Introdução: As infecções primárias da corrente sanguínea associadas ao cateter venoso central (IPCS) são um grande problema nas unidades de terapia intensiva (UTI) pediátricas e neonatais em todo o mundo. Evidências sugerem que a prevenção das IPCSs é crucial para o atendimento seguro ao paciente. Uma percentagem significativa (65-70%) das IPCSs são evitáveis utilizando as estratégias baseadas em evidências, incluindo os bundles. Estas medidas têm um papel bem estabelecido em pacientes adultos.O objetivo deste estudo foi avaliar, a partir de uma ampla revisão sistemática da literatura, o benefício da implementação do bundle do cateter central na prevenção das IPCSs em pacientes pediátricos e neonatais internados em UTI. Métodos: Foram pesquisadas as bases de dados Cochrane Library, Medline, Latin American and Caribbean Health Science Literature (LILACS), Centre for Reviews and Dissemination (CRD), Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), além de busca manual e literatura cinzenta entre 1 de janeiro de 2005 até 31 de dezembro de 2015. Não houve restrição dos estudos com relação ao idioma, a data ou status de publicação. Para avaliar o benefício do bundle do cateter central, foram selecionados estudos envolvendo pelo menos dois componentes (higiene de mãos, precauções de barreira máxima, antissepsia da pele, seleção adequada do sítio do cateter, revisão diária da necessidade do cateter) como medida preventiva para pacientes com cateter venoso central (CVC). O desfecho foi o número de IPCSs por 1000 cateteres-dias antes e depois da implementação do bundle. Resultados: Foram identificados inicialmente 6369 estudos, após a exclusão dos títulos duplicados e os inelegíveis, 31 estudos preencheram os critérios de elegibilidade. Os estudos foram heterogêneos tanto na composição do bundle quanto na estratégia de implementação. A mediana da densidade de incidência de IPCS foi de 5.9 por 1000 cateteres-dias (2.6-23.1) nas unidades de terapia intensiva pediátricas (UTIP) e 4.9 por 1000 cateteres-dias (2.0-24.1) nas unidades de terapia intensiva neonatais (UTIN). Após a implementação do bundle do cateter central, a densidade de incidência de IPCS variou de 0 a 14.9 por 1000 cateteres-dias (mediana de 2.1) nas UTIPs e 0.3 a 13.9 (mediana de 2.8) nas UTINs. Conclusões: As IPCSs continuam sendo um problema significativo em unidades de terapia intensiva pediátricas e neonatais, mas a implementação do bundle do cateter central pode reduzir significativamente as taxas dessas infecções. Intervenções assistenciais com as melhores práticas baseadas em evidência permitem uma redução substancial das IPCSs pela promoção de grupos ou bundles de procedimentos e tecnologias, e pela utilização de uma estratégia multimodal para a educação, formação, implementação e divulgação. / Background: Central-line-associated bloodstream infections (CLABSIs) are a major problem in neonatal and pediatric intensive care units (ICUs) worldwide. Evidence suggests that CLABSI prevention is crucial for safe patient care. A significant percentage of CLABSIs (65- 70%) are preventable using evidenced-based guidelines. Strategies to prevent these infections have included a myriad of different preventive maneuvers gathered as “bundles”. These measures have a well established role in the adult ICU setting. We aimed to assess the benefit of the implementation of central-line bundles to prevent CLABSIs in neonatal and pediatric ICU patients, populations where their actual efficacy is yet to be proven. Methods: We searched Cochrane Library, Medline, Latin American and Caribbean Health Science Literature (LILACS), Centre for Reviews and Dissemination (CRD), Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), manual search and gray literature to identify studies reporting the implementation of central-line bundles in pediatric ICU (PICU), or neonatal ICU (NICU) patients. We searched for studies published between Jan 1, 2005, and December 21, 2015, without language restriction. To evaluate the benefit of the central line bundle were selected studies involving at least two components (hand hygiene, maximal barrier precautions, skin antisepsis, optimal catheter site selection and daily review of line necessity) as a preventive measure to patients with central venous catheter (CVC). The outcome was the number of CLABSIs per 1000 catheter-days before and after implementation. Results: We initially identified 6369 records, and after excluding duplicates and those ineligible, 31 studies met the eligibility criteria. The studies reviewed were quite heterogeneous both in bundle composition and implementation strategy. Median CLABSIs incidence were 5.9 per 1000 catheter-days (range 2.6–23.1) on PICUs and 4.9 per 1000 catheter-days (range 2.0–24.1) on NICUs. After implementation of central-line bundles the CLABSI incidence ranged from 0 to 14.9 per 1000 catheter-days (median 2.1) on PICUs and 0.3 to 14.9 (median 2.8) on NICUs. Conclusions: CLABSIs remain a significant problem in neonatal and pediatric critical care units, but implementation of catheter care bundles can significantly reduce rates of these infections. Best practice interventions allow substantial CLABSI reduction by promotion of groups or bundles of procedures and technology, and by use of a multimodal strategy for education, training, implementation, and dissemination.

In a nuclear fuel cask, the heat generating spent fuel rods are packed in a housing and the resulting bundle is placed inside a cask of thick outer shell made of materials like lead or concrete. The cask presents a wide variation in geometrical dimensions ranging from the diameter of the rods to the diameter of the cask. To make the problem tractable, first the heat generating rod bundle alone is considered for analysis and the effective thermal conductance of the bundle is correlated in terms of the relevant parameters. In the second part, the bundle is represented as a solid of equivalent thermal conductance and the attention is focused on the modelling of the cask. The first part, dealing with the effective thermal conductance is solved using Fluent software, considering coupled conduction, natural convection and surface radiation in the heat generating rod bundle encased in a hexagonal sheath. Helium, argon, air and nitrogen are considered as working media inside the bundle. A correlation is obtained for the critical Rayleigh number which signifies the onset of natural convection. A correlation is also developed for the effective thermal conductance of the bundle, considering all the modes of transport, in terms of the maximum temperature in the rod bundle, pitch-to-diameter ratio, bundle dimension (or number of rods), heat generation rate and the sheath temperature. The correlation covers pitch-to-diameter ratios in the range 1.1-2, number of rods ranging from 19 to 217 and the heat generation rates encountered in practical applications. The second part deals with the heat transfer modeling of the cask with the bundle represented as a solid of effective (or equivalent) thermal conductance. The mathematical model describes two-dimensional conjugate natural convection and its interaction with surface radiation in the cask. Both Boussinesq and non-Boussinesq formulations have been considered for convection. Numerical solutions are obtained on a staggered mesh with a pressure correction method using a custom-made Fortran code. The surface radiation is coupled to the conduction and convection at the solid-fluid interfaces. Steady-state results are obtained using time-marching. Results for various quantities of interest, namely, the flow and temperature distributions, Nusselt numbers, and interface temperatures, are presented. The Grashof number based on the volumetric heat generation and gap width is varied from 105 to 5 ×109. The emissivities of the interfaces are varied from 0.2-0.8 for the radiative calculations. The solid-to-fluid thermal conductivity ratio for the inner cylinder is varied in the range 5-20 in the parametric studies. Simulations are also performed with thermal conductivity calculated in an iterative manner from bundle parameters. The dimensionless outer wall conductivity ratio is chosen to correspond to cask walls made of lead or concrete. The dimensionless thickness (with respect to gap width) of the outer shell is in the range of 0.0825-1, while the inner cylinder dimensionless radius is 0.2. Air is the working medium in the cask for which the Prandtl number is 0.71. Correlations are obtained for the average temperatures and Nusselt numbers at the inner interface in terms of the parameters. The radiation heat transfer is found to contribute significantly to the heat dissipation.

Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-05-31T15:07:36Z No. of bitstreams: 1 lucasvitorfonsecadeoliveira.pdf: 1420167 bytes, checksum: b5075b7ccc33c587012a46901a9b21af (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-07-02T12:44:37Z (GMT) No. of bitstreams: 1 lucasvitorfonsecadeoliveira.pdf: 1420167 bytes, checksum: b5075b7ccc33c587012a46901a9b21af (MD5) / Made available in DSpace on 2016-07-02T12:44:37Z (GMT). No. of bitstreams: 1 lucasvitorfonsecadeoliveira.pdf: 1420167 bytes, checksum: b5075b7ccc33c587012a46901a9b21af (MD5) Previous issue date: 2012-03-30 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Com a abertura legal do setor elétrico brasileiro na década de 90 para investimentos privados, em especial com a implantação sistemática de leilões para definição dos concessionários de transmissão, diversos estudos foram efetuados com o objetivo de viabilizar projetos de linha de transmissão de modo a concorrem nesses leilões. Grandes transmissoras, como Furnas, Chesf e Eletronorte promoveram pesquisas em consórcio com empresas construtoras de linhas e fabricante de ferragens e isoladores, com o objetivo de desenvolverem projetos com baixa relação Reais/MW transmitido. Neste cenário, muitos projetos de linhas de potência natural elevada foram idealizados e implantados, e como fruto desses projetos, publicações foram realizadas descrevendo os resultados obtidos. Todavia, apesar da quantidade, qualidade e riqueza das informações publicadas, a descrição do processo de otimização dos parâmetros elétricos da linha, em especial da impedância característica, não receberam destaque, sendo muita das vezes suprimida nos artigos. Neste sentido, este trabalho propõe a investigação de um método inovador de otimização da capacidade de transmissão de linhas de potência natural elevada, através da análise indireta dos efeitos da variação do posicionamento dos cabos condutores no feixe sobre a impedância característica da linha, por meio de uma abordagem original que utiliza basicamente o vetor de Poynting como função objetivo do Método de Otimização por Enxame de Partículas, sendo os campos elétricos e magnéticos necessários para definição do vetor de Poynting calculados por meio do Método dos Elementos de Contorno. O método foi validado utilizando como exemplos a otimização das configurações de feixes da linha de 500 kV Interligação Norte/SUL III – Trecho 2 e Linha de 500 kV Presidente Dutra / Teresina / Sobral / Fortaleza. Foram encontrados ganhos na capacidade de transmissão de 7% e 22% respectivamente devido à redução da impedância característica calculada após a otimização através da rotina Line Constants do programa ATP/EMTP, e comparando-a com os valores originais. / With the legal opening for private investments in the Brazilian energy sector in the 90's, in particular the systematic implementation of auctions for defining power transmission concessions, several studies were made with the aim of developing transmission line projects in order to compete in these auctions. Major transmission companies such as Furnas, Eletronorte and CHESF promoted consortium research with line builders and hardware and insulators manufacturers, in order to develop projects with low cost/MW transmitted. In this scenario, many projects of high surge-impedance loading lines were developed and implemented, and as a result of these projects, publications were made describing the results. However, despite the quantity, quality and resourcefulness of published information, the descriptions of the optimization process of electrical line parameters, especially regarding characteristic impedance, were not given prominence, being often suppressed from the articles. Thus, this study proposes the investigation of a method for optimizing the transmission capacity of high surge-impedance loading lines, varying the power cables in the bundle, indirectly reducing its characteristic impedance through an original approach that uses basically the Poynting's vector as objective function of the Particle Swarm Optimization method.The electric and magnetic fields needed for defining the Poynting vector were calculated using the Boundary Element Method. The method was validated through the optimization of bundle configuration, using as a model the characteristics of the 500 kV line North / South Interconnection III - Segment 2 and the 500 kV line Presidente Dutra / Teresina / Sobral / Fortaleza. It was found transmission capacity gains of 7% and 22% respectively, by reducing the characteristic impedance, which was calculated after the optimization using the EMTP/ATP Line Constants Program, comparing it with the original values.

Un besoin applicatif existe en terme de localisation 3D d’objets par vision. Cette technologie devient en effet de plus en plus populaire dans le milieu industriel où elle peut être utile lors de contrôle qualité, de robotisation de tâches ou encore d’aide à la maintenance par Réalité Augmentée. Néanmoins, le déploiement de telles applications est actuellement limité en raison de la difficulté à allier qualité de localisation, facilité de mise en oeuvre et généricité de la solution. En effet, la majorité des solutions implique : soit des étapes de mise en oeuvre complexes comme avec l’installation de capteurs de mouvement ou une préparation supervisée du modèle CAO; soit un manque de précision de la localisation dans le cadre de certaines applications nécessitant de prendre en compte des mouvements de fortes amplitudes de la caméra (provoquant du flou de bouger et des tremblements dans le flux vidéo) ainsi que des occultations partielles ou totales de l’objet ; soit enfin une restriction sur la nature de l’objet, celui-ci devant être texturé, de petite taille ou encore polyédrique pour avoir une bonne localisation. La plupart des solutions de localisation existantes correspondent à des approches de suivi basé modèle. Cette méthode consiste à estimer la pose relative entre la caméra et l’objet d’intérêt par mises en correspondance de primitives 3D extraites du modèle avec des primitives 2D extraites d’images d’un flux vidéo. Pour autant, cette approche atteint ses limites lorsque l’objet est difficilement observable dans l’image.Afin d’améliorer la localisation lorsque l’application concerne un objet fixe, de récentes solutions se sont appuyées en complément des primitives du modèle, sur des primitives de l’environnement reconstruites au cours du processus de localisation. Ces approches combinent algorithmes de SLAM (Simultaneous Localization And Mapping) et de suivi d’objet basé contours en utilisant les informations du modèle comme contrainte dans le processus d’optimisation du SLAM. Pour cela, un terme d’erreur est ajouté à la fonction de coût classique.Celui-ci mesure l’erreur de re-projection entre des primitives 3D issues des arêtes franches du modèle et les points de contour 2D dans l’image qui leur sont associés. L’ajout de cette contrainte permet d’exprimer la localisation du SLAM dans le repère de l’objet d’intérêt tout en réduisant sa dérive. Les solutions de SLAM contraint au modèle n’exploitant cependant que les contours francs du modèle, ne sont pas génériques et ne permettent de localiser que des objets polyédriques. De plus, l’ajout de cette contrainte entraîne une forte augmentation de la consommation mémoire, les images de contours nécessaires à l’étape de mise en correspondance devant être conservées.Les travaux présentés dans ce mémoire de thèse visent à fournir une solution répondant simultanément à l’ensemble des besoins concernant la facilité de déploiement, la qualité de localisation et la généricité sur la nature des objets suivis. Aussi, notre solution basée sur un algorithme de SLAM visuel contraint basé images clés, se restreint-elle au seul usage d’une caméra couleur, les caméras RGBD impliquant généralement une limite sur le volume, la nature réflective ou absorbante de l’objet, et sur la luminosité de son environnement. Cette étude est en outre restreinte à la seule exploitation de modèles 3D géométrique non texturés, les textures pouvant difficilement être considérées comme stables dans le temps (usure, taches...) et pouvant varier pour un même objet manufacturé. De plus, les modèles à base de nuages de descripteurs locaux ou les modèles surfaciques texturés sont actuellement des données peu disponibles dans l’industrie. Enfin, nous faisons le choix d’estimer la pose de la caméra de manière géométrique et non par apprentissage. Le suivi d’objets à l’aide d’apprentissage automatique est en effet encore difficilement exploitable en milieu industriel. (...) / In the industry domain, applications such as quality control, automation of complex tasks or maintenance support with Augmented Reality (AR) could greatly benefit from visual tracking of 3D objects. However, this technology is under-exploited due to the difficulty of providing deployment easiness, localization quality and genericity simultaneously. Most existing solutions indeed involve a complex or an expensive deployment of motion capture sensors, or require human supervision to simplify the 3D model. And finally, most tracking solutions are restricted to textured or polyhedral objects to achieved an accurate camera pose estimation.Tracking any object is a challenging task due to the large variety of object forms and appearances. Industrial objects may indeed have sharp edges, or occluding contours that correspond to non-static and view-point dependent edges. They may also be textured or textureless. Moreover, some applications require to take large amplitude motions as well as object occlusions into account, tasks that are not always dealt with common model-based tracking methods. These approaches indeed exploit 3D features extracted from a model, that are matched with 2D features in the image of a video-stream. However the accuracy and robustness of the camera localization depend on the visibility of the object as well as on the motion of the camera. To better constrain the localization when the object is static, recent solutions rely on environment features that are reconstructed online, in addition to the model ones. These approaches combine SLAM (Simultaneous Localization And Mapping) and model-based tracking solutions by using constraints from the 3D model of the object of interest. Constraining SLAM algorithms with a 3D model results in a drift free localization. However, such approaches are not generic since they are only adapted for textured or polyhedral objects. Furthermore, using the 3D model to constrain the optimization process may generate high memory consumption,and limit the optimization to a temporal window of few cameras. In this thesis, we propose a solution that fulfills the requirements concerning deployment easiness, localization quality and genericity. This solution, based on a visual key-frame-based constrained SLAM, only exploits an RGB camera and a geometric CAD model of the static object of interest. An RGB camera is indeed preferred over an RGBD sensor, since the latter imposes limits on the volume, the reflectiveness or the absorptiveness of the object, and the lighting conditions. A geometric CAD model is also preferred over a textured model since textures may hardly be considered as stable in time (deterioration, marks,...) and may vary for one manufactured object. Furthermore, textured CAD models are currently not widely spread. Contrarily to previous methods, the presented approach deals with polyhedral and curved objects by extracting dynamically 3D contour points from a model rendered on GPU. This extraction is integrated as a structure constraint into the constrained bundle adjustment of a SLAM algorithm. Moreover we propose different formalisms of this constraint to reduce the memory consumption of the optimization process. These formalisms correspond to hybrid structure/trajectory constraints, that uses output camera poses of a model-based tracker. These formalisms take into account the structure information given by the 3D model while relying on the formalism of trajectory constraints. The proposed solution is real-time, accurate and robust to occlusion or sudden motion. It has been evaluated on synthetic and real sequences of different kind of objects. The results show that the accuracy achieved on the camera trajectory is sufficient to ensure a solution perfectly adapted for high-quality Augmented Reality experiences for the industry.

Soit G un groupe algébrique semi-simple sur un corps de caractéristique 0. Ce mémoire discute d'un théorème d'annulation de la cohomologie supérieure du faisceau D des opérateurs différentiels sur une variété de drapeaux de G. On démontre que si P est un sous-groupe parabolique de G, alors H^i(G/P,D)=0 pour tout i>0. On donne en fait trois preuves indépendantes de ce théorème. La première preuve est de Hesselink et n'est valide que dans le cas où le sous-groupe parabolique est un sous-groupe de Borel. Elle utilise un argument de suites spectrales et le théorème de Borel-Weil-Bott. La seconde preuve est de Kempf et n'est valide que dans le cas où le radical unipotent de P agit trivialement sur son algèbre de Lie. Elle n'utilise que le théorème de Borel-Weil-Bott. Enfin, la troisième preuve est attribuée à Elkik. Elle est valide pour tout sous-groupe parabolique mais utilise le théorème de Grauert-Riemenschneider. On présente aussi une construction détaillée du faisceau des opérateurs différentiels sur une variété. / Let G be a semisimple algebraic group on a field of characteristic 0. This thesis discusses a vanishing theorem for the higher cohomology of the sheaf D of differential operators on a flag variety of G. We show that if P is a parabolic subgroup of G, then H^i(G/P,D)=0 for all i>0. In fact, we give three independent proofs of this theorem. The first proof, due to Hesselink, only works if the parabolic subgroup P is a Borel subgroup. It uses a spectral sequence argument as well as the Borel-Weil-Bott theorem. The second proof, due to Kempf, only works if the unipotent radical of P acts trivially on its Lie algebra. It only uses the Borel-Weil-Bott theorem. Finally, the third proof, due to Elkik, is valid for any parabolic subgroup. However, it uses the Grauert-Riemenschneider theorem. We also present a detailled construction of the sheaf of differential operators on a variety.

Soit G un groupe algébrique linéaire complexe, simple, connexe et simplement connexe. Étant donné un sous-groupe parabolique P G et un idéal nilpotent n p, il existe un morphisme propre d’effondrement G x P n = Gn. Il se factorise en une variété affine et normale N := SpecC [G P n] que nous appelons variété nilpotente. Sous l’hypothèse que l’effondrement soit génériquement fini, nous décrivons le groupe des classes de diviseurs équivariants de N à l’aide de C[N]-modules réflexifs équivariants de rang 1. Un représentant de chaque classe peut être choisi comme les sections globales d’un fibré en droite sur G x P' n' où G x P' n' = Gn' est un effondrement possiblement distinct qui se factorise à travers la même variété nilpotente. Dans le cas où le groupe G est de type A ou dans le cas d’un effondrement provenant de certains diagrammes de Dynkin pondérés spécifiques, nous démontrons que les représentants proviennent de poids qui peuvent être choisis comme dominants. Dans ce cas, nous démontrons que si le module représente un élément torsion du groupe des classes, alors il est Cohen–Macaulay. Nous en déduisons un théorème d’annulation en cohomologie. / Let G be a simple, connected, simply connected complex linear algebraic group with parabolic subgroup P G and nilpotent ideal n p. The proper collapsing map G x P n = Gn factors through the normal affine variety N := SpecC [G x P n] which is called a nilpotent variety. Assuming the collapsing is generically finite, we describe the equivariant divisor class group of N using rank 1 reflexive equivariant C[N]-modules. A representative of each class may be chosen as global sections of a line bundle over G x P' n' where G x P' n' = Gn' is a possibly distinct collapsing that factors through the same nilpotent variety. Assuming either G is of type A or the collapsing comes from specific weighted Dynkin diagrams,we showthat each representative arise from a weight that may be chosen dominant. Moreover, if the module represents a torsion element within the class group, then it is Cohen– Macaulay and we deduce a cohomological vanishing theorem.

Cette thèse comporte deux parties. Dans la première partie on étudie le motif de Chow d’un fibré en quadriques de dimension relative impaire sur une surface. On montre que ce motif admet une décomposition qui fait intervenir le motif de Prym du revêtement double de la courbe discriminante. Dans la deuxième partie on s’intéresse à des fibrations lagrangiennes, obtenues comme jacobiennes intermédiaires relatives des familles de variétés de Fano de dimension trois contenant une surface K3 fixée, et à l’existence d’une compactification symplectique. Dans un cas particulier, on étudie une compactification partielle en utilisant des calculs avec le logiciel Macaulay2. / This thesis consists of two parts. In the first part we study the Chow motive of a quadric bundle of odd relative dimension over a surface. We show that this motive admits a decomposition which involves the Prym motive of the double covering of the discriminant curve.In the second part, we consider Lagrangian fibrations, obtained as relative intermediate Jacobians of families of Fano threefolds containing a fixed K3 surface, and the existence of a symplectic compactification. In a particular case, we study a partial compactification using calculations with the software system Macaulay2.

La chimie des foldamères est un domaine de recherche en pleine expansion où les chimistes explorent la construction d’architectures artificielles variées mimant les structures repliées des biopolymères naturels. Les foldamères d’oligoamides quinoline, constituent une branche importante des foldamères montrant de nombreuses caractéristiques attractives, incluant la stabilité et la prédictibilité de leurs conformations repliées, qui en font de bons candidats pour des applications biologiques. Jusqu’à présent, la plupart des études sur les foldamères d’oligoamides quinolines ont été menées dans des solvants organiques. Cette thèse a pour objectif d’étendre leur portée au milieu aqueux et présente plusieurs méthodologies pour parvenir à leur solubilité, leur repliement, la variation de leurs chaines latérales, leur agrégation et leur capacité à former des cristaux dans l’eau.Tout d’abord, une méthode de synthèse en phase solide a été développée permettant l’accès rapide aux foldamères hybrides α-amino acide/quinoline (X/Q). Leur étude dans l’eau montre que contrairement aux foldamères hybrides de type (XQ)n, ceux de type (XQ2)n sont capables d’adopter une conformation hélicoïdale présentant un alignement des chaines α-amino acides dans l’espace. Ensuite, plusieurs chaines latérales courtes ont été identifiées pour doter les foldamères aromatiques d’une solubilité et d’une capacité à cristalliser dans l’eau. Six oligoamides quinoline ont ainsi été synthétisés pour une étude modèle. Des cristaux ont été obtenus pour toutes les séquences sauf une, présentant une excessive solubilité dans l’eau. Enfin, des efforts ont été faits pour construire des faisceaux d’hélices auto-assemblés dans l’eau à base d’effets hydrophobes et d’interactions électrostatiques. Les études RMN et cristallographiques ont indiqué que les effets hydrophobes étaient plus faibles qu’attendu et ne provoquaient pas d’agrégation forte. / Foldamer chemistry is a rapidly expanding research field where chemists explore the construction of various artificial architectures that mimic the folded structures of biopolymers found in nature. Quinoline oligoamide foldamers, as an important branch of foldamers, have been shown to possess many desirable features, including stability and predictability of their folded conformations, and are promising candidates to achieve biological applications. Up to now, most investigations of quinoline oligoamide foldamers have been carried out in organic solvents. This thesis is aimed to expand their scope in aqueous medium and presents several methodologies to achieve solubility, folding, side-chain variation, aggregation and crystal growth ability in water.First, a solid phase synthesis method was developed to enable the fast access to α-amino acid/quinoline (X/Q) hybrid oligoamide foldamers. The study of these hybrid foldamers in water showed that contrary to (XQ)n-type foldamers the (XQ2)n-type foldamers could adopt aromatic helical conformations with α-amino acid side chains aligned in space. Then, several short side chains were identified to endow aromatic foldamers with both solubility in, and crystal growth ability from water. Six quinoline oligoamides displaying these side chains were synthesized as a case study. Crystals were obtained from aqueous medium in all cases but one, exceedingly soluble in water. At last, efforts were made to construct self-assembled aromatic helix bundles in water based on hydrophobic effects and electrostatic interactions. NMR and crystallographic studies indicated that hydrophobic effects are weaker than expected and not strongly conducive of aggregation.

The objective of this thesis research is to improve our understanding of the flow obstacle effect on heat transfer at supercritical and high subcritical pressures by experimentally studying the effect of different obstacles on heat transfer in two vertical upward-flow test sections: a 3-rod bundle and an 8 mm ID tube. The heat transfer measurements cover the region of interest of the Canadian Super-critical Water Cooled Reactor (SCWR). A thorough analysis of the obstacle effect on supercritical heat transfer (SCHT) was performed. In the 3-rod bundle, two types of obstacles were employed: wire wraps and low-impact grid spacers. Wire wraps were found to be more effective than grid spacers to enhance the SCHT. In the tubular test section, obstacles appeared to suppress the heat transfer deterioration (HTD) or decrease its severity; obstacles also generally enhanced the SCHT both in the liquid-like and the gas- like region. The experiment in the tubular test section revealed that, at certain flow conditions (low mass flux, low inlet subcooling), flow obstacles can have an adverse impact on the SCHT. A criterion to predict the onset of this adverse effect was developed. At high subcritical pressures, obstacles increased the CHF and reduced the maximum post-CHF temperature. A comparison of the experimental data with prediction methods for the SCHT, single phase heat transfer, CHF and post-dryout heat transfer was performed. Lastly, a new correlation to predict the enhancement in SCHT due to obstacles was developed for heat transfer in the liquid-like and gas-like regions.

O nervo alveolar inferior (Nai), o mais espesso ramo do nervo mandibular (V par craniano), está funcionalmente relacionado à inervação da mandíbula e dentes inferiores, além de parte dos tecidos moles circunjacentes. Seu estudo morfológico, sobretudo em mandíbulas adultas, foi sistematicamente realizado, contudo, sem ainda haver um consenso definitivo para o seu padrão de ramificação. Desse modo, considerando-se a importância em se demonstrar um modelo de constituição básica para o Nai, realizou-se o presente estudo em fetos humanos da 19ª a 36ª semana de vida intrauterina. Foram utilizados 86 hemimandíbulas, de ambos os sexos, em que se avaliou o padrão morfológico intraósseo do Nai e de seus ramos, seus envoltórios conjuntivos e suas relações com as estruturas vasculares, utilizando-se de microdissecção e microscopia eletrônica de varredura (MEV). Relativamente ao padrão morfológico do segmento intramandibular do Nai, foram propostos 4 tipos de ramificação: Tipo I (16%), onde o Nai emite 3 ramos principais, os nervos alveolares inferiores posterior (Naip), médio (Naim) e anterior (Naia); Tipo II (34%), semelhante ao anterior, porém ausente o Naim; Tipo III (30%), semelhante ao primeiro, porém ausentes Naim e o Naia; e o Tipo IV (20%), a forma clássica do Nai, onde somente o Naia se ramifica a partir dele. Verificou-se uma série de conexões entre todos os feixes nervosos, sobretudo entre o Naip e o Nai, sendo que os ramos dentais e peridentais partem, em sua maioria, do Naip, Naim e Naia. Sobre os envoltórios conjuntivos, verificou-se que se espessam à medida que o feto se desenvolve, notando também a presença de uma bainha neurovascular comum a envolver o feixe vasculonervoso alveolar inferior. Quanto ao posicionamento da artéria alveolar inferior, adjacente ao forame da mandíbula, cruza o feixe nervoso, em sua maioria, pela face medial (41%) ou pela lateral (55%), para logo em seguida alcançar sua posição definitiva sobre a face superior do feixe nervoso. Quanto às veias alveolares inferiores, em número de 1 a 3, posicionam-se posteromedialmente às outras estruturas do feixe vasculonervoso. Para a veia de Serres, observada em todos os espécimes e envolta por um canal ósseo, propôs-se a terminologia veia paramandibular. / The inferior alveolar nerve (Nai), the thickest branch of the mandibular nerve (V pair of cranial nerve), is functionally related to jaw and lower teeth innervation as well as, being part of the surrounding smooth tissue. The Nai morphology has been systematically studied in mandible of adults however, no definitive consensus has been reached in relation to its branched pattern. Therefore, this study was been performed in 19 to 36 week-gestation fetuses, due to the importance of determining a basic model of Nai as available data refers only to its arrangement in adults. Micro dissection and Scanner Electron Microscopy (MEV) were performed on 86 human hemi-mandibles of both sexes in order to evaluate the morphological intraosseous pattern of Nai and its branches, its connective tissue and their relationship with vascular structures. In connection with the morphological pattern of intramandibular segment of Nai, four types of branches were proposed: Type I (16%) where Nai give rise to 3 main branches: posterior inferior alveolar nerve (Naip), medium (Naim), and anterior (Naia); Type II (34%), similar to Type I but Naim was absent; Type III (30%), similar to the first, however Naim and Naia were absent; and type IV (20%),the classic form of Nai, from which only Naia was raised. A series of connections was verified among all of the nervous bundles, especially between Nai and Naip. besides dental and periodontal branches commonly arising from Naip, Naim and Naia. In relation with the connective tissues, it was shown that they became thicker as the fetuses are developing; at this stage it was also noted one neurovascular sheath covering nerve bundles and blood vessels. Relatively to the inferior alveolar artery position, adjacent to mandible foramen, it can, frequently, cross the nerve bundle through medial (41%) or lateral surface (55%), reached after its final position on the superior surface of nerve bundle; the inferior alveolar veins (1 to 3), are posterior-medially positioned to the neurovascular bundle other structures. The terminology paramandibular vein was proposed to the Serres vein observed in all specimens studied which was surrounded by bone channel.