"March 2004" / Bibliography: leaves 168-172. / 365 leaves : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (M.D.)--University of Adelaide, Dept. of General Practice, 2004

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.

Introduction: Dementia is an age-associated neurodegenerative disorder characterized by a progressive loss of neuro-cognitive function and the emergence of a wide variety of behavioral symptoms. Alzheimer's disease (AD) is the most common types of dementia. Sleep disturbances in patients with Alzheimer's disease is common and previous studies from North America, Europe and Japan reported light therapy could improve the sleep circadian rhythm ( rest-activity) disturbances in AD. However, there was no previous Chinese study on light exposure and sleep quality nor the circadian rhythm in Chinese Alzheimer's disease patients. Objective : The objective of the present study was to investigate the association of light exposure intensity with the quality of sleep and behavioural symptoms in Chinese Alzheimer’s disease (AD) patients Method: This was a cross-sectional observational study. 203 Chinese elderly patients with Alzheimer's disease were recruited from the Memory Clinic in Queen Mary Hospital, the University of Hong Kong, from July 2014 to December 2014. Socio-demographic data and comorbid diseases information were collected from all subjects. Their sleep qualities, quantities and conditions of light exposure were recorded with a sleep logbook and light meter. Their cognitive function, disturbing behaviour, depressive mood and quality of life scales were assessed by a semi-structured questionnaire. Light exposure intensity measured by Light meter (Model SDL 400). Measure for cognitive function were the Abbreviated Mental Test (AMT), Behavioral symptoms measured by the Neuropsychiatric Inventory (NPI) and mood by Geriatric Depression Scale. (GDS-15) The association of outdoor or indoor light exposure with sleep quality and quantities were analyzed by descriptive, bivariate and multivariate analyses. Main outcome measures: The main outcome measure was the sleep quality and quantities of patient, measured by Pittsburgh Sleep Quality Index. (PSQI) Results: 203 subjects (60 males and 143 females) were recruited. 70.4 % of the studied subjects were females. Male to female ratio is 1:2.38. Mean age of them was 81.6 years. The mean (SD) scores of the recruited were: AMT = 4.5 (2.9); PSQI = 6.9 (3.4); NPI =14.4 (17.2); GDS-15= 4.3 (2.8); QOL-AD (patients) = 30.7 (4.9); QOL-AD (caregivers) = 29.5 (4.7) respectively. In bivariate analysis, the Global PSQI score was significantly associated with the morning and afternoon outdoor light exposure. (r = -0.634 and -0.466, respectively) For the total light exposure and mean light exposure, both of them showed strong significant negative correlation with Global PSQI score. (r = -0.769 and -0.769 respectively). Mean (SD) light exposure per day for morning and afternoon outdoor setting were 2372.9 lux (2564.7) and 1090.8 lux (1894.6) respectively. Mean(SD) light exposure per day was 1196.7 lux (866.1) Gender identity showed significant correlation with Global PSQI score (r = 0.034). Global PSQI score was significantly associated with the NPI total score (r = 0.261, p<0.001), the GDS-15 score (r = 0.336, p<0.001), the QOL-AD for patients (r = -0.257, p<0.001), and the QOL-AD for caregivers. (-0.313, p<0.001) In multivariate analyses, using general linear models, the Global PSQI score was highly independent associated with the total light exposure (p=0.000), and significantly associated with the NPI score and Gender (p = 0.011 and 0.021), after adjusting for potential confounders in bivariate analysis. (i.e. gender, activity of daily living status, hypertension and Chronic obstructive airway disease). Confounding factors were NPI and gender. Conclusion: In the present study, We found the intensity of natural light exposure was related to good sleep quality in older Chinese Alzheimer’s disease patients with age 65 years and above in Hong Kong as well as lesser episode of behavioural symptoms. Hence, daily outdoor light exposure is highly recommended for persons with Alzheimer’s disease. / published_or_final_version / Medicine / Master / Master of Medical Sciences

New mothers often complain of impaired cognitive functioning, and it is well documented that women experience a significant increase in sleep disturbance after the birth of a child. Sleep disturbance has been linked to impaired cognitive performance in several populations, including commercial truck drivers, airline pilots, and medical residents, though this relationship has rarely been studied in postpartum women. In the present study 13 pregnant women and a group of 22 non-pregnant controls completed one week of actigraphy followed by a battery of neuropsychological tests and questionnaires in the last month of pregnancy (Time 1) and again at four weeks postpartum (Time 2). Pregnant women experienced significantly more objective and subjective sleep disturbance than the control group at both time points. They also demonstrated more impairment in objective, but not subjective cognitive functioning. Preliminary analyses indicated increased objective sleep fragmentation from Time 1 to Time 2 predicted decreased objective cognitive performance from Time 1 to Time 2, though small sample size limited the power of these findings. Implications for perinatal women and need for future research were discussed.

Les troubles du sommeil restent peu étudiés chez la personne âgée (PA). Ils sont pourtant fréquents, associés à certaines maladies et peuvent être des marqueurs de pathologies latentes. L'objectif de cette thèse est d'étudier, chez la PA, les liens entre les troubles du sommeil (insomnie et somnolence diurne excessive (SDE)) et la survenue de maladies neuropsychiatriques ou cardiovasculaires à partir d'une cohorte prospective l'étude des 3 cités (3C) (9094 personnes âgées de 65 ans et plus recrutées sur 3 centres en France et suivies tous les 2 ans pendant 12 ans). Quatre études ont été réalisées dans le cadre de cette thèse. La 1ère suggère que les facteurs associés à la nature et au nombre de plaintes d'insomnie chez la PA ne seraient pas significativement différents selon le sexe. Cependant chez les femmes, les facteurs portant sur le style de vie tels que le traitement hormonal substitutif et un indice de masse corporelle élevé pourraient avoir un «effet protecteur». La 2ème montre que l'insomnie et la SDE seraient des facteurs de risque indépendants de dépression chez la PA même après l'exclusion des participants ayant eu une histoire passée de dépression. La 3ème met en évidence que le nombre de plaintes d'insomnie et les difficultés à maintenir le sommeil seraient négativement associés au déclin cognitif et la SDE apparaîtrait comme un facteur de risque de déclin cognitif chez la PA. Enfin, la 4ème indique que les plaintes d'insomnie seraient une conséquence des maladies cardiovasculaires, alors que la SDE serait un déterminant de maladie cardiovasculaire indépendant d'une histoire passée de maladie cardiovasculaire.Cette thèse apporte donc de nouvelles connaissances sur les déterminants de l'insomnie ainsi que sur les conséquences des troubles du sommeil sur la survenue de maladies neuropsychiatriques et cardiovasculaires. Elle suggère de nouvelles approches dans la prise en charge des troubles du sommeil et de leurs conséquences chez la PA. / Sleep complaints remain poorly studied in the elderly. However, they are common and associated with a number of specific diseases. They may also be markers of latent disease. The objective of this thesis is to study the relationship between sleep disorders (insomnia and excessive daytime sleepiness (EDS)) and the occurrence of neuropsychiatric and cardiovascular disorders in the elderly from a prospective cohort study: The Three Cities (3C) (9094 subjects aged 65 years and over recruited from three centers in France and followed every 2 years, during 12 years). Four studies were performed drawing from the 3C cohort. The first study suggests that factors associated with the type and the number of insomnia complaints in the elderly do not differ significantly according to gender. However, among women, factors related to lifestyle such as hormone replacement therapy and a higher body mass index may have a "protective effect". The second study shows that insomnia and EDS are independent risk factors for depression even after excluding participants who had a past history of depression. The third study reports that the number of insomnia complaints and difficulty in maintaining sleep appear to be negatively associated with cognitive decline whereas EDS may be a risk factor for cognitive decline in the elderly. Finally, the fourth study indicates that insomnia complaints are more likely a consequence of cardiovascular disease, while EDS seems to be a determinant of future cardiovascular disease independently of a past-history of cardiovascular disease. This thesis provides new knowledge on the determinants of insomnia and on the consequences of sleep complaints for the onset of neuropsychiatric disorders and cardiovascular disease. It suggests also new approaches for the prevention of these sleep complaints and their consequences in the elderly.

Comportamentos alimentares noturnos inadequados (CANI) são caracterizados por comportamento alimentar desorganizado exclusivamente durante o período da noite. Seus portadores apresentam comportamento alimentar diurno normal sem evidência de sintomas típicos de bulimia nervosa, transtorno da compulsão alimentar periódica ou hiperfagia psicogênica. É possível diferenciar duas síndromes distintas: a síndrome alimentar noturna (SAN) e o distúrbio alimentar relacionado ao sono (DARS). Este estudo avaliou voluntários portadores de CANI clinicamente e polissonograficamente, objetivando a identificação da presença de co-morbidades psiquiátricas, de comportamento alimentar e o padrão de sono. Para tanto foram convocados através da mídia indivíduos portadores de comportamento alimentar noturno inadequado caracterizado por episódios de ingestão alimentar hipercalórica noturna ocorrendo após o jantar ou refeição equivalente e antes de iniciado o sono e/ou presença de episódios bem definidos de ingestão alimentar após o início do sono, contando com um ou mais despertares noturnos com objetivo de comer ou beber; com idades entre 18 e 50 anos e com disponibilidade para participar dos protocolos da pesquisa. Foram utilizados como instrumentos de investigação uma anamnese clínica inicial, a Entrevista Clínica Estruturada para Transtornos do Eixo I do DSM-IV - SCID-I/P, o Basic Nordic Sleep Questionnaire (BNSQ), os diários de registros alimentar e de sono, além da realização de polissonografia. Responderam espontaneamente à convocação 138 indivíduos que inicialmente foram entrevistados por telefone. Destes, identificou-se que 79 indivíduos (57%) possuíam sintomas sugestivos de comportamento alimentar noturno inadequado, sem co-morbidade clínica associada que justificasse os sintomas. Compareceram efetivamente para participação da pesquisa 38 indivíduos. Destes 78,95% eram do sexo feminino, com idades médias de 42,21 ± 8,89anos no momento as avaliação, com IMC médio de 32,21 ± 7,58 Kg/m2 e idade média de início dos sintomas de 30,47 ± 8,82 anos. Aproximadamente 78,8% dos pacientes apresentavam sobrepeso ou obesidade. Avaliação de padrão alimentar revelou que 76,32% dos participantes apresentavam-se nada ou pouco faminto ao acordar pela manhã e 76,32% deles fazem a primeira refeição após as 09h. Em torno de 42,1% dos entrevistados apresentavam bastante ou extremo desejo para fazer lanches no período entre o jantar e a hora de dormir. O consumo alimentar diário superior a 50% após o jantar foi referido por 31,77% dos participantes avaliados, sendo que 60,53% afirmam consumir entre 25 e 50% do total alimentar diário após o jantar. Em torno de 57,9% afirmaram apresentar bastante ou extremo desejo ou urgência para realizar lanches quando acorda no meio da noite e 71% referiram que apresentam pelo menos um tanto de necessidade de comer para conseguir voltar a dormir. Referem estar conscientes durante o evento 78,9% dos voluntários, sendo que 44,7% apresentam nenhum ou pouco controle sobre este comportamento. Na avaliação do padrão de sono, 84% referiram acordar no meio da noite de 3 a 7 dias por semana, apresentando pelo menos 2 despertares por noite 68,4% deles. Queixaram-se de sono de má qualidade 47,4% dos voluntários e 26,3% apresentam necessidade de cochilos diurnos em 3 a 7 dias por semana. A avaliação da polissonografia revelou um aumento do índice de micro-despertares em 81,8% dos participantes avaliados, com redução da eficiência do sono abaixo da faixa considerada normal em 45,45% deles. O tempo total de vigília após iniciado o sono esteve aumentado em cerca de 80% dos voluntários com tempo médio de 60,43 ± 39,87 minutos. Pelo menos um diagnóstico psiquiátrico foi realizado em 71% dos voluntários. Transtornos do humor foram os diagnósticos mais prevalentes (57,89%), seguido de transtorno de ansiedade (13,16%). Em torno de 34,21% dos participantes já fizeram uso de benzodiazepínicos, entre eles lorazepam, alprazolam, clonazepam, midazolam, diazepam e bromazepam, objetivando melhora da qualidade de sono. Foi possível identificar sintomas típicos de SAN na amostra de voluntários avaliados apresentando hiperfagia noturna, anorexia matinal e episódio recorrentes de despertares notunos para ingestão de alimentos. Além de apresentarem pior qualidade de sono, com aumento dos despertares noturnos e conseqüente redução da eficiência do sono. Não foi identificado nenhum indivíduo com sintomas sugestivos de DARS. Com o presente, apesar de a amostra ser limitada em números de participantes, foi possível identificar que portadores de SAN apresentam piora de qualidade de sono, redução da eficiência do sono, aumento do índice de micro-despertares, aumento da prevalência de co-morbidades psiquiátricas e aumento da prevalência de sobrepeso e obesidade / Inadequate nocturnal eating behaviors (INEB) are characterized by disorganized feeding patterns occurring exclusively at night. These patients present a normal diurnal eating pattern without evidence of typical symptoms of bulimia nervosa, binge eating disorder or psychogenic overeating. It is possible to differentiate two distinct syndromes: night eating syndrome (NES) and sleep related eating disorders (SRED). This study evaluated volunteers with clinical and polysomnographic INEB, identifying the presence of psychiatric comorbidities, the behavior of food intake and sleep patterns. It was called individuals with night eating episodes characterized by inadequate intake of high calorie food at night after dinner and before the beginning of sleep and/or the presence of episodes of food intake after sleep, with at least one awakening in order to eat or drink, aged between 18 and 50 years and with availability to participate in protocols. Were used as research tools and an initial clinical history, the Structured Clinical Interview for Axis I Disorders DSM-IV - SCID-I / P, the Basic Nordic Sleep Questionnaire (BNSQ), the daily records of food and sleep, addition to polysomnography. Spontaneously responded to the call 138 individuals and then they were initially interviewed by telephone. Of these, we identified that 79 individuals (57%) had symptoms suggestive of inadequate nocturnal eating behavior. Third-eight individuals were effectively part of the research. Of these, 78.95% was female, mean age of 42.21 years at the time of evaluation, with an average BMI of 32.21 kg/m2 and mean age at onset of symptoms was 30.47 years. Approximately 78.8% of patients were overweight or obese. Evaluation of dietary habits revealed that 76.32% of participants had become nothing or a little hungry when they wake up in the morning and 76.32% of them make the first meal after 09h. Around 42.1% were very or extreme desire to make snacks at the period between dinner and bedtime. The daily food intake more than 50% after the dinner was reported by 31.77% of participants assessed, and 60.53% say that consume between 25 and 50% of total daily food intake after dinner. Around 57.9% said they have extreme urgency or desire to make snacks when wake up in the middle of the night and 71% said they have at least \"somewhat\" need to eat to get back to sleep. A report being conscious during the event 78.9% of the volunteers, and 44.7% says have no or little control over this behavior. In the assessment of sleep patterns, 84% reported waking up at night 3 to 7 days a week, with at least two awakenings per night was reported by 68.4% of them. The complaint of poor sleep quality was reported by 47.4% of the volunteers and 26.3% of them have need for daytime naps in 3 to 7 days a week. The evaluation of polysomnography showed an increase in the rate of micro-arousals in 81.8% of participants evaluated with reduced sleep efficiency below the range considered normal in 45.45% of them. The total time awake after falling asleep was increased by about 81% of volunteers with a mean of 60.43 minutes. At least one psychiatric diagnosis was performed in 71% of the volunteers. Mood disorders were the most prevalent diagnosis (57.89%), followed by anxiety disorder (13.16%). Around 34.21% of the participants have made use of benzodiazepines, including lorazepam, alprazolam, clonazepam, midazolam, diazepam and bromazepam, aiming at improving the quality of sleep. It was possible to identify symptoms of SAN in the sample of subjects studied as nocturnal hyperphagia, morning anorexia and recurrent episodes of awakenings for snacks. Associated with poor sleep quality with increased awakenings and consequent reduction of sleep efficiency. It was not find any individual with symptoms suggestive of SRED. With this, even though the sample is limited in numbers of participants, that patients with SAN have a lower quality of sleep, increased prevalence of psychiatric comorbidities and increased prevalence of obesity

Objetivo - Estimar a incidência dos distúrbios do sono e identificar seus fatores de risco em mulheres livres de problemas com o sono na primeira fase do Projeto de Saúde de Pindamonhangaba (PROSAPIN) realizado em 2007. Metodologia - Consiste da segunda etapa do PROSAPIN, realizada em 21 Unidades da Estratégia de Saúde da Família com 1.200 mulheres de 35 a 72 anos divididas entre participantes novas (sorteadas em 2014) e antigas (participantes do PROSAPIN 2007). Foram pesquisados por meio de questionários os seguintes distúrbios do sono: 1) sono ruim, pelo Índice de Qualidade do Sono de Pittsburgh; 2) insônia, também pelo questionário de Pittsburgh; 3) sonolência diurna excessiva, pela Escala de Sonolência de Epworth e 4) apnéia obstrutiva do sono, pelo Questionário de Berlin. Como variáveis independentes foram investigadas características sócio demográficas; história ginecológica; presença de morbidades; sintomas emocionais, climatéricos e musculoesqueléticos; hábitos de vida; uso de medicamentos; medidas antropométricas e exames de sangue. As análises, realizadas no Programa Stata versão 11.0, consistiram em: a) estimativa da prevalência de distúrbios do sono em geral e separada por tipos em 2014; b) comparação das prevalências entre os estudos de 2007 e 2014; c) identificação dos fatores associados a prevalência de distúrbios do sono em 2014; e d) estimativa da incidência dos distúrbios do sono em 2014 e seus fatores de risco. Resultados- A incidência de distúrbios do sono em sete anos foi de 75,0 por cento e os fatores de risco foram o triglicerídeo 150 mg/dl e a circunferência abdominal 100,5 cm; como proteção, o HDL 50 mg/dl e a escolaridade 1°colegial. As prevalências em 2007 e 2014 foram respectivamente: distúrbios do sono em geral 63,4 por cento e 82,7 por cento ; sono ruim 45,1 por cento e 54,9 por cento ; insônia 13,3 por cento e 19,0 por cento ; sonolência diurna excessiva 23,1 por cento e 24,1 por cento e apnéia obstrutiva do sono 25,1 por cento e 60,5 por cento . Os fatores associados a prevalência de distúrbios do sono em 2014 foram como risco a ansiedade intensa, o estresse relatado, o uso de antidepressivos e a glicose > 100mg/dl, como fatores de proteção, ser aposentada e considerada fisicamente muito ativa. Conclusão- A incidência dos distúrbios do sono em sete anos foi alta e seus fatores de risco foram metabólicos. A comparação das prevalências em dois pontos, 2007 e 2014, demonstrou aumento expressivo nos distúrbios do sono. / Objective - Estimate the incidence of sleep disorders and identify theirs risk factors in women without trouble sleeping this was the first step Pindamonhangaba Health Project (PROSAPIN) conducted in 2007. Methodology It was consist of in the second stage of PROSAPIN project realized on 21 units of the Family Health Strategy 1,200 women between 35 to 72 age was divided with brand new volunteers (chosen in 2014) and old (volunteers PROSAPIN 2007). They were surveyed by questionnaire the following sleep disorders:1) poor sleep by the Pittsburgh Sleep Quality Index; 2) insomnia, by the questionnaire Pittsburgh;3) excessive daytime sleepiness, the Epworth Sleepiness Scale and 4) obstructive sleep apnea, by Berlin Questionnaire. As independent socio demographic characteristics were investigated; gynecological history; presence of comorbidities; emotional symptoms, climatic and musculoskeletal; lifestyle; use of medications; anthropometric measurements and blood tests. These analysis, were performed for Stata version 11.0, were a)estimate the prevalence of sleep disorders separate for type during the year of 2014b) compare the prevalence studies between 2007 and 2014 c) identification of factors associated with prevalence of sleep disorders in 2014; d) estimate the incidence of sleep disorders during the year of 2014 and their risks factors. Results- The incidence of sleep disorders in seven years was 75.0 per cent and the risk factors were the triglycerides 150 mg / dl and waist circumference 100.5 cm; as protection, HDL 50 mg / dl and schooling 1 high school. The prevalence rates in 2007 and 2014 were as follows: sleep disorders in general 63.4 per cent and 82.7 per cent ; poor sleep 45.1 per cent and 54.9 per cent ; insomnia 13.3 per cent and 19.0 per cent ; EDS 23.1 per cent and 24.1 per cent and obstructive sleep apnea 25.1 per cent and 60.5 per cent . Factors associated with the prevalence of sleep disorders in 2014 were a risk to intense anxiety, stress reported, the use of antidepressants and glucose> 100 mg / dl, as protective factors be considered retired and physically very active. Conclusion - The incidence of sleep disorders in seven years was high and their risk factors were metabolic. Comparison of the prevalence of two points, 2007 and 2014 Showed a significant Increase in sleep disorders.

Objetivo: Determinar a qualidade de sono de adultos jovens com fissura labiopalatina operada, aferida por meio de três modalidades de questionários validados na literatura, e sua correlação com as variáveis: sexo, índice de massa corpórea (IMC), circunferência abdominal (CA), circunferência cervical (CC), tipo de oclusão (classificação de Angle), cirurgia ortognática (CO), cirurgia nasal (CN), retalho faríngeo (RF) e tipo de fissura (TF). Método: Foram avaliados, prospectivamente, 90 pacientes, com fissura de palato±lábio reparada, com idade média de 24±3 anos (20 a 29), sendo 49 do sexo masculino e 41 do sexo feminino. Dados como raça, peso e altura (IMC), tipo de fissura e cirurgias realizadas (cirurgia nasal, ortognática e retalho faríngeo) foram coletados dos prontuários. Todos pacientes realizaram exame físico, com medidas de CA, CC e classificação de Angle. A qualidade do sono foi investigada pelos questionários: Índice de Qualidade de Sono de Pittsburgh (IQSP), Escala de Sonolência de Epworth (ESE) e Questionário de Berlin (QB). A associação entre as variáveis foi feita por meio do teste do qui-quadrado, sendo aceitos como significantes valores de p<0,05. Local de execução: Laboratório de Fisiologia e Setor de Prótese do HRAC/USP. Resultados: Com a aplicação dos questionários IQSP, ESE e QB observou-se que 62% dos pacientes estudados apresentaram qualidade do sono ruim, 26% apresentaram sonolência diurna excessiva e 33% apresentavam alto risco para síndrome da apneia obstrutiva do sono (SAOS). Observou-se correlação positiva entre alto risco para SAOS, avaliado pelo QB, e as variáveis IMC e RF. Para as demais, não se demonstrou correlação estatisticamente significante. Conclusão: Com base nos resultados obtidos, conclui-se que uma parcela importante dos indivíduos com fissura labiopalatina operada apresentam qualidade do sono ruim, sonolência diurna excessiva e alto risco para SAOS. Os questionários se mostraram instrumentos de fácil aplicação e permitiram obter um panorama geral da qualidade de sono na população estudada, a ser investigada em maior profundidade com o uso da polissonografia, o método padrão-ouro para o diagnóstico das desordens respiratórias do sono / Objectives: To investigate sleep quality in young adults with repaired cleft lip and palate, measured by three different types of validated questionnaires, and its correlation with gender, body mass index (BMI), waist circumference (WC), neck circumference (NC), type of occlusion (Angle classification), orthognathic surgery (OS), pharyngeal flap (PF), nasal surgery (NS) and cleft type (CT). Methods: Ninety patients were analyzed, aged 20-29 years, 49 male and 41 female. The assessment of sleep quality was performed by applying three questionnaires: Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and Berlin Questionnaire (BQ). Results were correlated with gender, BMI, WC, NC, previous OS, PF, NS, CT and type of occlusion (Angle classification). The association between variables was performed using the chi-square test and p<0.05 was considered significant. Setting: Laboratory of Physiology and Clinics of Oral Rehabilitation, HRAC/USP. Results: PSQI, ESS and BQ have shown that 62% of the patients analyzed exhibited poor sleep quality, 26% had excessive daytime sleepiness and 33% had high risk for obstructive sleep apnea (OAS). Statistical analysis showed a positive correlation between high risk for OAS and BMI and PF was observed. The other variables analyzed did not correlate with the results obtained in the questionnaires. Conclusion: Based on these results, it is possible to conclude that a significant number of young adults with repaired cleft palate presented poor sleep quality, excessive daytime sleepiness and high risk for OSA. Questionnaires are tools for easy application and allowed to get an overall view of the sleep quality of the cleft population, to be further investigated by using polysomnography, the gold-standard method for the diagnosis of sleep respiratory disorders

No description available.

Objetivo - Estimar a incidência dos distúrbios do sono e identificar seus fatores de risco em mulheres livres de problemas com o sono na primeira fase do Projeto de Saúde de Pindamonhangaba (PROSAPIN) realizado em 2007. Metodologia - Consiste da segunda etapa do PROSAPIN, realizada em 21 Unidades da Estratégia de Saúde da Família com 1.200 mulheres de 35 a 72 anos divididas entre participantes novas (sorteadas em 2014) e antigas (participantes do PROSAPIN 2007). Foram pesquisados por meio de questionários os seguintes distúrbios do sono: 1) sono ruim, pelo Índice de Qualidade do Sono de Pittsburgh; 2) insônia, também pelo questionário de Pittsburgh; 3) sonolência diurna excessiva, pela Escala de Sonolência de Epworth e 4) apnéia obstrutiva do sono, pelo Questionário de Berlin. Como variáveis independentes foram investigadas características sócio demográficas; história ginecológica; presença de morbidades; sintomas emocionais, climatéricos e musculoesqueléticos; hábitos de vida; uso de medicamentos; medidas antropométricas e exames de sangue. As análises, realizadas no Programa Stata versão 11.0, consistiram em: a) estimativa da prevalência de distúrbios do sono em geral e separada por tipos em 2014; b) comparação das prevalências entre os estudos de 2007 e 2014; c) identificação dos fatores associados a prevalência de distúrbios do sono em 2014; e d) estimativa da incidência dos distúrbios do sono em 2014 e seus fatores de risco. Resultados- A incidência de distúrbios do sono em sete anos foi de 75,0 por cento e os fatores de risco foram o triglicerídeo 150 mg/dl e a circunferência abdominal 100,5 cm; como proteção, o HDL 50 mg/dl e a escolaridade 1°colegial. As prevalências em 2007 e 2014 foram respectivamente: distúrbios do sono em geral 63,4 por cento e 82,7 por cento ; sono ruim 45,1 por cento e 54,9 por cento ; insônia 13,3 por cento e 19,0 por cento ; sonolência diurna excessiva 23,1 por cento e 24,1 por cento e apnéia obstrutiva do sono 25,1 por cento e 60,5 por cento . Os fatores associados a prevalência de distúrbios do sono em 2014 foram como risco a ansiedade intensa, o estresse relatado, o uso de antidepressivos e a glicose > 100mg/dl, como fatores de proteção, ser aposentada e considerada fisicamente muito ativa. Conclusão- A incidência dos distúrbios do sono em sete anos foi alta e seus fatores de risco foram metabólicos. A comparação das prevalências em dois pontos, 2007 e 2014, demonstrou aumento expressivo nos distúrbios do sono. / Objective - Estimate the incidence of sleep disorders and identify theirs risk factors in women without trouble sleeping this was the first step Pindamonhangaba Health Project (PROSAPIN) conducted in 2007. Methodology It was consist of in the second stage of PROSAPIN project realized on 21 units of the Family Health Strategy 1,200 women between 35 to 72 age was divided with brand new volunteers (chosen in 2014) and old (volunteers PROSAPIN 2007). They were surveyed by questionnaire the following sleep disorders:1) poor sleep by the Pittsburgh Sleep Quality Index; 2) insomnia, by the questionnaire Pittsburgh;3) excessive daytime sleepiness, the Epworth Sleepiness Scale and 4) obstructive sleep apnea, by Berlin Questionnaire. As independent socio demographic characteristics were investigated; gynecological history; presence of comorbidities; emotional symptoms, climatic and musculoskeletal; lifestyle; use of medications; anthropometric measurements and blood tests. These analysis, were performed for Stata version 11.0, were a)estimate the prevalence of sleep disorders separate for type during the year of 2014b) compare the prevalence studies between 2007 and 2014 c) identification of factors associated with prevalence of sleep disorders in 2014; d) estimate the incidence of sleep disorders during the year of 2014 and their risks factors. Results- The incidence of sleep disorders in seven years was 75.0 per cent and the risk factors were the triglycerides 150 mg / dl and waist circumference 100.5 cm; as protection, HDL 50 mg / dl and schooling 1 high school. The prevalence rates in 2007 and 2014 were as follows: sleep disorders in general 63.4 per cent and 82.7 per cent ; poor sleep 45.1 per cent and 54.9 per cent ; insomnia 13.3 per cent and 19.0 per cent ; EDS 23.1 per cent and 24.1 per cent and obstructive sleep apnea 25.1 per cent and 60.5 per cent . Factors associated with the prevalence of sleep disorders in 2014 were a risk to intense anxiety, stress reported, the use of antidepressants and glucose> 100 mg / dl, as protective factors be considered retired and physically very active. Conclusion - The incidence of sleep disorders in seven years was high and their risk factors were metabolic. Comparison of the prevalence of two points, 2007 and 2014 Showed a significant Increase in sleep disorders.