Made available in DSpace on 2016-04-04T18:29:41Z (GMT). No. of bitstreams: 1 Renato Marchi.pdf: 1336693 bytes, checksum: bcdd5e2f052a29bb390cf3fc87b8af07 (MD5) Previous issue date: 2008-02-12 / Bipolar disorder (BD) is associated with ps ychosocial and family relationships disturbing, mortality and economic burden high rates . The treatment aims the acute episodes and prevents new episodes. There are high rates of non-adherence in BD. The objective of this study was to develop and validate a clinical rating scale capable to predict the patient compliance to treatment in BD in both gend ers. The procedure involved the search in pertinent scientific literature for reports of factors of non-adherence of bipolar patients, analysis of patients during pilot studies and contact with professionals who deal with those patients in order to develop a comprehensive list of possible symptoms. This procedure was followed by items' selection and testing of the preliminary form of the clinical rating scale. The scale was analyzed statistically. Reliability study showed a high level of internal consistency. Factor analysis revealed five factors related to the clinical treatment: behaviors and beliefs of the patient, therapeutic alliance, therapeutic procedures, association of psychotherapy interventions and adverse effects of drug therapy. Predictive validation showed that items' factors were able to measure the non - adherence to treatment. It was concluded that the Clinical Rating Scale to Predict the Compliance to Treatment in Bipolar Disorder can be considered a valid instrument to predict the patient compliance to medical treatment . / O Transtorno Bipolar do Humor (TBH) est? associado a altas taxas de desajustes psicossociais e familiares, mortalidade e preju?zos econ?micos. O tratamento visa o controle de epis?dios agudos e preven??o de novos epis?dios. As taxas de n?o - ades?o ao tratamento s?o altas em TBH. Este trabalho teve por objetivo elaborar e validar uma escala de avalia??o clinica , capaz de indicar a probabilidade de ades?o ao tratamento medico clinico dos pacientes bipolares de ambos os g?neros. O procedimento foi constitu?do de levantamento dos fatores ligados a n?o-ades?o ao tratamento em TBH na literatura pertinente, analise de pacientes bipolares durante estudo piloto, analise por juizes, sele??o dos itens e aplica??o da escala em sua fase inicial, para subseq?ente an?lise psicom?trica. A analise de precis?o do instrumento evidenciou n?vel satisfat?rio de consist?ncia interna. Extra?ram-se cinco fatores de acordo com a analise fatorial explorat?ria, ligados ao tratamento medico clinico: atitudes e cren?as do paciente, alian?a terap?utica, procedimentos terap?uticos, associa??o de interven??es psicoter?picas e efeitos adversos dos psicof?rmacos. A valida??o preditiva revelou que os itens referentes a tais fatores medem a n?o-ades?o ao tratamento. Conclui -se que a ECPAT-TBH pode ser considerada um instrumento v?lido para prever a ades?o ao tratamento m?dico.

Made available in DSpace on 2014-12-17T15:38:51Z (GMT). No. of bitstreams: 1 MarciaTMR.pdf: 675691 bytes, checksum: 8421c03f2a9a714352355d7c7ea5ed53 (MD5) Previous issue date: 2003-06-26 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The high blood pressure is a multifactorial chronic disease which possesses emotional and social features in the illness appearance and evolution and in the adherence to the treatment which involves a decision-making through patient so that he or she process the necessary changes on harmful living habits. Adhesion, traditionally, it is referred to the patient to answer to the doctor orientations or of other health professional, about the appearance to the appointment with a doctor, about the use of medicine or lifestyle changes and maintaining this adhesion is the main problem to be overcame. It is expected the adhesion will ever be a continual, stable and satisfactory action, disregarding the complexity of subjectivity processes which permeate the sicken. This research aimed to investigate the difficulties which the person with high blood pressure has to adhere to the treatment, from the signification processes which give sense to the actions dealing with the adhesion. The study was carried out with 48 users of assistance program to the high blood pressure patient from Hospital Universit?rio from Natal RN, between 40-65 age. The answers were submitted to a double analysis process: 1) answer systematization in categories and codes and admission in statistical program SPSS (Statistical Package of Social Science), for generation of descriptive statistics; 2) Sense and signification analysis which permeated the deepener statement and interpretatively. The greater difficulties found are present on low-salt and law-calorie diets, in the dealing with everyday feeling and stress, being these factors cited as direct motive to the high blood pressure, regardless of interviewee s sex. It is observed there is not adhesion, but adhering, as an experienced everyday process. This work contributes with its results, assessing the used strategies by program with the aim of increasing the adhesion rates / A Hipertens?o Arterial ? uma doen?a cr?nica, multifatorial, possuindo caracter?sticas emocionais e sociais implicadas no aparecimento e evolu??o da doen?a e na ader?ncia ao tratamento, que envolve uma tomada de decis?o por parte do seu portador para que sejam processadas as mudan?as necess?rias nos h?bitos de vida nocivos. Ades?o, tradicionalmente, refere-se ao paciente atender ?s orienta??es do m?dico ou de outro profissional de sa?de, no comparecimento ?s consultas marcadas, no uso do medicamento ou mudan?as de estilo de vida e manter esta ades?o ? o grande problema a ser vencido. Espera-se que a ades?o seja uma a??o cont?nua, est?vel e satisfat?ria sempre, desconsiderando a complexidade dos processos de subjetiva??o que permeiam o adoecer. A pesquisa objetivou investigar as dificuldades que a pessoa portadora de hipertens?o tem de aderir ao tratamento, a partir dos processos de significa??o que d?o sentido ?s a??es lidando com a ades?o. O estudo foi realizado com 48 usu?rios do programa de assist?ncia ao hipertenso do Hospital Universit?rio de Natal/RN, com idade entre 40 e 65 anos. As respostas foram submetidas a um duplo processo de an?lise: 1) sistematiza??o das respostas em categorias e c?digos e ingresso no programa estat?stico SPSS (Statistical Package of Social Science), para gera??o de estat?sticas descritivas; 2) an?lise dos sentidos e significados que permearam os depoimentos de forma mais aprofundada e interpretativa. As maiores dificuldades encontradas est?o presentes na dieta hiposs?dica e hipocal?rica, no lidar com sentimentos e stress da vida di?ria, sendo esses fatores citados como motivo direto para o aumento da press?o arterial, independentemente do sexo dos entrevistados. Observou-se que n?o existe ADES?O e sim ADERINDO, como um processo vivenciado diariamente. Este trabalho contribui, com os seus resultados, para avaliar as estrat?gias utilizadas pelo programa, visando um aumento dos ?ndices de ades?o

Made available in DSpace on 2014-12-17T14:06:48Z (GMT). No. of bitstreams: 1 TacioDBG.pdf: 1757176 bytes, checksum: 3cabe1cee719475706ab99a62bb862f6 (MD5) Previous issue date: 2007-11-13 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The work presents the effect of plasma treatment when applied in fibers or carbon/glass posts in the adhesion fiber/resin and posts/cement. This has for objective the modification of the surface of the fibers, as well as the wettability of the posts, seeking the improvement of the adhesion and of the connection fiber/resin in the processing of polymeric composites reinforced with the same ones. 120 posts (Reforpost) were used and 30 meters of fibers of carbon and of glass (Fibrex), of the company Angelus. The samples were divided in three groups of 40 specimens: GROUP I - 20 posts of glass fiber and 20 of carbon without treatment to it shapes, GROUP II -20 posts of glass fiber and 20 of carbon treated to it shapes in the surface and GROUP III - 20 posts of glass fiber and 20 of carbon make with fibers in natura after plasma treatment. The plasma treatment was accomplished with oxygen and with temperature in the camera fixed at 200?C, for one hour of exhibition. The posts and the fibers were characterized before and after the treatment. The wettability was measure by pendent drop method, and interface fiber/resin and posts/cement were observed by optical and electronic microscopy. It was observed that both wettability and texture were increased with plasma treatment / O presente trabalho aborda o tratamento superficial a plasma de pinos e fibras de carbono e de vidro, para uso odontol?gico. Este tem por objetivo a modifica??o da superf?cie das fibras, bem como a superf?cie dos pinos, visando a melhoria da ades?o fibra/resina e pino/cimento. Foram utilizados 120 pinos (Reforpost) e 30 metros de fibras de carbono e de vidro (Fibrex), da empresa Angelus. As amostras foram divididas em tr?s grupos de 40 esp?cimes: GRUPO I - 20 pinos de fibra de vidro e 20 de fibra de carbono sem tratamento em plasma, GRUPO II -20 pinos de fibra de vidro e 20 de carbono tratados a plasma na superf?cie e GRUPO III- 20 pinos de fibra de vidro e 20 de carbono confeccionados a partir do tratamento em plasma da fibra in natura . O tratamento em plasma foi realizado com atmosfera de oxig?nio durante 1 hora. Tanto as fibras como os pinos foram colocados a uma dist?ncia de 7cm, de modo a evitar o aquecimento dos mesmos. A temperatura do catodo foi de 200?C. Os pinos e as fibras foram caracterizados antes e ap?s o tratamento, atrav?s de metalografia, microscopia ?tica e eletr?nica de varredura. Em seguida, foram realizados ensaios de capilaridade das fibras, tor??o e molhabilidade nos pinos. Os resultados mostram que o tratamento empregado modifica a superf?cie das fibras, aumenta a molhabilidade dos pinos, modifica a textura superficial de ambos quando em compara??o com as amostras sem tratamento, como tamb?m demonstra um aumento da ades?o das interfaces fibra/matriz e pino/cimento resinoso

Made available in DSpace on 2014-12-17T14:47:07Z (GMT). No. of bitstreams: 1 SamillyMDL_DISSERT.pdf: 2432551 bytes, checksum: 39a06155ddac056ef776f3527c721cf7 (MD5) Previous issue date: 2014-08-01 / The therapeutic adherence is still a big problem among people with venous ulcers (VU) because the treatment is long, expensive and demand changes in lifestyle. In this context, this study aims to examine treatment adherence and quality of life (QOL) of people with VU assisted at primary health care. This is an analytical, cross-sectional study with a quantitative approach to treatment and data analysis. The study had the scenario 13 Family Health Units and 02 Units Mixed of Natal. The target population consisted of 44 persons with UV indicated by the teams of the Family Health Strategy between February and April 2014. Three instruments were used: an instrument to characterize the sociodemographic, health and care aspects, the Multidimensional Scale of Adherence Therapy composed of the dimensions: healthy lifestyle, compressive therapy and neurovascular monitoring and the Charing Cross Venous Ulcer Questionnaire (CCVUQ) that evaluates QOL in persons with VU composed by the domains: Total Score, Social Interaction, Domestic Activities, Aesthetics and Emotional State. The study was approved by the Ethics Committee in Research of the Federal University of Rio Grande do Norte, CAAE: 07556312.0.0000.5537. The data concerning the sociodemographic characteristics showed that there was a predominance of females (65.9%), age range as of 60 years (59.1%) and income of up to 1 minimum wage (81.8%). With the characterization of health, it was evident that most people reported chronic diseases (63.6%), sleep more than 6 hours (81.8%), present pain (81.8%), denying alcoholism (86 4%) and smoking (77.3%) and showed a number greater than or equal to 1 (77.3%) recurrences. Concerning the therapeutic adherence was found that in the dimension compressive therapy there poor adherence. No associations between the domains of adherence and sociodemographic and health variables were found. Was observed, however, better adherence among individuals without pain and with higher schooling. When analyzed the averages of the dimensions of therapeutic adherence with the care characteristics there was statistical significance between: adherence to compression therapy and guidance for use of compressive therapy (p = 0.002) and guidance for regular exercise (p = 0.026). Considering the mean of total score of CCVUQ (mean 51.47, SD 18.33) it is observed that the overall QOL of respondents has approximate value of the median of the scale (50). The mean of the domain Social Interaction (mean 44.23, SD 21.38) and Domestic Activities (mean 45.70, SD 23.21) were those who reported better QOL. There were weak correlations but significant between adherence to healthy lifestyle and Domains Total Score (p = 0.012), social interaction (p-value = 0.048), Aesthetics (p-value = 0.025) and Emotional State (0.017) of CCVUQ. From the data analysis it is concluded that among people with UV, there poor adherence to compressive therapy. Furthermore, we found no statistically significant association between treatment adherence and sociodemographic and health characteristics. It is added that there was a correlation between the healthy lifestyle dimension and domains CCVUQ / A ades?o terap?utica ainda ? um grande problema entre pessoas com ?lceras venosas (UV), uma vez que a presen?a dessa les?o demanda um tratamento longo, dispendioso, e altera??es no estilo de vida. Nesse contexto, este estudo tem como objetivo geral analisar a ades?o ao tratamento e a qualidade de vida (QV) das pessoas com UV atendidas na aten??o prim?ria ? sa?de. Trata-se de estudo anal?tico, transversal, com abordagem quantitativa de tratamento e an?lise de dados. O estudo teve como cen?rio 13 Unidades de Sa?de da Fam?lia e duas Unidades Mistas da cidade de Natal. A amostra foi composta por 44 pessoas com UV indicadas pelas equipes da Estrat?gia Sa?de da Fam?lia entre fevereiro e abril de 2014. Utilizaram-se tr?s instrumentos: instrumento de caracteriza??o dos aspectos sociodemogr?ficos, de sa?de e assistenciais; a Escala Multidimensional de Ades?o Terap?utica, composta pelas dimens?es: estilo de vida saud?vel, terapia compressiva e vigil?ncia neurovascular; e o Charing Cross Venous Ulcer Questionnaire (CCVUQ), que avalia QV em pessoas com UV atrav?s de quatro dom?nios: Intera??o Social, Atividades Dom?sticas, Est?tica e Estado Emocional, al?m de gerar um Escore Total. A pesquisa obteve parecer favor?vel do Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte, CAAE: 07556312.0.0000.5537. Os dados referentes ? caracteriza??o sociodemogr?fica demonstraram que houve predomin?ncia do sexo feminino (65,9%), da faixa et?ria a partir de 60 anos (59,1%) e renda de at? 1 sal?rio m?nimo (81,8%). A caracteriza??o de sa?de evidenciou que a maioria das pessoas relatou doen?as cr?nicas associadas (63,6%), sono maior que 6 horas (81,8%), presen?a de dor (81,8%) e mais de uma recidiva (77,3%). A maior parte negou etilismo (86,4%) e tabagismo (77,3%). Em rela??o ? ades?o terap?utica verificou-se pior ades?o na dimens?o terapia compressiva. N?o foram encontradas associa??es entre os dom?nios da ades?o e as vari?veis sociodemogr?ficas e de sa?de. Observou-se, no entanto, melhor ades?o entre os indiv?duos sem dor e com maior escolaridade. Ao analisar a rela??o das dimens?es da ades?o terap?utica com as caracter?sticas da assist?ncia observou-se associa??o entre: ades?o ? terapia compressiva e orienta??es para uso de terapia compressiva (p-valor = 0,002) e para exerc?cios regulares (p-valor = 0,026). Considerando a m?dia do escore total do CCVUQ (m?dia 51,47 e DP 18,33) observa-se que a QV geral dos pesquisados tem valor aproximado ao da mediana da escala (50). Os participantes apresentaram melhor qualidade de vida nos dom?nios Intera??o Social e Atividades Dom?sticas. Verificaram-se correla??es significativas, por?m fracas, entre ades?o ao estilo de vida saud?vel e o Escore Total (p = 0,012), Intera??o Social (p = 0,048), Est?tica (p = 0,025) e Estado Emocional (p = 0,017) do CCVUQ. A partir da an?lise dos dados conclui-se que a maior dificuldade de ades?o entre as pessoas com UV refere-se ? terapia compressiva. Observou-se correla??o apenas entre a dimens?o estilo de vida saud?vel e os dom?nios do CCVUQ

Made available in DSpace on 2014-12-17T13:51:38Z (GMT). No. of bitstreams: 1 FernandoPSO_TESE.pdf: 2860613 bytes, checksum: c176b9a96ce41e332623f6fc2475170a (MD5) Previous issue date: 2014-08-11 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / This study approaches bureaucratic organizational structures with the aim to understand the adherence procedure to virtual technologies in the stricto sensu educational administrative process. Thus, the author navigates through the formation of these organizations in Brazil with the intent to demonstrate the bureaucratic organizational culture and the consequent form of domination of those who detain power. In this epistemological construction, the author explores the culture s bureaucratic environment and the organizational power. In the analyses, it was observed the technological phenomenon in the ODL s administrative environment, which can explain the adherence procedure to structures and technological instruments for stricto sensu courses that, hypothetically, dilutes the traditional inherited organizational axiom. Therefore, it was utilized as object of study the Professional Master s degree in National Scale Public Administration PROFIAP, hence analyzing the documental content and the legislation related to institutionalization as well as the positioning of professors/coordinators and of the director of CAPES/MEC. Considering this axioms, it was concluded that the bureaucratic structures can admit ODL in the stricto sensu s environment. However, this can only be done as long as the adherence does not imply in a dilution of the traditional forms of power and institutional bureaucratic inherited dominance, as well as the alleged hegemony of the governmental structure in the educational administration adopted in person by the stricto sensu courses in Brazil / O estudo aborda as estruturas organizacionais burocr?ticas, a fim de compreender a forma da ades?o ?s tecnologias virtuais no processo administrativo-educacional para o stricto sensu. Para tanto, o autor navega na forma??o das organiza??es no Brasil, visando demostrar a cultura organizacional burocr?tica e a consequente forma de dom?nio daqueles que det?m o poder. Nessa constru??o epistemol?gica, o autor explora o ambiente burocr?tico da cultura e poder organizacional. Para tal an?lise, observa-se o fen?meno da tecnologia no ambiente administrativo da EAD, o qual pode explicar a forma da ades?o ?s estruturas e instrumentos tecnol?gicos para o stricto sensu, que, em tese, dilui o axioma organizacional tradicional herdado. Portanto, foi utilizado, enquanto objeto de estudo, o caso do Mestrado Profissional em Administra??o P?blica em Rede Nacional PROFIAP, analisando o conte?do documental e da legisla??o relacionada ? institucionaliza??o e o posicionamento de professores/coordenadores e diretor da CAPES/MEC. Concluiu-se, sob tais axiomas, que as estruturas burocr?ticas podem admitir, sim, a EAD no ambiente do stricto sensu. Isso desde que a ades?o n?o conote diluir as formas tradicionais de poder e dom?nio burocr?tico institucional herdado, assim como a suposta hegemonia da estrutura de governan?a da administra??o na educa??o adotada presencialmente pelo stricto sensu no Brasil

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2015-12-02T19:49:15Z No. of bitstreams: 1 DaniloCavalcanteBraz_TESE.pdf: 28469447 bytes, checksum: 99cbc13da13290f58060715e274f57b9 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2015-12-09T00:10:10Z (GMT) No. of bitstreams: 1 DaniloCavalcanteBraz_TESE.pdf: 28469447 bytes, checksum: 99cbc13da13290f58060715e274f57b9 (MD5) / Made available in DSpace on 2015-12-09T00:10:10Z (GMT). No. of bitstreams: 1 DaniloCavalcanteBraz_TESE.pdf: 28469447 bytes, checksum: 99cbc13da13290f58060715e274f57b9 (MD5) Previous issue date: 2014-06-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / A utiliza??o de materiais biom?dicos tendo como constituinte os nitretos, ?xidos e oxinitretos de tit?nio vem crescendo devido ?s propriedades biocompat?veis. Sendo assim, superf?cies de tit?nio foram tratadas termoquimicamente em atmosferas de plasma contendo misturas de Ar+N2+O2 e estudada a influ?ncia das diferentes superf?cies sobre a resposta da ades?o e agrega??o plaquet?ria. Foi verificado por an?lises de difra??o de raios-X com incid?ncia rasante (GIXRD) e espectroscopia micro Raman a presen?a de nitretos, oxinitretos e ?xidos de tit?nio, obtendo assim, diferentes propriedades em cada superf?cie. No caso da rugosidade, as amostras tratadas somente com arg?nio e nitrog?nio, foram as que obtiveram maior valor, sendo que o processo de sputtering ocasionado por esses dois gases ocasionou menores valores nos ensaios de nanodureza. Na an?lise de ?ngulo de contato com a ?gua, apesar de todas apresentarem car?ter hidrof?lico, houve uma diminui??o no valor do ?ngulo para amostras tratadas com adi??o de apenas com nitrog?nio ou oxig?nio, em compara??o com aquelas oxinitretadas. O ensaio de ?ngulo de contato tamb?m foi realizado com o plasma sangu?neo e foi obtida uma tend?ncia ao mesmo comportamento com a ?gua, ou seja, maiores valores para as superf?cies oxinitretadas. Com respeito aos ensaios de ades?o e agrega??o plaquet?ria verificou-se que as atmosferas contendo menor concentra??o de arg?nio (menor dilui??o) a distancia m?dia entre as plaquetas foi menor para amostras nitretadas e oxidadas quando comparadas com as amostras oxinitretadas. Para o grupo com maior concentra??o de arg?nio, al?m de apresentarem menores distancias m?dias entre as plaquetas, verificou-se maior tamanho de agregrado plaquet?rio, indicando o inicio da forma??o de trombos na superf?cie do material. A morfologia das plaquetas tamb?m informa o inicio do processo de agrega??o, e para as amostra nitretadas, as plaquetas apresentaram forma??o de psed?podes indicando a uma maior ader?ncia a superf?cie.

Made available in DSpace on 2014-12-17T15:39:01Z (GMT). No. of bitstreams: 1 MariannaCMDL_DISSERT.pdf: 1367439 bytes, checksum: d091551e753c01139c7e5672341527aa (MD5) Previous issue date: 2013-05-10 / the Millon Behavioral Medicine Diagnostic is an instrument, developed from a consensus among health professionals, to identify psychological factors that may compromise the conducting of medical treatment in order to allow a better adhesion. As it has been one of the most used tools to assess bariatric surgery, the objective of this research is to verify the evidence validity of Millon Behavioral Medicine Diagnostic (MBMD) for psychological assessment of candidates for bariatric surgery. Method: males and females volunteers, aged 18 to 70, grouped in 150 patients admitted for surgical procedures or suffering from chronic diseases (control group) and 426 patients candidates for bariatric surgery, contacted in person or by the internet. For the study in the face group were also administered Millon Index of Personality Styles (MIPS), the Millon Clinical Multiaxial Inventory-III (MCMI-III) and the General Health Questionnaire of Goldberg, just in bariatric surgery patients. Results: there are indicators of semantic adaptation of the instrument, with 27 factors in five areas of the instrument, all with satisfactory levels of validity. The reliabitity indicators were satisfactory in 18 of the 32 scales that comprise the MBMD, while relations with the other three instruments showed significant variations compared to the original indicators. The MBMD was sensitive to differences between groups about gender, age, education, marital status, body mass index, comorbidities and chronic disease patients and with or without obesity. The use of this instrument in the assessment of candidates for bariatric surgery presents indicators of validity in view the limitations as to the realiability of certain scales / o Millon Behavioral Medicine Diagnostic ? um instrumento elaborado a partir do consenso entre profissionais de sa?de, visando identificar fatores psicol?gicos que venham a comprometer tratamentos m?dicos para que sejam conduzidos de modo a viabilizar uma melhor ades?o. Como tem sido um dos instrumentos mais utilizados para avalia??o em cirurgia bari?trica em outros pa?ses, o objetivo desta pesquisa ? verificar evid?ncias de validade do Millon Behavioral Medicine Diagnostic (MBMD) para avalia??o psicol?gica de candidatos a cirurgia bari?trica. M?todo: volunt?rios dos sexos masculino e feminino, com idades entre 18 a 70, agrupados em 150 pacientes internados para procedimentos cir?rgicos ou portadores de doen?as cr?nicas (grupo controle) e 426 pacientes candidato ? cirurgia bari?trica, contatados presencialmente ou por interm?dio de uma p?gina na internet. Para os estudos tamb?m foram administrados no grupo presencial de bari?trica o Millon Index of Personality Styles (MIPS), o Millon Clinical Multiaxial Inventory-III (MCMI-III) e o Question?rio de Sa?de Geral de Goldberg, apenas nos pacientes de cirurgia bari?trica. Resultados: h? indicadores de adapta??o sem?ntica do instrumento, com 27 fatores em seus cinco dom?nios, todos com ?ndices satisfat?rios de validade. Os indicadores de precis?o se mostraram satisfat?rios em 18 das 32 escalas que comp?em o MBMD, ao passo que as rela??es com os outros tr?s instrumentos apresentaram varia??es importantes se comparados aos indicadores originais. O MBMD se mostrou sens?vel ?s diferen?as entre grupos quanto ao sexo, faixa et?ria, escolaridade, estado civil, ?ndice de Massa Corporal (IMC), presen?a de comorbidades e em portadores de doen?as cr?nicas com e sem obesidade. O uso deste instrumento nas avalia??es de candidatos ? cirurgia bari?trica apresenta indicadores de validade tendo em vista as limita??es quanto ? precis?o de determinadas escalas

Made available in DSpace on 2014-12-17T14:03:41Z (GMT). No. of bitstreams: 1 VanessaOS.pdf: 1126102 bytes, checksum: dba464c890585c6be32a3fd2dc600a81 (MD5) Previous issue date: 2006-06-12 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Sulfated Polysaccharides with unique chemical structures and important biological activities has been found in a diversity of sea invertebrates. For that, to exist a huger interest on the biotechnology field in the research theses sulfated compounds isolated from sea organisms. Despite the privileged brazilian position for these compounds attainment, there are still a few scientific informations about the isolated substances and their biological activities. A head the displayed, the present work has for objectives, to evaluate the pharmacological properties of the glycosaminoglycans isolated from the sea shrimp Litopenaeus schimitti on homeostasis, blood coagulation, leukocytes migration and platelet/leukocyte adhesion. For this, yhe glycosaminoglycans were extracted from crustacean tissues by proteolysis, fractionation with acetone and later submitted to pharmacological assays. The crustacean tissues showed compounds heparin-like, with anticoagulant activity of 45 IU/mg and 90 IU/mg, respectively. These molecules showed low residual hemorrhagic effects in the tested concentration (100 ?g/mL), when compared to unfractionated commercial heparin (UFH). Another dermatan sulfate-like compound, predominately constituted for disulfated disaccharides, was isolated from crustacean abdomen. This compound showed an efficient effect on leukocytes migration inhibition, in the concentration of 15 ?g/mL, reducing the cellular infiltration in 65% when compared to the controlled animals. In this same concentration, the DS reduced in 60% the protein concentration of the peritoneal exudates. In the concentration, this compound of 0.5 mg/mL, it was capable to reduce in 40% platelet/leukocytes adhesion. Our data demonstrate that these sulfated polysaccharides isolated from the shrimp L. schimitti will can be used as bioactive compounds, appearing as active principles for pharmacological development, anticoagulants and inflammatory response regulators / Polissacar?deos sulfatados com caracter?sticas estruturais distintas e importantes atividades biol?gicas t?m sido encontrados em uma diversidade de invertebrados marinhos. Por isso existe um grande interesse no campo da biotecnologia na pesquisa destes compostos sulfatados isolados de organismos aqu?ticos. No entanto, apesar da posi??o privilegiada do Brasil para a obten??o destes compostos, ainda s?o poucas as informa??es cient?ficas sobre as subst?ncias isoladas e suas atividades biol?gicas. Diante do exposto, este presente trabalho teve por objetivos avaliar os potenciais farmacol?gicos dos glicosaminoglicanos (GAGs) isolados do camar?o marinho Litopenaeus schimitti, sobre a hemostasia, coagula??o sang??nea, migra??o leucocit?ria e ades?o celular. Para isso os GAGs foram extra?dos dos tecidos do crust?ceo mediante prote?lise, fracionamento com acetona e posteriormente submetidos aos ensaios farmacol?gicos. Os tecidos do crust?ceo, abd?men e cefalot?rax, apresentaram compostos semelhantes ? heparina (heparin?ides) com atividade anticoagulante de 45 UI/mg e 90 UI/mg, respectivamente. Estas mol?culas apresentaram baixo efeito hemorr?gico residual na concentra??o de 100 ?g/mL, quando comparada com a heparina comercial n?o fracionada (HNF). Um outro composto semelhante ao dermatam sulfato (DS), constitu?do predominantemente por dissacar?deos dissulfatados foi isolado do abd?men do crust?ceo. Este composto apresentou, na concentra??o de 15 ?g/?L, uma inibi??o significativa (P<0.01) da migra??o leucocit?ria, reduzindo a infiltra??o celular em 65% quando comparado com os animais controle. Nessa mesma concentra??o o DS reduziu em 60% a concentra??o de prote?nas do lavado peritonial. As an?lises qualitativas da composi??o celular do exudato peritonial foram similares ao encontrado para os animais controles em todas as concentra??es testadas. Na concentra??o de 0,5 mg/mL foi capaz de reduzir em 40% a ades?o das plaquetas aos leuc?citos. Os dados obtidos demonstram que estes polissacar?deos sulfatados isolados do camar?o L.schimitti podem vir a ser utilizados como compostos bioativos, podendo surgir como princ?pios ativos para o desenvolvimento de f?rmacos, anticoagulantes e moduladores da resposta inflamat?ria

Made available in DSpace on 2014-12-17T15:32:31Z (GMT). No. of bitstreams: 1 ManoelAGN_tese.pdf: 5283581 bytes, checksum: 65511a1dd2487deff44e8db44d2a0cf5 (MD5) Previous issue date: 2006-08-18 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / The objective of this study was perform by the streptoavidin-biotin technique an immunohistochemical analysis of ?2?1, ?3?1e ?5?1 integrins in 11 normal oral mucosa (NOM), 16 oral inflammatory fibroepithelial hyperplasia (OIFH) and 25 oral epithelial dysplasia (OED) (16 mild, 2 moderates and 7 severe), to determine if exists qualitative alteration in the expression of these integrins and if this guard relation with the oral epithelial modifications. It was observed that for the ?2?1 integrin the majority of the sample showed a predominantly intense labeling diffusely distributed in the intercellular contacts and the cytoplasm of cells of the basal and suprabasal layers, without difference of this profile between the different types of specimens, however with a trend to weak or loss of expression in 21.1% of the OEDs, being all the specimens that had not expressed this heterodimer, severe OEDs. For the ?3?1 integrin the majority of the sample showed a weak or absent labeling in basal layer. The ?5?1 integrin showed a predominant strong diffuse labeling in the intercellular contacts and cytoplasm in the suprabasal layer, with difference only in the labeling intensity between the types of specimens, inhabiting this difference in the OEDs, where 12 (48%) specimens had shown a weak labeling. It was concluded that the evaluated integrins can be involved in the cell-cell, cell-ECM interactions modulating the cellular differentiation and maintenance of the epithelial structural arrangement. The variable expression of the ?5?1 integrin in the OEDs, could suggest, respectively, a role of this molecule in the cellular survival, with intention to perpetuate the modified phenotype in these lesions, or a suppressor role on the modified phenotype due to lack of interaction of this molecule with the fibronectina of the MEC / Este estudo se prop?s analisar atrav?s da t?cnica da estreptoavidina-biotina a express?o imuno-histoqu?mica das integrinas ?2?1, ?3?1e ?5?1 em 11 esp?cimes de mucosa oral normal (MON), 16 de hiperplasia fibroepitelial inflamat?ria oral (HFIO) e 25 de displasia epitelial oral (DEO) (16 leves, 2 moderadas e 7 graves), procurando determinar se existe altera??o qualitativa na express?o destas integrinas e se a mesma guarda rela??o com as modifica??es sofridas pelo epit?lio oral. Para a integrina ?2?1 a maioria dos esp?cimes exibiu uma marca??o predominantemente intensa e difusa nos contatos intercelulares e no citoplasma celular das camadas basal e suprabasal, sem diferen?a desse perfil entre os diferentes tipos de esp?cimes, por?m com uma tend?ncia a fraca ou perda da express?o em 21.1% das DEOs, sendo todos os esp?cimes que n?o expressaram marca??o para este heterod?mero DEOs graves. Para a integrina ?3?1 a maioria da amostra exibiu uma marca??o fraca ou ausente predominantemente em camada basal. A integrina ?5?1 exibiu uma forte marca??o difusa nos contatos intercelulares e citoplasm?tica na camada suprabasal, com diferen?a apenas na intensidade de marca??o entre os tipos de esp?cimes, residindo essa diferen?a nas DEOs, onde 12 (48%) esp?cimes exibiram uma fraca marca??o. Concluiu-se que as integrinas avaliadas podem estar envolvidas nas intera??es c?lula-c?lula e c?lula-MEC que garantem a diferencia??o celular e manuten??o do arranjo estrutural tecidual. A vari?vel express?o da integrina ?5?1 nas DEOs, poderia sugerir, respectivamente, um papel dessa mol?cula na sobrevida celular, com o intuito de perpetuar o fen?tipo alterado nessas les?es, ou uma a??o supressora desse fen?tipo devido ? falta de intera??o desta mol?cula com a fibronectina da MEC