This diploma thesis explores problematic areas of patients with Huntington's disease in their performance during activities of daily living (ADLs) from the perspective of patients and their caregivers. The aim of the research was also to assess a possible correlation between cognitive impairment and the patient's performance in ADL. Twenty-five patients with their caregivers met the selection criteria for the research. There were used standardized assessment methods available in Czech: the Montreal Cognitive Assessment (MoCA), the Canadian Occupational Performance Measure (COPM) and the questionnaire for caregivers called Bristol Activities of Daily Living Scale (BADLS-CZ). The statistical analyses consisted of methods of the nonparametric statistics, qualitative analysis was processed by data categorizing. Caregivers reported more problematic areas in ADLs which was significantly confirmed in the statistical hypothesis testing (p <0,05). A significant correlation was seen between the results of the questionnaire and the results of the MoCA assessment (rSp = -0,620; p <0,05). For various reasons, patients with Huntington's disease did not mention as many problematic areas in performing ADL as their caregivers. Therefore, it is appropriate in clinical practice to supplement the assessment of the patient's...

Name and surname: Bc. Iveta Kovářová Supervisor: Mgr. Alice Oktábcová Thesis title: Summary of Principles and Recommendations for Stroke Patients and their Families after Discharge from Acute Stroke Units Background: Stroke is a very serious and common disease with a high mortality. It is important for patients to start rehabilitation as soon as possible. Early discharge allows stroke patients return home to continue rehabilitation in familiar surroundings. The responsibility for continued rehabilitation is in the hands of patients and their families and the main aim is to adjust to everyday life. Objective: The aim of this work is to create an educational material "Summary of Principles and Recommendations for Stroke Patients and their Families after Discharge from Acute Stroke Units", to help patients in the stroke problematics. This Summary includes information about stroke issues, stroke epidemiology, consequences and risks, practical advices, compensatory aids, possibilities of rehabilitation and information on social counseling, speech therapy and outpatient rehabilitation with relevant contacts. A case report in the practical part of this work tries to summarize possibilities of home occupational therapy and get a feedback on the educational material. Methods: This research work summarizes...

Fundamento: O crescimento da população idosa é um fenômeno mundial. O envelhecimento aumenta o risco para a ocorrência de doenças crônicas que resultam em graus variáveis de perda da independência funcional. A elevação da idade também pode acarretar a redução da independência funcional, tornando os idosos dependentes para a realização de atividades da vida diária (AVDs) e atividades instrumentais da vida diária (AIVDs). Objetivos: O objetivo desse estudo foi avaliar a capacidade funcional, determinando a prevalência de independência funcional e as características associadas em indivíduos idosos, em uma amostra representativa de Porto Alegre, RS, bem como identificar sua associação com qualidade de vida. Essa pesquisa é um dos braços do estudo da Síndrome de Obesidade e Fatores de Risco – SOFT. Participantes e Métodos: Nesse estudo transversal, de base populacional, de indivíduos idosos com 60 e 90 anos, selecionados através de amostragem por estágios múltiplos de conglomerados, em 106 dos 2157 setores censitários de Porto Alegre. Em entrevistas domiciliares aplicou-se um questionário padronizado, para investigar características socioeconômicas, demográficas, hábitos de vida, fatores de risco para doença cardiovascular, além do índice de independência nas atividades de vida diária, desenvolvido por Katz, em1969, e a escala de independência nas atividades instrumentais da vida diária, criado por Lawton e Brody, em 1983, assim como o questionário de qualidade de vida Short Form-12 (Ware,1994). Utilizou-se o módulo Complex Samples, do SPSS, para as análises dos dados, a fim de ajustar para o efeito da amostragem. Testaram-se diferenças entre proporções utilizando-se o teste do quiquadrado de Pearson, ao analisarem-se as prevalências; análise de variância ou co-variância para compararem-se médias, e análise de regressão logística múltipla, para cálculo da odds ratio e intervalo de confiança de 95%. As análises foram para um nível de significância de 5%. Resultados: A média de idade foi semelhante entre homens e mulheres idosos, e a distribuição de idade e sexo foi similar à do censo do Instituto Brasileiro de Geografia e Estatística. Além de maior escolaridade (8,8 vs. 6,6 anos), os homens referiram estar casados mais freqüentemente (75,7%) do que as mulheres (31,9%), as quais eram predominantemente viúvas ou separadas e residiam sozinhas em maior proporção. Com exceção de cor da pele e de residir sozinho, as demais características associaram-se significativamente com a idade. Identificou-se uma relação inversa entre idade e escolaridade e com o estar casado ou residir com companheiro, e uma associação direta com aposentadoria, separação ou viuvez e o uso de dispositivos para andar. Associação direta e independente de idade e sexo foi observada entre escolaridade e independência para realizar as atividades instrumentais, mas não para as atividades da vida diária. A prática de atividade física regular foi preditora de independência funcional nas AVDs e nas AIVDs. Esse estudo verificou tendência a maior independência entre os homens para o total de domínios das AVDs (94% vs. 89%; p=0,09), assim como das AIVDs (94% vs. 88%; p=0,04). Nos homens, observou-se a redução da independência funcional para realizar a maior parte das AVDs e AIVDs com o avançar da idade. Entre as mulheres, destaca-se, a redução da independência funcional com a idade em todas as atividades, exceto usar o telefone. O sexo masculino esteve associado, independentemente da idade, a maiores escores dos componentes físico e mental da qualidade de vida. A idade associou-se inversamente com o componente físico, enquanto a escolaridade o fez de maneira direta. Entretanto, nenhuma dessas características mostrou relação com o componente mental. Ser ativo fisicamente e possuir menor número de condições crônicas se associaram tanto ao escore do componente físico quanto mental, de maneira fortemente significativa. Conclusão: Os indivíduos idosos investigados no Estudo SOFT, representam a população idosa de Porto Alegre. As diferenças entre homens e mulheres idosos incluem características socioeconômicas, hábitos de vida e independência funcional. Os homens apresentam maior qualidade de vida do que as mulheres, independentemente da idade. / Background: The growth of the elderly population is a worldwide phenomenon. The elderly have chronic diseases that lead to various degrees of incapacity, which increases with age and makes them dependent in their activities of the daily living (ADLs), and in the instrumental activities of the daily living (IADLs). Objectives: the objective of the present study was to assess the functional capacity, verifing the prevalence of functional independence in a representative sample from southern Brazil, as well as to identify its association with life quality. The present research is one of the subprojects of the study of Syndrome of Obesity and Risk Fators (SOFT). Participants and methods: This cross-sectional population-based study of elderly individuals, aged 60 to 90 years old, was selected through a multistage probability sample including participants from 106, out of 2157, census sectors of Porto Alegre. A standard questionnaire was applied in the household in order to investigate socioeconomic and demographic characteristics, life habits, risk factors for cardiovascular disease, as well as the Index of Independence in the activities of the daily living, developed by Katz (1969) and the Instrumental Activities of Daily Living Scale created by Lawton and Brody (1983). The questionnaire Short Form-12 of quality of life (Ware, 1996) was also administered. Complex Samples module of SPSS was used for data analysis in order to take into account the design effect. The differences between proportions were tested by Pearson’s chi-square test; the variance and covariance analyses were used to compare the averages and the multiple logistic regression analysis to calculate the odds ratio and 95% confidence interval. Results: the age average was similar between elderly man and women, and the sex and age distribution was similar to the one of the census of the Brazilian Institute of Geography and Statistics. Besides higher scholarity (8,8 vs. 6,6 years), men referred to being married more frequently (75,7%) than women (31,9%), which were mainly widows or were separated and residing alone more often than men. Except for the color of the skin and the fact of residing alone or not, all the researched characteristics were significantly associated with age. An inverse relationship between age and scholarity and between age and being married or residing with a companion was identified, as well as a direct relationship between age and being retired, being separated or a widow, and needing a walking assistance device. Also, it was observed a direct relationship, regardless of age and sex, between scholarity and independence to perform instrumental activities of the daily living, not however, to the activities of daily living. The practice of regular physical activity was a predicting factor for functional independence in both ADLs and IADLs. This study verified a larger tendency for independence among men for the total of the ADLs (94% vs. 89% for women; p=0,09) and IADLs(94% vs. 88% for women; p=0,04) domains. The reduction of functional independence with age among men was observed in most of the ADLs and IADLs. Among women there was a reduction of functional independence in every activity, except the use of the telephone. The masculine sex was associated, regardless of age, to higher scores on the physical and mental components of quality of life. Age associated inversely with the physical component, while scholarity made it directly, but none of those characteristics showed any relationship with the mental component. Being physically active and possessing a lower number of chronic diseases associated significantly with both mental and physical scores. Conclusion: the elderly individuals investigated in the SOFT study are representative of the elderly population of Porto Alegre. The differences between elderly man and women include: socio-economical characteristics, life habits and functional independence. Men present a higher quality of life than women regardless of age.

Wealth, well-being and the standard of living of the population are among the most important topics of economic policy and statistics. This diploma thesis deals with statistical concepts of wealth measurement, especially the wealth of households. The aim of the thesis is to introduce various indicators that deal with the mentioned issues. This thesis will describe Gross Domestic Product, Household Consumption, EU-SILC Survey, or Alternative Indicators Assessing the Living Standard of the Population. The most important indicator characterizing the wealth of households will be the net worth of households. On the presented indicators I will describe the development of wealth of households in the Czech Republic since 1993. Another part of the thesis is focused on describing the relationship between net worth and other indicators of wealth through cointegration analysis of time series. In this cointegration analysis, the ADL model and the EC model will be used. The last part of the thesis is aimed at the international comparison of the wealth of households within selected European countries. For this comparison will be use a cluster analysis to build clusters of states with a similar household wealth.

The aim of this diploma thesis is to analyze the development of the prices of real estate in the Czech Republic. The thesis is divided into three main parts. The first one deals with the theoretical introduction to valuation of the real estate. Moreover, the thesis presents the current development of the prices of real estate on the Czech market. The last part focuses on co-integration analysis, within which an ADL model is created. This model serves as a base for an error correction model, which describes short-term as well as long-term relations within the time series. The explanatory variables are gross domestic product, consumer price index, the amount of finished apartments, interest rate of mortgage loans, common rate of unemployment, and average gross monthly income. It is the one-equation model which describes the relation among the already mentioned explanatory variables and the HPI index. analysis of the development of the prices of real estate

Ce travail doctoral a pour objectif d’analyser la signification du terme pardon dans tous ses emplois en langue française contemporaine. Le cadre théorique de la sémantique argumentative et de la TBS nous a permis de schématiser et de comprendre non seulement les différences de signification dans les emplois du nom commun mais également de discerner le mode d’action de la locution dans toutes ses fonctions argumentatives.Après avoir mis de côté ce qui appartient à la construction encyclopédique de la notion du pardon, à savoir le caractère d’un acte souverain, l’analyse argumentative a permis de décrire toute la richesse de la signification du terme en tant qu’état, processus et achèvement, ainsi que son caractère fondamental de promesse. Elle nous a également amené à dissocier d’un côté l’acte d’excuse performatif dans les échanges réparateurs et, de l’autre, des fonctions argumentatives variées dans les emplois conversationnels et de politesse.Notre démarche a permis d’enrichir les apports du dictionnaire et de l’approche lexicologique. A l’issue de l’analyse d’une centaine d’exemples, nous avons pu rapprocher le terme pardon de celui de paix. / This doctoral work aims to analyze the meaning of the term forgiveness in all its uses in contemporary French.The theoretical framework of the argumentative semantics and the TBS allowed us to schematize and understand not only the differences of meaning in the uses of the common noun but also to discern the mode of action of the phrase in all its argumentative functions.After setting aside what belongs to the encyclopedic construction of the notion of forgiveness, namely the character of a sovereign act, the argumentative analysis has allowed to describe all the richness of the meaning of the term as a state, a process and a completion, as well as its fundamental promise. It has also led us to dissociate on the one hand the performative excuse act in repairs and, on the other hand, various argumentative functions in conversational and politeness jobs.Our approach has enriched the contributions of the dictionary and the lexicological approach. At the end of the analysis of a hundred examples, we were able to bring the term forgiveness closer to that of peace.

Klassificering av dagliga aktiviteter (ADL) kan användas i system som bevakar människors aktiviteter i olika syften. T.ex., i nödsituationssystem. Med machine learning och bärbara sensor som samlar in data kan ADL klassificeras med hög noggrannhet. I detta arbete, ett proof-of-concept system med tre olika machine learning algoritmer utvärderas och jämförs mellan tre olika dataset, ett som är allmänt tillgängligt på (Ugulino, et al., 2012), och två som har samlats in i rapporten med hjälp av en android enhet. Algoritmerna som har använts är: Multiclass Decision Forest, Multiclass Decision Jungle and Multiclass Neural Network. Sensorerna som har använts är en accelerometer och ett gyroskop. Resultatet visar hur ett konceptuellt system kan byggas i Azure Machine Learning Studio, och hur tre olika algoritmer presterar vid klassificering av tre olika dataset. En algoritm visar högre precision vid klassning av Ugolino’s dataset, jämfört med machine learning modellen som ursprungligen används i rapporten. / Classifying Activities of daily life (ADL) can be used in a system that monitor people’s activities for different purposes. For example, in emergency systems. Machine learning is a way to classify ADL with high accuracy, using wearable sensors as an input. In this paper, a proof-of-concept system consisting of three different machine learning algorithms is evaluated and compared between tree different datasets, one publicly available at (Ugulino, et al., 2012), and two collected in this paper using an android device’s accelerometer and gyroscope sensor. The algorithms are: Multiclass Decision Forest, Multiclass Decision Jungle and Multiclass Neural Network. The two sensors used are an accelerometer and a gyroscope. The result shows how a system can be implemented using Azure Machine Learning Studio, and how three different algorithms performs when classifying three different datasets. One algorithm achieves a higher accuracy compared to the machine learning model initially used with the Ugolino data set.

京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第21306号 / 人健博第62号 / 新制||人健||5(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 黒木 裕士, 教授 恒藤 暁, 教授 坂井 義治 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM

The Electric/Electronic architecture of vehicle becomes more complex and costly, self-adaption can reduce the system, enhance the adaptive meanwhile reduce energy consumption and costs. The self-adaption needs the cooperation of both hardware and software reconfigurations, such that after the software is reconfigured the automotive network continues to fulfill the time constraints for time-critical applications. The thesis focuses on the real-time network reconfiguration. It uses EAST-ADL to model a real-time automotive system with timing events and constraints, which conforms to AUTOSAR timing extensions. The network media access is analyzed based on the model and a scheduling algorithm is developed. Then the concept is implemented by a use case, which is transformed from an EAST-ADL model to an executable simulation.

The Electric/Electronic architecture of vehicle becomes more complex and costly, self-adaption can reduce the system, enhance the adaptive meanwhile reduce energy consumption and costs. The self-adaption needs the cooperation of both hardware and software reconfigurations, such that after the software is reconfigured the automotive network continues to fulfill the time constraints for time-critical applications. The thesis focuses on the real-time network reconfiguration. It uses EAST-ADL to model a real-time automotive system with timing events and constraints, which conforms to AUTOSAR timing extensions. The network media access is analyzed based on the model and a scheduling algorithm is developed. Then the concept is implemented by a use case, which is transformed from an EAST-ADL model to an executable simulation.:1. Introduction 2. Research Fundamentals 2.1. AUTOSAR Specifications for Modeling Function Communication 2.2. Media Access Control in Real-time Network 3. Function Communication Model and Determination of Network Configuration 3.1. Function Communication Model 3.2. Scheduling Algorithm for Media Access 4. Implementation of Communication Model and Plugin for Model Transformation 4.1. EAST-ADL Modeling Language 4.2. Implementation of Function Communication Model in EAST-ADL 4.3. Model Transformation Plugin and Simulation Tool Integration 5. Evaluation of the Function Communication Model 5.1. Use-Case Model for Evaluation 5.2. Time Values of Use-Case Model 5.3. Analysis and Evaluation of Simulation Result 6. Conclusion and Outlook 6.1. Conclusion of the Work 6.2. Outlook of the Future Work A. OMNeT++ Simulation Log B. EAST-ADL Model to Artop Model Mapping Bibliography Nomenclature