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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Traduction de valeurs-guides d’exposition pour l’acide perfluorooctanoïque (PFOA) en équivalents de biosurveillance

Tewfik, Ernest-Louli 03 1900 (has links)
Contexte : L’acide perfluorooctanoïque (PFOA) est présent dans le sang de presque tous les participants dans les études de biosurveillance. L’appréciation des risques pour la santé qui sont associés aux concentrations sanguines de PFOA est difficile, car les valeurs guides d'exposition (VGE) sont généralement exprimées en termes de dose externe. Des équivalents de biosurveillance (ÉB) compatibles avec les VGE pourraient faciliter l'interprétation des concentrations de PFOA dans le contexte du risque pour la santé. Objectifs : i) Dériver des ÉB pour le PFOA sérique ou plasmatique correspondant aux VGE de la Environmental Protection Agency des États-Unis (U.S. EPA), de la Agency for Toxic Substances and Disease Registry (ATSDR) et de Santé Canada, et ii) comparer les ÉB avec les concentrations de PFOA mesurées dans des enquêtes nationales de biosurveillance. Méthodes : En partant des points de départ à partir desquels les VGE ont été estimées, nous avons dérivé des ÉB à l'aide de données ou modèles pharmacocinétiques et de facteurs d'incertitude. À l'aide d'un modèle pharmacocinétique animal de gestation et de lactation, nous avons converti les points de départ chez les souris gestantes (U.S. EPA 2016, ATSDR) en concentrations sériques chez l’organisme en développement pour quatre mesures de dose (concentrations moyenne prénatale, moyenne postnatale, moyenne totale, et maximale). Les concentrations équivalentes chez le fœtus humain et l’enfant ont ensuite été converties en ÉB correspondants dans le sérum maternel humain au moment de la conception à l'aide d’une modèle pharmacocinétique humain de grossesse et d’allaitement. Le point de départ chez les rongeurs adultes (Santé Canada) a été converti en un ÉB dans le sérum humain adulte à l'aide de données expérimentales. Pour le point de départ basé sur l'épidémiologie (valeur provisoire de 2022 de l’U.S.EPA), un BE a été dérivé à l'aide d'un modèle pharmacocinétique humain de grossesse et d’allaitement. Les BE dérivés ont été comparés à des données de biosurveillance canadiennes et américaines. Résultats : Les ÉB étaient de 684 ng/mL pour Santé Canada, de 0.012 ng/mL pour l’U.S. EPA (valeur provisoire de 2022), et variaient de 15 à 29 ng/mL pour l’U.S. EPA (valeur de 2016) et de 6 à 10 ng/mL pour l’ATSDR. Les 95ème centiles des concentrations sériques dans l'Enquête canadienne sur les mesures de la santé (ECMS) de 2018-2019 et dans la National Health and Nutrition Examination Survey (NHANES) de 2017-2018 étaient légèrement inférieures à l’ÉB de l’ATSDR et deux ordres de grandeur plus élevées que l'ÉB pour la valeur provisoire de 2022 de l’U.S. EPA. Conclusion : Les ÉB couvraient quatre ordres de grandeur. Les concentrations de PFOA mesurés dans des enquêtes nationales de biosurveillance canadiennes et américaines étaient supérieures ou similaires à certains de ces ÉB. / Background: Perfluorooctanoic acid (PFOA) is detected in the blood of virtually everyone participating in biomonitoring studies. Assessing the health risks associated with blood PFOA levels is challenging because exposure guidance values (EGVs) are typically expressed in terms of external dose. Biomonitoring equivalents (BEs) consistent with EGVs could facilitate interpreting biomarker levels in a health risk context. Objective: To i) derive BEs for serum/plasma PFOA corresponding to the EGVs of the U.S. Environmental Protection Agency (U.S. EPA), the Agency for Toxic Substances and Disease Registry (ATSDR) and Health Canada, and ii) compare with PFOA levels measured in national biomonitoring surveys. Methods: Starting from the points of departure from which EGVs were estimated, we derived BEs using pharmacokinetic data/models and uncertainty factors. Using an animal gestational/lactational pharmacokinetic model, we converted points of departure in pregnant dams (U.S. EPA 2016, ATSDR) into serum concentrations in the developing organism for four dose metrics: average prenatal, average postnatal, average overall, and maximum concentrations. Equivalent human fetus and child concentrations were then converted into corresponding BEs in maternal serum at time of conception using a pharmacokinetic model of human gestation/lactation. The point of departure in adult rodents (Health Canada) was converted into a BE in adult serum using experimental data. For the epidemiology-based point of departure (U.S.EPA 2022, draft), a BE was derived using a human pharmacokinetic model of gestation/lactation. BEs were compared with Canadian and U.S. biomonitoring data. Results: BEs (ng/mL) were 684 for Health Canada, 0.012 for the U.S. EPA (2022 draft), and ranged from 15-29 for the U.S. EPA (2016) and from 6-10 for ATSDR. Ninety-fifth percentiles of serum levels from the 2018-2019 Canadian Health Measures Survey (CHMS) and the 2017-2018 National Health and Nutrition Examination Survey (NHANES) were slightly below the BE for the ATSDR, and two orders of magnitude above the BE for the U.S. EPA (2022 draft). Conclusion: BEs varied over four orders of magnitude. Levels measured in Canadian and U.S. national surveys were higher than or close to some of these BEs.
12

Role Of Perfluorooctanoic Acid On Serum Fatty Acids, Nhanes, 2003-2004

Maisonet, Mildred, Yadav, Ruby, Leinaar, Edward 01 January 2015 (has links)
Background: Fatty acids (FA) have a role on energy storage and membrane formation. FA consists of an aliphatic chain with varying number of carbon and a carboxylic functional group. Perfluorooctanoic acid (PFOA) exhibits a similar structure to that of the FA. Given their structural resemblance, we hypothesized that alterations in FA metabolism could arise from competition with PFOA for endogenous FA binding sites in transport and with FA binding proteins. Objectives: Explore associations of serum concentrations of perfluorooctanoic acid (PFOA) with serum concentrations of linoleic (LA), eicosapentanoic (EPA), and docosapentanoic (DHA) acid in adults. Methods: We analyzed data from 1,829, 20-80 years old participants in the 2003–2004 National Health and Nutrition Examination Survey (NHANES). Linear regression models were used to estimate adjusted predicted means of the FA (in µmol/L) for quartiles of PFOA (in ng/mL) and explore linear trends. Results: Increasing concentrations of PFOA were not associated with adjusted predicted means of serum LA (Q1 3534, Q2 3445, Q3 3778, Q4 3399) (p trends=0.6460). Increasing concentrations of PFOA, however, were associated with increasing trends in adjusted predicted means of serum EPA (Q1 49.8, Q2 51.5, Q3 60.9, Q4 55.7).
13

The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)

O'Brien, Jason 03 May 2011 (has links)
Perfluoroalkyl compounds (PFCs) are a group of chemical surfactants most notably used in non-stick and stain-resistance applications. Due to their wide-spread use and inherent resistance to degradation, several PFCs have become persistent environmental contaminants. Despite the high concentrations of PFCs reported in wild birds and their eggs, very little is known about the toxicological effects they have on avian species. This thesis investigates the developmental toxicity of PFCs in an avian model species: the domestic chicken (Gallus gallus domesticus). Egg injection experiments were performed to assess the in ovo toxicity of perfluorooctane sulfonate (technical grade, T-PFOS), perfluorooctanoic acid (PFOA), perfluorodecane sulfonate (PFDS) and perfluoroundecanoic acid (PFUdA). Real-time RT-PCR was then used to measure the transcription of candidate biomarker genes in the liver tissue of day 20 embryos. Candidate genes were selected based on their responsiveness to PFC exposure in previously conducted in vitro screening assays. In ovo exposure to PFOS resulted in a dose-dependent decrease in embryo pipping success (a measure of hatching success) with an LD50 of 93 μg/g (3.54 μg/g-672,910 μg/g, 95% confidence interval), however the expression of peroxisome proliferator-activated receptor alpha (PPARα)-regulated genes was not affected in liver tissue as hypothesized. PFOA, PFDS and PFUdA had no effect on the pipping success of chicken embryos. The expression of cytochrome P450 1A4 (CYP1A4) and liver fatty acid binding protein (L-FABP) mRNA increased in embryo liver tissue following in ovo exposure to PFUdA but was only statistically significant at 10 μg/g, which is several orders of magnitude higher than concentrations reported in wild bird eggs. The isomer-specific accumulation of PFOS in chicken embryo livers was also investigated using an in-port derivatization gas-chromatography/mass spectrometry (GC-MS) method. Prior to incubation, chicken eggs were injected with T-PFOS, composed of 63% linear isomer (L-PFOS) and 37.3% branched isomers. The isomer profiles in day-20 embryo liver tissue showed up to 20% enrichment in the proportion of L-PFOS, compared to T-PFOS, with a corresponding decrease in the proportion of branched isomers. This enrichment was inversely proportional to dose. Finally, the transcriptional profiles of cultured chicken embryonic hepatocytes (CEH) exposed to either T-PFOS or L-PFOS were compared using Agilent 4x44k Chicken (V2) Gene Expression microarrays. At equal concentrations (10 μM), T-PFOS altered the expression of significantly more genes (340 genes, >1.5 fold change, false discovery rate adjusted p<0.05) compared to L-PFOS (130 genes). Functional analysis showed that L-PFOS and T-PFOS affected genes involved in lipid metabolism, cellular growth and proliferation, and cell-cell signaling. Pathway and interactome analysis suggested that gene expression may be affected through RXR, oxidative stress response, TP53 signaling, MYC signaling, Wnt/β-catenin signaling and PPARγ and SREBP receptors. In all functional categories and pathways examined, T-PFOS had a more pronounced disruptive effect on transctional regulation than L-PFOS. In summary, egg injection experiments showed that T-PFOS (but not linear PFOA, PFDS or PFUdA) may affect the hatching success of the chicken at environmentally relevant concentrations. It was also demonstrated that the accumulation of PFOS in embryonic liver is isomer specific, and leads to an enrichment of L-PFOS. The increased transcriptional disruption caused by T-PFOS in cultured hepatocytes over L-PFOS suggests that the branched isomers may be largely responsible for the toxicological effects of PFOS. Combined, the results from this thesis demonstrate the importance of considering PFOS isomer burdens during risk assessment. In addition, gene expression analysis identified several candidate mechanisms for PFOS toxicity.
14

The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)

O'Brien, Jason 03 May 2011 (has links)
Perfluoroalkyl compounds (PFCs) are a group of chemical surfactants most notably used in non-stick and stain-resistance applications. Due to their wide-spread use and inherent resistance to degradation, several PFCs have become persistent environmental contaminants. Despite the high concentrations of PFCs reported in wild birds and their eggs, very little is known about the toxicological effects they have on avian species. This thesis investigates the developmental toxicity of PFCs in an avian model species: the domestic chicken (Gallus gallus domesticus). Egg injection experiments were performed to assess the in ovo toxicity of perfluorooctane sulfonate (technical grade, T-PFOS), perfluorooctanoic acid (PFOA), perfluorodecane sulfonate (PFDS) and perfluoroundecanoic acid (PFUdA). Real-time RT-PCR was then used to measure the transcription of candidate biomarker genes in the liver tissue of day 20 embryos. Candidate genes were selected based on their responsiveness to PFC exposure in previously conducted in vitro screening assays. In ovo exposure to PFOS resulted in a dose-dependent decrease in embryo pipping success (a measure of hatching success) with an LD50 of 93 μg/g (3.54 μg/g-672,910 μg/g, 95% confidence interval), however the expression of peroxisome proliferator-activated receptor alpha (PPARα)-regulated genes was not affected in liver tissue as hypothesized. PFOA, PFDS and PFUdA had no effect on the pipping success of chicken embryos. The expression of cytochrome P450 1A4 (CYP1A4) and liver fatty acid binding protein (L-FABP) mRNA increased in embryo liver tissue following in ovo exposure to PFUdA but was only statistically significant at 10 μg/g, which is several orders of magnitude higher than concentrations reported in wild bird eggs. The isomer-specific accumulation of PFOS in chicken embryo livers was also investigated using an in-port derivatization gas-chromatography/mass spectrometry (GC-MS) method. Prior to incubation, chicken eggs were injected with T-PFOS, composed of 63% linear isomer (L-PFOS) and 37.3% branched isomers. The isomer profiles in day-20 embryo liver tissue showed up to 20% enrichment in the proportion of L-PFOS, compared to T-PFOS, with a corresponding decrease in the proportion of branched isomers. This enrichment was inversely proportional to dose. Finally, the transcriptional profiles of cultured chicken embryonic hepatocytes (CEH) exposed to either T-PFOS or L-PFOS were compared using Agilent 4x44k Chicken (V2) Gene Expression microarrays. At equal concentrations (10 μM), T-PFOS altered the expression of significantly more genes (340 genes, >1.5 fold change, false discovery rate adjusted p<0.05) compared to L-PFOS (130 genes). Functional analysis showed that L-PFOS and T-PFOS affected genes involved in lipid metabolism, cellular growth and proliferation, and cell-cell signaling. Pathway and interactome analysis suggested that gene expression may be affected through RXR, oxidative stress response, TP53 signaling, MYC signaling, Wnt/β-catenin signaling and PPARγ and SREBP receptors. In all functional categories and pathways examined, T-PFOS had a more pronounced disruptive effect on transctional regulation than L-PFOS. In summary, egg injection experiments showed that T-PFOS (but not linear PFOA, PFDS or PFUdA) may affect the hatching success of the chicken at environmentally relevant concentrations. It was also demonstrated that the accumulation of PFOS in embryonic liver is isomer specific, and leads to an enrichment of L-PFOS. The increased transcriptional disruption caused by T-PFOS in cultured hepatocytes over L-PFOS suggests that the branched isomers may be largely responsible for the toxicological effects of PFOS. Combined, the results from this thesis demonstrate the importance of considering PFOS isomer burdens during risk assessment. In addition, gene expression analysis identified several candidate mechanisms for PFOS toxicity.
15

The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)

O'Brien, Jason 03 May 2011 (has links)
Perfluoroalkyl compounds (PFCs) are a group of chemical surfactants most notably used in non-stick and stain-resistance applications. Due to their wide-spread use and inherent resistance to degradation, several PFCs have become persistent environmental contaminants. Despite the high concentrations of PFCs reported in wild birds and their eggs, very little is known about the toxicological effects they have on avian species. This thesis investigates the developmental toxicity of PFCs in an avian model species: the domestic chicken (Gallus gallus domesticus). Egg injection experiments were performed to assess the in ovo toxicity of perfluorooctane sulfonate (technical grade, T-PFOS), perfluorooctanoic acid (PFOA), perfluorodecane sulfonate (PFDS) and perfluoroundecanoic acid (PFUdA). Real-time RT-PCR was then used to measure the transcription of candidate biomarker genes in the liver tissue of day 20 embryos. Candidate genes were selected based on their responsiveness to PFC exposure in previously conducted in vitro screening assays. In ovo exposure to PFOS resulted in a dose-dependent decrease in embryo pipping success (a measure of hatching success) with an LD50 of 93 μg/g (3.54 μg/g-672,910 μg/g, 95% confidence interval), however the expression of peroxisome proliferator-activated receptor alpha (PPARα)-regulated genes was not affected in liver tissue as hypothesized. PFOA, PFDS and PFUdA had no effect on the pipping success of chicken embryos. The expression of cytochrome P450 1A4 (CYP1A4) and liver fatty acid binding protein (L-FABP) mRNA increased in embryo liver tissue following in ovo exposure to PFUdA but was only statistically significant at 10 μg/g, which is several orders of magnitude higher than concentrations reported in wild bird eggs. The isomer-specific accumulation of PFOS in chicken embryo livers was also investigated using an in-port derivatization gas-chromatography/mass spectrometry (GC-MS) method. Prior to incubation, chicken eggs were injected with T-PFOS, composed of 63% linear isomer (L-PFOS) and 37.3% branched isomers. The isomer profiles in day-20 embryo liver tissue showed up to 20% enrichment in the proportion of L-PFOS, compared to T-PFOS, with a corresponding decrease in the proportion of branched isomers. This enrichment was inversely proportional to dose. Finally, the transcriptional profiles of cultured chicken embryonic hepatocytes (CEH) exposed to either T-PFOS or L-PFOS were compared using Agilent 4x44k Chicken (V2) Gene Expression microarrays. At equal concentrations (10 μM), T-PFOS altered the expression of significantly more genes (340 genes, >1.5 fold change, false discovery rate adjusted p<0.05) compared to L-PFOS (130 genes). Functional analysis showed that L-PFOS and T-PFOS affected genes involved in lipid metabolism, cellular growth and proliferation, and cell-cell signaling. Pathway and interactome analysis suggested that gene expression may be affected through RXR, oxidative stress response, TP53 signaling, MYC signaling, Wnt/β-catenin signaling and PPARγ and SREBP receptors. In all functional categories and pathways examined, T-PFOS had a more pronounced disruptive effect on transctional regulation than L-PFOS. In summary, egg injection experiments showed that T-PFOS (but not linear PFOA, PFDS or PFUdA) may affect the hatching success of the chicken at environmentally relevant concentrations. It was also demonstrated that the accumulation of PFOS in embryonic liver is isomer specific, and leads to an enrichment of L-PFOS. The increased transcriptional disruption caused by T-PFOS in cultured hepatocytes over L-PFOS suggests that the branched isomers may be largely responsible for the toxicological effects of PFOS. Combined, the results from this thesis demonstrate the importance of considering PFOS isomer burdens during risk assessment. In addition, gene expression analysis identified several candidate mechanisms for PFOS toxicity.
16

The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)

O'Brien, Jason January 2011 (has links)
Perfluoroalkyl compounds (PFCs) are a group of chemical surfactants most notably used in non-stick and stain-resistance applications. Due to their wide-spread use and inherent resistance to degradation, several PFCs have become persistent environmental contaminants. Despite the high concentrations of PFCs reported in wild birds and their eggs, very little is known about the toxicological effects they have on avian species. This thesis investigates the developmental toxicity of PFCs in an avian model species: the domestic chicken (Gallus gallus domesticus). Egg injection experiments were performed to assess the in ovo toxicity of perfluorooctane sulfonate (technical grade, T-PFOS), perfluorooctanoic acid (PFOA), perfluorodecane sulfonate (PFDS) and perfluoroundecanoic acid (PFUdA). Real-time RT-PCR was then used to measure the transcription of candidate biomarker genes in the liver tissue of day 20 embryos. Candidate genes were selected based on their responsiveness to PFC exposure in previously conducted in vitro screening assays. In ovo exposure to PFOS resulted in a dose-dependent decrease in embryo pipping success (a measure of hatching success) with an LD50 of 93 μg/g (3.54 μg/g-672,910 μg/g, 95% confidence interval), however the expression of peroxisome proliferator-activated receptor alpha (PPARα)-regulated genes was not affected in liver tissue as hypothesized. PFOA, PFDS and PFUdA had no effect on the pipping success of chicken embryos. The expression of cytochrome P450 1A4 (CYP1A4) and liver fatty acid binding protein (L-FABP) mRNA increased in embryo liver tissue following in ovo exposure to PFUdA but was only statistically significant at 10 μg/g, which is several orders of magnitude higher than concentrations reported in wild bird eggs. The isomer-specific accumulation of PFOS in chicken embryo livers was also investigated using an in-port derivatization gas-chromatography/mass spectrometry (GC-MS) method. Prior to incubation, chicken eggs were injected with T-PFOS, composed of 63% linear isomer (L-PFOS) and 37.3% branched isomers. The isomer profiles in day-20 embryo liver tissue showed up to 20% enrichment in the proportion of L-PFOS, compared to T-PFOS, with a corresponding decrease in the proportion of branched isomers. This enrichment was inversely proportional to dose. Finally, the transcriptional profiles of cultured chicken embryonic hepatocytes (CEH) exposed to either T-PFOS or L-PFOS were compared using Agilent 4x44k Chicken (V2) Gene Expression microarrays. At equal concentrations (10 μM), T-PFOS altered the expression of significantly more genes (340 genes, >1.5 fold change, false discovery rate adjusted p<0.05) compared to L-PFOS (130 genes). Functional analysis showed that L-PFOS and T-PFOS affected genes involved in lipid metabolism, cellular growth and proliferation, and cell-cell signaling. Pathway and interactome analysis suggested that gene expression may be affected through RXR, oxidative stress response, TP53 signaling, MYC signaling, Wnt/β-catenin signaling and PPARγ and SREBP receptors. In all functional categories and pathways examined, T-PFOS had a more pronounced disruptive effect on transctional regulation than L-PFOS. In summary, egg injection experiments showed that T-PFOS (but not linear PFOA, PFDS or PFUdA) may affect the hatching success of the chicken at environmentally relevant concentrations. It was also demonstrated that the accumulation of PFOS in embryonic liver is isomer specific, and leads to an enrichment of L-PFOS. The increased transcriptional disruption caused by T-PFOS in cultured hepatocytes over L-PFOS suggests that the branched isomers may be largely responsible for the toxicological effects of PFOS. Combined, the results from this thesis demonstrate the importance of considering PFOS isomer burdens during risk assessment. In addition, gene expression analysis identified several candidate mechanisms for PFOS toxicity.
17

Toxicity Studies Of Per- and Polyfluoroalkyl Substances (PFAS)

Shittu, Adenike Rofiyat 02 September 2021 (has links)
No description available.
18

Perfluorooctane sulfonate and perfluorooctanoate contamination of riparian wetlands of the Eerste, Diep and Salt Rivers

Mudumbi, John-Baptist Nzukizi January 2012 (has links)
Thesis (MTech (Environmental Management))--Cape Peninsula University of Technology, 2012. / Perfluorinated compounds (PFCs), in particular perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have been found in aquatic environments throughout the world. Recent studies have reported that owing to their bioaccumulative nature, PFCs may also be present in various water sources, resulting in human and wild-life exposure. Although, these PFCs usually occur at low concentration levels, their presence in the environment has nevertheless been a concern in both developed and developing countries, since water remains an important natural resource for most living species. Water and sediment from rivers are one of the matrices in which PFC contamination is studied, since rivers receive water from various sources. However, limited studies have been conducted in South Africa on PFC contamination of river water and sediments. Although PFCs are sometimes unintentionally released into the environment, the concentration and type of PFCs that contaminate water sources vary among countries and depend on the types of industry releasing them into the environment, suggesting that PFC contamination patterns can be expected to differ from country to country, with PFOA and PFOS being the predominant perfluorinated contaminants. The aim of this study was therefore to determine the concentration of PFOS and PFOA in riparian wetlands of the Western Cape, focusing on the Eerste, Diep and Salt rivers, which are the primary rivers in the largest catchment areas of the Western Cape, South Africa.
19

Greener Water Repellency? Feasible alternatives to fluoro chemicals for DWOR treatments on textiles

Åkerblom, Denize, Göranzon, Erik January 2014 (has links)
BACKGROUND: Perfluorinated compounds (PFCs) have been used as durable water and oil repellent treatments in clothing for more than 50 years. The reason for its popularity is related to the chemical structure, which also makes these compounds persistent in the environment. Numerous studies have shown negative environmental and health effects related to high concentrations of perfluorinated compounds in blood serum. Due to these studies, this paper aimed to find out if perfluorinated compounds could be replaced by non-perfluorinated without compromising performance related to water and oil repellency. METHODOLOGY: A reference sample impregnated with fluorocarbons was compared with the following non-perfluorinated treatments, aliphatic polyurethane (comb polymer) organic silicone and acid (comb polymer) and hydrocarbon (dendrimer). Impregnations were subjected to abrasion, UV-radiation and washing and after each destructive treatment; oil and water repellency tests were conducted. The environmental and health effect of all treatments were examined in a theoretical study. RESULTS: Due to difficulties with the impregnation process, comparable results could only be concluded with the perfluorinated and the hydrocarbon compound. The hydrocarbon was superior the perfluorinated compound to abrasion but for usage simulation methods that allowed chemical reactions, hence UV-radiation and washing, the fluorocarbons showed better resistance. CONCLUSION: Results show that the hydrocarbon treatment could replace perfluorinated treatments commercially when only water and not oil repellency is required. The alternative treatments in this study are not yet sufficiently examined with respect to environmental and health and can therefore not be called greener with certainty. / Program: Textilingenjörsutbildningen
20

Prenatal Exposure to Perfluoroalkyl Acids and Serum Testosterone Concentrations at 15 Years of Age in Female ALSPAC Study Participants

Maisonet, Mildred, Calafat, Antonia M., Marcus, Michele, Jaakkola, Jouni J.K., Lashen, Hany 01 December 2015 (has links)
Background: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator–activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to these substances has the potential to alter testosterone concentrations. Objectives: We explored associations of total testosterone and sex hormone–binding globulin (SHBG) concentrations at age 15 years with prenatal exposures to PFOS, PFOA, perfluorohexane sulfonic acid (PFHxS), and perfluoronanoic acid (PFNA) in females. Methods: Prenatal concentrations of the perfluoroalkyl acids (PFAAs) were measured in serum collected from pregnant mothers at enrollment (1991–1992) in the Avon Longitudinal Study of Parents and Children (ALSPAC). The median gestational age when the maternal blood sample was obtained was 16 weeks (interquartile range, 11–28 weeks). Total testosterone and SHBG concentrations were measured in serum obtained from their daughters at 15 years of age. Associations between prenatal PFAAs concentrations and reproductive outcomes were estimated using linear regression models (n = 72). Results: Adjusted total testosterone concentrations were on average 0.18-nmol/L (95% CI: 0.01, 0.35) higher in daughters with prenatal PFOS in the upper concentration tertile compared with daughters with prenatal PFOS in the lower tertile. Adjusted total testosterone concentrations were also higher in daughters with prenatal concentrations of PFOA (β = 0.24; 95% CI: 0.05, 0.43) and PFHxS (β = 0.18; 95% CI: 0.00, 0.35) in the upper tertile compared with daughters with concentrations in the lower tertile. We did not find evidence of associations between PFNA and total testosterone or between any of the PFAAs and SHBG. Conclusions: Our findings were based on a small study sample and should be interpreted with caution. However, they suggest that prenatal exposure to some PFAAs may alter testosterone concentrations in females.

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