La présente recherche a pour but d’examiner, de façon exploratoire, les transformations de l’écriture journalistique de la presse écrite au blogue. Le cadre théorique s’appuie sur trois thèmes : les transformations du journalisme, le journalisme à l’ère du Web 2.0 et l’écriture journalistique en mouvance. Puisque l’objectif de la recherche consiste à cerner les différences d’écriture entre la presse écrite et le blogue, la méthode préconisée est l’analyse de contenu. Celle-ci nous permet d’inventorier divers éléments d’articles journalistiques à l’étude, puis de les comparer. Le traitement des données s’est fait au moyen d’une grille d’analyse, composée de variables et d’indicateurs soigneusement choisis et répartis dans trois catégories d’analyse : grammaticale, structurelle et rhétorique. Les résultats colligés confirment que les articles de presse écrite et les billets de blogue des journalistes à l’étude diffèrent et donc que ceux-ci adoptent des stratégies rédactionnelles différentes selon le support pour lequel ils rédigent.

As man moved out on the internet, so did the companies. One of the most successful business models in the digital era is the digital platform. A digital platform acts as an intermediary on multi-sided markets and enjoys, amongst others, lucrative network effects. One of the main factors behind the great success of digital platforms is the usage of big data combined with algorithms that are enhanced by machine learning. However, as big data is becoming more and more indispensable for any modern company, questions have been raised about whether digital platforms should be able to withhold the massive amount of big data exclusively, or whether they could be forced to share it. This paper investigates these questions through the lens of EU-competition law, especially under Article 102 TFEU and the doctrine of essential facilities.  To address the problem of digital platforms and big data, the business models of digital platforms, the economic forces behind them, and their usage of data are assessed to conclude whether an intervention by the Union could be motivated. It is concluded that the markets where digital platforms act are prone to tip and that the characteristics of big data in combination with sophisticated algorithms create a positive feedback loop, creating barriers to entry. Thus, there are severe risks of external market failures, making an intervention feasible. The paper secondly assesses the essential facility doctrine and evaluates the four elements that needs to be fulfilled for big data to be covered by the doctrine. Even though the business model of digital platforms challenges the traditional instruments of EU-competition law, the author argues that three out of four elements of the essential facilities doctrine are fulfilled. However, as data to its character is non-rivalrous and non-exclusive the data held by the incumbent cannot be considered indispensable, making the essential facilities doctrine inapplicable. Finally, alternative instruments under EU-competition law are assessed to find a solution to the problems attributable to a refusal to supply big data. The paper concludes that there are no optimal solutions, but the best of the potential instruments is to find a new form of abuse under article 102 TFEU or to add a modified version of the essential facilities doctrine to the newly proposed legislation DMA.

Background: Facial fat grafting for rejuvenation is one of the most popular facial aesthetic procedures in plastic surgery. It is always challenging and since there are a lot of techniques for adipose tissue (AT) harvesting, there are no standard procedures that guarantee natural and long-lasting results. We developed the selective tissue engineering photo stimulation technique (One STEP™) in which we used a novel infrared 1210-nm wavelength laser diode for fat preserved harvesting and direct fat injection that we named PicoGraft™, with no fat manipulation. Methods: This is a retrospective descriptive study in which we included all senior author’s patients that got facial fat grafting using the One STEP™ technique. We compared the AT aspirated, after laser emission (STEP-PicoGraft) and the standard assisted liposuction samples (SAL) in cultures. We study the mitochondrial activity of the ASC between STEP and SAL in fresh samples and after 24 h. The evaluation of the results included subjective changes regarding wrinkles, grooves, palpebral bags, hyperchromic spots, and fat hypotrophy of our patients. Results: Between July 2013 and May 2018, a total of 245 patients underwent facial fat grafting using this novel technique. We observed adipocytes preserved after STEP harvesting comparing morphologic changes in SAL samples with a high concentration of inflammatory particles in cultures. ASC mitochondrial activity shows an important difference of more than 7 times in STEP samples in fresh analysis that increase 12 times in 24 h. The subjective results show a good improvement in the periorbital area. The changes on the skin and subcutaneous tissue are seen from the second month and continue to improve up to 12 months. Conclusions: Facial fat grafting using the PicoGraft™ obtained by One STEP™ technique gives excellent volumetric and regenerative results in a single treatment without volumetric hypercorrection, and it is a good alternative for facial rejuvenation. The fat graft obtained with this novel technique is homogenous, without lumps, and has high concentration of viable stimulated ADSC and a high number of viable adipocytes. Level of evidence: Level III, therapeutic study. / Revisión por pares

Context: The facial subunit principle organizes the facial skin into subunits. Facial reconstruction for skin cancer based on aesthetic units consists of replacing the entire subunit when a large part of a subunit has been removed. Aims: To determine the prevalence of facial skin cancer, their location by facial aesthetic units, and the type of facial reconstruction used in each of them. Settings and Design: An observational cross-sectional study was conducted at the Head and Neck Surgery Service of a general hospital between 2017 and 2018. Materials and Methods: A population census was conducted during this period. Statistical Analysis Used: The categorical variables were expressed as frequencies (percentages). Continuous variables were described as the means and standard deviations or medians and interquartile ranges. Results: The most common skin cancer was basal cell skin cancer, followed by epithelial skin cancer and, at last, melanoma. In general, the most frequent localization of these cancers was the nose. Conclusions: In spite of primary closure being the most common form of reconstruction, a considerable number of patients required facial reconstruction based on aesthetic facial units, with satisfying results. / Revisión por pares

Objective: A systematic review and meta-analysis was performed to evaluate the safety and efficacy of drug-eluting stents (DES) vs bare-metal stents (BMS) in atrial fibrillation (AF) patients. Methods: We systematically searched 5 engines until May 2019 for cohort studies and randomized controlled trials (RCTs). Primary outcomes were major bleeding and major adverse cardiac events (MACE) including cardiac death, myocardial infarction, target vessel revascularization (TVR) or stent thrombosis. Effects of inverse variance random meta-analyses were described with relative risks (RR) and their 95% confidence intervals (CI). We also stratified analyses by type (triple [TAT] vs dual [DAT]) and duration (short-vs long-term) of antithrombotic therapy. Results: Ten studies (3 RCTs; 7 cohorts) including 10,353 patients (DES: 59.6%) were identified. DES did not show higher risk of major bleeding than BMS (5.6% vs 6.9%, RR 1.07; 95%CI, 0.89–1.28, p = 0.47; I2 = 0%) or MACE (12% vs 13.6%; RR 0.96; 95%CI 0.81–1.13, p = 0.60; I2 = 44%). Although, DES almost decreased TVR risk (6.4% vs 8.4%, RR 0.78; 95%CI, 0.61–1.01, p = 0.06; I2 = 15%). Stratified analyses by type and duration of antithrombotic therapy showed no differences in major bleeding or MACE between both types of stents. In DES, long-term TAT showed higher major bleeding risk than long-term DAT (7.7% vs 4.7%, RR 1.48, 95%CI 1.08–2.03, p = 0.01; I2 = 12%). For both types of stents, MACE risk was similar between TAT and DAT. Conclusions: In patients with AF undergoing PCI, DES had similar rate of major bleeding and MACE than BMS. DAT seems to be a safer antithrombotic therapy compared with TAT. / Janssen Pharmaceuticals / Revisión por pares

The protozoan parasite Leishmania (Viannia) braziliensis (L. braziliensis) is the main cause of human tegumentary leishmaniasis in the New World, a disease affecting the skin and/or mucosal tissues. Despite its importance, the study of the unique biology of L. braziliensis through reverse genetics analyses has so far lagged behind in comparison with Old World Leishmania spp. In this study, we successfully applied a cloning-free, PCR-based CRISPR–Cas9 technology in L. braziliensis that was previously developed for Old World Leishmania major and New World L. mexicana species. As proof of principle, we demonstrate the targeted replacement of a transgene (eGFP) and two L. braziliensis single-copy genes (HSP23 and HSP100). We obtained homozygous Cas9-free HSP23-and HSP100-null mutants in L. braziliensis that matched the phenotypes reported previously for the respective L. donovani null mutants. The function of HSP23 is indeed conserved throughout the Trypanosomatida as L. major HSP23 null mutants could be complemented phenotypically with transgenes from a range of trypanosomatids. In summary, the feasibility of genetic manipulation of L. braziliensis by CRISPR–Cas9-mediated gene editing sets the stage for testing the role of specific genes in that parasite’s biology, including functional studies of virulence factors in relevant animal models to reveal novel therapeutic targets to combat American tegumentary leishmaniasis. / Alexander von Humboldt-Stiftung / Revisión por pares

Since the internet revolution, and with the ever-growing presence of the internet in our everyday lives, being able to control as much data as possible has become an indispensable part of any business looking to succeed on digital markets. This is where Big Data has become crucial. Being able to gather, but more importantly process and understand data, has allowed companies to tailor their services according to the unspoken wants of the consumer as well as optimize ad sales according to consumers’ online patterns. Considering the significant power over digital markets possessed by certain companies, it becomes critical to examine such companies from a competition law perspective. Refusal to supply, which is an abuse of a dominant position according to Article 102 TFEU, can be used to compel abusive undertakings to share a product or service, which they alone possess, and which is indispensable input in another product, with competitors. This is otherwise known as the Essential Facilities Doctrine. If the Big Data used by attention platforms such as Facebook or Google were to be considered such an indispensable product, these undertakings would be required to share Big Data with competitors. While Big Data enables the dominant positions held by powerful attention platforms today, there are certain aspects of it and its particular uses by such platforms that do not allow for the application of the Essential Facilities Doctrine. Considering the significance of Big Data for these undertakings, however, there may be need for a reform of the Essential Facilities Doctrine. From a purely competition standpoint, allowing the application of the Essential Facilities Doctrine to Big Data would be beneficial, particularly considering the doctrine’s effect on innovation. However, enforcing an obligation to share Big Data with competitors would be in breach of privacy policies within the EU. While competition decisions made by the Commission do not directly concern rules set forth in such policies, the Commission is still obligated to respect the right to privacy set forth in the EU Charter of Fundamental Rights. Thus, while the significance of Big Data demands a change in how it is approached by competition law, the Essential Facilities Doctrine is not the appropriate remedy.

Male sex workers (MSW) in the Dominican Republic (DR) have multiple sexual partners, including personal and client-relationships, and are disproportionately affected by human immunodeficiency virus (HIV). We examined the prevalence of condomless anal and/or vaginal intercourse (CI) among MSW in the DR as a function of social network factors. Self-report surveys and social network interviews were administered to MSW recruited through venue-based sampling (N = 220). A generalized linear model was used to complete a Poisson Regression model and identify variables significantly associated with the outcome of interest. CI was more common with female (28.3%) than with male partners (4.9%). Factors associated with CI with the last female partner included older age of MSW, CI with the last male partner, having a stable female partner (a consistent or main partner), and having ≥1 family member in the participants’ social network. Partner and social network characteristics associated with CI among MSW suggest the utility of dyadic and network interventions to reduce HIV risk. / National Institute of Mental Health / Revisión por pares

Since 2012-2013 influenza season, World Health Organization (who) recommends the formulation of tetravalent vaccines. Globally, many countries already use tetravalent vaccines in their national immunization programs, while in Latin America only a small number. Two Influenza b lineages co-circulate, their epidemiological behavior is unpredictable. On average they represent 22.6% of influenza cases and more than 50% in predominant seasons. The lack of concordance between recommended and circulating strains was 25 and 32% in the 2010-2017 and 2000-2013 seasons, respectively. There are no clinical differences between influenza A and B. It occurs more frequently from five to 19 years of age. Influenza b has a higher proportion of attributable deaths than influenza a (1.1 vs. 0.4%), or 2.65 (95% ci 1.18-5.94). A greater number of hospitalizations when the strains mismatch (46.3 vs. 28.5%; p <.0001). Different evaluations have demonstrated its cost effectiveness. The compilation of this information supports the use of quadrivalent vaccines in Latin American countries. / Revisión por pares

The aim of this study was to describe the frequency of migration to study medicine in Peru. We conducted a secondary data analysis of the Red-LIRHUS study (2011-2012). We included 3 680 Peruvian students. Approximately, 23.2% migrated for medical school. Less than 1% were international migrants. We found a higher proportion of migrant students in Universities outside of Lima than in Universities in Lima (27.1% vs. 15.8%). There was also a higher proportion of migrants in private universities (28.3% vs. 16.0%) Migrant students were more likely to live alone (27.4% vs. 6.4%) and to report having failed a module/course (51.0% vs. 38.6%) compared to non-migrant students. It is necessary to evaluate potential interventions for the preservation of the well-being of people who migrate for their medical training. / Revisión por pares