Progression and pattern of changes in different biomarkers of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) like [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) have been carefully investigated over the past decades. However, there have been substantially less studies investigating the potential of combining these imaging modalities to make use of multimodal information to further improve understanding, detection and differentiation of various dementia syndromes. Further the role of preprocessing has been rarely addressed in previous research although different preprocessing algorithms have been shown to substantially affect diagnostic accuracy of dementia. In the present work common preprocessing procedures used to scale FDG-PET data were compared to each other. Further, FDG-PET and MRI information were jointly analyzed using univariate and multivariate techniques. The results suggest a highly differential effect of different scaling procedures of FDG-PET data onto detection and differentiation of various dementia syndromes. Additionally, it has been shown that combining multimodal information does further improve automatic detection and differentiation of AD and FTLD.

Throughout the world, there is a great demand to map out the increasing environmental changes and life habitats on Earth. The vast majority of Earth Observations today, are collected using satellites. The Global Watch Center (GWC) initiative was started with the purpose of producing a global situational awareness of the premises for all life on Earth. By collecting, studying and analyzing vast amounts of data in an automatic, scalable and transparent way, the GWC aims are to work towards reaching the United Nations (UN) Sustainable Development Goals (SDG). The GWC vision is to make use of qualified accessible data together with leading organizations in order to lay the foundation of the important decisions that have the biggest potential to make an actual difference for the common awaited future. As a show-case for the initiative, the UN strategic department has recommended a specific use-case, involving mapping large accumulation of waste in areas greatly affected, which they believe will profit the initiative very much. This Master Thesis aim is, in an automatic and scalable way, to detect and classify dumpsites in Kampala, the capital of Uganda, by using available satellite imagery. The hopes are that showing technical feasibility and presenting interesting remarks will aid in spurring further interest in coming closer to a realization of the initiative. The technical approach is to use a lightweight version of Automatic Target Recognition. This is conventionally used in military applications but is here used, to detect and classify features of large accumulations of solid-waste by using techniques from the field of Image Analysis and Data Mining. Choice of data source, this study's area of interest as well as choice of methodology for Feature Extraction and choice of the Machine Learning algorithm Support Vector Machine will all be described and implemented. With a classification precision of 95 percent will technical results be presented, with the ambition to promote further work and contribute to the GWC initiative with valuable information for later realization.

Aujourd’hui, les recherches portant sur le geste manquent de modèles génériques. Les spécialistes du geste doivent osciller entre une formalisation excessivement conceptuelle et une description purement visuelle du mouvement. Nous reprenons les concepts développés par le chorégraphe Rudolf Laban pour l’analyse de la danse classique contemporaine, et proposons leur extension afin d’élaborer un modèle générique du geste basé sur ses éléments expressifs. Nous présentons également deux corpus de gestes 3D que nous avons constitués. Le premier, ORCHESTRE-3D, se compose de gestes pré-segmentés de chefs d’orchestre enregistrés en répétition. Son annotation à l’aide d’émotions musicales est destinée à l’étude du contenu émotionnel de la direction musicale. Le deuxième corpus, HTI 2014-2015, propose des séquences d’actions variées de la vie quotidienne. Dans une première approche de reconnaissance dite « globale », nous définissons un descripteur qui se rapporte à l’entièreté du geste. Ce type de caractérisation nous permet de discriminer diverses actions, ainsi que de reconnaître les différentes émotions musicales que portent les gestes des chefs d’orchestre de notre base ORCHESTRE-3D. Dans une seconde approche dite « dynamique », nous définissons un descripteur de trame gestuelle (e.g. défini pour tout instant du geste). Les descripteurs de trame sont utilisés des poses-clés du mouvement, de sorte à en obtenir à tout instant une représentation simplifiée et utilisable pour reconnaître des actions à la volée. Nous testons notre approche sur plusieurs bases de geste, dont notre propre corpus HTI 2014-2015 / Nowadays, researches dealing with gesture analysis suffer from a lack of unified mathematical models. On the one hand, gesture formalizations by human sciences remain purely theoretical and are not inclined to any quantification. On the other hand, the commonly used motion descriptors are generally purely intuitive, and limited to the visual aspects of the gesture. In the present work, we retain Laban Movement Analysis (LMA – originally designed for the study of dance movements) as a framework for building our own gesture descriptors, based on expressivity. Two datasets are introduced: the first one is called ORCHESTRE-3D, and is composed of pre-segmented orchestra conductors’ gestures, which have been annotated with the help of lexicon of musical emotions. The second one, HTI 2014-2015, comprises sequences of multiple daily actions. In a first experiment, we define a global feature vector based upon the expressive indices of our model and dedicated to the characterization of the whole gesture. This descriptor is used for action recognition purpose and to discriminate the different emotions of our orchestra conductors’ dataset. In a second approach, the different elements of our expressive model are used as a frame descriptor (e.g., describing the gesture at a given time). The feature space provided by such local characteristics is used to extract key poses of the motion. With the help of such poses, we obtain a per-frame sub-representation of body motions which is available for real-time action recognition purpose

Indiana University-Purdue University Indianapolis (IUPUI) / Intrinsically disordered proteins (IDPs) are flexible proteins without defined 3D structures. Studies show that IDPs are abundant in nature and actively involved in numerous biological processes. Two crucial subjects in the study of IDPs lie in analyzing IDPs’ functions and identifying them. We thus carried out three projects to better understand IDPs. In the 1st project, we propose a method that separates IDPs into different function groups. We used the approach of CH-CDF plot, which is based the combined use of two predictors and subclassifies proteins into 4 groups: structured, mixed, disordered, and rare. Studies show different structural biases for each group. The mixed class has more order-promoting residues and more ordered regions than the disordered class. In addition, the disordered class is highly active in mitosis-related processes among others. Meanwhile, the mixed class is highly associated with signaling pathways, where having both ordered and disordered regions could possibly be important. The 2nd project is about identifying if an unknown protein is entirely disordered. One of the earliest predictors for this purpose, the charge-hydropathy plot (C-H plot), exploited the charge and hydropathy features of the protein. Not only is this algorithm simple yet powerful, its input parameters, charge and hydropathy, are informative and readily interpretable. We found that using different hydropathy scales significantly affects the prediction accuracy. Therefore, we sought to identify a new hydropathy scale that optimizes the prediction. This new scale achieves an accuracy of 91%, a significant improvement over the original 79%. In our 3rd project, we developed a per-residue C-H IDP predictor, in which three hydropathy scales are optimized individually. This is to account for the amino acid composition differences in three regions of a protein sequence (N, C terminus and internal). We then combined them into a single per-residue predictor that achieves an accuracy of 74% for per-residue predictions for proteins containing long IDP regions.

Eftersom samhället blir allt mer datadrivet revolutionerar användningen av AI och maskininlärning sättet företag fungerar och utvecklas på. Denna studie utforskar användningen av AI, Big Data och Natural Language Processing (NLP) för att förbättra affärsverksamhet och intelligens i företag. Huvudsyftet med denna avhandling är att undersöka om den nuvarande klassificeringsprocessen hos värdorganisationen kan upprätthållas med minskade driftskostnader, särskilt lägre moln-GPU-kostnader. Detta har potential att förbättra klassificeringsmetoden, förbättra produkten som företaget erbjuder sina kunder på grund av ökad klassificeringsnoggrannhet och stärka deras värdeerbjudande. Vidare utvärderas tre tillvägagångssätt mot varandra och implementationerna visar utvecklingen inom området. Modellerna som jämförs i denna studie inkluderar traditionella maskininlärningsmetoder som Support Vector Machine (SVM) och Logistisk Regression, tillsammans med state-of-the-art transformermodeller som BERT, både Pre-Trained och Fine-Tuned. Artikeln visar att det finns en avvägning mellan prestanda och kostnad vilket illustrerar problemet som många företag, som Valu8, står inför när de utvärderar vilket tillvägagångssätt de ska implementera. Denna avvägning diskuteras och analyseras sedan mer detaljerat för att utforska möjliga kompromisser från varje perspektiv i ett försök att hitta en balanserad lösning som kombinerar prestandaeffektivitet och kostnadseffektivitet. / As society is becoming more data-driven, Artificial Intelligence (AI) and Machine Learning are revolutionizing how companies operate and evolve. This study explores the use of AI, Big Data, and Natural Language Processing (NLP) in improving business operations and intelligence in enterprises. The primary objective of this thesis is to examine if the current classification process at the host company can be maintained with reduced operating costs, specifically lower cloud GPU costs. This can improve the classification method, enhance the product the company offers its customers due to increased classification accuracy, and strengthen its value proposition. Furthermore, three approaches are evaluated against each other, and the implementations showcase the evolution within the field. The models compared in this study include traditional machine learning methods such as Support Vector Machine (SVM) and Logistic Regression, alongside state-of-the-art transformer models like BERT, both Pre-Trained and Fine-Tuned. The paper shows a trade-off between performance and cost, showcasing the problem many companies like Valu8 stand before when evaluating which approach to implement. This trade-off is discussed and analyzed in further detail to explore possible compromises from each perspective to strike a balanced solution that combines performance efficiency and cost-effectiveness.

Indiana University-Purdue University Indianapolis (IUPUI) / This research performs a comparative study of techniques for combining spatial data and multivariate statistical methods for characterizing water quality conditions in a river basin. The study has been performed on the White River basin in central Indiana, and uses sixteen physical and chemical water quality parameters collected from 44 different monitoring sites, along with various spatial data related to land use – land cover, soil characteristics, terrain characteristics, eco-regions, etc. Various parameters related to the spatial data were analyzed using ArcHydro tools and were included in the multivariate analysis methods for the purpose of creating classification equations that relate spatial and spatio-temporal attributes of the watershed to water quality data at monitoring stations. The study compares the use of various statistical estimates (mean, geometric mean, trimmed mean, and median) of monitored water quality variables to represent annual and seasonal water quality conditions. The relationship between these estimates and the spatial data is then modeled via linear and non-linear multivariate methods. The linear statistical multivariate method uses a combination of principal component analysis, cluster analysis, and discriminant analysis, whereas the non-linear multivariate method uses a combination of Kohonen Self-Organizing Maps, Cluster Analysis, and Support Vector Machines. The final models were tested with recent and independent data collected from stations in the Eagle Creek watershed, within the White River basin. In 6 out of 20 models the Support Vector Machine more accurately classified the Eagle Creek stations, and in 2 out of 20 models the Linear Discriminant Analysis model achieved better results. Neither the linear or non-linear models had an apparent advantage for the remaining 12 models. This research provides an insight into the variability and uncertainty in the interpretation of the various statistical estimates and statistical models, when water quality monitoring data is combined with spatial data for characterizing general spatial and spatio-temporal trends.

In this paper an analysis is conducted regarding whether a higher classification accuracy of facial expressions are possible. The approach used is that the seven basic emotional states are combined into a binary classification problem. Five different machine learning algorithms are implemented: Support vector machines, Extreme learning Machine and three different Convolutional Neural Networks (CNN). The utilized CNN:S were one conventional, one based on VGG16 and transfer learning and one based on residual theory known as RESNET50. The experiment was conducted on two datasets, one small containing no contamination called JAFFE and one big containing contamination called FER2013. The highest accuracy was achieved with the CNN:s where RESNET50 had the highest classification accuracy. When comparing the classification accuracy with the state of the art accuracy an improvement of around 0.09 was achieved on the FER2013 dataset. This dataset does however include some ambiguities regarding what facial expression is shown. It would henceforth be of interest to conduct an experiment where humans classify the facial expressions in the dataset in order to achieve a benchmark.

Recently, Attention Deficit Hyperactive Disorder (ADHD) is getting a lot of attention mainly for two reasons. First, it is one of the most commonly found childhood behavioral disorders. Around 5-10% of the children all over the world are diagnosed with ADHD. Second, the root cause of the problem is still unknown and therefore no biological measure exists to diagnose ADHD. Instead, doctors need to diagnose it based on the clinical symptoms, such as inattention, impulsivity and hyperactivity, which are all subjective. Functional Magnetic Resonance Imaging (fMRI) data has become a popular tool to understand the functioning of the brain such as identifying the brain regions responsible for different cognitive tasks or analyzing the statistical differences of the brain functioning between the diseased and control subjects. ADHD is also being studied using the fMRI data. In this dissertation we aim to solve the problem of automatic diagnosis of the ADHD subjects using their resting state fMRI (rs-fMRI) data. As a core step of our approach, we model the functions of a brain as a connectivity network, which is expected to capture the information about how synchronous different brain regions are in terms of their functional activities. The network is constructed by representing different brain regions as the nodes where any two nodes of the network are connected by an edge if the correlation of the activity patterns of the two nodes is higher than some threshold. The brain regions, represented as the nodes of the network, can be selected at different granularities e.g. single voxels or cluster of functionally homogeneous voxels. The topological differences of the constructed networks of the ADHD and control group of subjects are then exploited in the classification approach. We have developed a simple method employing the Bag-of-Words (BoW) framework for the classification of the ADHD subjects. We represent each node in the network by a 4-D feature vector: node degree and 3-D location. The 4-D vectors of all the network nodes of the training data are then grouped in a number of clusters using K-means; where each such cluster is termed as a word. Finally, each subject is represented by a histogram (bag) of such words. The Support Vector Machine (SVM) classifier is used for the detection of the ADHD subjects using their histogram representation. The method is able to achieve 64% classification accuracy. The above simple approach has several shortcomings. First, there is a loss of spatial information while constructing the histogram because it only counts the occurrences of words ignoring the spatial positions. Second, features from the whole brain are used for classification, but some of the brain regions may not contain any useful information and may only increase the feature dimensions and noise of the system. Third, in our study we used only one network feature, the degree of a node which measures the connectivity of the node, while other complex network features may be useful for solving the proposed problem. In order to address the above shortcomings, we hypothesize that only a subset of the nodes of the network possesses important information for the classification of the ADHD subjects. To identify the important nodes of the network we have developed a novel algorithm. The algorithm generates different random subset of nodes each time extracting the features from a subset to compute the feature vector and perform classification. The subsets are then ranked based on the classification accuracy and the occurrences of each node in the top ranked subsets are measured. Our algorithm selects the highly occurring nodes for the final classification. Furthermore, along with the node degree, we employ three more node features: network cycles, the varying distance degree and the edge weight sum. We concatenate the features of the selected nodes in a fixed order to preserve the relative spatial information. Experimental validation suggests that the use of the features from the nodes selected using our algorithm indeed help to improve the classification accuracy. Also, our finding is in concordance with the existing literature as the brain regions identified by our algorithms are independently found by many other studies on the ADHD. We achieved a classification accuracy of 69.59% using this approach. However, since this method represents each voxel as a node of the network which makes the number of nodes of the network several thousands. As a result, the network construction step becomes computationally very expensive. Another limitation of the approach is that the network features, which are computed for each node of the network, captures only the local structures while ignore the global structure of the network. Next, in order to capture the global structure of the networks, we use the Multi-Dimensional Scaling (MDS) technique to project all the subjects from an unknown network-space to a low dimensional space based on their inter-network distance measures. For the purpose of computing distance between two networks, we represent each node by a set of attributes such as the node degree, the average power, the physical location, the neighbor node degrees, and the average powers of the neighbor nodes. The nodes of the two networks are then mapped in such a way that for all pair of nodes, the sum of the attribute distances, which is the inter-network distance, is minimized. To reduce the network computation cost, we enforce that the maximum relevant information is preserved with minimum redundancy. To achieve this, the nodes of the network are constructed with clusters of highly active voxels while the activity levels of the voxels are measured based on the average power of their corresponding fMRI time-series. Our method shows promise as we achieve impressive classification accuracies (73.55%) on the ADHD-200 data set. Our results also reveal that the detection rates are higher when classification is performed separately on the male and female groups of subjects. So far, we have only used the fMRI data for solving the ADHD diagnosis problem. Finally, we investigated the answers of the following questions. Do the structural brain images contain useful information related to the ADHD diagnosis problem? Can the classification accuracy of the automatic diagnosis system be improved combining the information of the structural and functional brain data? Towards that end, we developed a new method to combine the information of structural and functional brain images in a late fusion framework. For structural data we input the gray matter (GM) brain images to a Convolutional Neural Network (CNN). The output of the CNN is a feature vector per subject which is used to train the SVM classifier. For the functional data we compute the average power of each voxel based on its fMRI time series. The average power of the fMRI time series of a voxel measures the activity level of the voxel. We found significant differences in the voxel power distribution patterns of the ADHD and control groups of subjects. The Local binary pattern (LBP) texture feature is used on the voxel power map to capture these differences. We achieved 74.23% accuracy using GM features, 77.30% using LBP features and 79.14% using combined information. In summary this dissertation demonstrated that the structural and functional brain imaging data are useful for the automatic detection of the ADHD subjects as we achieve impressive classification accuracies on the ADHD-200 data set. Our study also helps to identify the brain regions which are useful for ADHD subject classification. These findings can help in understanding the pathophysiology of the problem. Finally, we expect that our approaches will contribute towards the development of a biological measure for the diagnosis of the ADHD subjects.

Statistical process control (SPC) applies the science of statistics to various process control in order to provide higher-quality products and better services. The K chart is one among the many important tools that SPC offers. Creation of the K chart is based on Support Vector Data Description (SVDD), a popular data classifier method inspired by Support Vector Machine (SVM). As any methods associated with SVM, SVDD benefits from a wide variety of choices of kernel, which determines the effectiveness of the whole model. Among the most popular choices is the Euclidean distance-based Gaussian kernel, which enables SVDD to obtain a flexible data description, thus enhances its overall predictive capability. This thesis explores an even more robust approach by incorporating the Mahalanobis distance-based kernel (hereinafter referred to as Mahalanobis kernel) to SVDD and compare it with SVDD using the traditional Gaussian kernel. Method's sensitivity is benchmarked by Average Run Lengths obtained from multiple Monte Carlo simulations. Data of such simulations are generated from multivariate normal, multivariate Student's (t), and multivariate gamma populations using R, a popular software environment for statistical computing. One case study is also discussed using a real data set received from Halberg Chronobiology Center. Compared to Gaussian kernel, Mahalanobis kernel makes SVDD and thus the K chart significantly more sensitive to shifts in mean vector, and also in covariance matrix.

Artificial Intelligence in Automotive Industry / Cost reduction is one of the main concerns in industry. Companies invest considerably for better performance in end-of-line fault diagnosis systems. A common strategy is to use data obtained from existing instrumentation. This research investigates the challenge of learning from historical data that have already been collected by companies. Machine learning is basically one of the most common and powerful techniques of artificial intelligence that can learn from data and identify fault features with no need for human interaction. In this research, labeled sound and vibration measurements are processed into fault signatures for vehicle starter motors and alternators. A fault detection and identification system has been developed to identify fault types for end-of-line testing of motors. However, labels are relatively difficult to obtain, expensive, time consuming and require experienced humans, while unlabeled samples needs less effort to collect. Thus, learning from unlabeled data together with the guidance of few labels would be a better solution. Furthermore, in this research, learning from unlabeled data with absolutely no human intervention is also implemented and discussed as well. / Thesis / Master of Applied Science (MASc)