Since the reform and opening up in 1978, China's higher vocational education has flourished, and a large number of high-quality workers and highly skilled talents have been trained for the rapid development of China's economy and society. With the advent of industrial 4.0 eras, China has also opened a new journey to build a socialist modern country in an all-round way, and has also put forward higher requirements for the quality of higher vocational education. Teachers are the first resources of education, and the first priority of the development of education is the development of teachers. In order to improve the quality of higher vocational education, we must improve the quality of teachers in higher vocational education at first. At present, it has become an important issue that the quantity and quality of 'double-qualified' teachers cannot meet the needs of the development of higher vocational education in China. Therefore, it is of great significance to carry out the research on the development of human resources of 'double-qualified' teachers in higher vocational colleges, to explore the system and the effective development strategy of 'double-qualified' teachers in order to enrich the theory of vocational and technical pedagogy and meet the needs of the development of higher vocational education. The 'double-qualified' teachers in higher vocational colleges in this study are refer to the professional teachers who has good professional ethics, knowledge, ability, performance, and whose Professional and technical title in teachers and related profession is intermediate or above. In simple terms, the 'double-qualified' teacher of vocational education is a teacher who has both theoretical teaching and practical teaching capabilities. The development of human resources of 'double-qualified' teachers in higher vocational colleges refers to the activities of cultivating 'double-qualified' teachers, including formulating the policy of cultivating 'double-qualified' teachers, encouraging teachers to obtain the qualification of 'double-qualified' teachers, and carrying out the training planning and training activities of 'double-qualified' teachers. Higher vocational colleges in Guangxi, China are taken as the main research object the research literature approach, survey approach and comparative approach are used in this study. Through the investigation, it is found that there are four main problems in the development of 'double-qualified' teachers in Guangxi higher vocational colleges, that is, the number of 'double-qualified' teachers is insufficient, the quality is not high, the professional distribution is uneven, and the development speed is slow. After an in-depth analysis of the existing problems, it is found that there are 28 main reasons that affect the human resource development performance of the 'double-qualified' teachers in the higher vocational colleges in Guangxi. Based on the theory of human resource development, system theory, and synergetics, 'Double-qualified' Teachers' Development Synergetics is constructed in the paper. A new viewpoint is put forward, that is, the development of 'double-qualified' teachers is a systematic project. This paper reveals that the development of 'double-qualified' teachers needs the cooperation of government, school and enterprise, which provides theoretical guidance for guiding the development of 'double-qualified' teachers. The Evaluation Index System of Double-qualified Teachers' Development in Higher Vocational Colleges is constructed by means of analytic hierarchy process (AHP), which is composed of 19 indexes at 4 levels and provides a scientific and practical tool for judging the development performance of 'double-qualified' teachers in Guangxi higher vocational colleges. In order to learn from the advanced experience in the world, this paper makes an in-depth study on the training of vocational education teachers in Germany, and obtains five enlightenments. First, the 'double-qualified' teachers are the foundation in vocational education. Second, legalization is the institutional guarantee for the development of 'double-qualified' teachers. Third, the close cooperation between the government, colleges, guilds and enterprises is the organizational guarantee for the development of 'double-qualified' teachers. Fourth, duality (universities and enterprises) is a scientific method for the development of 'double-qualified' teachers. The study of vocational education is the guide to the development of vocational education teachers in Germany. On the basis of the above research, this paper puts forward 35 countermeasures and suggestions to improve the development performance of 'double-qualified' teachers in Guangxi higher vocational colleges. The innovation of this study is mainly manifested in two aspects: First, it constructs 'Double-qualified' Teachers' Development Synergetics', a theory of guiding the development of 'double-qualified' teachers. This paper preliminarily expounds five principles of collaborative development of 'double-qualified' teachers. Second, it is the innovation of application tools. A 4-level, 19-index evaluation index system for the development of 'double-qualified' teachers in higher vocational colleges is constructed by using analytic hierarchy process (AHP), which provides a practical tool for correctly guiding the development of 'double-qualified' teachers in higher vocational colleges and scientifically judging the development performance of 'double-qualified' teachers in higher vocational colleges. There is a lot of content in the research on the development of human resources of 'double-qualified' teachers in higher vocational colleges. Although some achievements have been made in this study, there are still many shortcomings, which need to be further studied. For example, the enrichment and perfection of 'Double-qualified' Teachers' Development Synergetics, the application and popularization of the Evaluation Index System of 'Double-qualified' Teachers' Development in Higher Vocational Colleges, and so on. Let us work together to make more contributions to the construction of 'double-qualified' teachers in higher vocational colleges.

Heterojunctions were generated between tungsten trioxide and tetraphenyl porphyrin with reduced graphene oxide or exfoliated graphite support for mineralisation of acid blue 25 dye under visible light radiation. Moreover, degradation of pharmaceuticals was conducted using p-n heterojunctions between WO3 and Co3O4 and a direct Z-scheme heterojunction between BiOI and Co3O4 prepared using in-situ method and solvothermal self-assembly method respectively. The synthesized materials were characterised using Raman, FTIR, SEM/EDS, TEM, XRD, TGA, BET, UV-Vis and PL techniques. UV-Vis, TOC and HPLC-QTOF-MS were used to study the degradation efficiency and pathway. Scavenger trapping experiments were conducted to propose the charge transfer mechanisms. The highest degradation efficiency (99 %) was achieved for the dye and the pharmaceuticals using visible light. The mineralisation ability of the fabricated nanomaterials was pH dependent with acidic conditions favouring the removal of the dye (pH 5) while alkaline conditions favoured the mineralisation of pharmaceuticals (pH 10 – 11). / Civil and Chemical Engineering

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Engaging in M&A is a common corporate strategy and deals are often motivated by synergies, the concept that the value of the combined entities is greater than the sum of their standalone values. However, it is often difficult to capture synergistic value in reality and increasing the probability of a successful acquisition requires a thorough assessment of potential synergistic effects pre-acquisition. In this thesis, we have analyzed the strategic rationale, synergies, and valuation methods used in acquisitions of industrial software companies. Through multiple case studies comprising empirical material from interviews, valuation models and other transaction-related documents, we have studied five bolt-on acquisitions, three of which were completed by subsidiaries of Marrow and the remaining two by an industrial software company under private equity ownership. Main conclusions from the study are: • The foremost strategic rationale and source of synergy is revenue enhancements through acquiring technology and leveraging established sales channels to cross-sell and accelerate market access for the target’s products • A prevalent cost synergy is consolidation and/or renegotiation of contracts with third party software providers whose products are used in industrial software development • Financial synergies are not explicitly estimated nor valued • Valuation is conducted using both the DCF and multiple method with a varying degree of sophistication in the underlying estimations, ranging from a granular bottom-up approach for each line item to a top-down approach based on experience and intuition Lastly, the results indicate that synergies may to a greater extent be a function of the strategic rationale rather than a function of industry. However, acquisitions of industrial software companies seem to be underpinned by the same strategic rationale, namely revenue enhancements through leveraging sales channels and cross-selling. Thus, the corresponding synergies may be comparatively more common in this industry. / Att genomföra förvärv är en vanligt förekommande företagsstrategi och affärer motiveras ofta av synergier, konceptet att värdet på det sammanslagna företaget är större än värdet på summan av de enskilda företagen. Dock är det ofta svårt att realisera värdet av synergierna i praktiken och det krävs därför en grundlig utvärdering av potentiella synergieffekter innan förvärvet för att öka sannolikheten för ett lyckat förvärv. I denna uppsats analyserar vi de strategiska motiven, synergier samt värderingsmetoder som används vid förvärv av företag inom industriell mjukvara. Genom flertal casestudier bestående av empiriskt material från intervjuer, värderingsmodeller och transaktionsrelaterade dokument har vi studerat fem till¨aggsförvärv, tre av vilka genomfördes av dotterbolag till Marrow och de resterande två av ett företag inom industriell mjukvara under ägarskap av private equity. De huvudsakliga slutsatserna från studien är: • Den främsta strategiska rationalen och källa till synergi är intäktsförbättringar genom förvärv av teknologi och utnyttjande av etablerade säljkanaler för att korsförsälja samt accelerera marknadstillgången för det förvärade företagets produkter • En framstående kostnadssynergi är konsolidering och/eller omförhandling av kontrakt med tredjepartsleverantörer vars produkter används för att utveckla industriell mjukvara • Finansiella synergier är varken explicit estimerade eller värderade • Värdering utförs med både DCF och multipelmetod där graden av sofistikering i de underliggande estimaten varierar, från att granulärt estimera varje post till överslagsestimat baserade på erfarenhet och intuition Slutligen, resultaten indikerar att synergier kan i större utsträckning vara en funktion av den strategiska rationalen snarare än en funktion av industri. Emellertid ter det sig att förvärv av företag inom industriell mjukvara motiveras av samma strategiska rational, nämligen intäktsförbättringar genom utnyttjande av säljkanaler och korsföräljning. Därmed kan de korresponderande synergierna vara komparativt mer frekvent förekommande i denna industri.

Магистерская диссертация посвящена исследованию тенденций кобрендинга на рынке банковских услуг. Целью исследования является систематизация и выработка рекомендаций по повышению эффективности кобрендовых проектов Сбербанка. В результате проведенного исследования сделан вывод о том, что наличие кобрендинговых проектов является важной частью маркетинговой стратегии банка и способствует повышению конкурентоспособности и прибыли. / Master thesis investigates the tendencies of co-branded and offered in the market of banking services and analysis. The aim of the study is to systematize and develop recommendations to improve the efficiency of Sberbank's co-branded projects. As a result of the study, it is concluded that the presence of co-branded projects is an important part of the Bank's marketing strategy and contributes to competitiveness and profit.

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No description available.

Companies spend trillions of dollars on mergers and acquisitions (M&A) every year, and tens of thousands of new M&A deals are announced every year. However, despite the huge costs, only 10% to 30% of the M&As announced, get finalized (Christensen et al., 2011).There is extensive research conducted on why M&As fail, and their implications for the companies involved in the transaction. However, these large deals do not only impact the firms directly involved in the deal.  Microsoft, one of the world’s most influential companies, made on the 18th of January 2022 an acquisition announcement regarding its intent to acquire Activation Blizzard, one of the world’s largest game studios. The announcement made headlines all over the world and resulted in protests from competitors of the two companies. One of these competitors, Sony, experienced a 13% drop in stock price due to the acquisition announcement.  This thesis investigates the effect of acquisition announcements on the stock return of competitors to the target company. The study is examining the competitors stock return during the month leading up to the announcement, as well as the stock return during the month following the announcement. The authors have taken inspiration from a previous study “Acquisitions: A curse or blessing for direct competitors? The impact of target ownership structure” conducted by Mataigne et al. (2021).  By reviewing over 700 market reactions to acquisition announcements over a 10-year period, the authors were able to statistically test the differences in mean stock return. The authors were able to conclude that acquisition announcements have a negative impact on the stock return of competitors, and thereby answer the proposed research question: “What is the effect of acquisitions announcements on the stock returns of target company’s competitors in Sweden?”. Competitors to the target firm of an acquisition will experience the most significant change in their stock returns in the time period close to the announcement, after which the reaction will stabilize. The empirical findings of the study contribute to the field of knowledge using Behavioral Finance, the Efficient Market Hypothesis, the Capital Asset Pricing Model, the Stakeholder Theory, the Mitchell Model, and various market valuation methods.  Evidently, theories as part of the Behavioral Finance scope, such as the Efficient Market Hypothesis, provide support to the findings following the acquisition announcement. Theories such as the Stakeholder Theory and the Mitchell Model have helped identify competitors' stakeholder role to show how various events and organizations affect them as stakeholders in the market.  This study, which utilizes over 60.000 datapoints from daily price data for its analysis, takes a deductive approach within the positivist paradigm framework. The data is statistically tested using paired t-tests.

Die jüngsten Fortschritte in der Behandlung haben das Gesamtüberleben von Kindern mit akuter lymphoblastischer Leukämie (ALL) verbessert. Dennoch erleiden 20 % der Kinder mit ALL Rückfälle, was die Notwendigkeit neuer zielgerichteter Behandlungsstrategien erhöht. Ein Empfindlichkeitsprofil wurde in ALL-Zelllinien (n=18) und patientenabgeleiteten Zellen (n=14) mit heterogenem genetischem Hintergrund unter Verwendung einer Wirkstoffbibliothek (n=46 Verbindungen) erstellt. Dies identifizierte neuartige Arzneimittelempfindlichkeitsmuster, wie z.B. für den H3K27me3-Demethylase-Inhibitor GSKJ4, dessen Empfindlichkeit mit der CREBBP-Expression im Kontext der Dexamethason-Resistenz korrelierte. In einem Screening von Wirkstoffkombinationen (n=12 Wirkstoffe) wurde Venetoclax als vielversprechendster Kombinationspartner identifiziert. Die höchsten synergistischen Effekte wurden bei der Kombination von Venetoclax mit dem CK2-Inhibitor Silmitasertib, dem PARP-Inhibitor Olaparib und dem MEK-Inhibitor Selumetinib beobachtet. Die Induktion von Apoptose und ein synergistischer Effekt wurden in zahlreichen BCP-ALL-Zelllinien, PDX und Primärproben validiert, wobei diese Kombination besonders wirksam in den venetoclax-resistentesten Proben war. Silmitasertib sensibilisierte die Zellen für Venetoclax durch die Induktion des MCL1-Proteasom-Abbaus über die Herabregulierung der AKT-Signalübertragung und die Hochregulierung der GSK3B-Aktivität. Ein neuartiges In-vivo-Zebrafisch-Embryomodell validierte die Wirksamkeit von Venetoclax und Silmitasertib sowie die Herabregulierung von MCL1. Insgesamt wurde eine Plattform für das Screening von Einzelwirkstoffen und Wirkstoffkombinationen vorgestellt, die neuartige Arzneimittelempfindlichkeitsmuster sowie vielversprechende synergistische Wirkstoffpartner identifizierte, die im Fall von Silmitasertib und Venetoclax funktionell charakterisiert und deren Wirkung in klinisch nahen Proben sowie in einem In-vivo-Zebrafischmodell validiert wurden. / Recent advances in treatment have improved overall survival for children with acute lymphoblastic leukemia (ALL). However, 20% of children with ALL still relapse, raising the need for the implementation of novel targeted treatment strategies. Drug sensitivity profiling was performed in ALL cell lines (n=18) and patient derived cells (n= 14) with heterogeneous genetic backgrounds using a candidate drug library (n=46 compounds). This identified novel drug sensitivity patterns such as for the H3K27me3 demethylase inhibitor GSKJ4, which sensitivity correlated to CREBBP expression in the context of dexamethasone resistance. In a drug combination screening (n=12 drugs), venetoclax was identified as the most promising combination partner. Highest synergistic effects where seen when combining venetoclax with CK2 inhibitor silmitasertib, PARP inhibitor Olaparib and MEK inhibitor selumetinib. Induction of apoptosis and a synergistic effect was validated across numerous BCP-ALL cell lines, patient derived xenografts (PDX) and primary samples, being particularly effective in the most venetoclax resistant samples. Silmitasertib sensitized cells to venetoclax by the induction of MCL1 proteasome degradation via downregulating AKT signaling and thus upregulating GSK3B activity. A novel in vivo zebrafish embryo model validated the effectivity of venetoclax and silmitasertib and MCL1 downregulation. Overall, a single drug and drug combination screening platform is presented, which identified novel drug sensitivity patterns as well as promising synergistic drug partners that, in the case of silmitasertib and venetoclax, were functionally characterized and its effect validated in clinically near samples as well as in an in vivo zebrafish model.

Smac-Mimetika (SMCs) sind eine Klasse von Tetrapeptid-abgeleiteten Medikamenten, die dem homodimeren, pro-apoptotischen Protein Smac nachempfunden sind. Sie binden und hemmen die Apoptose-Inhibitoren (IAPs), eine Klasse von anti-apoptotischen Proteinen, die von vielen medikamentenresistenten Krebszellen überexprimiert werden. In dieser Arbeit wurden Strategien zur Steigerung und Kontrolle der Aktivität von SMCs durch Konjugation an Oligonukleotide (ON) untersucht. ONs wie Desoxyribonukleinsäure (DNA) oder das peptidbasierte Analogon Peptidnukleinsäure (PNA) bieten einzigartige Erkennungseigenschaften, die zur Detektion und/oder zur Modulation der Expression krebsspezifischer Genprodukte genutzt werden können. Letzteres kann z. B. mit Antisense-Oligonukleotiden (ASOs) erreicht werden, kurzen einzelsträngigen DNA- oder RNA-Molekülen, die die Translation einer komplementären Zielsequenz blockieren. Im ersten Teil der Arbeit wurden Konjugate aus SMCs und ASOs auf Synergie-Effekte getestet. Viele menschliche Krebszelllinien sind gegen SMCs resistent, weil andere anti-apoptotische Proteine wie das zelluläre FLICE-ähnliche Protein (c-FLIP) als Ausfallsicherung wirken. Es konnte gezeigt werden, dass diese Resistenz durch Kupplung eines SMC an ein anti-c-FLIP ASO überwunden werden kann. Im zweiten Teil wurden kurze ON-Sonden verwendet, um ein templiertes Reaktionssystem zur gezielten Aktivierung eines SMCs in Gegenwart von X-linked Apoptose-Inhibitor (XIAP) mRNA zu erzeugen. Es wurden zwei verschiedene Ansätze untersucht: Ein templierter Acyl-Transfer, bei dem hochaffine, bivalente SMCs aus niedrig affinen, monovalenten Vorläufern erzeugt werden und eine Demaskierung der für die Bindungsaffinität von SMCs entscheidenden, N-terminalen Aminogruppe durch templierte Reduktion eines Azids. Für die zweite Strategie wurden zwei verschiedene Reaktionen verglichen, die Staudinger-Reduktion mit Phosphinen und eine katalytische Photoreduktion mit einem Ruthenium-Komplex. / Smac mimetic compounds (SMCs) are a class of tetrapeptide-derived drugs, modelled after the homodimeric, pro-apoptotic protein Smac. They bind and antagonize Inhibitor of Apoptosis Proteins (IAPs), a class of anti-apoptotic proteins overexpressed by many drug-resistant cancer cells. In this work, strategies to enhance and control the activity of SMCs by conjugating them to oligo-nucleotides (ON) were investigated. ONs like deoxyribonucleic acid (DNA) or the peptide-based analog peptide nucleic acid (PNA) offer unique recognition properties that can be used to detect and/or modulate the expression of cancer-specific gene products. The latter can be achieved with antisense oligonucleotides (ASOs), short single-stranded DNA or RNA molecules that block the translation of a complementary sequence of interest. In the first part of this work, conjugates between SMCs and ASOs were tested for synergy. Many human cancer cell lines are resistant to SMCs because other anti-apoptotic proteins like the cellular FLICE-like protein (c-FLIP) act as a failsafe. It could be demonstrated that by joining an SMC with an anti-c-FLIP ASO this resistance can be overcome. In the second part, short ON probes were used to create a templated reaction system to conditionally activate an SMC in the presence of x-linked inhibitor of apoptosis (XIAP) mRNA. Two different approaches were explored: A templated acyl transfer that yields high affinity bivalent SMCs from low affinity, monovalent precursors and unmasking of the N-terminal amino group, which is crucial for the binding affinity of SMCs, by templated reduction of an azide. For the second strategy, two different chemistries were compared, Staudinger reduction with phosphines and a catalytic photoreduction using a ruthenium complex.