Television shows, especially cartoons, are one of the most common types of media in children’s lives. Although there is a well-established connection between television exposure and difficulties with attention, it is unclear if all types of television are equally impactful. Given the amount of time children are exposed to television, there is a need to better understand which components of shows may or may not impact one’s attentional and executive functioning abilities. One such factor is the pace of the content. The current study expands on this limited area of the literature by utilizing a 9-minute 30-second long cartoon video, which has been edited at both a fast and slow pace, to examine the influence of pace on measures of attention and executive functioning (the Stop Signal Task and the Attentional Network Test) in both Typically Developing children (N = 24) and children with Attention-Deficit/Hyperactivity Disorder (ADHD; N = 17). Two (group; children with ADHD vs. Typically Developing children) x two (pace; fast vs. slow) ANCOVAs were conducted separately with each outcome measure as the dependent variable, group (ADHD and Typically Developing) and pace (fast and slow) as the independent variables, and IQ and Internalizing Problems as covariates. Findings suggested that although the majority of results were non-significant, effect sizes for group and pace (and associated covariates) varied across outcome measures. The Alerting and Executive Control ANT Networks also had non-significant but small effect sizes for the group by pace interactions. Planned comparisons of estimated marginal means revealed a non-significant and small effect of pace for children with ADHD, but no effect for Typically Developing children, for both interactions. Implications for those who work with and care for children are reviewed, and study limitations and future research directions are discussed.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第21603号 / 理博第4510号 / 新制||理||1647(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)准教授 森 哲, 教授 沼田 英治, 教授 中務 真人 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

38thAnnual International Committee of Adlerian Summer Schools and Institutes (ICASSI), Marsascala, Malta, July, 2005; Adlerian Summer School, Lake Taupo, New Zealand, April, 2002; Individual Psychology Association of Idaho (IPAI), Boise, Idaho, March, 2002; Adlerian Conference, Ottawa, Ontario, Canada, November, 2001; North American Society of Adlerian Psychology, Annual Convention, Tucson, Arizona, June, 2001.

No description available.

L’automatisme cardiaque est généré par un mécanisme fondamental partiellement compris et controversé, initié par des cardiomyocytes spécialisés dans le nœud sino-atrial (NSA). Ces cellules pacemaker (cNSA) présentent une phase spontanée de dépolarisation diastolique (DD), qui mène le potentiel de membrane de la fin de la repolarisation du potentiel d’action (PA) au seuil de déclenchement du PA suivant. Cette activité spontanée implique plusieurs canaux ioniques à la surface de la membrane plasmique et la dynamique calcique intracellulaire. Les cardiomyocytes contractiles du myocarde expriment majoritairement le canal calcique Cav1.2 tandis que les cNSA en expriment d’autres isoformes. Ce sont les canaux calciques de type L (LTCC) Cav1.3 et de type T (TTCC) Cav3.1, qui sont impliqués dans la DD. Les souris génétiquement modifiées pour Cav1.3 et/ou Cav3.1 ont des caractéristiques physiopathologiques et sont utilisées comme modèle d’étude des dysfonctions sinusales de l’homme. La cartographie optique du NSA isolé a permis de révéler une activité électrophysiologique intrinsèque altérée par les mutations. L’expérimentation en patch clamp et en imagerie calcique des cNSA isolées montrent que les mutations altèrent la mécanistique cellulaire du pacemaker. Le couplage de ces approches à l’utilisation d’outils pharmacologiques spécifiques a permis d’évaluer la contribution des différents éléments à cette mécanistique cellulaire et de préciser les controverses sur les fondements de l’automatisme cardiaque. Cette thématique de recherche présente des enjeux majeurs dans le domaine de la santé puisque les perspectives thérapeutiques et les stratégies pharmacologiques pour traiter les dysfonctions sinusales nécessitent une connaissance intégrale du mécanisme. / Heart automaticity is generated by a basic pacemaker mechanism not fully understood and still controversial. Pacemaker activity is initiated by specialized cardiomyocytes in the Sino-atrial node (SAN). The spontaneous phase of diastolic depolarization (DDP) characterizes SAN cells (SANc). This phase drives the membrane potential of SANc from the end of the repolarization to the threshold of the next action potential (AP). This spontaneous activity involves several ion channels on the plasma membrane and the intracellular dynamic of calcium. In terms of calcium channels, atrial and ventricular cardiomyocytes express mostly Cav1.2 whereas SANc express two additional isoforms. Specifically, in SANc are expressed Cav1.3 LTCC (L type Calcium channels) and the Cav3.1 TTCC (T type Calcium channels), which are activated during the DD. Genetically modified mice inactivated for Cav1.3, Cav3.1 and Cav1.3/Cav3.1 we generated and used as a models of study of human SAN dysfunctions. In particular, we highlighted the impairment of the pacemaker activity in these mice by optical mapping of the intact SAN, and by patch clamping and calcium imaging of isolated SANc. Coupling this approaches with pharmacological tools allowed us to evaluating the contribution of the various elements constituting to the pacemaker mechanism. This thematic of research presents major issues in terms of public health. Indeed, we need a better understanding of the pacemaker mechanism to develop pharmacological strategies against SAN dysfunction.

The diploma thesis is focused on cryptography with smart cards. It describes smart cards from hardware and software side. The thesis compares well known operating systems used on smart cards. Specified operating systems are widely analyzed. There is introduction to password authenticated key establishment protocols. PACE protocol is described in details together with implementation proposal. The implementation on the Basic card platform follows. In the end there is the time analysis of the implementation and further improvements are suggested.

Thesis (M.A. (Godsdienswetenskap))

This study evaluated the effects of Project PACE, a program designed to increase physical activity, on the physical activity level and selected psychosocial variables of sedentary adolescent females ages 12 to 18. Psychosocial variables included self efficacy, attitude, perception of barriers, perceived social support, and knowledge. Of the 69 participants, 40 were enrolled in the treatment group and 29 were enrolled in the control group at the start of the study. The only significant differences were found for attitudes towards physical activity at base line. Findings from this study suggest that implementation of Project PACE protocol in school settings may produce some positive effects, but no significant findings were detected.

Many potential benefits of new product introductions (NPI) have been identified in existing literature, yet there are empirical and theoretical evidence that suggests that such benefits are not assured. Building on the concepts of time compression diseconomies, absorptive capacity, and time diversification, we argue that benefits that a firm derives from introducing new products depend on the process of NPI, which we conceptualize as how and what products are introduced by the firm. We propose that pace, rhythm, and the scope are three important characteristics of the process of NPI that affect firm value. Further, we argue that this effect is moderated by organizational marketing and technological intensities. We use an unbalanced panel dataset of the products introduced by public firms between 1991 and 2015 to investigate the proposed framework in the bio-pharmaceutical industry. We estimate the proposed model using a multilevel modeling framework, accounting for endogeneity, unobserved heterogeneity, and heteroscedasticity. The proposed framework and modeling approach provide empirical support for the role of pace, rhythm and scope of NPI on firm performance, and guide managers on choosing the right growth strategy to improve new product performance.

Dans la plupart des études, on s'intéresse au changement climatique futur en analysant l'évolution du climat entre une référence actuelle fixée et une période future. Le réchauffement est de plus en plus fort au fil du 21ème siècle. Dans un contexte où les conditions climatiques sont toujours en train d'évoluer, les écosystèmes doivent continuellement s'adapter à des modifications diverses du climat. Dans le cadre de cette thèse, je propose d'analyser les projections climatiques sous un angle alternatif. Afin d’être caractéristique des représentations des populations urbaines et rurales, je définis et analyse des indicateurs liés à la vitesse des changements de température, de précipitations et de végétation. Un ensemble de simulations CMIP5 de 18 modèles de climat est sélectionné. La vitesse est représentée par des différences entre deux périodes successives de 20 ans. Cette notion de vitesse pourrait offrir de nouveaux outils pour interagir avec les communautés scientifiques travaillant sur les impacts et l'adaptation.Sans politiques d’atténuation du changement (scénario RCP8.5), le réchauffement global sera au moins deux fois plus rapide à la fin du siècle qu’actuellement, et même trois fois dans certaines régions. Près de la moitié des surfaces continentales, principalement les zones tropicales, seront touchées par des décalages significatifs de la distribution de la température entre deux périodes de 20 ans d’ici à 2060, i.e. au moins 4 fois plus qu’actuellement. Dans ces régions, des années extrêmement chaudes ayant un temps de retour de 50 ans deviendront habituelles en l’espace de 20 ans seulement. La fraction de la population mondiale étant exposée à ces changements pourrait atteindre environ 60% (i.e. 6 milliards de personnes et 7 fois plus qu’actuellement). Il suffit de relativement légères mesures d’atténuation (RCP6.0) pour que la vitesse du réchauffement ne dépasse pas les valeurs actuelles et que 3 fois moins de personnes soient exposées à des décalages significatifs de température.Les vitesses d’humidification et d’assèchement en termes de précipitations augmenteront de 30 à 40%. Leur répartition géographique deviendra plus stable spatialement et les tendances tendront à persister sur les mêmes régions, et ce malgré l’accélération du réchauffement global. Cette stabilisation résulte de la contribution grandissante des processus thermodynamiques par rapport à ceux contrôlés par la circulation générale. La combinaison de l’accélération des tendances et de leur persistance peut avoir un impact sur l’adaptation des sociétés et des écosystèmes, particulièrement sur le bassin méditerranéen, en Amérique centrale, en Inde et dans les régions arctiques. Une telle évolution est déjà visible actuellement, mais pourrait disparaître avec de fortes mesures d’atténuation (RCP2.6).Les changements de la végétation peuvent être des repères visuels du changement climatique. Dans les moyennes et hautes latitudes Nord, le cycle saisonnier des arbres et des herbacées suit la vitesse du réchauffement. Sans politiques d’atténuation, le début de la saison foliaire avance et sa durée augmente plus rapidement au fil du siècle. La couverture de la végétation se densifie quelque soit le scénario proportionnellement à l’augmentation de la température. Le cycle saisonnier des cultures des moyennes latitudes dépend directement de la température et celui des cultures tropicales de l’évolution des caractéristiques de la saison des pluies. Sous les autres latitudes, aucune évolution robuste du cycle saisonnier n’est projetée. La vitesse des changements de répartition de la végétation a déjà doublé entre 1880 et 1950 correspondant à un changement marqué de l'utilisation des sols. Elle est stable tout au long du siècle si la végétation interagit dynamiquement avec le climat dans les modèles, traduisant un ralentissement du changement de l'utilisation des sols et l'accélération des changements de végétation sous l'effet du changement climatique. / In most climate studies, climate change is approached by focusing on the evolution between a fixed current baseline and a future period, emphasizing stronger warming as we move further over the 21st century. Under climate conditions that are continuously evolving, human and natural systems might have to constantly adapt to a changing climate. This thesis proposes an alternative approach to climate projections. Here, I consider and analyze indicators of the pace of changes relative to temperature, precipitation and vegetation in order to be relevant for both urban and rural populations. An ensemble of CMIP5 simulations from 18 climate models is selected. The pace is represented by differences between two subsequent 20-year periods. Considering the pace of change would be beneficial for climate impacts and adaptation analyses.The models predict that the warming rate strongly increases without any mitigation policies (RCP8.5 scenario). It is twice as high by the end of the century compared to the current period, and even three times higher in some regions. Significant shifts in temperature distributions between two subsequent 20-year periods are projected to involve almost half of all land surfaces and most tropical areas by 2060 onwards (i.e. at least four times as many regions than currently). In these regions, an extremely warm year with a return period of about 50 years would become quite common only 20 years later. The fraction of the world population exposed to such shifts might reach about 60% (6 billion people, i.e. seven times more than currently). Low mitigation measures (RCP6.0) allow the warming rate to be kept at current values, and reduce the fraction of the world population exposed to significant shifts of temperature distributions by one third.Under RCP8.5, rainfall moistening and drying rates both increase by 30-40% above current levels. As we move further over the century, their patterns become geographically stationary and the trends become persistent. The stabilization of the geographical rate patterns that occurs despite the acceleration of global warming can be physically explained: it results from the increasing contribution of thermodynamic processes compared to dynamic processes in the control of precipitation change. The combination of intensification and increasing persistence of precipitation rate patterns may affect the way human societies and ecosystems adapt to climate change, especially in the Mediterranean basin, Central America, South Asia and the Arctic. Such an evolution in precipitation has already become noticeable over the last few decades, but it could be reversed if strong mitigation policies were quickly implemented (RCP2.6).Changes in vegetation could be visual landmarks of climate change. In mid- and high-latitudes of the Northern Hemisphere, the phenology of grass and trees follows the warming rate. Without any mitigation policies, the start of spring occurs earlier, and its duration is extended faster as we move over the century. The vegetation cover becomes denser, regardless of the selected pathway, in proportion to the temperature rise. The seasonal cycle of mid-latitude crops also depends on the temperature, and the seasonal cycle of tropical crops directly follows the features of the wet season. In all other latitudes, no robust evolution of the seasonal cycle is projected. The pace of change of vegetation cover since 1880 already doubled before 1950, mainly due to a strong change in land use. This pace is then projected to be stable over the entire 21st century if the vegetation dynamically interacts with the climate system in the models. This corresponds to a reduction of land-use change and to the acceleration of changes of vegetation cover under climate change.