Made available in DSpace on 2014-06-12T23:04:13Z (GMT). No. of bitstreams: 2 arquivo8850_1.pdf: 2028888 bytes, checksum: 97a08be09d0c0592daf310c3b039a36a (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2007 / O CEC oral representa 90% de todos os tumores malignos que afetam a boca. A infecção por HPV (Papilomavírus Humano) demonstrou ser um fator relevante no desenvolvimento do carcinoma oral, assim como o polimorfismo do Códon 72 (alelo-G) do gene TP53, cuja transcrição da proteína supressora tumoral p53 é modificado. A degradação da p53 ocorre em função da interação entre a oncoproteína viral E6 junto ao sistema proteolítico ubiqütina-proteossômica. O objetivo deste trabalho foi identificar a presença do HPV no CEC oral e verificar a associação com o polimorfismo do códon 53 do gene TP53 . O grupo experimental foi composto por 24 pacientes com CEC oral , os quais freqüentavam a rotina do Hospital do Câncer de Pernambuco. O grupo controle fora composto por 21 indivíduos que apresentavam o mesmo ambiente familiar e as mesmas relações sociais dos pacientes estudados. O material biológico foi obtido pela esfoliação da mucosa oral e o DNA extraído através do método de Salting Out. A detecção do HPV foi realizada por PCR a partir da utilização dos primers GP5 + GP6 +. A identificação do polimorfismo do códon 72 (alelo-G) foi feita por PCR - RFLP. Os resultados foram negativos para a presença do HPV. Não foi observada associação entre a presença do polimorfismo alelo-G nos pacientes com CEC oral na amostra avaliada (X2 = 4,048; P = 0,132). Os resultados confirmaram que os homens (X2 = 5,88; P = 0,01) e fumantes (X2 = 8,84; P = 0,002) apresentaram uma maior freqüência de diagnóstico positivo para o CEC oral, assim como foram encontrados valores estatisticamente significativos para a idade dos indivíduos estudados (X = 5,88; P = 0,01). Os resultados não sugerem uma associação com o polimorfismo do gene TP53 (alelo-G) e da infecção por HPV com CEC oral. Os resultados para o sexo e tabagismo estão de acordo com a literatura científica

Orientador: Maria Laura Trindade Mayrink-Sabinson / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem / Made available in DSpace on 2018-07-19T22:36:36Z (GMT). No. of bitstreams: 1 Vargas_SuzanaLima_M.pdf: 19468834 bytes, checksum: ddc7114a0ec3be10e4d109126dcbade2 (MD5) Previous issue date: 1994 / Resumo: Este trabalho teve como objetivo refletir sobre a construção da relação entre a oralidade e a escrita pela criança na atividade de narrar oralmente e por escrito, e refletir sobre como o adulto contribui neste processo. O tema da pesquisa pareceu-nos pertinente devido ao fato de as escolas esperarem que as cnanças estejam produzindo bons textos narrativos ao final das séries iniciais. Nossas questões específicas de pesquisa foram, portanto: (a) investigar se há espaços em contexto escolar de alfabetização para o desenvolvimento do discurso narrativo oral e escrito; (b) investigar quais as orientações e os limites fornecidos pelo adulto e pelas crianças para a construção de narrativas orais e escritas. Para responder a essas questões, coletamos dados durante os meses de maio e junho de 1992, em duas turmas de 1a. série, de duas escolas da região de Campinas, (uma pública e outra particular). Os dados foram obtidos em visitas semanais às duas escolas, através do registro. em audio de algumas interações em torno da produção de narrativas orais (47 horas de gravação) e através da participação em alguns momentos de produção de narrativas escritas (em torno de 300 produções de texto). Analisando os dados, percebemos que, apenas esporadicamente eram sistematizadas atividades em torno do discurso narrativo oral e escrito, apesar de as, professoras das duas turmas terem dito valorizar a narrativa enquanto tipo de discurso a ser trabalhado. Observamos que a maioria das produções escritas e orais dos sujeitos da pesquisa não podem ser definidas como narrativas, mas, talvez, como "historinhas" que repetem o que a escola lhes disse ou como textos que apresentam o predomínio de elementos descritivos. Encontramos algumas situações que evidenciaram a constituição das especificidades das duas modalidades lingüísticas pelas crianças, que adequam o uso de determinados recursos expressivos da oralidade e da escrita ao contexto de produção discursiva. Nesse processo, notamos a contribuição da professora e das outras crianças, que atuavam no modo de dizer do outro, com comentários que vão desde as convenções ortográficas às questões sobre o conteúdo do texto lido, sua informatividade, a veracidade das informações fomecidas, os tipos de mecanismos coesivos utilizados, ou seja, adulto e criança realizam intervenções no sentido de promover uma discussão sobre quais as estruturas apropriadas ou não, na construção de textos orais e escritos. Os resultados apontam para a necessidade de se estabelecer uma mediação entre a oralidade e a escrita através de práticas de uso da linguagem que viabilizem a construção de hipóteses sobre as duas modalidades, como manifestações lingüísticas que ora se aproximam e ora se afastam no seu modo de significar / Abstract: Not informed. / Mestrado / Mestre em Linguística Aplicada

Bibliography: pages 205-207. / The community of the Wupperthal Mission Station and its satellite stations, forms the focus of this text. The mission is situated in the Tra-Tra River Valley in the Cederberg Mountains of the Western Cape. In this text, I have sketched a series of vignettes to portray the lives of certain individuals, characters in the community's past and certain events throughout the history of the mission. The work is largely an oral history project, combined with a certain degree of philosophy of history as well as incorporating secondary sources where applicable. Though post-modem in certain aspects, this work incorporates sound modernist thought and academic practice. It is intended to be accessible to a wide readership, and prove to be entertaining as well as insightful. The scholarly endeavour driving this text is as sincere, as the history is real. It is a journey I encourage the reader to take with an open mind, taking time to savour the richness of the peoples' experiences. It is their quest for legitimacy, a combined search for truth, and my personal adventure.

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Thesis advisor: Babak Momeni / Rothia mucilaginosa is a gram-positive bacterium that is found in the human oral microbiota. Under normal circumstances, it exhibits a commensal relationship with humans. However, in immunocompromised patients and those with medical implants, these bacteria can pose a serious health risk. In this thesis I outline experiments performed to reveal more about the normal role of R. mucilaginosa within the oral microbiota in the hopes of better understanding its transition to virulence. R. mucilaginosa was grown alongside several of its major co-inhabitants in the oral microbiota in pairwise fashion on solid growth media to search for signs of interspecies interactions. After initial screening, those pairs that showed consistent patterns of interaction were selected for further analysis via fluorescence microscopy. A consistent interaction pattern was confirmed between R. mucilaginosa and Streptococcus gordonii. Interactions were also noted between Corynebacterium durum and R. mucilaginosa as well as between Corynebacterium durum and Neisseria elongata. / Thesis (BS) — Boston College, 2018. / Submitted to: Boston College. College of Arts and Sciences. / Discipline: Scholar of the College. / Discipline: Biology.

Magister Scientiae Dentium - MSc(Dent) / Oral epithelial dysplasia (OED) is a growth anomaly which occurs as a result of atypical, abnormal proliferation and a change in the architecture and cytological features of cells of epithelial origin, which ultimately results in the formation of a lesion with disturbed differentiation and maturation The purpose of this study was to describe the OED cases diagnosed at Tygerberg Oral health centre in a 7-year period between 2012 and 2019. The patients’ medical records from Tygerberg Oral Health Centre and National Health Laboratory Service (NHLS) were reviewed. All diagnosed cases of OED were identified and the data retrieved for further assessment and comparison. The individual medical records and follow up data were assessed. Seventy cases of OED were diagnosed in the period assessed. Of those 70 cases, the median age was 58 and the interquartile range was from 48 – 62. Thirty-six of the diagnosed patients were female and thirty-four were males. The majority of lesions diagnosed with OED were found on the tongue, floor of the mouth (FOM) and buccal mucosa. Majority of the lesions were found in non-smokers and non-alcohol consumers. These two categories both presented with mild cases of OED. From the results, it was derived that OED has no intra-oral location predilection. Moreover, OED is not directly associated with smoking.

Introduction: About one in four seniors have periodontal disease and significant disparities have been shown to exist between some population groups. This study aimed to ascertain if differences exist in oral health conditions among statistical zones in Tennessee divided into east, middle and western zones. We also sought to explore factors predicting poor oral health outcomes in these zones. We postulated that oral health would differ between at least two zones in Tennessee and socio-demographic and socio-economic factors would predict oral health outcome. Methods: We combined data from the Behavioral Risk Surveillance System using Data from years 2010, 2012, 2014, 2016 (n= 5181). Outcome variable was number of permanent teeth removed which was ordered as- none, one to five, six or more but not all and all. Zones were divided into East Tennessee comprising- Kingsport-Bristol-Bristol Tennessee-Virginia metropolitan statistical area, Knoxville, Tennessee Metropolitan Statistical Area. Middle/Central Tennessee comprising Chattanooga, Tennessee-Georgia, Metropolitan Statistical Area, Nashville-Davidson-Murfreesboro-Franklin, Tennessee Metropolitan Statistical Area and West Tennessee including Memphis, Tennessee-Memphis-Arizona, Metropolitan Statistical Area. Other independent variables included in our models were general health, could not see a doctor because of cost, history of diabetes, smoked at least 100 cigarettes, use of smokeless tobacco products, adults who had visited a dentist and poor physical health. Covariates were income level, education level, employment status, race/ethnicity, year and marital status. Descriptive statistics and initial univariate analysis were done. Variables significant at alpha level of 0.05 were included in the final adjusted Ordinal Logistic regression model with logit link function. Results: From our sample, 37.1% were males and 67.9% were females. Most (43.4%) were married, most had a high school level of education (34%), most were retired (73.5%) and a higher percentage (12.4%) earned less than 25,000 per annum from all sources. A higher number were White (62.7%), and smokers (51.4%) and 31% had at least one permanent tooth removed. All variables and covariates except poor physical and mental health were significantly associated with the outcome variable (P<0.05). On adjusting for covariates, sex, income, employment status and zone of residence in Tennessee were significantly associated with a difference in the number of permanent teeth removed. The observed difference between the Eastern part of Tennessee and the Western part of Tennessee was significantly. Conclusion: Zone of residence, sex, employment status and income predict oral health outcomes in Tennessee. People in East Tennessee are more likely to have increased permanent teeth removed compared to those in the west.

Prior studies have shown that the low-level microbiome in the placenta is most similar to the non-pregnant oral microbiome, suggesting a hematogenous route of bacterial transmission. Based on these studies, we theorized that a disruption of the normal balance of pathogenic and commensal microorganisms in the oral cavity will lead to conditions that favor colonization of the placenta and amniotic cavity, leading to inflammation and preterm birth. We hypothesized that an altered oral microbiome profile will promote preterm birth. Our study aimed to compare metagenomic profiles of saliva and tongue in women delivering preterm to those of women delivering at term. Unstimulated saliva and tongue brushings were collected according to an IRB-approved protocol from patients who delivered preterm, and from age and race-matched patients who delivered at term. Exclusion criteria included obvious risk factors for preterm birth or other major complications (multiple gestation; history of or current cervical cerclage; history of hypertension or diabetes; prior history of preterm birth or preeclampsia; age less than 16 or greater than 45) as well as immunologic problems (HIV, organ transplant, etc). Oral samples were collected within 24-48 hours after delivery. Samples were analyzed using 16S rDNA-based sequencing, where the DNA was extracted and then amplified by PCR using 16S rDNA primers. Data was processed using the UPARSE/SINTAX pipeline, and differentially abundant taxa were determined using the LEfSe method and MaAsLin2. The parent study enrolled 100 patients who delivered preterm and 205 patients who delivered at term. A subset of patients had oral samples collected, and 95 saliva and 70 tongue samples were analyzed using 16S rDNA-based sequencing. Communities from tongue and saliva were significantly different between women who delivered preterm and those who delivered at term, although not between those delivering low birthweight versus normal birthweight infants. When assessing beta diversity using the unweighted unifrac metric, patients who delivered very preterm (VPT, < 32 weeks) had a tongue microbiome that was consistently and statistically different from the tongue microbiome of patients who delivered both term (T, > 37 weeks) and late preterm (LPT, 32-<37). Differences remained significant after controlling for tobacco use. In a three-way comparison of saliva samples between the groups using MaAsLin2, the genus Lachnoanaerobaculum was significantly less abundant in the VPT group. Our studies suggest a tongue and salivary microbiome that differs between women delivering term and late preterm versus very preterm. Future studies are required to prospectively confirm differences and may yield data to design noninvasive tests to predict preterm birth risk. / 2021-06-12T00:00:00Z

Bakgrund: Munnen kan inte ses som separat från resten av kroppen eftersom munhälsan påverkar den generella hälsan. Syfte: Syftet var att belysa betydelsen av användandet av munbedömningsinstrument för vårdpersonalen. Metod: Allmän litteraturstudie. Resultat: Genom en innehållsanalys framkom de två subkategorierna; Ger möjlighet att upptäcka och Tydliggör fortsatt behov av munbedömning. Dessa ledde till kategorin; Munbedömningsinstrumentet ger struktur. Diskussion: Genom att göra en munbedömning på patienten kan vårdpersonalen lindra/förebygga lidande eftersom munhälsoproblem upptäcks och kan åtgärdas. All vårdpersonal måste förstå varför munvård och munbedömningar är viktigt och munbedömningsinstrument behöver vara tillförlitligt och lättanvänt. Rutiner måste finnas i varje vårdverksamhet, ett munbedömningsinstrument bör väljas ut med omsorg och anpassas till verksamheten.Konklusion: Användandet av ett munbedömningsinstrument kan leda till ökad struktur i vårdpersonalens munvårdsarbete. / Background: Since oral health has an influence on general health, the mouth can’t be viewed as separate from the rest of the body. Aim: To highlight the importance the use of an oral assessment tool has for the nursing staff. Method: A literature review. Result: Through analysis of the text content two subcategories emerged; Gives possibility to detect and Clarifies further need of oral assessment. They led to the category: The oral assessment tool gives structure. Discussion: By performing an oral assessment on the patient, through detection and correction of oral health problems suffering can be reduced/ prevented by the nursing staff. All of the nursing staff must understand why oral care and oral assessments are important and the oral assessment tool needs to be dependable and easy to use. In every type of health organization there needs to be routines for the use of the oral assessment tool, it should be selected with care and adjusted to the organization. Conclusion: The use of an oral assessment tool could lead to an increased structure in the oral care nursing provided by the nursing staff.

The goal of this thesis is to find out if racial and antisemitic propaganda had an impact on Czech people. This goal was realised on antisemitic programmes which were aired in Český rozhlas during the years 1938- 1945. Then I made interviews with people who lived during Protectorate Bohemia and Moravia and who already participated on my previous research. The interviews helped to find out whether the antisemitic propaganda had any impact on the people and if it had, to what extent.