Made available in DSpace on 2016-03-15T19:38:04Z (GMT). No. of bitstreams: 1 ANA LEDA SILVA MORAES.pdf: 1708515 bytes, checksum: 8e07dd190f9a5fd165c14e35c2c626b0 (MD5) Previous issue date: 2016-02-01 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Epidemiology is the science that studies the occurrence of diseases in a population. The results of these studies allow a comprehension of a disease propagation and enable actions in order to control epidemics. There are many mathematical models used in epidemiological studies; in which SIR-like models are the most used. In this model, the population is divided into three groups: S - susceptible individuals to infection, I - infected individuals, and R - recovered individuals. The proposal of this thesis is, based on a new SIR model, taking into consideration the effect of recovered individuals on the propagation of contagious diseases and on the recovery of sick individuals. This can be relevant to the study of propagation of typical diseases in children, since immune individuals can catalyze the encounters among susceptible children and infected children, as well as to contribute to the recovery of sick individuals. The predictive ability of the proposed model is evaluated from the records refering to the incidence of chickenpox in Belgium, Germany and Italy, in a pre-vaccination era. / Epidemiologia é a ciência que estuda as ocorrências de doenças numa população. Os resultados desses estudos permitem uma compreensão do comportamento da incidência da doença e possibilita ações a fim de controlar epidemias. Há vários modelos matemáticos que são utilizados para estudos epidemiológicos, sendo modelos do tipo SIR os mais empregados. Nesse modelo, divide-se a população em três classes: 𝑆 - indivíduos suscetíveis à infecção, 𝐼 - indivíduos infectados, e 𝑅 - indivíduos recuperados. A proposta desta dissertação é, a partir de um novo modelo SIR, levar em consideração o efeito de indivíduos recuperados na propagação de doenças contagiosas e na recuperação de indivíduos doentes. Isso pode ser relevante no estudo da propagação de infecções típicas de crianças, já que indivíduos imunes podem servir como catalisador de encontros entre crianças suscetíveis e crianças infectadas, bem como contribuir para a recuperação de indivíduos doentes. A capacidade preditiva do modelo proposto é avaliada a partir dos registros referentes à incidência de varicela na Alemanha, Bélgica e Itália, numa era pré-vacinação.

Syftet med detta examensarbete är att ta reda på hur kollektivtrafiken påverkats indirekt av covid-19, då med minskat resande, förändrat beteende kring resande på grund av restriktioner och den smittorisken som finns. Målet är att förstå effekterna på den lokala busstrafiken i en stadsdel i Gävle. Ämnet för examensarbetet valdes utifrån intresset att öka kunskapen om hur samhället påverkas av den högst aktuella världsomspännande pandemin, covid-19. Litteraturstudien över tidigare och nutida forskning visar att av den smittspridning som har förekommit och förekommer i samhället har en del skett inom kollektivtrafiken. Samtidigt infördes kraftiga restriktioner för resande i och med utbrottet av covid-19. Med den utgångpunkten valdes att undersöka hur resandet påverkats, och i så fall vad som eventuellt påverkat vid sidan av restriktionerna. För att kunna hålla givna tidsramar avgränsades arbetet till att omfatta bussresandet i Gävle, och mer specifikt i stadsdelen Sätra. Boende i stadsdelen tillfrågades om sina resvanor genom att svara på en web-baserad enkät. Enkäten innehöll elva frågor om resmönster, resvanor och inställningen till busstrafiken de senaste 12 månaderna, från april 2020 till april 2021. Även intervjuer genomfördes under arbetets gång. De gjordes med tre trafikplanerare från det lokala bussbolaget, X-trafik samt Vy bussar, vilka är de som planerar busstrafiken i staden. Resultatet av enkäten och intervjuerna visar på att användningen av busstrafiken har gått ner under det undersökta året. Statistik från bussbolaget visar på en nedgång med 28% för helåret 2020. Analysen av enkäterna tyder på att den minskade användningen beror dels på en generell rädsla för covid-19, dels på de restriktioner och råd som gällde samt en oro över att bli smittad om man använder kollektivtrafiken. Avslutningsvis behöver rollen som kollektivtrafik har och kommer att fortsätta ha i människor liv att fortsätta undersökas för att få bättre kunskap om hur människor tar till sig råd och restriktioner samt hur man agerar utifrån dessa. Vi behöver nya verktyg för att få ett mer resilient samhälle, så att vi bättre kan hantera, tyvärr, förväntade framtida pandemier.

Börsintroduktioner är ett ämne som undersökts i många tidigare studier, men där fokuset oftast legat på vilka effekterna det har på det börsnoterade företaget i stället för dess konkurrenter. Tidigare forskning har undersökt hur en börsintroduktion påverkar konkurrenternas aktiekurser och funnit att det resulterar i både negativa och positiva effekter. Syftet med studien är att undersöka om det förekommer temporära effekter på konkurrenters aktiekurser vid börsintroduktioner på Euronext-marknaden. För att genomföra detta utformas en eventstudie som består av 25 dagar kring börsnoteringsdagen. Utifrån detta så beräknas den kumulativa avvikelseavkastningen under eventfönstret som använts för att genomföra en multivarit regressionsanalys som syftar att isolera effekterna i de olika variabler. Effekterna som ämnas att isoleras är konkurrenseffekten, positiva kontagiösa effekter samt negativa och positiva utbudschocker vars alla påvisats finnas i tidigare studier. Resultaten från studien indikerar att det uppstår både negativa och positiva effekter på konkurrenternas aktiekurser vid en börsintroduktion, men att de negativa effekterna är starkare. Studien visar därmed på att det förekommer negativa temporära avvikelseavkastningar på konkurrenternas aktiekurser vid börsintroduktioner på Euronext-marknaden. / Initial public offerings (IPOs) have been the subject of many previous studies, but the focus has mainly been on the effects they have on the listed company rather than its competitors. Previous research has examined how an IPO affects competitor's stock prices and found that it results in both negative and positive effects. The purpose of this study is to investigate whether there are temporary effects on competitor's stock prices around IPOs on the Euronext market. To accomplish this, an event study is designed, consisting of a 25-day window around the IPO date. Based on this, the cumulative abnormal returns during the event window are calculated and used to conduct a multivariate regression analysis aimed at isolating the effects in the various variables. The effects to be isolated include competitive effects, positive contagion effects, and negative and positive supply shocks, all of which have been shown to exist in previous studies. The results of the study indicate that there are both negative and positive effects on competitor's stock prices during an IPO, but that the negative effects are stronger. Thus, the study shows that it exists a negative temporary abnormal return on competitor's stock prices around IPOs on the Euronext market.

Ce travail porte sur le développement de l’hygiène publique dans le royaume de Grèce entre 1833, année de l’accession au trône du prince Othon de Bavière, et 1845, lorsqu’un système complet des lazarets et d’offices de santé trace les frontières politiques et épidémiologiques du royaume. Après avoir traité les structures de prévention sanitaire érigées tantôt à l’intérieur du pays (vaccinateurs, médecins publics, médecins municipaux) tantôt sur ses frontières, nous étudions les mesures pour lutter contre les maladies contagieuses (surtout la peste et la variole) et contre les miasmes. Nous nous efforçons d’analyser également les maladies qui déterminent la mortalité à l’époque ainsi que les théories médicales qui expliquent les mesures appliquées, en essayant de dépasser certains aspects de la distinction classique d’Erwin Ackerknecht entre contagionnisme et infectionnisme. Enfin, nous abordons la formation du corps médical officiel, processus qui a entraîné des changements dans la pratique médicale. Cet intérêt pour l’hygiène publique impose l’étude de la construction de l’Etat et de sa ‘base biologique’. L’hygiène publique définit les menaces contre lesquelles elle s’érige en même temps qu’elle construit et met en sécurité la collectivité. Dans l’Etat de police du caméraliste Othon I, ces développements sont l’affaire de la bureaucratie, de l’administration, de la force publique et de la science de la police sanitaire. Son but était la construction et la mise en ordre de l’espace public, de l’espace d’action de l’Etat, qui est tout autant naturel que social. Cet établissement d’un ordre favorise la centralisation sanitaire en même temps qu’il prétend discipliner (processus de civilisation) les éléments naturels et les forces sociales pour qu’ils puissent être coordonnés sans résistances ; autrement dit, l’action d’imposer un ordre pacifie. La police sanitaire contrôle ces processus, en reconfigurant les liens que les hommes tissent entre eux, avec la géographie, avec la nature et avec leurs maladies. / This study is about the organization of public hygiene in the kingdom of Greece between 1833, when prince Otto of Bavaria ascends to the throne, and 1845, when the political and epidemiological frontiers of the kingdom are traced by a complete system of lazarettos and sanitary offices. We will firstly analyze the structures of sanitary prevention in the interior of the country (vaccinators, public health doctors, municipal doctors) as well as at its frontiers, and then we will focus on the measures against contagious diseases (such as the plague and smallpox) and against miasmas. We are also interested in examining the main diseases that determine the mortality of the period under scrutiny and the medical theories that explain the applicable sanitary measures. At the same time, we will review some of the aspects of the classical distinction of Erwin Ackerknecht between contagionism and miasmatic theory. Finally, we will study the difficult formation of an official group of medical professionals. The interest in public hygiene imposes the study of the biological construction of the state and, subsequently, of the state itself. Public hygiene defines the threats which it tries to prevent, and it creates and secures the collectivity. In the Police State of the cameralist king Otto, these developments are controlled by the bureaucracy, the administration, the public force and the science of medical police. Its purpose is to construct and order the public space, the space of state action, which is natural as well as social. This action of ordering imposes the centralization of health and at the same time it normalizes the natural elements and the social forces so that they can coordinate without resistance; in other words, the action of ordering pacifies. Medical police controls these processes by reconfiguring the ties that bind individuals with each other and with the geography, the nature and their diseases.

Thesis (MA)--Stellenbosch University, 2014. / ENGLISH ABSTRACT: This study deals with the build-up to, and resultant reactions against, regulating sexual practices in the Cape Colony, especially the Contagious Diseases Acts in 1868 and 1885. The focus will be on the existence of venereal disease as a colonial epidemic. The wider context in terms of Britain, India, Hong Kong, Singapore and Australia will also be taken into account. The research is based on a theoretical framework made up of three components; gender, power and moral politics. The role of gender will be looked at through the existence of the double standard and the prostitute. Power and the existing relations between the colonies and the colonisers will be looked at by addressing the issue of race, superiority and the exportation of the colonial mindset. Moral politics will be analysed through the discussion of purity campaigns, women’s role in society and the medical aspect of politics. Within this thematic framework, the focus of the study will then move to the Cape Colony and the existence of regularity practices there. This study seeks to establish the ways in which regulation developed at the Cape and in doing so hopes to contribute to the existing historiography. / AFRIKAANSE OPSOMMING: Hierdie studie fokus op die aanloop tot en die daaropvolgende reaksies ten opsigte van regulatoriese sekspraktyke, waarvan die bekendste die Aansteeklike Siektes Wette van 1869 en 1885 was. Daar word na die bestaan van veneriese siekte as ‘n koloniale epidemie gekyk. Die breër konteks van Brittanje, Indië, Hong Kong, Singapoer en Australië word ook in ag geneem. Die navorsing is gebaseer op ‘n teoretiese raamwerk van drie komponente: geslagtelikheid (“gender”) , mag en morele politiek. Die rol van geslagtelikheid word betrag na gelang die bestaan van dubbele standaarde en die prostituut. Mag en die bestaande verhoudinge tussen die koloniseerders en die wat gekoloniseer, word aangespreek deur te let op die kwessie van ras, meerderwaardigheid en die toepassing van ‘n koloniale denkpatroon. Morele politiek word ontleed deur te let op die bespreking van kuisheid kampanjes, vroue se rol in die samelewing en die mediese aspekte van politiek. Binne hierdie teoretiese raamwerk word die bestaan van regulatoriese praktyke in die Kaapkolonie bespreek. Die studie poog om vas te stel op welke wyses regulatoriese praktyke in die Kaapkolonie ontwikkel het en sodoende word gepoog om ‘n bydrae tot die bestaande historiografie te maak.

The canine transmissible venereal tumour (CTVT) is a contagious cancer that is naturally transmitted between dogs by the allogeneic transfer of living cancer cells during coitus. CTVT first arose several thousand years ago and has been reported in dog populations worldwide. The goals of this Thesis were (1) to gain further understanding of CTVT distribution patterns and prevalence around the world, (2) to use genetics to trace the historical spread of CTVT and (3) to map the genetic as well as phenotypic diversity of CTVT tumours around the world. To understand the distribution patterns of CTVT, I obtained information from 645 veterinarians and animal health workers in 109 countries, and generated a snapshot of the locations in which this disease is found. Additionally, as preparation for further genetic analysis, I collected samples from over one thousand CTVT cases from more than 50 countries, optimised methods for high-throughput DNA extraction and quantification and optimised a qPCR-based assay for CTVT diagnosis and host contamination detection. With the goal of tracing the historical spread of CTVT and learning about the genetic diversity of this disease, I sequenced complete mitochondrial genomes of 449 CTVT tumours and their matched hosts. The analysis of the CTVT mitochondrial diversity revealed that CTVT has captured mitochondrial DNA (mtDNA) through horizontal transfer events at least five times during the history of the lineage, delineating five tumour clades. CTVT appears to have spread rapidly around the world within the last 2,000 years, perhaps transported by dogs travelling along historic maritime trade routes. This work indicated that negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and that recombination has caused occasional mtDNA re-assortment. A histology-based screen of CTVT clades did not show any significant phenotypic differences between groups. In order to determine how the five mtDNA clades relate to each other, I analysed data from 539 CTVT exomes. This revealed that a single canine mtDNA haplogroup has recurrently and recently undergone multiple horizontal transfer events. Analysis of this haplotype highlighted a number of candidate genetic variants which may be conferring a selective advantage to this haplotype in CTVT, possibly by influencing mtDNA transcription or replication. Overall, genetic and phenotypic analysis of CTVT tumours from across the globe has broadened our understanding of CTVT diversity, and provided important insights into the biology of a unique transmissible cancer.

This diploma thesis on the theme:"The implementation of the International Health Regulations, 2005 in Czech Republic.", is divided into theoretical and practical part.The theoretical part focuses on the International Health Regulations 2005 capacity required, and the measures proposed in the Czech Republic. It describes the history of the International Health Regulations and the implementation of International Health Regulations 2005, in Czech Republic.I also deal, in this part of thesis, about highly contagious diseases.Data processing research for this study was collected in the district of Český Krumlov. The research was conducted by a qualitative method.The sample consisted of 8 respondents.The aim of the study was to determine whether practitioners know how to proceed in case of a patient with a highly contagious disease in their office.This diploma thesis could serve as a source of information, whether the Czech Republic meet the requirements formulated by the World Health Organization in the International Health Regulations 2005.

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.

This thesis examines whether and how historians’ reliance on medical treatises has limited the historiography of contagion as it relates to fourteenth through sixteenth century England. It analyses the context, contents, audience, and codicology of six English tractates, four on the plague and two on the sweating sickness. Before the early seventeenth century, most English tractates were translations/adaptations of Continental works, with ‘uniquely English’ content added. Although the plague dominates studies of pre-modern disease, focusing on the plague hinders comparative analyses that can reveal much about contemporary understanding of contagion. The socio-political-professional contexts in which the tractates were written and disseminated affected their contents, circulation and, ultimately, audiences. Although largely ignored by historians, the tractates’ prefatory dedications, together with their codicology, reveals that the texts were likely accessible to non-elite audiences. Rather than being limited to its medical sense, contagion formed part of the larger discourse about the human condition.