Ce travail s’inscrit dans le cadre de l’étude de plateformes polyphénoliques et, plus spécifiquement, des calixarènes. Des macrocycles oligomériques tels que les calixarènes, cyclodextrines, cyclotrivératrylènes, pillararènes, etc. sont fortement utilisés dans de nombreuses applications telles que la reconnaissance moléculaire, la détection, la séparation, le greffage sur surface, etc. Le développement de telles applications requiert toutefois modification sélective de ces macrocycles pour leur conférer des propriétés utiles aux applications visées (e.g. affinité envers certaines espèces chimiques, hydrosolubilité, activité photoluminescente). La modification sélective de tels macrocycles oligomériques est cependant loin d’être triviale car, en plus de requérir un contrôle des chimio- régio- et stéréosélectivités classiques, la réaction d’un nombre défini de fonctions identiques est une problématique clé qui doit être résolue. En effet, la fonctionnalisation des oligomères cycliques tels que les calixarènes passe par la formation de produits mono-, di-, tri-fonctionnalisés, et ainsi de suite de manière itérative. Par analogie avec des processus itératifs, nous avons proposé le terme « itérosélectivité » pour décrire la sélectivité qui gouverne le nombre de transformations chimiques répétées. Dans ce contexte, nous avons proposé des stratégies rationnelles et hautement sélectives pour la fonctionnalisation de calixarènes. Ces stratégies exploitent principalement des réactions de carbamatation pour introduire sélectivement des groupements tert-butylaminocarbonyle (Bac) sur les positions phénoliques des calixarènes. Citons notamment la carbamatation « all-but-one » qui permet d’introduire itérosélectivement des groupements Bac sur tous les phénols sauf un pour une grande variété de calixarènes. De plus, l’utilisation de ces groupements Bac comme groupe protecteur nous a permis de synthétiser de nombreux dérivés calixaréniques jusqu’alors inaccessibles suivant les voies de fonctionnalisation connues. Certains de ces composés présentent notamment une chiralité inhérente. En dehors de nos travaux, aucune voie de fonctionnalisation sélective de calixarènes décrite à ce jour n’est aussi générale et efficace. Nous avons également présenté une nouvelle voie d’oxydation de calixarènes en calixquinones. Cette voie présente moins de risques pour la santé et l’environnement que la méthode la plus couramment utilisée à ce jour employant un sel de thallium, métal extrêmement toxique. Les différents aspects synthétiques développés ont permis de synthétiser des boites moléculaires originales dérivées de calixarènes qui ont été étudiées pour leurs propriétés intéressantes dans le cadre de la reconnaissance sélective de petites molécules dont l’eau et le DMSO, ainsi que le piégeage de gaz à l’état solide dont l’hexafluorure de soufre qui est le gaz à effet de serre le plus puissant répertorié à ce jour. Pour finir, la caractérisation poussée d’une bibliothèque de dérivés calixaréniques par spectroscopie de résonance magnétique nucléaire a permis de décrire une méthode générale pour la caractérisation structurale et conformationnelle des calixarènes. / This work concerns the study of polyphenolic platforms, and more particularly, of calixarenes. Oligomeric macrocycles such as calixarenes, cyclodextrins, cyclotriveratrylenes, pillararenes, etc. are widely used as molecular platforms in supramolecular chemistry and in particular for the design of sensors, catalysts, multivalent systems, biomimetic receptors, etc. In general, the synthesis of such supramolecular systems requires the controlled introduction of functional groups on the precursor platform. However, the development of efficient methods for selective modification of macrocyclic oligomers remains extremely challenging. Indeed, in addition to the control of the classical chemo-, regio-, and stereoselectivities, the reaction of a defined number of identical functional groups is a key issue that must be solved. Indeed, the functionalization of oligomeric macrocycles such as calixarenes goes through the formation of mono-, di, tri-functionalized products and so on, iteratively. By analogy with iterative processes, we proposed to name “iteroselectivity” the kind of selectivity that governs the number of repeating chemical transformations. In this context, we proposed rational and highly selective strategies for the functionalization of calixarenes. These strategies are mainly based on the carbamatation of calixarene phenolic functions to introduce tert-butylaminocarbonyl groups (i.e. Bac groups). Our leading example is the “all-but-one” carbamatation which can be used to introduce Bac groups on all but one phenol of a large variety of calixarenes. Moreover, using Bac groups as protecting groups led to the synthesis of numerous calixarene derivatives which were, until now, not accessible through conventional means. It is noteworthy that some of these compounds are inherently chiral. No other selective functionalization method described for calixarenes is as general and efficient than this “all-but-one” carbamatation. Besides, we also described a new oxidation method to synthesize calixquinone starting from calixarenes. This method is less risky and more environment-friendly than the most commonly used method which rely on thallium salts, an extremely toxic metal. Through the various synthetic methods developed herein, we also developed calixarene-based molecular boxes. The host–guest properties of these molecular boxes were studied revealing their ability to include small molecules such as water or DMSO. We also developed a method to sequester gases in the solid state relying on an original concept involving calix[6]arene-based molecular boxes. This was exemplified with the sequestration of SF6, known as the most potent greenhouse gas. At last, the extensive characterization of a library of calixarene derivatives by nuclear magnetic resonance spectroscopy led to the development of a general method for the structural and conformational characterization of calixarenes. / Doctorat en Sciences / info:eu-repo/semantics/nonPublished

The subject of the thesis is the preparation of project documentation for construction of the new building boarding house with a wine cellar near the recreation area Leopoldov, the local Městyse Buchlovice. Due to the location near the attractive location with a rich tradition of folklore object at the same time offers space for a presentation and wine tasting for the public, with the possibility of organizing smaller events. For added convenience, the services offered includes the construction of a total capacity of 48 beds. The total required capacity are dealt with in two separate buildings of rectangular plan in mutually perpendicular arrangement. The visible design of both buildings respects the landscape and sensitive integration of the building into the surrounding buildings. SO-01 Wineries Object wineries (production 60.000l/rok) with a wine cellar for the production, storage and presentation of wine products, a lounge for 48 people and an accommodation for 10 persons.The building is brick, single-storey, basement, covered with a wooden roof truss attic, partially flat grass roof. SO-02 Guest house Construction of accommodation (guest house) with a capacity of 38 persons for accommodation of visitors wine cellar. The building is brick, single-storey, basement, covered with a wooden roof truss attic utilized. The property adjoining a paved parking area.

This thesis deals with the project documentation of the accommodation facility. Specifically, it is a guest house situated at the outskirts of Blansko – Ceskovice. Guest house kapacity is 22 beds and 50 seated restaurant. The object is designed as a three-floor with a partial basement. Basement floor will consist of storage, utility room and squash court. In the first floor is located main entrance, reception desk and restaurant with facilities. In the second floor are rooms for guests. The building is walled with saddle roof.

This thesis addresses the design documentation for Guest House in Uherský Ostroh at street Dlouhá 249. The building is designed to accommodate up to 48 guests, which is available restaurant. The restaurant has a capacity of sixty people, the kitchen is expected to serving 200 meals per day. The proposed facility is located in the plane is no basement and has two floors. The building is covered with a gable roof in part, in part walkable flat roof.

This diploma thesis focuses on design of an accommodation guest house – apartments and stables. The apartment object has two above-ground floors and a partial basement. Two social rooms and a room for staff are located in the part of the basement that reaches above ground. The dinning room, sanitary facilities and apartments for people with reduced mobility are located on the first floor. Four apartments are located in a residential attic. The recreational building is made of ceramic bricks and has a gabled roof and counter skylights. The agricultural building will be used for stabling horses, parking agricultural machinery and storing hay and feed. Stables are designed as a timber frame construction with a supporting frame made of timber pillars coated with the Fermacell boards. The building has a gabled roof with a skylight above the horse boxes for ventilation. The thesis contains drawings and technical documentation and it is composed as an implementation project.

Hyperbranched poly(ethylene imine) with Mw 5,000 and 25,000 Da and different degrees of substitution with maltose (PEI-Mal) was firstly described by Appelhans et al. Its biocompatibility and the potential to complex anionic molecules was demonstrated previously. In this study, the characterisation of host-guest interactions of PEI-Mal with various anionic water-soluble guest molecules with aromatic moieties in the structure (adenosine triphosphate, rose bengal, and acid red 26) in solution was provided. Also, a multicomponent drug@PEI-Mal@hydrogel system was achieved.

<p>Managers within the hospitality industry are often required to handle irate guests through various service-recovery situations and thus are exposed to frequent guest aggression. Consequently, manager work is associated with high stress and anxiety. This study used several theories to understand the complex landscape of manager stress and anxiety within the hospitality industry. The Conservation of Resource Theory (Hobfoll, 1989), Stress as Offense to Self Theory (Semmer et al., 2007), and the Social Exchange Theory (Baumeister & Leary, 2005) are used as the foundation to delineate the roles of guest aggression and workplace social support played in reducing manager turnover intention through stress and anxiety. The study results identify that stress and anxiety are vital in impacting turnover intention; however, only certain forms of workplace social support (such as appraisal support) moderate the relationship in such a way that turnover intention decreases.</p> <p>The study design utilized a moderated-mediation analysis with a two-time cross-sectional survey. Respondents were guest-facing managers in various hospitality organizations, including restaurants, hotels, and clubs. Two hundred and sixty-three participants completed the first and second waves of the survey, and after data cleaning, a total of 260 usable responses remained. This study employed Hayes' (2018) mediation analysis model 4 and the moderated mediation analysis model 58 to test all hypotheses.</p> <p>This study shows that guest aggression is a significant predictor of turnover intention, and anxiety mediates the relationship leading to turnover intention. At the same time, stress only has a direct effect itself on turnover intention. In addition, this study found that some forms of workplace social support increased turnover intention, while supervisor appraisal (words of affirmation) moderated the relationship. Ultimately, this study helps guide organizations in making decisions that may reduce managers' intention to quit while providing a foundation for future researchers to examine how workplace social support uniquely affects managers.</p>

Most of the computer simulations of molecules in Metal-Organic Frameworks (MOFs) to be found in the literature are done with rigid framework. But, Molecular Dynamics (MD) simulations of the self-diffusivity, Ds, of ethane within the one-dimensional 4.5 Å channels of the MOF type Zn(tbip)(H2 tbip = 5-tert-butyl isophthalic acid) presented in this work have shown not only quantitative, but also qualitative, differences in the Ds values for fixed and flexible lattices. Particularly, the dependence of Ds upon the concentration of molecules, c, is strongly influenced by the lattice flexibility. The reasons for this influence are investigated with the aid of probability density plots, free energy landscapes and barriers, along with a determination of the structural changes accompanying increasing c. It is found that for flexible lattices, the tighter, more constrained parts of the channels become wider at higher c; this allows more molecules to diffuse in the central region of the channels. The investigations for Zn(tbip) have been extended to three equimolar mixtures of ethane/ethane, CO2/ethane and CO2/methanol. The simulations take into account the lattice flexibility. The diffusional characteristics are discussed in relation to molecule properties and lattice geometry. The results show that Zn(tbip) may be a useful material for separating methane/ethane and CO2/ethane mixtures at low concentrations, and CO2/methanol mixtures at high concentrations. The temperature and concentration dependence of the self-diffusivity of propane diffusion in Zn(tbip) have been investigated as well by performing normal MD and hyper-MD with bias potential simulations. The obtained temperature dependence of the self-diffusivities is analyzed using an Arrhenius relationship, yielding the activation energy to be 9.53 kJ/mol and the pre-exponential factor to be 4.48×10-9 m2s-1. Using this hyper-MD method, interesting mechanisms of the propane molecules able to pass each other and exchange their sites in the channels can be observed. Because of mutual hindrance of propane molecules, the propane self-diffusivities decrease with increasing concentration.

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Smart technology has become very extensive and popular in many areas of our lives in the last few years. Their role is to make life and activities performed by the user easier, faster, better and more interesting. Smart technology has been used for years in areas such as education, industry and transport. The response of the hospitality industry is to implement technology in hotels, usually the more luxurious ones, that improves the operation of employees and is a convenience for hotel guests. The name of this concept is a smart hotel, which is similar to the already existing smart house and smart city concepts. The purpose of the study was to examine the concept of smart hotel and investigate the impact that smart technology has on guests’ satisfaction, privacy and service quality. The study was conducted using mixed methods research whereby both qualitative and quantitative data were collected in parallel, analyzed individually and then linked with each other. Qualitative data collection constituted of in-dept interviews with hotel employees and hotel guests, and the quantitative part of the study was based on the online survey with hotel guests. The main findings are a proposal definition of a smart hotel, and the belief that smart technology contributes to a better quality of provided services by employees and increases the grade of satisfaction among guests. However, the result also shows that a greater role of hotels is needed in order to reduce the disproportion of equal access to smart technology for all hotel guests.