The domestication of animals is a process of great interest to many scientific fields, including genetics. Differences in coat colour between wild and domesticated animals have been of scientific interest for a long time. Coat colours are easily recognizable phenotypes and so have been studied since the dawn of modern genetics. Many phenotypes that are similar across species have the same genetic basis, but there are numerous exceptions. Similar phenotypes within a species can also have different genetic backgrounds. The progressive advances in genetic research methodology have given new insights into both the molecular basis for coat colours and the history of domestication over the last decades. The variation in coat colours seen today is believed to be caused mainly by human selection. Similarities in morphological changes between different species during domestication, including colour phenotypes such as white spotting, have long been noted. This is known as the domestication syndrome and two major hypotheses for this have been suggested: the neural crest hypothesis and the thyroid hormone hypothesis. This thesis gives an overview of the current knowledge about the genetic basis of coat colours in mammals, the genetic aspects of domestication of animals, and how the two are related.

<p> The implication of the title of this thesis, Emily Dickinson's Spectrum, is that this poet had a highly individual attitude towards colour, an attitude which the analysis of colour-imagery in the poet's writings will illuminate. The first chapter of the thesis demonstrates how the poet's scientific background enabled her to set up a spectrum that differed from the "received" Newtonian spectrum in many ways. The second chapter shows how Dickinson's originality, a quality often noticed by critics, is to a large extent the product of her ability to manipulate the colours of her spectrum in a manner analogous to the practice of the pictorial artist. The third chapter explains, however, that though her use of colour was indeed original, her practice reflects the international anti-Newtonian "colour-revolution" of the era in which she lived, a revolution in which she had a significant role to play notwithstanding her apparent seclusion in Amherst. In the final chapter, Emily Dickinson's spectrum is set out, and each of its chief colours is shown to be a concise means of referring to a different complex or node of emotions that are at once personal and universal in their import.</p> / Thesis / Doctor of Philosophy (PhD)

No / The spatial and temporal properties of human colour vision are examined using isoluminant, red¿green and blue¿yellow tritanopic gratings. Chromatic sensitivity is found to be low-pass as a function of both spatial and temporal frequency along all the chromatic axes investigated, including the tritanopic confusion lines employed to examine the properties of the S-cone driven mechanism. Comparison of sensitivity to on-off and contrast reversing stimuli indicates that transient mechanisms contribute to the detection of red¿green patterns but that the detection of S-cone specific patterns is governed by sustained mechanisms. By compensating for transient contributions to red¿green sensitivity, it is shown that sensitivity of chromatic mechanisms dominated by L- and M-cone input are closely matched to those with S-cone input.

Yes / We used triple silent substitution stimuli to characterize human S-cone electroretinograms (ERGs) in normal trichromats. Short-wavelength-cone (S-cone) ERGs were found to have different morphological features and temporal frequency response characteristics compared to ERGs derived from L-cones, M-cones, and rod photoreceptors in normal participants. Furthermore, in two cases of retinal pathology, blue cone monochromatism (BCM) and enhanced S-cone syndrome (ESCS), S-cone ERGs elicited by our stimuli were preserved and enhanced, respectively. The results from both normal and pathological retinae demonstrate that triple silent substitution stimuli can be used to generate ERGs that provide an assay of human S-cone function. / Deutsche Forschungsgemeinschaft (DFG) (KR1317/13-1); Bundesministerium für Bildung und Forschung (BMBF) (01DN14009)

Yes / Edge detection plays an important role in human vision, and although it is clear that there are luminance edge detectors, it is not known whether there are chromatic edge detectors as well.We showed observers a horizontal edge blurred by a Gaussian filter (with widths of r ¼ 0.1125, 0.225, or 0.458) embedded in blurred Brown noise. Observers had to choose which of two stimuli contained the edge. Brown noise was used in preference to white noise to reveal localized edge detectors. Edges and noise were defined by either luminance or chromatic contrast (isoluminant L/M and S-cone opponent). Classification image analysis was applied to observer responses. In this analysis, the random components of the stimulus are correlated with observer responses to reveal a template that shows how observers weighted different parts of the stimulus to arrive at their decision.We found classification images for both luminance and isoluminant chromatic stimuli that had shapes very similar to derivatives of Gaussian filters. The widths of these classification images tracked the widths of the edges, but the chromatic edge classification images were wider than the luminance ones. These results are consistent with edge detection filters sensitive to luminance contrast and isoluminant chromatic contrast. / Royal Society Travel Grant IE130877 and in part by Canadian Institutes of Health Research (CIHR) grant MOP-10819

The work in this thesis is concerned with examining the retinal and cortical contributions to human trichromatic colour vision. Chromatic processing at the cortex level was examined using visual evoked potentials (VEPs). These responses were elicited by chromatic spot stimuli, which were manipulated in order to selectively activate the chromatic processing system. Chromatic processing at the retinal level was examined using the electroretinograms (ERGs) for which cone isolating stimuli were used to assess the nature of L and M cone inputs to cone-opponent mechanisms. The results from the VEP experiments suggest VEP morphology is dependent upon 1) chromatic and or luminance contrast content of the stimulus, 2) stimulus size, and 3) extent to which the chromatic stimulus activates either the L/M or S/(L+M) opponent mechanism. The experiments indicate that chromatic stimulation is indexed by large N1 component and small offset responses. Optimal stimulus size for chromatic isolation is 2-4 ° along L/M axes and 6° along S/(L+M) axis. From the ERG experiments, It has been shown that the low (12Hz) and high (30Hz) temporal frequency flickering stimuli can isolate the chromatic and luminance processing mechanisms in the retina. For low temporal frequency ERGs, the L:M ratio was close to unity and L/M phase difference was close to 180°. For high temporal frequency ERGs, the L:M ratio was more than unity and L/M phase difference was close to 90°. In addition to this, the variation in L:M ratio across the retinal eccentricity was also examined. These results suggest, for the chromatic processing, L:M ratio is close to unity independent of retinal eccentricity and individuals. For the luminance processing, L:M ratio is more than unity and depends upon the region of the retina being stimulated. These findings indicate the maintenance of cone selective input for the chromatic processing across the human retina.

Flax (Linum usitatissimum L.) is a commercial oilseed crop in Canada. Globally flax is known for industrial oil and fiber. Flaxseed contains Omega 3 fatty acid, lignans like secoisolariciresinol diglucoside (SDG), flavonoids and polysaccharides which offer potential health benefits. Conventional flax cultivars are brown seeded and few mutant lines are yellow seeded. The darkness of seed colour depends on the presence of polymerized proanthocyanidins (PA; condensed tannins) in the seed coat. PAs are the product of the phenylpropanoid pathway. Previous genetic studies by Mittapalli and Rowland (2003) on G1186/94 showed the seed colour trait was governed by the homozygous recessive alleles at D locus and the same locus is closely linked to white or pink flower petals. To start with, single seeds of already developed stable recombinant inbred lines (RILs) (of F8:9 generation) from a cross of yellow seeded European recessive line (G1186/94) and brown seeded CDC Bethune (popular variety) were grown. In this study, seed colour phenotyping was done by measuring seed colour of each RIL in Red-Green-Blue (RGB) values. To understand the genetic basis of flax seed and flower colour, mapping with single sequence repeats (SSRs) and CAPS (Cleaved Amplified Polymorphic Sequences) markers were used. For the first time, a framework genetic linkage map was constructed from populations of CDC Bethune/ G1186/94 containing 19 linkage groups (LGs). LG 1 with four SSR markers was found to be linked with the seed colour locus D. During the fine-mapping, two SSR markers (LuM566 and Lu2351) were found to be linked with the seed colour trait. The D locus has been confined in a 2.8 cM region and the closest marker was LuM566 at a distance of 0.6 cM. This was observed to be a stable locus in two growth trials and in different environments with logarithm of odds (LOD) above 39 and more than 84 % of the trait expressed by the major locus in both trials. As there were no recombinants (off types) for flower colour in F8:9 plants i.e brown-seeded lines produced blue flowers and yellow-seeded lines produced white flowers, the same locus holds well for the flower colour trait. The marker associated with seed and flower colour in G1186/94 (European recessive yellow line) was identified and can be used in flax breeding. Additionally, an interesting putative candidate gene of potential significance was identified through genomics assisted gene search from the flax whole genome sequence database. The gene expression analyses showed lower expression of putative flavonoid 3’ hydroxylase (F3’H) (a gene involved in flavonoid biosynthesis pathway) in both seed coat and flower petal tissues of G1186/94 as compared to CDC Bethune. Therefore, this study represents the first report on genetic mapping based putative candidate gene finding for recessive yellow seed colour mutation in the D locus in flax.

Ce travail cherche à défendre une théorie objectiviste des couleurs en conciliant deux thèses tenues habituellement pour incompatibles : le physicalisme, selon lequel les couleurs sont des propriétés physiques décrites par la science, et la thèse de la révélation, selon laquelle la nature des couleurs est révélée par l’expérience. Ces deux thèses sont tenues pour inconciliables parce que les couleurs se présentent comme des qualités, alors que la science traite de quantités. Après être revenu sur l’histoire du problème en montrant comment on peut comprendre la controverse moderne sur les qualités secondes à partir de la thèse de la révélation, je montre comment comprendre cette dernière thèse et je soutiens que toute théorie plausible des couleurs doit soutenir la révélation. Je soutiens que les couleurs sont des événements transitoires, et non pas des propriétés permanentes des objets. La lumière ne se contente pas de révéler la couleur des objets, mais la produit : les couleurs sont des effets de l'interaction de la lumière avec l'objet ou, quand il s'agit de sources primaires de lumière, des événements se produisant en leur sein. Cette thèse semble offrir une réponse, au moins partielle, à des arguments classiques à l'encontre de l'objectivité des couleurs, notamment certaines versions de l'argument de la relativité. Surtout, cette catégorisation nouvelle des couleurs permet de concilier les descriptions qualitatives et chromatiques des couleurs avec leurs descriptions quantitatives et physiques, permettant ainsi de concilier l’image manifeste et l’image scientifique du monde. / This work tries to defend an objectivist theory of colour by a reconciliation of two theses generally considered as incompatible: physicalism, the theory that colours are scientific properties of objects, and revelation, the thesis that the nature of a colour is revealed by an experience of this colour. Those theses are considered as incompatible because colours are presented as qualities, while science is only about quantities. After a chapter about the history of the problem, showing how we can understand the modern controversy on secondary qualities thanks to the revelation thesis, I show how to understand revelation, distinguishing it from phenomenology, and claim that a correct theory of colour must support revelation. After that, I argue that colours are transitory events, not standing properties: light produce colours, which are effects of the interaction of light with matter or, for primary light sources, events happening in them. This thesis gives a partial answer to some arguments against objectivism, notably variability arguments. Above all, this new categorization of colour reconciles the qualitative chromatic descriptions of colours with their quantitative physical descriptions, thus allowing reconciliation between the manifest and the scientific images of the world.

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<p>In the newspaper printing industry, offset is the dominating printing method and the use of multicolour printing has increased rapidly in newspapers during the last decade. The offset printing process relies on the assumption that an uniform film of ink of right thickness is transferred onto the printing areas. The quality of reproduction of colour images in offset printing is dependent on a number of parameters in a chain of steps and in the end it is the amount and the distribution of ink deposited on the substrate that create the sensation and thus the perceived colours. We identify three control points in the offset printing process and present methods for assessing the printing process quality in two of these points:</p><p>• Methods for determining if the printing plates carry the correct image</p><p>• Methods for determining the amount of ink deposited onto the newsprint</p><p>A new concept of colour impression is introduced as a measure of the amount of ink deposited on the newsprint. Two factors contribute to values of the colour impression, the halftone dot-size and ink density. Colour impression values are determined on gray-bars using a CCD-camera based system. Colour impression values can also be determined in an area containing an arbitrary combination of cyan magenta and yellow inks. The correct amount of ink is known either from a reference print or from prepress information. Thus, the deviation of the amount of ink can be determined that can be used as control value by a press operator or as input to a control system.</p><p>How a closed loop controller can be designed based on the colour impression values is also shown.</p><p>It is demonstrated that the methods developed can be used for off-line print quality monitoring and ink feed control, or preferably in an online system in a newspaper printing press.</p> / Report code: LiU-TEK-LIC-2005:02.