Access to abstract permanently restricted to Ball State community only / Access to thesis permanently restricted to Ball State community only / School of Physical Education, Sport, and Exercise Science

This thesis presents four studies that examine the potential role that intrusive thoughts, dissociation and mindfulness in self-harming behaviours in young people and adults. A large online study was conducted with students and staff at a UK university. This examined a range of risk factors for self-harm derived from the literature, including dissociation, family background/trauma history and intrusive thoughts. This study was followed up with a qualitative study investigating triggers of self-harm, and the role of intrusive thoughts. A third study then looked at these factors in young people who were inpatients in an American psychiatric hospital, and who had all expressed intent to self- harm or commit suicide. This study also introduced a measure of trait mindfulness in order to investigate this potential way of dealing with intrusive thoughts. Finally, the risk factors identified in these studies were further investigated with an online survey with undergraduate students at a second UK university, dissociation, mindfulness and thought suppression. Intrusive thoughts were found to differ in content, frequency and effect between people with experience of self-harm and those without. A subgroup of potentially maladaptive behaviours were found to be associated with high scores on the predictors of self-harm, and therefore potentially predictive of self-harm. In the young people in hospital, the extent to which they reacted to their intrusive thoughts was inversely associated with the extent to which they were naturally mindful. Trait mindfulness scores were lower for those individuals with a history of childhood trauma, and for those meeting diagnostic criteria for Borderline Personality Disorder, in which self-harm is a key feature. These findings together suggest that mindfulness skills may play an important role in both dealing with intrusive thoughts and for protecting against self-harm. Overall, intrusive thoughts and dissociation were associated with experience of self- harming behaviours, while mindfulness skills were negatively associated with self-harm. Some potentially maladaptive behaviours (including smoking and eating pathology) represent risk factors for self-harm, and therefore may provide professionals with a way of identifying people for early intervention, if further longitudinal research shows evidence of progression. Alternatively, the differences in mindfulness between this group and the self-harmers may indicate that mindfulness training could benefit people who self-harm.

Introduction/Background: Suicide in older people is a historically neglected research area. Local audits had suggested that Cornwall had a higher than average suicide rate, and people aged 75 years and over appeared to be at particularly high risk. Heterogeneity between studies and variations in presenting suicide statistics can make comparison of rates difficult. Aims: The study aimed to explore in depth the epidemiology of suicide in elderly people in Cornwall, to develop an understanding of the risk factors (including sources of stress), suicide methods, locations, and warnings, and consequently to identify potential preventive strategies. Methods: A mixed methods approach was taken, combining quantitative epidemiological study of suicide using Office for National Statistics (ONS) Public Health Mortality Files with qualitative retrospective case study analysis using coroner’s records and local audit database. All completed suicides (and some systematically selected open verdicts) in people aged 75 years and over occurring in Cornwall between 2006 and 2010 were included. A questionnaire survey of rural community dwelling people aged 75 years and over (n = 49) in a part of Cornwall was also carried out to identify the main sources of stress associated with ageing in the local area. Results: Some discrepancies in the number of open verdicts reported by the coroner and ONS were noted. Although suicide in the over 75 age group was responsible for only 0.3 % of all-cause mortality in males and 0.1 % in females, the overall suicide rate in this age group in Cornwall was significantly higher than the average for the UK, with a Standardised Mortality Ratio of 172 (95 % CI 123 to 236). Males aged between 75 and 84 years had the highest suicide rate in Cornwall (mean of 25.8 deaths per 100,000 population, 95 % CI 1.1 to 50.5). Jumping from a height and suffocation were the most frequently used methods, accounting for 8 and 7 of the 34 deaths respectively. 28 of the 34 suicides took place at home. Depressive illness, physical illness and bereavement were the most commonly identified risk factors. Concerns revealed in survey responses were closely related to suicide risk factors, including fear of losing independence, bereavement, physical illness, isolation, and fear of becoming a burden. Warnings included previous self-harm or attempted suicide, suicide ideation or plans, behavioural changes and researching euthanasia. Discussion: As persons aged 75 and over are at significantly higher risk of suicide in Cornwall than other regions, there is a need to reduce the number of suicides in this group. Possible preventive measures include reducing access to means (in particular for jumping incidents), earlier detection of depression in the physically ill, bereavement counselling, more social groups and support groups in rural areas, helping people to retain their independence, and a change in societal attitudes towards elderly people. There may also be a need to improve the accuracy of suicide statistics. Conclusion: Health services, councils, voluntary groups and the community as a whole should work together to prevent suicide in older people. Future controlled studies should assess the effectiveness of interventions and focus more on differences between subgroups of elderly people.

Bakgrund Posttraumatiskt stressyndrom bör betraktas som en folkhälsosjukdom där diagnostisering och behandling behöver uppmärksammas. Ungdomar som överlevt livshotande händelser tenderar att återuppleva dessa traumatiska händelser och undviker att handskas med känslorna som uppkommer, vilket kan leda till psykiska besvär. Syfte Att undersöka riskfaktorer som finns för att utveckla posttraumatiskt stressyndrom bland ungdomar samt undersöka vilka datainsamlingsmetoder de inkluderade artiklarna valt. Metod Deskriptiv design användes i litteraturstudien som inkluderar 13 stycken vetenskapliga artiklar från databaserna PsycInfo och PubMed. Likheter och skillnader i artiklarnas resultat identifierades och använda datainsamlingsmetoder sammanställdes. Huvudresultat Att vara utsatt för våld och traumatiska händelser såsom fysisk skada eller se någon lida/dö, vara tjej, äldre ungdom, utsatt för daglig stress, splittrad familj och sämre socialt stöd var riskfaktorer för att utveckla posttraumatiskt stressyndrom. Tio av tretton artiklar hade kvantitativ ansats och använde frågeformulär för att få svar på vilka riskfaktorer det fanns. En artikel hade kvantitativ ansats men använde inte frågeformulär och två hade endast kvalitativ ansats i form av intervju som datainsamlingsmetod. Slutsats Denna litteraturstudie identifierade olika riskfaktorer som ligger till grund för utveckling av PTSD bland ungdomar. De vanligaste som återkom i nästan alla studier var att utsättas för våld, vara med om traumatiska händelser, vara tjej, sämre socialt stöd inom familj och skola, förlora en anhörig och vardagliga stressorer. Att som sjuksköterska och övrig vårdpersonal inneha denna kunskap kan bidra till att tidigare kunna identifiera ungdomar med PTSD samt anpassa omvårdnaden till denna grupp på bästa sätt. / Background Posttraumatic stress disorder should be considered as a public health disease where diagnosing and treatment require attention. Adolescents who have survived life-threatening events tend to relive these traumatic events and avoid to deal with the emotions that occur, which can lead to mental disorders. Aim Identify which risk factors there is to develop posttraumatic stress disorder among adolescents and examine which data collection methods the included articles have chosen. Method Descriptive design has been used in this literature study including 13 articles collected from the databases PsycInfo and PubMed and has been categorized by similarities and differences. The articles data collection methods has been presented from the methodological aspect. Main results To be exposed to violence and traumatic events as physical injury or see someone suffer/die, be a girl, older adolescent, exposed to daily stress, broken family and have less social support were some risk factors for developing posttraumatic stress disorder. Ten of thirteen articles had a quantitative approach and used questionnaire to get responses for which risk factors there was. One article had a quantitative approach but did not use a questionnaire and two articles had qualitative approach and used interview as data collection method. Conclusion In this literature study different risk factors were identified underlying to develop PTSD among adolescents. The most common risk factors in almost all of the studies were to be exposed to violence, experience traumatic events, be a girl, have less social support from family and school, lose a family member and daily stress. As a nurse it is important to keep this in mind so the care for the adolescents are as good as possible and that coping is used in the right way.

Résumé : Aux soins intensifs (SI), une diminution du décompte plaquettaire peut avoir un impact important. Des études ont démontré une association entre la thrombopénie et la durée de séjour, les saignements, les transfusions et la mortalité. Les facteurs qui prédisent une thrombopénie varient selon les populations étudiées. Les médicaments sont souvent suspectés, mais peu ont été indépendamment associés à la thrombopénie aux SI. Les études publiées à ce jour souffrent de plusieurs limites. Les objectifs de cette thèse étaient de décrire l’épidémiologie, identifier les facteurs de risque associés, d’évaluer l’impact sur la morbidité et la mortalité et d’évaluer les causes indépendantes médicamenteuses de thrombopénie aux SI. Une cohorte rétrospective a été créée à partir de données administratives et cliniques afin de décrire l’épidémiologie, et d’évaluer les facteurs prédictifs et les conséquences de la thrombopénie aux SI. Par la suite, une étude cas-témoin a été entreprise en sélectionnant les patients qui ont souffert d’une thrombopénie de cause indéterminée afin de déterminer les associations entre les médicaments fréquemment utilisés aux SI et la thrombopénie. Un total de 20 711 patients a été inclus dans l’analyse. La prévalence et l’incidence de thrombopénie ont été de 13,3% et 7,8%, respectivement. La thrombopénie a été indépendamment associée à une augmentation des saignements majeurs (aRC 1,32 95% CI 1,20-1,46). Après des ajustements statistiques, la thrombopénie était associée à une augmentation de mortalité (aRC 1,25 IC95% 1,20-1,31). L’impact sur la mortalité a été le plus important dans les catégories d’admission suivantes: cancer, respiratoire, digestif, génito-urinaire et infectieuses. Les facteurs de risque indépendants suivants ont été identifiés: l’âge, le genre masculin, la ventilation mécanique, l’alcoolisme, la cirrhose hépatique, le décompte plaquettaire à l’admission, l’hypersplénisme, le ballon intra-aortique, le choc septique, l’hépatite aiguë, la chirurgie de pontage coronarien et les maladies thromboemboliques. Dans l’étude cas-témoin, 200 cas de thrombopénie ont été identifiés après l’exclusion des maladies fortement associées. Ces cas ont été appariés à 200 témoins admis dans la même année. Parmi les 15 classes de médicaments évalués, seules les quinolones 1,67 (IC95% 1,00-2,87) ont été indépendamment associées à la thrombopénie dans le modèle final. En conclusion, la thrombopénie est indépendamment associée à une hausse de la mortalité qui varie grandement selon la catégorie d’admission. Les facteurs de risque sont nombreux et incluent des facteurs modifiables. Bien que les médicaments soient fréquemment soupçonnés, seules les quinolones semblent être associées à la thrombopénie aux SI. // Abstract : In the intensive care unit, a reduction in platelet counts can have a major impact on patient outcomes. Studies have showed an association between thrombocytopenia and length of stay, bleeding, blood product administration and mortality. Predictors of thrombocytopenia in the intensive care setting vary according to studies. Although medications are often suspected as potential causes, few have been independently associated with thrombocytopenia. In addition, published studies have many limits including small sample sizes, probable residual confounding, and inclusion of invasive interventions. The objectives of the thesis are to describe the epidemiology of thrombocytopenia, identify its risk factors, evaluate its impact on morbidity and mortality, and evaluate the drug-induced causes of thrombocytopenia. A retrospective cohort was created using administrative and clinical data. In the first study, multivariate analysis was used to identify risk factors. In the second study, a case control strategy was used to determine the association between thrombocytopenia and drugs commonly used in the intensive care unit previously associated with thrombocytopenia. A total of 20 711 patients were included in the analysis. The prevalence and incidence of thrombocytopenia defined as a platelet count below 100 x 10[superscript 9]/L were 13.3% and 7.8%, respectively. Thrombocytopenia was independently associated with an increase in the risk of major bleeding (aOR 1.32 95% CI 1.20-1.46). After adjusting for confounders, thrombocytopenia was associated with an increased risk of hospital mortality (aOR 1.25 IC95% 1.20-1.31). The impact of thrombocytopenia on mortality was the most important in the following diagnostic categories: cancer, respiratory, digestive, genitourinary, and infectious. The following independent risk factors were identified: age, male gender, admission platelet counts, mechanical ventilation, alcoholism, liver cirrhosis, hypersplenism, intra aortic balloon pumps, septic shock, acute hepatitis, coronary bypass surgery and venous thromboembolism. In the case control study, 200 cases were identified after exclusion of patients with diseases strongly associated with thrombocytopenia and paired with 200 controls admitted in the same year. Among the 15 medication classes evaluated, only quinolones 1.67 (IC95% 1.00-2.87) were independently associated with thrombocytopenia. In conclusion, thrombocytopenia is independently associated with an increased risk of mortality, which varies according to diagnostic admission categories. Risk factors are numerous and some are modifiable. Although medications are often suspected, only quinolones were statistically associated with thrombocytopenia.

Bakgrund: Depression blir allt vanligare men ändå diagnostiseras endast cirka hälften av dem som drabbas. Svårigheterna med att bli diagnostiserad ökar med åldern då äldre ofta upplever mer somatiska symtom vid depression och sjukvården har en stor kunskapslucka kring identifieringen och vilka riskfaktorer som inverkar. Syfte: Syftet var att belysa riskfaktorer som kan inverka på utvecklingen av en depression hos äldre och de möjligheter sjuksköterskor har att identifiera depression hos äldre personer. Metod: En litteraturöversikt gjordes på valt ämne. Studier söktes genom databaserna: MEDLINE, CINAHL Complete, ASSIA och Psychology and Behavioral Sciences Collection. De sökord som användes var: depression, older adults, older, nurse/nurses, identify, recognize, risk factors och elderly. Fribergs analysmetod användes vid analys av artiklarna. Resultat: Resultatet i litteraturöversikten redovisas utifrån de två kategorier som framkom genom analysen av artiklarna. Första kategorin beskriver de riskfaktorer som kan inverka på depression hos äldre och den andra beskriver sjuksköterskans möjligheter till att identifiera depression. De riskfaktorer som kan inverka på en depression är livskvalitetens inverkan och somatisk inverkan. Sjuksköterskans möjligheter till att identifiera depression sammanställdes till kunskap och utbildning samt tid för samtal. Diskussion: Styrkor och svagheter diskuteras i metoddiskussionen och resultatet diskuteras i relation till syfte, bakgrund och Barkers tidsvattenmodell i resultatdiskussionen. / Background: Depression is becoming more common but only half of the cases are getting diagnosed. The difficulties of getting a diagnose increases with age and the elderly have more somatic symptoms of depression. There is a huge knowledge gap within healthcare sector relating to the identification of depression and the risk factors that influence it. Aim: The aim is to highlight the risk factors that may influence the development of depression among the elderly and the opportunities nurses have to identify depression among the older people. Method: A litterature review was made on the chosen topic. Studies were searched through the databases: MEDLINE, CINAHL Complete, ASSIA and Psychology and Behavioral Sciences Collection. The keywords that were used was: depression, older adults, older, nurse/nurses, identify, recognize, risk factors and elderly. Friberg’s analytical method was used to analys the articles. Results: Two categories were presented in the result. The first category descibes the risk factors that may effect depression among the elderly and the second category describes the nurses possibilities to identify depression. The risk factors that may effect a depression are: quality of life and somatic impact. The nurses ability to identify depression among elderly were compiled into knowledge, education and time for dialog. Discussion: Strength and weaknesses are discussed in the method discussion while the results are discussed in relation to the purpose, background and Barkers tidalmodel in the result discussion.

Einleitung: Der Verdacht, dass Hunde mit einem Bandscheibenvorfall eine Prädisposition für die Entstehung einer Pankreatitis haben könnten, wurde in der Veterinärmedizin bereits in den frühen 1980er Jahren diskutiert. Trotz dieser bereits vor vielen Jahren erhobenen Vermutungen, wurde der Zusammenhang zwischen der Entstehung einer Pankreatitis und einem zeitgleich vorliegenden Bandscheibenvorfall auch im Hinblick auf mögliche Risikofaktoren wie dem Einfluss der Narkose oder dem Einsatz von Medikamenten (v. a. Glukokortikoide und nichtsteroidale Antiphlogistika) bisher nicht näher untersucht. Ziele der Untersuchungen: Im Rahmen der vorliegenden prospektiven Studie sollte untersucht werden, ob Bandscheibenvorfälle ein Risikofaktor für die Entstehung einer Pankreatitis beim Hund darstellen. Ferner sollte geklärt werden, ob die Narkose und die Gabe von Glukokortikoiden und/oder nichtsteroidalen Antiphlogistika zusätzlich das Risiko der Entstehung einer Pankreatitis bei Hunden mit einem Bandscheibenvorfall erhöhen. Material und Methoden: Insgesamt wurden 106 Hunde, bei denen aufgrund der klinischen Symptome der Verdacht einer Rückenmarksläsion bestand, an fünf aufeinander folgenden Tagen klinisch untersucht. Besonderes Augenmerk wurde hierbei auf Symptome gelegt, welche typischerweise bei Pankreatitiden zu beobachten sind (reduziertes Allgemeinbefinden, Schwäche, Anorexie, dolentes Abdomen, Vomitus, Regurgitieren, Diarrhoe, Fieber, Dehydratation). Ferner wurde am Tag 0 und Tag 4 der stationären Aufnahme die Konzentration der caninen pankreasspezifischen Lipase im Serum gemessen (Spec cPL und Snap cPL). Am Tag 0 wurde von dem Vorliegen einer Pankreatitis ausgegangen, wenn klinische Befunde im Sinne einer Pankreatitis sowie eine abnorm erhöhte Konzentration der caninen pankreasspezifischen Lipase im Serum (>400 μg/L) auffällig waren. Am Tag 4 erfolgte zudem eine sonographische Untersuchung des Abdomens. Somit basierte die Diagnosestellung einer Pankreatitis an diesem Tag auf dem Vorliegen von zwei der folgenden drei Kriterien: klinische Befunde im Sinne einer Pankreatitis, abnorm erhöhte Konzentration der caninen pankreasspezifischen Lipase im Serum, sonographische Hinweise für das Vorliegen einer Pankreatitis. Im Rahmen der statistischen Auswertung wurden zudem auch Patienten erfasst, welche in einem oder in mehreren der oben genannten Kriterien ein fragliches Ergebnis aufwiesen. Entsprechend ihrer neurologischen Ausfallserscheinungen sowie der Befunde im Rahmen der bildgebenden Diagnostik (Myelographie, Computertomographie, Kernspintomographie) wurden die Patienten in eine der folgenden drei Untersuchungsgruppen eingeteilt: 1. Hunde mit einem chirurgisch versorgten Bandscheibenvorfall (n = 71) 2. Hunde mit einem konservativ therapierten Bandscheibenvorfall (n = 20) und 3. Hunde mit einer akuten intramedullären Läsion (n = 15). Die statistische Auswerte erfolgte aufgrund der geringen Stichprobengrößen vorwiegend deskriptiv. Die Daten wurden mittels des Shapiro-Wilk-Tests auf Normalverteilung überprüft, die durchgeführten Gruppenvergleiche erfolgten unter Verwendung des Kruskal-Wallis und Mann-Whitney-U-Tests. Zudem wurden die betrachteten Merkmale mit dem Fisher Test und dem Chi-Quadrat-Test auf Unabhängigkeit überprüft. Das Signifikanzniveau wurde für alle Tests mit p < 0,05 festgelegt. Ergebnisse: Basierend auf den klinischen Symptomen und der Konzentration der caninen pankreasspezifischen Lipase im Serum konnte insgesamt am Tag 0 bei vier Hunden (3,8 %) eine Pankreatitis diagnostiziert werden. Am Tag 4 waren es, basierend auf den drei Kriterien, welche für die Diagnosestellung einer Pankreatitis herangezogen werden, insgesamt acht Patienten (7,5 %). Hunde mit einem Bandscheibenvorfall (chirurgisch beziehungsweise konservativ therapiert) wiesen am Tag 0 beziehungsweise Tag 4 in 4,3 % (n = 4) beziehungsweise 7,7 % (n = 7) der Fälle eine Pankreatitis auf. Aufgrund der geringen Häufigkeiten in den einzelnen Untersuchungsgruppen, war eine Berechnung eines signifikanten Unterschieds zwischen den Gruppen nicht möglich. Hinsichtlich einer möglichen Korrelation zwischen einer Narkose und der Entstehung einer Pankreatitis bei Hunden mit einer Rückenmarksläsion konnte kein signifikanter Zusammenhang festgestellt werden. Auch die Gabe von Glukokortikoiden und/oder nichtsteroidalen Antiphlogistika hatte hier keinen signifikanten Einfluss auf die Entstehung einer Pankreatitis. Schlussfolgerung: Vergleicht man die Ergebnisse der vorliegenden Studie mit der in der Literatur angegebenen Prävalenz für akute Pankreatitiden beim Hund (0,7-3,5 %), so kann geschlussfolgert werden, dass eine Rückenmarksläsion, insbesondere ein Bandscheibenvorfall, als Risikofaktor für die Entstehung einer akuten Pankreatitis beim Hund in Betracht gezogen werden muss. Demgegenüber erhöhen weder die Narkose noch die Gabe von Glukokortikoiden und/oder nichtsteroidalen Antiphlogistika zusätzlich das Risiko der Entstehung einer Pankreatitis bei Hunden mit einer Rückenmarksläsion. / Objective: The suspicion that dogs with intervertebral disc disease are at greater risk of developing pancreatitis is being discussed in veterinary medicine since the early 1980s. So far no study has been published examining the correlation between intervertebral disk disease and the development of pancreatitis in dogs, especially in combination with general anaesthesia and anti-inflammatory medication (glucocorticoids and/or nonsteroidal anti-inflammatory drugs). The aim of this study was therefore 1) to evaluate intervertebral disk disease as possible risk factor of pancreatitis and 2) to ascertain if general anaesthesia and the administration of glucocorticoids and/or nonsteroidal anti-inflammatory drugs further increase the risk of pancreatitis in dogs with intervertebral disk disease. Material and methods: One hundred and six dogs with symptoms associated with spinal cord injury were clinically examined over a period of five days. Special attention was payed to symptoms usually seen with pancreatitis such as anorexia, vomitus and abdominal pain. Furthermore the concentration of canine pancreatic lipase in the blood serum was measured with Spec cPL and Snap cPL at day 0 and day 4 after admission. At day 0 the diagnosis of pancreatitis was based on clinical symptoms associated with pancreatitis in combination with an increased concentration of canine pancreatic lipase in the blood serum (>400 μg/L). A sonography of the pancreas was performed at day 4 to evaluate the organ itself and the surrounding tissue for lesions associated with pancreatitis. Therefore the diagnosis of pancreatitis at day 4 was based on positive results in at least two of the three following criteria: symptoms associated with pancreatitis, elevation of the concentration of canine pancreatic lipase in the blood serum, sonographic changes of the pancreas parenchyma and the surrounding tissue associated with pancreatitis. For statistical analysis questionable results in one or more of these criteria were also documented. According to the neurologic symptoms and the findings of diagnostic imaging (myelography, computed tomography and magnetic resonance imaging), dogs were categorized in one of the following groups: 1. dogs with surgically treated intervertebral disk disease (n = 71), 2. dogs with medically treated intervertebral disk disease (n = 20), 3. dogs with an acute intramedullary lesion (n = 15). Due to the small sample size, statistics were primarily performed descriptively. Data were tested for normal distribution using the Shapiro-Wilk test. If Group comparisons were feasible, they were performed using the Kruskal-Wallis test and the Mann-Whitney-U test. Fisher test and the Chi-Square test were used to test for association between group affiliation and possible risk factors for the development of pancreatitis. A value of P < 0.5 was considered significant for all analysis. Results: Based on clinical symptoms and an elevated concentration of the canine pancreatic lipase (> 400μg/l) at day 0, four dogs (3.8 %) were diagnosed with pancreatitis. According to the clinical symptoms, the concentration of the canine pancreatic lipase and sonographic changes, a total number of eight dogs (7.5 %) were diagnosed with pancreatitis at day 4. Considering only the dogs with intervertebral disk disease (surgically and medically treated) 4.3 % (n = 4) and 7.7 % (n = 7) were diagnosed with pancreatitis at day 0 and day 4, respectively. Due to the small sample size, the calculation of significant differences between the three subgroups was not feasible. There was no significant correlation between general anaesthesia and the development of pancreatitis. Furthermore, the administration of glucocorticoids and/or nonsteroidal anti-inflammatory drugs is not significantly associated with the genesis of pancreatitis.

Introduction HIV remains a severe global health problem. The Republic of Chad is moderately affected (1.3%), compared to Cameroon who suffers more of the burden of the HIV/AIDS (4.5%). We described the HIV risk factors in two neighboring Central African Republics, and compared the gaps in both countries. Methods This was a retrospective cross-sectional study; data was obtained from the Demographic and Health Survey. A stratified multi-stage cluster sample design was conducted. The sample size was 5248 in Chad and 7191 in Cameroon. We used SAS to fit a multilevel logistic model, and conducted a multivariate analysis. Results The median age of respondents was 30 (IQR, 20-40) years in Chad, and 28 (IQR, 20-40) in Cameroon. Only 12.45% reported had ever been tested for HIV in Chad, (41.77% in Cameroon). In Chad, 46.40% of participants did not know a place to get HIV test, (11.15% in Cameroon). The median number of lifetime sexual partners was 2 (IQR, 1-4) in Chad, and 6 (IQR, 3-15) in Cameroon. Among Chadian participants 31.63% had only one lifetime sexual partner, (10.76% in Cameroon). In Chad 86.95% of participants reported having no sex partner other than their spouse in the last 12 months; (57.3% in Cameroon). Conclusion Condom use and HIV testing rates were very low among Chadian men comparing to Cameroonian men; however, Cameroonian men were more likely to engage in multiple sexual partners and extra-marital relationship than Chadian men.

Percutaneous kidney biopsies have been performed since 1944 to establish diagnoses and treatment. Risk factors based on a limited amount of data have shown age, blood pressure, kidney function and needle size as some risk factors for biopsy complications. Although the techniques of biopsy have improved over the years, it is still an invasive procedure and serious complications can occur. The overall aim of this thesis was to obtain a large series of data from biopsy procedures and to use these to bring further light on risk factors to help minimize the risk for patients and to optimize diagnostics. Specific aims were to clarify if different factors, such as gender, diagnoses, localization of biopsies, needle types and sizes, could be useful to help minimize complication risks in native kidney biopsies (Nkb) and transplant kidney biopsies (Txb). Another point to investigate was the value of the Resistive Index (RI) obtained at ultrasound before performing Txb. Materials and methods: A protocol for prospective multicentre registration of various factors and complications associated with Nkb and Txb was designed. Consecutive data were obtained from seven hospitals. All biopsies, except one computer tomography-guided Nkb, were performed using real-time ultrasound guidance and an automated spring-loaded biopsy device. For the biopsies 14- to 20- Gauge (G) needles were used. The kidney function level, i.e. estimated glomerular filtration rate (eGFR), was calculated using the Modification of Diet in Renal Disease (MDRD) formula (GFR in mL/min per 1.73m2). For statistical analyses the IBM SPSS Statistic 22 (Armonk, NY, USA) and OpenEpi (Open Source Epidemiologic Statistics for Public Health, www.OpenEpi.com) were used. Data were presented as Odds Ratio (OR), Risk Ratio (RR) and Confidence Intervals (CI). A two sided p-value of &lt;0.05 was considered significant. In total 1299 consecutive biopsies (1039 native and 260 transplant kidneys) in 1178 patients (456 women and 722 men) were used for investigation. The median age of patients was 55 years (range 16 to 90 years). Major (require an intervention) and minor biopsy complications (no need of intervention) were registered. Results: The overall frequency of biopsy complications for Nkb was 8.8% (major 6.7%, minor 2.1%) and for Txb was 6.5% (major 3.8%, minor 2.7%); no death. Women had a higher risk for development of major (10.7% versus 4.7%, OR 2.4, CI 1.4-4.2) and overall biopsy complications (13.2% versus 6.5%, OR 2.2, CI 1.4-3.5) compared to men in Nkb. In Nkb, major complications were more common after biopsies from the right kidney in women versus men (10.8% vs 3.1%, OR 3.7, CI 1.5–9.5), in patients with lower versus higher BMI (25.5 vs 27.3, p=0.016) and for younger versus older age (44.8 vs 52.3 years, p=0.002). Lower (90 mmHg) compared to higher (98 mmHg) mean arterial pressure in Txb indicated a risk of major complications (p=0.039). Factors such as number of passes and kidney function did not influence complication rates. Biopsy needles of 16 G compared to 18 G showed more glomeruli per pass in Nkb (11 vs 8, p&lt;0.001) and in Txb (12 vs 8, p&lt;0.001). Sub-analysis revealed that 18 G 19 mm side-notch needles in Nkb resulted in more major (11.3% vs 3%, OR 4.1, CI 1.4-12.3) and overall complications (12.4% vs 4.8%, OR 2.8, CI 1.1-7.1) in women than in men. If the physician had performed less compared to more than four Nkb per year, minor (3.5% vs 1.4%, OR 2.6, CI 1.1-6.2) and overall complications (11.5% vs 7.4%, OR 1.6, CI 1.1-2.5) were more common. The localization of biopsy within the kidney (Nkb and Txb) was not a risk factor for complications. Patients with IgA-nephritis compared to patients with other diseases had a higher risk of major complications (11.7% vs 6.4 %, OR 1.8, CI 1.1–3.2). More major complications were found in Nkb if they had higher versus lower degree of glomerulosclerosis (31% vs 20 %, p=0.008) and in Txb if there was a higher versus lower degree of interstitial fibrosis (82% vs 33%, p&lt;0.001). Re-biopsies (Nkb) were more common in patients with IgA-nephritis than those with other diseases (4.7% vs 1.3 %, OR 4, CI 1.5–11), in younger versus older age (42.6 vs 52.3 years, p=0.031), and in those with a higher versus lower degree of interstitial fibrosis (63% vs 34 %, p=0.046). In Txb, a RI≥0.8 compared to RI&lt;0.8 predicted major (13.3% vs 3.2%, RR 4.2, CI 1.3-14.1) and overall biopsy complications (16.7% vs 5.3%, RR 3.2, CI 1.2-8.6). In the group &lt;0.8, RI correlated with age (rs=0.28, p&lt;0.001) and systolic blood pressure (rs=0.18, p=0.02). In the group ≥0.8, RI correlated with degree of interstitial fibrosis (rs=0.65, p=0.006) and systolic blood pressure (rs=0.40, p=0.03). The multiple regression analysis showed that the &lt;0.8 RI group correlated only with age (p&lt;0.001), whereas the ≥0.8 RI group correlated only with the degree of interstitial fibrosis (p=0.003). Conclusions: The present results motivate greater attention to be paid to the possibility of major side-effects after Nkb in women and biopsies from their right side, but as well in younger patients, and in those with lower BMI. This also applies for patients with presumptive IgA-nephritis and higher degree of glomerulosclerosis. In Txb, patients with higher degree of interstitial fibrosis had a greater risk of major complications. Moreover, the present data indicate that Nkb and Txb should be preferably taken with 16 G needles with 20 mm sample size. This results in better histological quality and there is a lower risk for major complications as compared to 18 G needles. The localization of biopsy within the kidney (Nkb and Txb) does not alter complication rates. For Nkb there were fewer complications if the physician had performed at least four biopsies per year. A RI≥0.8 in Txb indicates a greater risk for major and overall complications.

Our purpose with this study was to understand how social welfare board perceive neglect and what they consider are unacceptable flaws in parental capacity. The central focus of the study is located in the assessment of the social welfare boards when they consider that the parental capacity is unacceptable. The study aims to answer the following questions:   How does social welfare board understand neglect? How perceive social welfare board unacceptable parental capacity?   Our study is based on a document analysis of fourteen cases from administrative rulings where social welfare board applied for LVU 1§ 2§ because of flaws in care. We have used hermeneutic interpretation to look at the empirical material. The theoretical framework of the study consists systems theory and Bronfenbrenner’s bioecological model with focus on the family as the basic system.   The result we found was that the unacceptable parental capacity consisted of  parental individual problems. Problems we could identify at the parents were mental illness, disability, relationship conflicts, violence and abuse. Social welfare board had payed attention to several types of neglect. We identified moral care, emotional care, physical care and fysical violence.   Our conclusion is that it not only was just one specific problem in the family without that it were several parallel problems which led to that social welfare board consisted that the parental capacity is unacceptable. The study shows that the term neglect is difficult to define and is a interpretation question of the social welfare board to assess whether each boundary goes where the child is considered to fare badly.