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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
201

混沌及不確定環境下的成長策略-以S公司為例 / The growth strategy in chaos and uncertain environment

彭國書 Unknown Date (has links)
在全球經濟化形式下,新資訊時代的變化帶來企業所面臨環境有更高的不確定性,市場變幻莫測,國際經濟環境動盪,企業的生存面臨著前所未有的挑戰,世界金融危機所帶來的困境、裁員、企業升級等危機,這些都迫使企業經營者不得不去思考如何應對環境快速變化之特性及採取必要的經營策略。企業在劇烈的環境變化中如何發揮自身的競爭優勢,並與其他企業合作互贏,來應對外部持續變化的不確定環境。 本研究由文獻資料分析出企業所面臨不確定環境中所應用的策略,確認不確定環境中可採用的策略方法,對競合策略、企業文化、企業創新與轉型、SWOT分析法及平衡計分卡進行歸納總結。 本文以膠帶行業一集團中的子公司為研究對象,對膠帶行業的產業結構進行分析,重點介紹大陸PVC市場並對膠帶行業未來的發展趨勢進行預測展望。再對企業目前所處的策略地域、經濟環境、企業環境、環保趨勢進行分析。運用價值網、SWOT分析法、平衡計分卡等分析方法對企業目前的運營狀況進行總結,研究企業現推行的經營策略及未來發展之路,並在最後得出企業實施策略後的成長效益進行總結。 / In the global economic times, the change of new information age cause the business has to faced greater uncertainties environment, the market is uncertain, international economic environment unrest, the enterprise is faced with unprecedented challenges and the world financial crisis brought difficulties, downsizing and enterprises upgraded etc. All these forces managers to think how to solve the problem of environmental rapid changes and take necessary measures . Enterprises how to play its own competitive advantage and cooperation with other enterprises in the severe changes environmental , how to fit the constantly changing environment. This research based on the documentation to analysis of strategy when enterprise in the unsure environment.This research to confirm the strategy could adopted in the unsure environment. Summarize the Co-opetition,corporate culture, innovation and change, swot analysis and balanced scorecard This thesis study with a group of the subsidiary in the tape industry.To analysis the industrial structure and focus on the plastic PVC market of China.The future development tendency of tape industry forecasted.Then analysis strategic areas of enterprises, business environment, corporate environment and the trend of environmental protection.Analysis the present state of the enterprise with the vuale net,SWOT anaylsis and balanced scorecard to research the present operate strategy and the direction of future development.At last,come to the benefits of growth after the enterprises implement strategy.
202

EFFEKTEN AV VIKTMANIPULERAD UTRUSTNING PÅ DRAGSKOTTSHASTIGHET OCH GREPPSTYRKA I INNEBANDY : EN SEX VECKORS STUDIE PÅ MANLIGA 17-ÅRIGA INNEBANDYSPELARE / The effect on drag shot velocity and grip strength with weight manipulated equipment : A six week study on male 17-year old floorball players

Linke, Mats, Saarela, Tobias January 2011 (has links)
Innebandy är en växande idrott, som framför allt utövas i Sverige, Finland och Schweiz, men där väldigt lite forskning ännu finns publicerad. Tidigare studier inom ishockey och baseboll har visat att träning med viktmanipulerad utrustning förbättrat bland annat greppstyrka och svinghastigheten av slagträ i baseboll. Annan forskning har visat på att det är en förbättring i det neuromuskulära samspelet snarare än ökad muskelmassa som förbättrat prestationen vid dynamisk motståndsträning. Skotthastigheten anses vara en viktig faktor inom innebandy för prestationen och eftersom det inom baseboll har visats att viktmanipulerad utrustning kan förbättra svinghastigheten så vore det intressant att se om samma resultat kan uppnås inom innebandy. Syftet med studien var att undersöka effekten av innebandyträning med en viktmanipulerad innebandyklubba med avseende på dragskottshastighet och greppstyrka hos manliga innebandyspelare samt undersöka korrelationen mellan dragskottshastighet och greppstyrka. Även testpersonernas subjektiva uppfattning av träningen med den viktmanipuleradeutrustningen undersöktes. Testgruppen bestod av 13 stycken 17-åriga manliga innebandyspelare. Under en sex veckors period genomförde testpersonerna 30 minuter av sin vanliga innebandyträning med den viktmanipulerade klubban (40 gram tyngre) tre gånger i veckan. Dragskotten filmades med en höghastighetskamera (Casio Exilim EX-FH25) med 250 fps och analyserades sedan i Dartfish för att mäta hastigheten. För att fastställa greppstyrkan användes en handdynamometer (Jamar – Baseline Hydraulic Hand Dynamometer). Träningen resulterade i en signifikant skillnad hos testpersonernas greppstyrka i den nedre handen på klubban (p<0,05). Däremot hittades ingen signifikant skillnad för den övre handens greppstyrka eller dragskottshastigheten. Studien visade heller inte på någon korrelation mellan dragskottshastighet och greppstyrka hos testpersonerna. Testpersonerna hade olika åsikter kring hur den extra tyngden påverkade innebandytekniken.De funna resultaten indikerar att träning med viktmanipulerad utrustning i innebandy signifikant förbättrar spelarnas greppstyrka i den nedre handen. Den ökade kraftutvecklingen kan eventuellt förklaras av ett ökat neuromuskulärt samspel. Studien ger en ökad förståelse för hur dynamisk motståndsträning kan implementeras i den dagliga innebandyträningen, vilket kan tillämpas vid planeringen av träningsprogram. / Floorball is a sport with increasing number of participants, which has not been studied extensively according to the literature. Previous studies on ice hockey and baseball have shown that training with weight manipulated equipment improved grip strength and swing speed. Other research has shown that the increased performance with dynamic resistance training rather occurs from the improvements in the neuromuscular facilitation than an increase in muscle mass. In floorball shooting velocity is considered to be an important factor of the performance. Since it has been shown in baseball that training with weight manipulated equipment can improve the bat velocity, it would be interesting to see if the same results can be found in floorball. The purpose of this study was to investigate the effect of grip strength and drag shot velocity in floorball training with a weight manipulated floorball stick. The study also investigated the relationship between grip strength and drag shot velocity. The test subjects’ subjective perception about the training method was also investigated. Thirteen 17-year-old male floorball players participated in the study. During a six weeks period the subjects used the weight manipulated equipment during 30 minutes, three times per week during their regular team practice. 40 grams lead tape was attached to the player's equipment to increase the resistance. The drag shots were filmed with a high speed camera (Casio Exilim EX-FH25) at 250 fps. The drag shot velocity was analyzed in Dartfish. To assess grip strength a hand dynamometer (Jamar - Baseline Hydraulic Hand Dynamometer)was used. The training resulted in a significant increase for the subjects’ grip strength in the lower hand on the stick (p <0,05). The study found no significant difference for the upper hand grip strength or drag shot velocity. No correlation between drag shot velocity and handgripstrength among the subjects were found. Conclusion: The results found in this study indicate that training with weight manipulated equipment can significantly improve the player’s lower hand grip strength. The results can eventually be explained by more effective fiber recruitment in the muscles. Studying floorball can contribute to increase the interest in research on floorball and increase the understanding for how dynamic resistance training can be incorporated in daily floorball practice.
203

Portfolio of original compositions

陳錦標, Chan, Kam Biu, Joshua. January 1994 (has links)
published_or_final_version / Music / Doctoral / Doctor of Philosophy
204

Kinezioteipo poveikis, sergančiųjų išsėtine skleroze, statinei pusiausvyrai / Effect of kinesio taping on standing balance in subjects with multiple sclerosis

Lopucha, Loreta 21 June 2012 (has links)
Tyrimo problema: Pasaulyje išsėtine skleroze serga apie 2,5 mln. žmonių. Lietuva priklauso didelio sergamumo išsėtine skleroze zonai (Klizaitienė, 2008). Vienas iš pagrindinių simptomų, pasireiškiančių jau ankstyvoje šios ligos stadijoje, yra pusiausvyros sutrikimas (Prosperini et al., 2010; Cameron et al., 2008; Martin & Phillips, 2006). Darbo aktualumas: Kinezioteipas yra pigi, lengvai prieinama ir neinvazinė priemonė, galinti pagerinti sergančiųjų išsėtine skleroze statinę pusiausvyrą ir gyvenimo kokybę, sumažinti atsitiktinių griuvimų riziką. Tyrimo hipotezė: Kinezioteipas, užklijuotas ant dvilypio ir priekinio blauzdos, gali pagerinti sergančiųjų išsėtine skleroze statinę pusiausvyrą. Tyrimo tikslas: Nustatyti kinezioteipo poveikį sergančiųjų išsėtine skleroze statinei pusiausvyrai. Tyrimo uždaviniai: 1. Įvertinti tiriamųjų statinę pusiausvyrą stovint atsimerkus ir užsimerkus be kinezioteipo ir su kinezioteipu, užklijuotu ant dvilypio ir priekinio blauzdos raumens funkcine korekcine technika. 2. Įvertinti tiriamųjų statinę pusiausvyrą stovint atsimerkus ir užsimerkus be kinezioteipo ir su kinezioteipu, užklijuotu placebo ant keturgalvio raumens. 3. Įvertinti skirtingų kinezioteipavimo technikų efektyvumą tiriamųjų statinei pusiausvyrai. Tyrimo metodai: Tyrimas buvo atliktas ,,Palangos reabilitacijos ligoninėje“ 2012 m. sausio 19-20 dienomis kuriame dalyvavo 16 darbingų asmenų, kuriems diagnozuota išsėtinė sklerozė. • Buvo atliekamas aklas vienpusis tyrimas. •... [toliau žr. visą tekstą] / About 2,5 million people suffer from multiple sclerosis. Lithuania belongs to a zone of high rate of people suffering from this desease (Klizaitienė, 2008). On of the main symptoms, appearing in the early stage of this desease is imbalance (Prosperini et al., 2010; Cameron et al., 2008; Martin & Phillips, 2006). Relevance of the topic: Kinesio Tape is a cheap, available and non-invasive means which can improve static balance, quality of life and reduce coincidental risk of falls for those who have multiple sclerosis. Hypothesis: Kinesio Tape sticked to gastrocnemius and tibialis anterior muscle can improve the postural stability of those who have multiple sclerosis. The aim of the research: To establish the effect of the Kinesio Tape of those who suffer fro multiple sclerosis and to estimate the postural stability. The task of the research: 1. Estimate the posture while standing with tight legs with open and closed eyes with Kinesio Tape and with Kinesio Tape, sticked on the gastrocnemius and tibialis anterior muscle with the help of functional correctional technique. 2. Estimate the posture while standing with tight legs with open and closed eyes with Kinesio Tape and with Kinesio Tape, sticked on the quadriceps muscle with the placebo technique. 3. Estimate the efficiency of Kinesio Tape on postural stability of those who were in the research. Methods of the research: The research was performed on 19th and 20th of January in 2012 in rehabilitation hospital Palanga. There... [to full text]
205

Realisierung einer Demonstratoranlage für die Orbitalwickeltechnologie

Wallasch, Rainer, Tirschmann, Ramon, Spieler, M., Nendel, W., Kroll, L. 06 July 2015 (has links) (PDF)
Im Rahmen des Exzellenzclusters MERGE an der TU Chemnitz erfolgt die Entwicklung eines kontinuierlichen großserientauglichen Verfahrens zur Herstellung komplexer geschlossener Strukturbauteile. Hierbei werden vorimprägnierte faserverstärkte thermoplastische Halbzeuge (thermoplastische Tapes) in einem Kombinationsverfahren aus thermoplastischen Tapelegen und Tapewickeln verarbeitet. Für dieses kontinuierliche Orbitalwickelverfahren wurde ein spezieller Technologiedemonstrator entwickelt mit dessen Hilfe Machbarkeitsstudien zur Erbringung des Funktionsnachweises durchgeführt werden. Die oben genannte Versuchsanlage ermöglicht die Erzeugung rotationssymmetrischer Profile, die zudem einen inkonstanten Querschnitt aufweisen können. Für die Anlagenkonzeptionierung wurde ein Beispielprofil eines Strukturbauteils ausgewählt und die Anlagendimensionierung durchgeführt. Basierend auf dem Entwurf werden zur Anlagendimensionierung die Parameter der Einzelantriebe mit Hilfe inverser Kinematik simulativ und analytisch abgeleitet und durch anschließende Simulation in CreoElements/Pro® vervollständigt. Die konstruktive Realisierung erfolgte mittels Solid Works. Die abschließende simulative Validierung wurde wiederum mittels CreoElements/Pro® durchgeführt. Diese Arbeiten entstanden im Rahmen des Bundesexzellenzclusters EXC 1075 "Technologiefusion für multifunktionale Leichtbaustrukturen" und wurde von der Deutschen Forschungsgemeinschaft gefördert. Die Autoren danken für die finanzielle Unterstützung.
206

Transdermal penetration enhancement and clinical efficacy of Aloe marlothii and Aloe ferox compared to Aloe vera / Lizelle Trifena Fox

Fox, Lizelle Trifena January 2014 (has links)
Extensive research has already been performed on Aloe vera therefore it is important that researchers include other aloe species, such as Aloe marlothii and Aloe ferox, in studies involving aloe plant materials (Loots et al., 2007:6891). The use of natural products has regained popularity and in recent years the demand for alternative medication has risen considerably (Walji & Wiktorowicz, 2013:86). The hydration state of the human skin is fundamental for its normal functioning (Verdier-Sévrain & Bonté, 2007:75), with healthy skin possessing a water content higher than 10% (w/v) (Blank, 1952:439). This demonstrates the importance of the topical application of skin moisturisers as part of basic skin care regime (Verdier-Sévrain & Bonté, 2007:75). The first part of this project focused on the in vivo skin hydration effects of the precipitated polysaccharide components of A. vera, A. ferox and A. marlothii leaf gel materials (3% (w/v)) after single (30, 90 and 150 min after application) and multiple applications (twice daily application over a period of four weeks) on healthy volunteers, respectively. The anti-erythema effects of these aloe materials on sodium lauryl sulphate irritated skin were also examined. The skin hydration effects of the aloe materials were determined with the Corneometer® CM 825 and Visioscan® VC 98 during the short term study (single application) and longer term study (multiple applications). In addition, as an indirect measurement of skin hydration, the Cutometer® dual MPA 580 was used to measure skin elasticity during the longer term study. To determine the anti-erythema effects of the aloe materials when applied to irritated skin areas, the haemoglobin content of the skin was measured with a Mexameter® MX 18. The results from the in vivo study indicated that A. ferox gel material dehydrated the skin, whereas A. vera and A. marlothii gel materials hydrated the skin during the short term study. Results from the longer term study showed that all the aloe leaf materials have skin dehydration effects, probably due to the aloe absorbing moisture from the skin into the applied gel layer upon drying. From the anti-erythema study, it was seen that A. vera and A. ferox materials had the potential to reduce erythema on the skin similar to that of the positive control group (i.e. hydrocortisone gel) after six days of treatment. The skin possesses exceptional barrier properties which can mostly be ascribed to the outermost layer of the skin, the stratum corneum (SC). Due to the physical barrier the skin has against drug permeation, the delivery of drug molecules into and across the skin continues to be challenging (Lane, 2013:13) and to overcome this barrier, penetration enhancers can be used to efficiently deliver drugs across the skin (Barry, 2002:522). The aim of the second part of this project was to determine the skin penetration enhancing effects of the gel and whole leaf materials of A. vera, A. marlothii and A. ferox. Ketoprofen was used as the marker compound and a high performance liquid chromatography (HPLC) method was developed and validated to determine the amount of ketoprofen present in the samples. Prior to the skin diffusion studies, membrane release studies were performed to test whether the solutions containing different concentrations of the aloe leaf materials (i.e. 3.00%, 1.50% and 0.75% (w/v)) released ketoprofen from their gel-like structures. From these studies, it was evident the 0.75% (w/v) concentration had the highest average percentage ketoprofen release, which was subsequently chosen as the concentration for the aloe leaf materials tested in the transdermal skin diffusion studies. The in vitro permeation study was conducted across dermatomed (400 μm thick) skin in Franz diffusion cells. Tape stripping was performed after completion of the diffusion studies to determine the concentration ketoprofen present in the SC-epidermis and epidermis-dermis layers of the skin. Results from the in vitro permeation study showed that A. vera gel enhanced the flux of ketoprofen to the highest extent (20.464 μg/cm2.h) when compared to the control group (8.020 μg/cm2.h). Aloe marlothii gel (12.756 μg/cm2.h) and A. ferox whole leaf material (12.187 μg/cm2.h) also enhanced the permeation of ketoprofen across the skin compared to the control group. A. vera gel material was the most efficient transdermal drug penetration enhancer of the selected aloe species investigated. In order to determine by which mechanism the aloe leaf materials enhanced the skin permeation of ketoprofen (Hadgraft et al., 2003:141), the permeation profiles were analysed using a non-linear curve-fitting procedure (Díez-Sales et al., 1991:3) to obtain α, β and kp values. A change in the α-value indicated the aloe leaf material influenced the partition coefficient (K), whereas a change in β indicated the aloe leaf material influenced the diffusivity (D) (with the assumption that h, the diffusional path length is constant) (Otto et al., 2010:278). The calculated α-values indicated the drug permeation enhancing effect of A. vera gel can be ascribed to an increased partitioning of the drug into the skin. The calculated β-values showed A. ferox whole leaf altered the diffusion characteristics of the skin for ketoprofen. The tape stripping results showed A. marlothii whole leaf delivered the highest concentration of the ketoprofen into the SC-epidermis and epidermis-dermis layers of the skin. / PhD (Pharmaceutics), North-West University, Potchefstroom Campus, 2014
207

Transdermal penetration enhancement and clinical efficacy of Aloe marlothii and Aloe ferox compared to Aloe vera / Lizelle Trifena Fox

Fox, Lizelle Trifena January 2014 (has links)
Extensive research has already been performed on Aloe vera therefore it is important that researchers include other aloe species, such as Aloe marlothii and Aloe ferox, in studies involving aloe plant materials (Loots et al., 2007:6891). The use of natural products has regained popularity and in recent years the demand for alternative medication has risen considerably (Walji & Wiktorowicz, 2013:86). The hydration state of the human skin is fundamental for its normal functioning (Verdier-Sévrain & Bonté, 2007:75), with healthy skin possessing a water content higher than 10% (w/v) (Blank, 1952:439). This demonstrates the importance of the topical application of skin moisturisers as part of basic skin care regime (Verdier-Sévrain & Bonté, 2007:75). The first part of this project focused on the in vivo skin hydration effects of the precipitated polysaccharide components of A. vera, A. ferox and A. marlothii leaf gel materials (3% (w/v)) after single (30, 90 and 150 min after application) and multiple applications (twice daily application over a period of four weeks) on healthy volunteers, respectively. The anti-erythema effects of these aloe materials on sodium lauryl sulphate irritated skin were also examined. The skin hydration effects of the aloe materials were determined with the Corneometer® CM 825 and Visioscan® VC 98 during the short term study (single application) and longer term study (multiple applications). In addition, as an indirect measurement of skin hydration, the Cutometer® dual MPA 580 was used to measure skin elasticity during the longer term study. To determine the anti-erythema effects of the aloe materials when applied to irritated skin areas, the haemoglobin content of the skin was measured with a Mexameter® MX 18. The results from the in vivo study indicated that A. ferox gel material dehydrated the skin, whereas A. vera and A. marlothii gel materials hydrated the skin during the short term study. Results from the longer term study showed that all the aloe leaf materials have skin dehydration effects, probably due to the aloe absorbing moisture from the skin into the applied gel layer upon drying. From the anti-erythema study, it was seen that A. vera and A. ferox materials had the potential to reduce erythema on the skin similar to that of the positive control group (i.e. hydrocortisone gel) after six days of treatment. The skin possesses exceptional barrier properties which can mostly be ascribed to the outermost layer of the skin, the stratum corneum (SC). Due to the physical barrier the skin has against drug permeation, the delivery of drug molecules into and across the skin continues to be challenging (Lane, 2013:13) and to overcome this barrier, penetration enhancers can be used to efficiently deliver drugs across the skin (Barry, 2002:522). The aim of the second part of this project was to determine the skin penetration enhancing effects of the gel and whole leaf materials of A. vera, A. marlothii and A. ferox. Ketoprofen was used as the marker compound and a high performance liquid chromatography (HPLC) method was developed and validated to determine the amount of ketoprofen present in the samples. Prior to the skin diffusion studies, membrane release studies were performed to test whether the solutions containing different concentrations of the aloe leaf materials (i.e. 3.00%, 1.50% and 0.75% (w/v)) released ketoprofen from their gel-like structures. From these studies, it was evident the 0.75% (w/v) concentration had the highest average percentage ketoprofen release, which was subsequently chosen as the concentration for the aloe leaf materials tested in the transdermal skin diffusion studies. The in vitro permeation study was conducted across dermatomed (400 μm thick) skin in Franz diffusion cells. Tape stripping was performed after completion of the diffusion studies to determine the concentration ketoprofen present in the SC-epidermis and epidermis-dermis layers of the skin. Results from the in vitro permeation study showed that A. vera gel enhanced the flux of ketoprofen to the highest extent (20.464 μg/cm2.h) when compared to the control group (8.020 μg/cm2.h). Aloe marlothii gel (12.756 μg/cm2.h) and A. ferox whole leaf material (12.187 μg/cm2.h) also enhanced the permeation of ketoprofen across the skin compared to the control group. A. vera gel material was the most efficient transdermal drug penetration enhancer of the selected aloe species investigated. In order to determine by which mechanism the aloe leaf materials enhanced the skin permeation of ketoprofen (Hadgraft et al., 2003:141), the permeation profiles were analysed using a non-linear curve-fitting procedure (Díez-Sales et al., 1991:3) to obtain α, β and kp values. A change in the α-value indicated the aloe leaf material influenced the partition coefficient (K), whereas a change in β indicated the aloe leaf material influenced the diffusivity (D) (with the assumption that h, the diffusional path length is constant) (Otto et al., 2010:278). The calculated α-values indicated the drug permeation enhancing effect of A. vera gel can be ascribed to an increased partitioning of the drug into the skin. The calculated β-values showed A. ferox whole leaf altered the diffusion characteristics of the skin for ketoprofen. The tape stripping results showed A. marlothii whole leaf delivered the highest concentration of the ketoprofen into the SC-epidermis and epidermis-dermis layers of the skin. / PhD (Pharmaceutics), North-West University, Potchefstroom Campus, 2014
208

Pheroid technology for the topical delivery of depigmenting agents transforming growth factor–ß1 and tumor necrosis factor–a / Berenice Campbell

Campbell, Berenice January 2010 (has links)
Pigmentation disorders occur in multiple conditions (Hakozaki et al., 2006:105). Although many modalities of treatments are available, none are completely satisfactory (Briganti et al., 2003:101). Two cytokines normally present in the skin, transforming growth factor–beta1 (TGF–81) and tumour necrosis factor–alpha (TNF–9), have been shown to inhibit melanin synthesis (Martinez–Esparza, 2001:972). The stratum corneum has been commonly accepted as the main barrier to percutaneous absorption. Many techniques have been applied to overcome this barrier properties and to enhance penetration with varying success (Pellet et al., 1997:92). The objective of this study was to investigate the topical delivery of the above mentioned peptide drugs with aid of the Pheroid drug delivery system. Pheroid technology is a delivery system that promotes the absorption and increases the efficacy of dermatological, biological and oral medicines in various pharmacological groups (Grobler et al., 2008:4). Pheroid entraps drugs with high efficiency and delivers them with remarkable speed to target sites (Grobler, 2004:4). In order to avoid degradation of these peptides, bestatin hydrochloride (an aminopeptidase inhibitor), was used (Lkhagvaa et al., 2008:386). Topical drug delivery was achieved by means of vertical Franz cell diffusion studies performed over a 6 and 12 h period. ELISA (enzyme linked immunosorbent assay) detection was used to detect cytokine concentrations. Entrapped cytokine solutions were monitored by confocal laser scanning microscopy (CLSM). Upon removal of donor and receptor compartments, skin discs were subjected to tape stripping in order to establish the amount of active present within the stratum corneum and epidermis as well as the remaining dermis (Pellet et al., 1997:92). When comparing the two studies with each other, it is evident that the diffused concentration values obtained with PBS (phosphate buffer solution, pH 7.4) was lower than that obtained with the Pheroid drug delivery system. Both cytokine concentrations were successfully delivered topically as a minimum of concentrations for both actives were detected. This positive result was confirmed as well by the amount of active detected in stratum corneum–epidermis and epidermis–dermis solutions. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011.
209

Pheroid technology for the topical delivery of depigmenting agents transforming growth factor–ß1 and tumor necrosis factor–a / Berenice Campbell

Campbell, Berenice January 2010 (has links)
Pigmentation disorders occur in multiple conditions (Hakozaki et al., 2006:105). Although many modalities of treatments are available, none are completely satisfactory (Briganti et al., 2003:101). Two cytokines normally present in the skin, transforming growth factor–beta1 (TGF–81) and tumour necrosis factor–alpha (TNF–9), have been shown to inhibit melanin synthesis (Martinez–Esparza, 2001:972). The stratum corneum has been commonly accepted as the main barrier to percutaneous absorption. Many techniques have been applied to overcome this barrier properties and to enhance penetration with varying success (Pellet et al., 1997:92). The objective of this study was to investigate the topical delivery of the above mentioned peptide drugs with aid of the Pheroid drug delivery system. Pheroid technology is a delivery system that promotes the absorption and increases the efficacy of dermatological, biological and oral medicines in various pharmacological groups (Grobler et al., 2008:4). Pheroid entraps drugs with high efficiency and delivers them with remarkable speed to target sites (Grobler, 2004:4). In order to avoid degradation of these peptides, bestatin hydrochloride (an aminopeptidase inhibitor), was used (Lkhagvaa et al., 2008:386). Topical drug delivery was achieved by means of vertical Franz cell diffusion studies performed over a 6 and 12 h period. ELISA (enzyme linked immunosorbent assay) detection was used to detect cytokine concentrations. Entrapped cytokine solutions were monitored by confocal laser scanning microscopy (CLSM). Upon removal of donor and receptor compartments, skin discs were subjected to tape stripping in order to establish the amount of active present within the stratum corneum and epidermis as well as the remaining dermis (Pellet et al., 1997:92). When comparing the two studies with each other, it is evident that the diffused concentration values obtained with PBS (phosphate buffer solution, pH 7.4) was lower than that obtained with the Pheroid drug delivery system. Both cytokine concentrations were successfully delivered topically as a minimum of concentrations for both actives were detected. This positive result was confirmed as well by the amount of active detected in stratum corneum–epidermis and epidermis–dermis solutions. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011.
210

Kinezioteipavimo efektyvumas pacientų, sergančių išsėtine skleroze,pusiausvyrai / Effect of kinesio taping on static and dynamic balance in subjects with multiple sclerosis

Banienė, Ugnė 18 June 2014 (has links)
Tyrimo problema: Apie 2,5 mln. žmonių visame pasaulyje serga išsėtine skleroze. Lietuva priklauso didelio sergamumo išsėtine skleroze zonai (Kizlaitienė, 2008). Vienas iš pagrindinių simptomų, pasireiškiančių ankstyvoje šios ligos stadijoje, yra pusiausvyros sutrikimas (Prosperini et al., 2010; Cameron et al., 2008; Martin, Phillips, 2006). Darbo aktualumas: Kinezioteipas yra lengvai prieinama ir neivazinė priemonė, galinti pagerinti sergančiųjų išsėtine skleroze statinę ir dinaminę pusiausvyrą, gyvenimo kokybę, sumažinti griuvimų riziką. Tyrimo hipotezė: Kinezioteipas, užklijuotas ant dvilypio ir priekinio blauzdos raumens, gali pagerinti sergančiųjų išsėtine skleroze statinę ir dinaminę pusiausvyrą. Tyrimo tikslas: Nustatyti kinezioteipo poveikį sergančiųjų išsėtine skleroze statinei ir dinaminei pusiausvyrai. Tyrimo uždaviniai: 1. Įvertinti tiriamųjų statinę ir dinaminę pusiausvyrą su kinezioteipu, užklijuotu ant dvilypio ir priekinio blauzdos raumens funkcine korekcine technika. 2. Įvertinti tiriamųjų statinę ir dinaminę pusiausvyrą su kinezioteipu, užklijuotu placebo ant keturgalvio raumens. 3. Įvertinti skirtingų kinezioteipavimo technikų efektyvumą tiriamųjų statinei ir dinaminei pusiausvyrai. Tyrimo metodai: Tyrimas atliktas Lietuvos Sveikatos Mokslų Universiteto Reabilitacijos Klinikoje, 2014 kovo 21 – 28 dienomis, jame dalyvavo 48 darbingi asmenys, sergantys išsėtine skleroze. Atliktas aklas vienpusis tyrimas, tiriamieji atsitiktiniu atrankos būdu suskirstyti į... [toliau žr. visą tekstą] / Abaut 2,5 million people suffer from multiple sclerosis. Lithuania belongs to a zone of high rate of people suffering from this desease (Klizaitienė, 2008). On of the main symptoms, appearing in the early stage of this desease is imbalance (Prosperini et al., 2010; Cameron et al., 2008; Martin & Phillips, 2006). Relevance of the topic: Kinesio Tape is a available and non-invasive means which can improve static balance, quality of life and reduce coincidental risk of falls for those who have multiple sclerosis. Hypothesis: Kinesio Tape sticked to gastrocnemius and tibialis anterior muscle can improve the postural stability of those who have multiple sclerosis. The aim of the research: To establish the effect of the Kinesio Tape of those who suffer from multiple sclerosis and to estimate the postural stability. The task of the research: 1. Estimate the static and dynamic posture with Kinesio Tape sticked on the gastrocnemius and tibialis anterior muscle with the help of functional correctional technique. 2. Estimate the static and dynamic posture with Kinesio Tape sticked on the quadriceps muscle with the placebo technique. 3. Estimate the efficiency of Kinesio Tape on postural stability of those who were in the research. Methods of the research: The study was conducted in Lithuanian University of Health Sciences, in Rehabilitation clinic in March 21th – 28th. There were 48 patients with Multiple Sclerosis participating in the study. The patients were randomized into two... [to full text]

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