel Model Framework for simulating microfluidic single-cell cultivations with 36 different simulation modalities, each integrating dominant cell growth theories and generative modelling techniques. I also present a comparative analysis of how different Frequentist and Bayesian probabilistic inference techniques such as Nuisance Variable Elimination and Variational Inference work in the context of a case study of the estimation of a single model describing a microfluidic cell cultivation.