MORAIS, Álvaro Dellano Rios. O povo fez sua santa: canonização espontânea nas narrativas dos devotos de Mártir Francisca de Aurora. 2008. 125f. Dissertação (Mestrado em Sociologia) – Universidade Federal do Ceará, Departamento de Ciências Sociais, Programa de Pós-Graduação em Sociologia, Fortaleza-CE, 2008. / Submitted by nazareno mesquita (nazagon36@yahoo.com.br) on 2011-11-17T14:09:44Z No. of bitstreams: 1 Art_2008_ADR.Morais.pdf: 784298 bytes, checksum: 421d29f77757998b99bb3dd4327b4549 (MD5) / Approved for entry into archive by Maria Josineide Góis(josineide@ufc.br) on 2011-11-23T13:10:50Z (GMT) No. of bitstreams: 1 Art_2008_ADR.Morais.pdf: 784298 bytes, checksum: 421d29f77757998b99bb3dd4327b4549 (MD5) / Made available in DSpace on 2011-11-23T13:10:50Z (GMT). No. of bitstreams: 1 Art_2008_ADR.Morais.pdf: 784298 bytes, checksum: 421d29f77757998b99bb3dd4327b4549 (MD5) Previous issue date: 2008 / This study intends to understand how a process of “spontaneous canonization” works, in the context of Brazilian religiosity. The idea of Paul Zumthor defines a sociological phenomenon in which persons (alive, dead or imaginary ones) are taken as saints by the people, but they aren’t recognized by the Catholic Church as saints. The object of this research is the case of Martyr Francisca, a popular saint whose cult is located in Aurora (Ceará - Brazil). The study focuses on narratives that reconstruct the history of the martyr, analyzing spoken and written sources. When she was 16, Francisca Augusta da Silva was murdered by her ex-groom, in 1958. Where she fell dead, the people of Aurora built a small chapel. This chapel attracted believers who search helping from the saint of Aurora. / O presente estudo procura compreender como se dá o processo de “canonização espontânea”, no contexto do campo religioso brasileiro. O conceito de Paul Zumthor define um fenômeno sociológico segundo o qual indivíduos (vivos, mortos ou imaginários) são tomados por santos, em uma determinada comunidade, sem que assim sejam reconhecidos pela Igreja Católica. A investigação se concentra no caso de Mártir Francisca, santa popular cujo culto se localiza em Aurora, na região do Cariri (Ceará). O estudo se volta para as narrativas que reconstituem a história da mártir, tratando das fontes orais e escritas. Em 1958, quando contava 16 anos de vida, Francisca Augusta da Silva foi assassinada pelo ex-noivo. No local de sua morte, foi erguida uma pequena capela que logo passou a atrair fiéis em busca da ajuda da santa de Aurora.

DUTRA, Luana Leticia Alves. Avaliação dos genes AURKA e AURKB em pacientes pediátricos portadores de leucemia linfóide aguda. 2015. 71 f. Dissertação (Mestrado em Patologia) – Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2015. / Submitted by denise santos (denise.santos@ufc.br) on 2015-11-19T13:04:41Z No. of bitstreams: 1 2015_dis_lladutra.pdf: 2557352 bytes, checksum: e975042e7681efc6efceafbfb84d43f4 (MD5) / Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2015-11-19T13:32:20Z (GMT) No. of bitstreams: 1 2015_dis_lladutra.pdf: 2557352 bytes, checksum: e975042e7681efc6efceafbfb84d43f4 (MD5) / Made available in DSpace on 2015-11-19T13:32:20Z (GMT). No. of bitstreams: 1 2015_dis_lladutra.pdf: 2557352 bytes, checksum: e975042e7681efc6efceafbfb84d43f4 (MD5) Previous issue date: 2015 / Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. It is a hematologic malignant neoplasm derived from undifferentiated young lymphoid lineage cells that accumulate and replace the normal population of blood cells. The Aurora kinase genes A, B and C are involved in cell cycle and encode proteins of great importance in the regulation of the mitosis process - separation of sister chromatids during metaphase / anaphase. The aim of this study was to evaluate the AURKA and AURKB genes in pediatric patients with ALL-B treated at Hospital Infantil Albert Sabin (HIAS). This was a cross-sectional, observational and analytical study and 30 patients were enrolled. The sex, age, and laboratory data profile were obtained from medical records of patients diagnosed at HIAS. The analysis of mutations in AURKA and AURKB genes was performed by the fluorescence in situ hybridization technique (FISH) using probes specific for each gene. Statistical analysis was performed using GraphPad Prism 5 and used 5% significance level for all tests. Of all children 53.33% were male and 46.67% female, with age ranging from 1 to 16, and average of 7.1 years. Using the FAB classification, 86.67% of patients had ALL-L1 and 13.33% had ALL-L2. According to the EGIL classification, 33.33% were pre-B ALL and 66.67% were common ALL. The mean hemoglobin levels, hematocrit, white blood cells and platelet counts were, respectively, 7.50 g/dL, 22.80%, 69.494/mm3 and 56.439,64/mm3. 73.33% of the children studied had some type of numerical or structural karyotipic abnormality. Regarding the risk classification, 26.67% were favorable, 40% intermediate and 33.33% unfavorable risk. Patients with unfavorable karyotype had a higher white blood cell count (p = 0.0025), and the analysis of other parameters was not significant. Monosomy and polysomy of AURKA gene and polysomy of AURKB gene were observed. Some kind karyotypic change was observed in approximately 50% of cases, the more frequent change was in AURKB. Most patients with abnormal AURKB gene presented a favorable karyotype, and white blood cell and platelet counts less altered. The study of AURKA and AURKB genes showed that these genes may be markers of genomic instability and that AURKB seems more involved in the pathogenesis of childhood ALL, being also a good prognostic factor. / A leucemia linfóide aguda (LLA) é a neoplasia mais frequente na infância. É uma neoplasia hematológica maligna derivada de células linfocitárias indiferenciadas com acúmulo de células jovens e substituição da população normal de células sanguíneas. Os genes Aurora quinase A, B e C estão envolvidos no ciclo celular e codificam proteínas de grande importância na regulação do processo de mitose - separação das cromátides irmãs durante a metáfase/anáfase. O objetivo desse estudo foi avaliar os genes AURKA e AURKB em pacientes pediátricos portadores de LLA-B tratados no Hospital Infantil Albert Sabin (HIAS). Tratou-se de um estudo transversal, observacional e analítico. A amostra utilizada no estudo foi de 30 pacientes. O perfil de sexo, idade e dados laboratoriais foi obtido em prontuários dos pacientes e no serviço de diagnóstico do HIAS. A análise de mutações nos genes AURKA e AURKB foi pela técnica de Fluorescência por Hibridização in Situ (FISH), com o uso de sondas específicas para cada gene. A análises estatística foi realizada no GraphPad Prism 5 e teve nível de significância de 5% para todos os testes. Do total de crianças 53,33% foram do sexo masculino e 46,67% do sexo feminino, com faixa de idade variando de 1 a 16 anos, e média de 7,1 anos. Quanto a classificação FAB, 86,67% dos pacientes eram portadores de LLA-L1 e 13,33% de LLA-L2. Na classificação EGIL, 33,33% eram LLA pré-B e 66,67% eram LLA-comum. Os valores médios de hemoglobina, hematócrito, leucócitos e plaquetas foram, respectivamente, 7,50 g/dL, 22,80%, 69.494/mm3 e 56.439,64/mm3. O cariótipo de 73,33% das crianças estudadas apresentou algum tipo de alteração numérica ou estrutural. Em relação à classificação de risco, 26,67% foram favoráveis, 40% intermediários e 33,33% desfavoráveis. Na relação entre parâmetros hematológicos e classificação de risco, pacientes com cariótipo desfavorável apresentaram leucometria mais elevada (p=0,0025), as análises com os outros parâmetros não foram significantes. No estudo de AURKA e AURKB foi possível observar monossomia e polissomia do gene AURKA e polissomia do gene AURKB. Dos pacientes com algum tipo de alteração no cariótipo, foi observada alteração em algum dos genes em aproximadamente 50% dos casos, sendo a alteração no AURKB mais frequente. A maioria dos pacientes com alteração no gene AURKB apresentou cariótipo favorável, assim como leucometria e contagem de plaquetas menos alteradas. O estudo dos genes AURKA e AURKB mostrou que esses genes podem ser iniciadores no processo de instabilidade genômica das células leucêmicas e que a AURKB parece estar mais envolvida na patogênese da LLA infantil, assim como fator de bom prognóstico.

According to current models, 19th century American quilts are presented as simple objects of cultural heritage or considered for their similarities to other forms of modern art. This thesis follows a three part approach in order to study these objects which are valuable sources of historical information in their full context. This approach includes the historical, social/aesthetic, and material contexts of the objects. The topic of the study is the quilts of the Bethel and Aurora colonies, 19th century Christian "utopian" sects in Missouri and Oregon. While societies such as the Bethel and Aurora colonies shunned many aspects of modernization, quilts appear to be an area of connection with the outside world. The quilts serve as material evidence for the tension between communal and secular worldviews in the colonies.

The gravemarkers of the Aurora Colony Cemetery offer a means of examining identity and change within this early Oregon utopian community. Led by charismatic Wilhelm Keil and composed predominantly of people of German heritage, the members of the Aurora Colony sought to distance themselves from worldly influences through emigration to the Willamette Valley. In existence from 1856 to 1883, they sought to maintain shared cultural practices while, as farmers and artisans, relying simultaneously upon inclusive commerce with the outside world. Contextual analysis of this mortuaryscape provides a venue for understanding the interplay of separatist ideology and extralocal forces among Colony members and the following generation of their descendants. Artifactual data from relationships found among their mortuary objects reflects patterns of change in material, typology, composition, and language spanning the years 1862-1920. Subsequently, such objects express the tide of acculturation and dissolution experienced within the Colony.

La chromatine est le support de l'information génétique tout le long du cycle cellulaire. Elle est soumise à des modifications diverses et rigoureusement coordonnées par les complexes CDK-Cyclines, sous le contrôle de mécanismes de surveillance. En mitose, la kinase Aurora est un acteur clé qui contrôle la ségrégation correcte des chromosomes. Aurora participe à la bi-orientation des centromères, à la condensation des chromosomes et à la cytocinèse. Le dysfonctionnement de cette kinase conduit alors à une instabilité chromosomique et à l'aneuploïdie, un phénotype observé dans la majorité des cancers solides. Les travaux réalisés au cours de cette thèse démontrent un nouveau rôle pour cette kinase dans la dispersion et la disjonction des télomères en mitose chez la levure S. Pombe. La dispersion des télomères s'accompagne en métaphase de la dissociation aux télomères des protéines Swi6/HP1 et cohésine Rad21. Tandis que la disjonction a lieu en anaphase après la phosphorylation de la sous-unité de condensine Cnd2. L'inhibition d'Aurora induit la formation de ponts chromosomiques anaphasiques qui révèle des défauts de séparation des télomères. La délétion d'une protéine spécifique aux télomères, Ccq1, protège la cellule de la formation de ces ponts chromosomiques en favorisant le chargement de la condensine en anaphase malgré l'inhibition d'Aurora. / Chromatin is the support of the genetic information throughout the cell cycle. It is subject to various modifications that occur with precise coordination. This coordination is led by CDK-cyclins under the control of cell cycle checkpoints. In mitosis, correct chromosome segregation is ensured by Aurora kinases. Aurora participates to centromere bi-orientation, chromosome condensation and cytokinesis. A dysfunction in the activity of this kinase leads to chromosomal instability and aneuploidy, phenotypes frequently observed in cancer. The results obtained during this thesis reveal a new function for fission yeast Aurora kinase during mitosis in telomere dispersion and disjunction. Telomere dispersion is triggered in metaphase by the dissociation of Swi6/HP1 and cohesion Rad21 from telomeres. Then, during anaphase, the phosphorylation of the condensin subunit Cnd2 is required for telomere disjunction. Aurora inhibition leads to anaphase chromosome bridges with unseparated telomeres. Deletion of a specific telomeric protein, Ccq1, prevents the formation of anaphase chromosome bridges by favoring condensin loading despite Aurora inhibition.

Palynological analyses of 13 samples from two sediment cores retrieved from the Sabrina Coast, East Antarctica, provide the first information regarding the paleovegetation within the Aurora Subglacial Basin. The assemblages, hereafter referred to as the Sabrina Flora, are dominated by angiosperms, with complexes of Gambierina (G.) rudata and G. edwardsii representing 38–66% of the assemblage and an abundant and diverse Proteaceae component. The Sabrina Flora also includes Battenipollis sectilis, Forcipites sp. and Nothofagidites spp. (mostly belonging to the N. cf. rocaensis-flemingii complex), along with a few fern spores, including Laevigatosporites ovatus, a moderate presence of conifers, and previously undescribed morphospecies, two of which are described herein. A majority of the assemblage is interpreted as deposited contemporaneously with sedimentation, including Gambierina spp., which is traditionally assigned a Cretaceous–earliest Eocene age range. However, our age diagnosis for the Sabrina Flora, based on key morphospecies, indicates that sediment was most likely deposited between the latest Paleocene to possibly early–middle Eocene, if Gambierina rudata and G. edwardsii extended longer than previously thought. Additionally, we observed abundant dinoflagellate cysts of Campanian age. The absence of typical Paleocene–middle Eocene dinoflagellate cysts suggests that strata recovered were fluvial-dominated or proximal marine, with a major contribution of reworking of Campanian marine sediment. This study adds to the available East Antarctic palynological data and provides information on regional differences along the East Antarctic margin, as well as with southern Australia. The pollen diversity and the large relative abundance of Gambierina spp., along with the rarity of Nothofagidities spp., (fusca group), and the lack of megathermal elements (e.g., Arecaceae) separate the Sabrina Flora from those of other East Antarctic margin and southern Australian basin sites.

Particles trapped in the magnetosphere are naturally accelerated by the exchange of electromagnetic and kinetic energy, resulting in relativistic plasma populations. Through a number of processes, these particles can be scattered into the atmosphere and lost to interactions. Such precipitating particles can affect radio communications, ozone chemistry, and thermal structures. For these reasons, it is important to characterize loss mechanisms and quantify precipitation rates. This thesis examines one particular loss mechanism known as current sheet scattering (CSS). If interactions are negligible, charged particles in a magnetic field have approximately conserved quantities that characterize their motion provided the background field changes sufficiently slowly over space and time. The first of these ‘adiabatic invariants,’ the magnetic moment, is related to the particle’s mirror point along its bounce trajectory—the location at which the particle reverses direction in its journey from weaker to stronger B. In the equatorial region of the near-Earth magnetotail, where the radius of field line curvature of the magnetic field can become comparable to the gyroradius of ≈ 100 keV electrons, the homogeneity conditions needed for conservation of the magnetic moment of this population are broken. Upon passing through this location, known as the current sheet, these particles experience a chaotic change in their magnetic moment, and thus an alteration of their mirror point. This is the phenomenon of CSS. If the resulting mirror point lies within the atmosphere, the particle will most likely be lost through interactions. CSS is often investigated for highly relativistic electrons. However, recent observations suggest that this mechanism may account for a significant proportion of precipitating electrons between 100 and 300 keV during the substorm growth phase, a common space weather event wherein magnetic field lines in the near-Earth magnetotail become highly stretched. In this thesis, we test the efficacy of CSS as a loss mechanism for < 300 keV electrons by developing a relativistic charged particle tracer capable of solving complex trajectories in realistic magnetospheric magnetic field models. We then find distributional characteristics through Monte Carlo methods, comparing simulated ratios of loss- to total-flux with observations of the same quantities for a single substorm event. These observations are obtained by comparison of in situ measurements made by THEMIS (Time History of Events and Macroscale Interactions during Substorms) with ionospheric energy flux remotely sensed by PFISR (Poker Flat Incoherent Scatter Radar). Given an input distribution from THEMIS satellite measurements, we find agreement between observed and simulated loss- to total-flux ratios within an order of magnitude, with closer agreement for electrons between 100 and 300 keV. This implies CSS can explain a significant proportion of observed precipitation for the event studied and demonstrates its role as a prominent radiation belt loss mechanism. In particular, these findings suggest that the measured loss flux of < 300 keV electrons during such events can be immediately related to the geometry of the near-Earth magnetotail. This is further supported by a parametric study of initially field aligned distributions spawned at various nightside locations, showing a low-energy peak in the loss- to total-flux ratio at the boundary between the outermost radiation belt and the magnetotail. Measurements of particle orientation taken from THEMIS are low resolution, and agreement between simulated and observed loss- to total-flux ratios can be increased by assuming a more field aligned distribution for electrons below 100 keV. This suggests the presence of other physical processes besides CSS that may preferentially structure the pitch angle distributions of low energy electrons to be field aligned. Additional analysis is needed to identify these possible mechanisms. In summary, findings from this work support the role of CSS as an important contributor to < 300 keV electron loss during the substorm growth phase. Though there is an underestimation of loss for < 100 keV electrons, it is known that the empirical magnetic field models employed overestimate the radius of curvature in the current sheet. Furthermore, the dawn-dusk electric field has been neglected, though it has the possibility to produce field aligned electrons through current sheet acceleration. The inclusion of these effects in future studies may further improve agreement between simulation and observations.

With the growing accessibility of space, this thesis work sets out to explore space-based swarms to do multipoint magnetometer measurements of current systems embedded within the Aurora Borealis as an initial foray into concepts for space physics applications using swarms of small spacecraft. As a pathfinder, ANDESITE---a 6U CubeSat with eight deployable picosatellites---was built as part of this research. The mission will fly a local network of magnetometers above the Northern Lights. With the spacecraft due to launch on an upcoming ELaNa mission, here we discuss the details of the science motivation, the mathematical framework for current field reconstruction, the particular hardware implementation selected, the calibration procedures, and the pragmatic management needed to realize the spacecraft. After describing ANDESITE and defining its capability, we also propose a follow-on that uses propulsive nodes in a swarm, allowing measurements that can adaptively change to capture the physical phenomena of interest. To do this a flock of satellites needs to fall into the desired formation and maintain it for the duration of the science mission. A simple optimal controller is developed to model the deployment of the satellites. Using a Monte Carlo approach for the uncertain initial conditions, we bound the fuel cost of the mission and test the feasibility of the concept. To illustrate the system analysis needed to effectively design such swarms, this thesis also develops a framework that characterizes the spatial frequency response of the kilometer-scale filter created by the swarm as it flies through various current density structures in the ionospheric plasma. We then subjugate a nominal ANDESITE formation and the controlled swarm specified to the same analysis framework. The choice of sampling scheme and rigorous basic mathematical analysis are essential in the development of a multipoint-measurement mission. We then turn to a novel capability exploiting current trends in the commercial industry. Magnetometers deployed on the largest constellation to date are leveraged as a space-based magnetometer network. The constellation, operated by Planet Labs Inc., consists of nearly 200 satellites in two polar sun-synchronous orbits, with median spacecraft separations on the order of 375 km, and some occasions of opportunity providing much closer spacing. Each spacecraft contains a magneto-inductive magnetometer, able to sample the ambient magnetic field at 0.1 Hz to 10 Hz with <200 nT sensitivity. A feasibility study is presented wherein seven satellites from the Planet constellation were used to investigate space-time patterns in the current systems overlying an active auroral arc over a 10-minute interval. Throughout the this work advantages, limitations, and caveats in exploiting networks of lower quality magnetometers are discussed, pointing out the path forward to creating a global network that can monitor the space environment.

Ground-based and in-situ observations of the aurora demonstrate an extreme richness in fine structure, with spatial scales down to tens of metres and time variations occurring on a fraction of a second. To further our understanding of the aurora, it is esssential to understand the mechanisms responsible for the small-scale structuring, since this is an intrinsic property of the auroral plasma. Still many questions about dynamics and structuring of aurora on small scales remain unanswered. In this thesis the low-light optical instrument ASK (Auroral Structure and Kinetics) is used to image small-scale structures in the aurora at very high spatial and temporal resolution. ASK is a multi-spectral instrument, imaging the aurora in three selected emission lines simultaneously. This provides information on the energy of the precipitating electrons. The SIF (Spectrographic Imaging Facility) instrument has been used in conjunction with ASK, to give a more complete picture of the spectral characteristics of the aurora, and to determine the contamination of the emission lines by other emissions. Data from ASK and SIF is used to study the relation between the morphology and dynamics of small-scale structures in the aurora and the energy of the precipitating electrons. By comparing electron density profiles provided by EISCAT (European Incoherent SCATter) measurements with modeling results, information on characteristic energy and energy flux of the precipitating electrons can be obtained. One of the ASK channels is imaging a metastable O+ emission, which has a lifetime of 5 s. By tracing the afterglow in this channel optically a direct measure of the E × B drift and thus of the local ionospheric electric fields is provided. / QC 20101109

京都大学 / 新制・課程博士 / 博士(生命科学) / 甲第24946号 / 生博第508号 / 新制||生||68(附属図書館) / 京都大学大学院生命科学研究科高次生命科学専攻 / (主査)教授 松田 道行, 教授 松本 智裕, 教授 原田 浩 / 学位規則第4条第1項該当 / Doctor of Philosophy in Life Sciences / Kyoto University / DGAM