Investigating multitasking information behaviour, particularly while using the web, has become an increasingly important research area. People s reliance on the web to seek and find information has encouraged a number of researchers to investigate the characteristics of information seeking behaviour and the web seeking strategies used. The current research set out to explore multitasking information behaviour while using the web in relation to people s personal characteristics, working memory, and flow (a state where people feel in control and immersed in the task). Also investigated were the effects of pre-determined knowledge about search tasks and the artefact characteristics. In addition, the study also investigated cognitive states (interactions between the user and the system) and cognitive coordination shifts (the way people change their actions to search effectively) while multitasking on the web. The research was exploratory using a mixed method approach. Thirty University students participated; 10 psychologists, 10 accountants and 10 mechanical engineers. The data collection tools used were: pre and post questionnaires, pre-interviews, a working memory test, a flow state scale test, audio-visual data, web search logs, think aloud data, observation, and the critical decision method. Based on the working memory test, the participants were divided into two groups, those with high scores and those with lower scores. Similarly, participants were divided into two groups based on their flow state scale tests. All participants searched information on the web for four topics: two for which they had prior knowledge and two more without prior knowledge. The results revealed that working memory capacity affects multitasking information behaviour during web searching. For example, the participants in the high working memory group and high flow group had a significantly greater number of cognitive coordination and state shifts than the low working memory group and low flow group. Further, the perception of task complexity was related to working memory capacity; those with low memory capacity thought task complexity increased towards the end of tasks for which they had no prior knowledge compared to tasks for which they had prior knowledge. The results also showed that all participants, regardless of their working memory capacity and flow level, had the same the first frequent cognitive coordination and cognitive state sequences: from strategy to topic. In respect of disciplinary differences, accountants rated task complexity at the end of the web seeking procedure to be statistically less significant for information tasks with prior knowledge compared to the participants from the other disciplines. Moreover, multitasking information behaviour characteristics such as the number of queries, web search sessions and opened tabs/windows during searches has been affected by the disciplines. The findings of the research enabled an exploratory integrated model to be created, which illustrates the nature of multitasking information behaviour when using the web. One other contribution of this research was to develop new more specific and closely grounded definitions of task complexity and artefact characteristics). This new research may influence the creation of more effective web search systems by placing more emphasis on our understanding of the complex cognitive mechanisms of multitasking information behaviour when using the web.

The purpose of this study was to investigate what the EGD teacher needed in order to facilitate the successful implementation of CAD as an education tool into the EGD classroom. The researcher aimed to understand how teachers perceive CAD with regard to its usefulness and ease of use in an EGD class. The primary research question was as follows: What is needed to facilitate the implementation of CAD into the EGD classroom? The secondary research questions were: ? What are the barriers that prevent teachers from implementing CAD in their EGD classes? ? What lessons can be learnt from those schools where CAD has already been implemented? In the literature, the researcher looked at EGD as a subject presented in high school as well as the early roots of CAD. The external factors influencing the implementation of ICT in the classroom and the importance of CAD as a teaching tool were explored throughout the study. The theoretical framework used to support this study was the Technology Acceptance Model (TAM). The research approach towards this study was qualitative by nature and followed a multiple-case study design (Yin, 2003). The participants of the study were identified through a convenient-purposive sampling method. The researcher analysed data through an interpretivist point of view. The data analysis was done through the use of thematic analysis methods. / Dissertation (MEd)--University of Pretoria, 2017. / Science, Mathematics and Technology Education / MEd / Unrestricted

eIF3 and eIF4E are very important eukaryotic translation initiation factors. eIF3 is practically involved in every step of translation initiation, eIF4E is important mainly for its ability to bind the cap. Mammalian factor eIF3 consists of thirteen subunits, many subunits have a function apart from translation, such as in apoptosis and mitosis. It was proved that upregulated or downregulated expression of some subunits as well as upregulated expression of eIF4E is linked with different types of tumours and malignancies in human. In the first part of my work, I was examining the amount of transcripts of subunits eIF3a, b, d, e, f, g, h, i and j in cell lines which are used for study of acute lymphoblastic leukaemia. I tried to find if there is a difference in the amount of trancripts between lines or between lines and control line in these subunits. According to experiments and statistical analysis, I proved increased amount of mRNA for eIF3b subunit in control cell line NC-NC in comparison with other used leukaemic cell line except from line NALM6. Other differences were not statistically important. In the second part of my work, I was analysing 3' UTR region of transcripts of eIF4E1 and utilising of polyadenylation signals in this trancript. I used the leukeamic cell lines again. The experiments clearly...

The purpose of this study was to determine if three different tests of phonological awareness: the Comprehensive Test of Phonological Processes (CTOPP) (Wagner, Torgesen, & Rashotte, 1999), The Phonological Awareness Test (PAT) (Robertson & Salter, 1997), and the Pre-Literacy Skills Screening (PLSS) (Crumrine & Lonegan, 1999) measure the same phonological awareness skills (content) in the same manner (procedures) and, whether typically-developing kindergarten-age students perform similarly on each of the tests. Twenty-five kindergarten students consisting of 14 males and 11 females (mean CA of 72.24 months) participated in this study. All participants were attending the second half of kindergarten in a public school in Orlando, Florida. Prior to the administration of the three tools, all participants were administered the Fluharty Preschool Speech and Language Screening Test - Second Edition (Fluharty-2) (Fluharty, 2001) to ensure that no formal speech and/or language assessment was needed. A comparison of the CTOPP, PAT, and PLSS revealed that the PAT and CTOPP produced similar outcomes. That is, participants who performed well on one tool also did well on the other. Results of this study have shown that tasks on these two tools are comparable measures of phonological awareness known to strongly predict future reading ability. However, when the PLSS was compared to either the CTOPP or PAT, similar outcomes were not obtained. Three participants were identified "at risk" for reading disability on the PLSS. No participants were identified "at risk" on either the CTOPP or PAT. Using a standardized battery to identify children "at-risk" for reading failure and planning intervention may be more advantageous than using a screening measure like the PLSS. Even though it will take more time to complete, a comprehensive assessment battery may be of more value to the clinician. A summary, possible limitations of study, and suggestions for future research are discussed.

Recently, psychedelic science (PS) has been going through a resurge with a vast increase in publications. Psychedelic-Assisted Therapy (PAT) is demonstrating promising results across the treatment of various psychiatric disorders; however, psychedelic science remains absent from the curriculum of both medical and psychology students in Sweden. This study examined medical students' attitudes towards PS, comparing them with psychology students' attitudes, which were previously investigated. The medical students' knowledge and attitudes towards psychedelic science and its therapeutic potential were analysed using a cross-sectional survey study design. Data from psychology students were collected in the spring of 2023, while data from medical students were collected in the fall of 2023. Both datasets were based on a digital survey, Attitudes on Psychedelics Questionnaire, APQ. Multiple Mann-Whitney U tests and a chi-square test were performed across the two groups. n = 316 psychology students and n = 709 medical students answered the survey. Psychology students held more positive attitudes, rated themself as more knowledgeable and followed new findings about psychedelic science to a higher degree compared to medical students. There were no differences between the groups concerning the interests in learning about psychedelics as part of their curriculum, nor the current amount of education in PS they have received. Students who have used psychedelics themselves for recreational purposes held more positive attitudes compared to non-users. This study revealed an unmet request for education about PS from students. We argue this lack of education in PS may delay a future potential implementation of PAT in Sweden.

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Bakgrund: Regelbaserad redovisning innefattar en tydlig och detaljerad vägledning medans principbaserad redovisning är mer öppen för bedömningar och tolkningar. Valet mellan dessa redovisningsmetoder kan studeras genom mindre aktiebolags val av K-regelverk där K2 är regelbaserat och K3 är principbaserat. Denna studie kan bidra till forskningen genom att studeramönster i beslutet genom en teoretisk modell. Syfte: Syftet med denna uppsats är att förklara vilka faktorer som påverkar beslutsfattarna i valet mellan regelbaserad och principbaserad redovisning. Metod: Denna studie har utförts med en deduktiv forskningsansats där befintliga teorier och tidigare forskning har ut gjort grunden för studien. En teoretisk modell har skapats genom en integration av Positive accounting theory, institutionell teori och beslutsteorier. En kvantitativ undersökning utfördes genom en enkätundersökning där den teoretiska modellen låg till grund för enkätfrågorna, analysen och resultatet i studien. Slutsats: Det går utifrån PAT, IT och Beslutsteori att förklara vad som har påverkat en beslutsfattare i valet mellan regelbaserad och principbaseradredovisning. De faktorer som påverkar en beslutsfattare är revisorns rekommendationer, koncerntillhörighet, resultatet, externa påtryckningar, administrativa kostnader, underlättande av redovisningen och rättvisande bild av företaget.

Detta examensarbete granskar analysverktyg ur ett tvärvetenskapligt perspektiv. Det finns en hel del olika analysverktyg idag som analyserar specifika typer av omik data och därför undersöker vi hur många det finns samt vad de kan göra. Genom att definiera ett antal specifika krav såsom hur många typer av omik data den kan hantera, noggrannhet av verktygets analys så kan man se vilka som är mest lämpliga analysverktygen när det gäller kartläggning av omik data. Resultaten visar att det idag inte finns analysverktyg som uppfyller de specifikt angivna kraven eller huvudsyftet genom testning av programvaran. Ingenuity analysverktyget är det närmaste vi kan komma för de krav som vi söker. På begäran av slutanvändaren testades två analysverktyg för att se om en kombination av dessa kan uppfylla slut användarens krav. Analysverktyget Uniprot batch converter testas med FEvER men resultat är inte framgångsrikt, då kombinationen av dessa verktyg inte är bättre än Ingenuity analysverktyget. Fokus vänds mot en alternativ kombination som är en hemsida och heter NCBI. Hemsidan har en sökmotor kopplad till flera olika analysverktyg som är gratis att använda. Genom sökmotorn kan ”omik” data kombineras och mer än ett inmatat värde kan hanteras i taget. Eftersom tekniken snabbt går framåt innebär det däremot att nya analysverktyg behövs för data hantering och inom en snar framtid så har vi kanske ett analysverktyg som uppfyller kraven av slutanvändarna. / This thesis examines PATs from a multidisciplinary view. There are a lot of PAT's existing today analyzing specific type of omics data, therefore we investigate them and what they can do. By defining some specific requirements such as how many omics data types it can handle, the accuracy of the PAT can be obtained to get the most suitable PAT when it comes to mapping omics data to pathways. Results show that no PATs found today fulfills the specific set of requirements or the main goal though software testing. The Ingenuity PAT is the closest to fulfill the requirements. Requested by the end user, two PATs are tested in combination to see if these can fulfill the requirements of the end user. Uniprot batch converter was tested with FEvER and results did not turn out successfully since the combination of the two PATs is no better than the Ingenuity PAT. Focus then turned to an alternative combination, a homepage called NCBI that have search engines connected to several free PATs available thus fulfilling the requirements. Through the search engine “omics” data can be combined and more than one input can be taken at a time. Since technology is rapidly moving forward, the need for new tools for data interpretation also grows. It means that in a near future we may be able to find a PAT that fulfills the requirements of the end users.

Yes / Three-dimensional printing (3DP) has the potential to cause a paradigm shift in the manufacture of pharmaceuticals, enabling personalised medicines to be produced on-demand. To facilitate integration into healthcare, non-destructive characterisation techniques are required to ensure final product quality. Here, the use of process analytical technologies (PAT), including near infrared spectroscopy (NIR) and Raman confocal microscopy, were evaluated on paracetamol-loaded 3D printed cylindrical tablets composed of an acrylic polymer (Eudragit L100-55). Using a portable NIR spectrometer, a calibration model was developed, which predicted successfully drug concentration across the range of 4–40% w/w. The model demonstrated excellent linearity (R2 = 0.996) and accuracy (RMSEP = 0.63%) and results were confirmed with conventional HPLC analysis. The model maintained high accuracy for tablets of a different geometry (torus shapes), a different formulation type (oral films) and when the polymer was changed from acrylic to cellulosic (hypromellose, HPMC). Raman confocal microscopy showed a homogenous drug distribution, with paracetamol predominantly present in the amorphous form as a solid dispersion. Overall, this article is the first to report the use of a rapid ‘point-and-shoot’ approach as a non-destructive quality control method, supporting the integration of 3DP for medicine production into clinical practice. / Open Access funded by Engineering and Physical Sciences Research Council United Kingdom (EPSRC), UK for their financial support (EP/L01646X).

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