• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 119
  • 54
  • 43
  • 17
  • 13
  • 8
  • 8
  • 8
  • 7
  • 7
  • 4
  • 3
  • 3
  • 2
  • 1
  • Tagged with
  • 349
  • 52
  • 48
  • 40
  • 37
  • 36
  • 31
  • 28
  • 25
  • 24
  • 24
  • 22
  • 21
  • 19
  • 19
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
161

Evaluation Of Kollidon® SR for Ph-Independent Extended Release Matrix Systems

Draganoiu, Elena Simona 30 June 2003 (has links)
No description available.
162

Mechanisms of Xanthophyll Uptake in Retinal Pigment Epithelial Cells

Thomas, Sara E. January 2016 (has links)
No description available.
163

Regulation of Mitotic Progression by Btf and TRAP150

Cheedu, Divya January 2016 (has links)
No description available.
164

Constraint based network communications in a virtual environment of a proprietary hardware

Bhonagiri, Saaish, Mudugonda, Soumith Kumar January 2022 (has links)
The specialized hardware remains a key component of the mobile networks, but at the same time, the telecom industry is adapting a vision of a fully programable distributed end-to-end network with cloud style management and Software-Defined Networking. In the specialized hardware programmable network, it will be possible to place workloads across abstracted compute and networking infrastructure. But, whereas virtualization standard compute resources is a mature technology and well supported in cloud management systems such as OpenStack and Kubernetes, this is not the case for specialized hardware with more complex constraints. There is a significant gap in terms of advanced constraints and service level aware schedulers. The main objective of this thesis is that the specialised hardware needs to adapt to the features of edge computing. Edge computing provides the opportunity to explore how technologies can advance industrial processes. To achieve flexibility by choosing where the workload should be processed on the board based on available resources. Utilising this technology, highly intensive applications can be handled at the network’s edge. There is a necessity to virtualize the proprietary hardware and run workloads in VMs and containers. In this thesis, we discuss kernel bypass, PCI passthrough and MPI communication technologies in a virtual environment by considering the hardware constraints and software requirements so that these technologies can be integrated into OpenStack and Kubernetes in future.
165

AN INVESTIGATION OF THE CONCURRENT CRITERION-RELATED VALIDITY OF THE COMPREHENSIVE EXECUTIVE FUNCTION INVENTORY (CEFI) - SELF-REPORT MEASURE

Seiple, Deborah Ann January 2016 (has links)
Executive function (EF) processes are crucial for meeting demands in the classroom. Because of this impact on schooling, it is important to have tools that accurately measure EF in order to facilitate the identification of student needs and the development of interventions. This project assessed the concurrent, criterion-related validity of one of these tools, the Comprehensive Executive Functioning Inventory, Self-Report (CEFI-SR; Naglieri & Goldstein, 2013). This study correlated adolescents’ reports about their own behavior to scores derived from a direct measure of executive function to determine if teens were able to accurately rate their own EF abilities, indicating that the CEFI-SR had concurrent validity. Seventy-nine seventh and eighth grade students from a suburban middle school were recruited. The average age for the sample was 13 years and 10 months old, and 62% of the sample consisted of female students. Participants completed the CEFI-SR in small groups, and then, the lead examiner returned to the school to complete direct one-on-one testing with each student. Data were analyzed using Pearson product-moment correlations and t-tests. The t-tests were used to determine if significant differences between groups were present. Results from the t-tests indicated that there were no significant differences in performance across genders or grades. Additionally, no significant correlations were found between the rating scale scores and the results of the direct testing. These findings do not support the hypotheses that the CEFI-SR subscales would have moderate correlations with the direct testing scores from the NEPSY-II, indicating that the two measures may not be measuring the same constructs. / School Psychology
166

Interactions of the Air Electrode with Electrolyte and Interconnect in Solid Oxide Cells

Jin, Tongan 31 August 2011 (has links)
The interactions between different components of solid oxide cells (SOCs) are critical issues for achieving the tens of thousands of hour's goal for long-term performance stability and lifetime. The interactions between the ceramic electrolyte, porous ceramic air electrode, and metallic interconnect materials — including solid state interfacial reactions and vaporization/deposition of some volatile elements — have been investigated in the simulated SOC operating environment. The interactions demonstrate the material degradation mechanisms of the cell components and the effects of different factors such as chemical composition and microstructure of the materials, as well as atmosphere and current load on the air electrode side. In the aspect of materials, this work contributes to the degradation mechanism on the air electrode side and provides practical material design criteria for long-term SOC operation. In this research, an yttria-stabilized zirconia electrolyte (YSZ)/strontium-doped lanthanum manganite electrode (LSM)/AISI 441 stainless steel interconnect tri-layer structure has been fabricated in order to simulate the air electrode working environment of a real cell. The tri-layer samples have been treated in dry/moist air atmospheres at 800°C for up to 500 h. The LSM air electrode shows slight grain growth, but the growth is less in moist atmospheres. The amount of Cr deposition on the LSM surface is slightly more for the samples thermally treated in the moist atmospheres. At the YSZ/LSM interface, La enrichment is significant while Mn depletion occurs. The Cr deposition at the YSZ/LSM interface is observed. The stoichiometry of the air electrode is an important factor for the interactions. The air electrode composition has been varied by changing the x value in (La0.8Sr0.2)xMnO₃ from 0.95 to 1.05 (LSM95, LSM100, and LSM105). The enrichment of La at the YSZ/LSM interface inhibits the Cr deposition. The mechanisms of Cr poisoning and LSM elemental surface segregation are discussed. A 200 mA·cm-2 current load have been applied on the simulated cells. Mn is a key element for Cr deposition under polarization. Excessive Mn in the LSM lessens the formation of La-containing phases at the YSZ/LSM interface and accelerates Cr deposition. Deficient Mn in LSM leads to extensive interfacial reaction with YSZ forming more La-containing phase and inhibiting Cr deposition. / Ph. D.
167

Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing

Payne, Laura Beth 19 June 2016 (has links)
The human proteome is exponentially derived from a limited number of genes via alternative splicing, where one gene gives rise to multiple proteins. Alternatively spliced gene products, although crucial for normal physiology, are also linked to an increasing number of pathologies. Consequently, a growing focus is currently being placed on elucidating the extrinsic cues and ensuing signaling mechanisms which direct changes in gene splicing to yield functionally distinct proteins. Of note is the dysregulation of the vascular endothelial growth factor (VEGF) receptor, Flt1 and its soluble splice variants, sFlt1_v1 and sFlt1_v2, in the pregnancy-related disorder, preeclampsia. Preeclampsia is characterized by proteinuria and hypertension and is responsible for almost 600,000 maternal and fetal yearly deaths, worldwide. Here, we examined the impact of endothelial mitogens VEGF and FGF2 (fibroblast growth factor 2), both of which are upregulated in preeclampsia, on Flt1 transcript variants in umbilical vein endothelial cells. We tested the hypothesis that VEGF modulates the expression of Flt1 variants via the signaling kinase Akt and its impact on SR proteins. VEGF was observed to induce expression of overall Flt1 mRNA, principally as variants Flt1 and sFlt1_v1. Conversely, FGF2 induced a shift in splicing toward sFlt1_v2 without significant increase in overall Flt1. Based on inhibitor studies, the VEGF and FGF2 signals were transduced via ERK, but with the involvement of different upstream components. We mapped predicted SR protein binding to Flt1 pre-mRNA and identified two candidate proteins, SRSF2 and SRSF3, that may be involved in VEGF- or FGF2-induced Flt1 pre-mRNA splicing. Examination of SRSF2 and SRSF3 relative mRNA expression levels, following inhibition of VEGF- and FGF2-activated kinases, indicates that FGF2 significantly downregulates SRSF3 mRNA levels via PKC-independent activation of ERK. Additionally, our data suggest that FGF2 may impact Flt1 and sFlt1_v1 via SR protein kinases Akt and SRPK, while conversely regulating sFlt1_v2 levels via Clk. We did not find evidence of VEGF-induced Flt1 variant splicing via SR protein kinase activation or SRSF2 and SRSF3 mRNA levels. Thus, VEGF and FGF2 signals were tranduced via related but distinct mechanisms to differentially influence Flt1 pre-mRNA splicing. These findings implicate VEGF and FGF2 and their related intracellular signaling mechanisms in soluble Flt1 regulation. / Ph. D.
168

Ion microprobe assessment of the heterogeneity of Mg/Ca, Sr/Ca and Mn/Ca ratios in Pecten maximus and Mytilus edulis (bivalvia) shell calcite precipitated at constant temperature.

Clarke, Leon J., Kennedy, H.A., Richardson, C.A., Freitas, P.S. January 2009 (has links)
No / Small-scale heterogeneity of biogenic carbonate elemental composition can be a significant source of error in the accurate use of element/Ca ratios as geochemical proxies. In this study ion microprobe (SIMS) profiles showed significant small-scale variability of Mg/Ca, Sr/Ca and Mn/Ca ratios in new shell calcite of the marine bivalves Pecten maximus and Mytilus edulis that was precipitated during a constant-temperature culturing experiment. Elevated Mg/Ca, Sr/Ca and Mn/Ca ratios were found to be associated with the deposition of elaborate shell features, i.e. a shell surface stria in P. maximus and surface shell disturbance marks in both species, the latter a common occurrence in bivalve shells. In both species the observed small-scale elemental heterogeneity most likely was not controlled by variable transport of ions to the extra-pallial fluid, but by factors such as the influence of shell organic content and/or crystal size and orientation, the latter reflecting conditions at the shell crystalsolution interface. In the mid and innermost regions of the P. maximus shell the lack of significant small-scale variation of Mg/Ca ratios, which is consistent with growth at constant temperature, suggest a potential application as a palaeotemperature proxy. Cross-growth band element/Ca ratio profiles in the interior of bivalve shells may provide more promising palaeo-environmental tools than sampling from the outer region of bivalve shells.
169

Hållbara investeringar : En analys av svenska SR-investerare En studie om hur svenska aktiesparares ESG-snitt påverkas av demografiska och socioekonomiska aspekter / Sustainable investments : An analyze of Swedish SR-investorsA study of how Swedish stockholders’ ESG mean can be affected by demographic and socioeconomic aspects.

Månsson, Johanna, Tingström, Astrid January 2019 (has links)
Bakgrund: Hos svenska investerare finns ett ökat intresse för hållbara investeringar, således har även efterfrågan på att mäta bolags hållbarhetsarbete utifrån ESG-kriterier ökat. Forskning om vem, utifrån demografiska och socioekonomiska aspekter, som väljer att investera i aktier med ett ESG-betyg är begränsad. Tidigare forskning har främst studerat hållbart fondsparande genom enkätundersökningar. Syfte: Studien ämnar analysera huruvida skillnader i ESG-snitt i svenska SR- investerares aktieportföljer kan förklaras av demografiska och socioekonomiska skillnader. Därtill ämnar studien identifiera vilken demografisk grupp som har störst preferens för respektive beståndsdel av ESG. Genomförande: Med hjälp av ett unikt data-set genomförs multivariata regressioner, vilket möjliggör en jämförelse av ESG-snitt i aktieportföljer för olika demografiska grupper. Genom frågeställningar diskuteras och jämförs resultaten med tidigare forskning. Slutsats: Studien finner att den svenska SR-investeraren med högst ESG-snitt i aktieportföljen är en äldre kvinna, med låg inkomst och boende i en storstad. Därtill finner studien att medelålders och äldre kvinnor, med låg inkomst samt boende i och utanför en storstad, har störst preferens för respektive beståndsdel av ESG. Därutöver finner studien både likheter och skillnader mellan dessa resultat och tidigare forskning. / Background: Swedish investors have an increased interest in sustainable investments, thus the demand for measuring companies’ sustainability work, based on ESG criteria, has increased. Research on who, based on demographic and socioeconomic aspects, that choose to invest in ESG shares is limited. Previous research has mainly studied sustainable fund savings through surveys. Purpose: The thesis aims to analyze whether differences in ESG mean in the stock portfolios of Swedish SR-investors can be explained by demographic and socioeconomic differences. Furthermore, the thesis aims to identify what demographic group has the highest preference for each sub group of ESG. Completion: Through a unique data set, we perform multivariate regressions, which enables a comparison of ESG means in stock portfolios of different demographic groups. Through research questions, we discuss and compare the results with previous research. Conclusion: The study finds that the Swedish SR-investor with the highest ESG mean in the stock portfolio is most likely an older woman, with low income and living in a larger city. Furthermore, the study finds that middle aged and older women, with low income and living in and outside a larger city, have the highest preference for each sub group of ESG. In addition, the study finds both similarities and differences between these results and previous research.
170

Die Rolle der Serin/Threonin-Phosphatasen bei der Dysregulation des Calcium-Stoffwechsels in der menschlichen Herzerkrankung / The role of serine/threonine phosphatases in cardiac calcium homeostasis in the development of human heart failure

Eiringhaus, Jörg 16 January 2019 (has links)
No description available.

Page generated in 0.0159 seconds