Les maladies auto-immunes et systémiques sont des maladies sur lequel le champ de la recherche pose son œil de façon appuyée depuis 15 ans, du fait de l’émergence de thérapies biologiques ciblées. Ces pathologies sont volontiers hétérogènes, au mieux de fréquence ou caractéristiques particulières dans les populations d’origine Africaine. La connaissance de l’épidémiologie, et des caractéristiques de ces maladies est un préalable essentiel à la mise en place de recherche plus fondamentale pour aider à décomposer leurs physiopathologies souvent extrêmement complexes. En effet, la comparaison de différences marquées entre deux expressions dans des populations différentes d’une même maladie peut permettre d’aider à en dénouer le fil. Nous proposons dans ce travail une estimation des caractéristiques du lupus cutané et du lupus systémique en Guyane Française qui retrouve une faible fréquence de la maladie, la plus faible jamais retrouvée dans une population subsaharienne. Nous décrivons en Martinique sur le plan épidémiologique comme clinique une forme rare de myosite appelée syndrome des anti-synthétases semblant très particulière, l’épidémiologie et la description de la maladie de Kikuchi-Fujimoto pour la première fois dans la littérature, l’épidémiologie et les caractéristiques à base de population de la maladie de Behcet, des principales vascularites (périartérite noueuse, micropolyangéite, granulomatose éosinophile avec polyangéite, granulomatose avec polyangéite), de l’hypertension pulmonaire des connectivites qui semblent plus fréquentes que chez les Européens. Les néphropathies du lupus systémiques sont décrites dans la population Guadeloupéenne montrant une grande fréquence des néphropathies prolifératives. Le protocole EUROLUPUS qui permet le traitement de ces néphropathies prolifératives du lupus systémique avec de faibles doses de cyclophosphamide et de corticoïdes, est évalué en Martinique sur 30 patients alors qu’il ne l’a jamais été dans une population d’origine Africaine. Il semble y être aussi efficace que chez les patients d’origine Européenne, alors que les néphropathies y ont un pronostic meilleur. La maladie de Sjögren primaire est décrite en Martinique très proche de ce qu’on trouve en Europe sur le plan du tableau clinique et évolutif alors que cela n’est l’objet d’aucune étude dans une population d’origine noire Africaine. Nous avons par ailleurs montré en Martinique l’amélioration de la prise en charge du lupus systémique en Martinique au travers de la régression au fil du temps d’une des complications de la corticothérapie les plus pénibles pour les patients, l’ostéonécrose aseptique. La sclérodermie systémique est décrite à base de population avec épidémiologie dans les deux départements de Guadeloupe et Martinique, montrant des caractéristiques proches de celles retrouvées chez les AfroAméricains. Nous avons aussi montré la fréquence et la gravité des atteintes ORL des myopathies inflammatoires sur ces 2 départements avec une fréquence inhabituelle de certaines maladies auto-immunes dont le lupus systémique et les myosites inflammatoires associées aux anticorps anti-SRP, et l’absence de myosite à inclusion. Au total, nous apportons une somme de connaissance descriptive de ces maladies auto-immunes et systémiques permettant la mise en place de recherches plus fondamentales avec des bases solides par rapport aux profils hétérogènes de ces maladies. / Auto-immunes and systemic diseases are priorities for researchers since 15 years. This is related to the emergence of biological therapies, associated to great efficacy. Although, these diseases are heterogeneous, depending of different parameters such as ethnicity or geography. In the African descent population, we encounter unusual or particular manifestations of these diseases. Also, the knowledge of epidemiology and population based descriptions are crucial to properly initiate works on these populations, but also to understand a particularly complex physiopathology by using differences between populations. We describe in this work the population based characteristics of pure cutaneous lupus and systemic lupus, including an epidemiology of the incidence of the lowest incidence ever found in a population of African heritage. We also describe a population based series of anti-synthetase syndrome, confirming that the presentation is totally different compared to caucasians, and allows in Martinique the incidence, never explored before. We also provide the first evaluation of Kikuchi-Fujimoto disease in a population of African origin, and the first incidence ever realized. We do the same evaluation of the epidemiology of Behcet’s disease in a black origin population that shows that this disease was at a similar frequency in Martinique and in Europe. Micropolyangeitis, polyarteritis, eosinophilic granulomatosis with polyangeitis and Granulomatosis with polyangeitis were evaluated in an epidemiologic study in Martinique, with addition of some cases from other French American region for a more powerful characteristics description. These diseases seem less frequent than in Europe, associated with less severity except for micropolyangeitis. EUROLUPUS, a protocol with low dose IV cyclophosphamide and low dose steroids, used to treat proliferative nephritis of systemic lupus is shown to have the same efficacy in Martinique than in patients of European origin. Primary Sjögren syndrome, evaluated in Martinique, is very similar in expression than what is found in Europe. The decrease overtime of aseptic osteonecrosis, a steroid side effect, is a witness of better control of systemic lupus activity with less usage permitted by protocols and new immunosuppressive drugs such as mycophenolate. Systemic sclerosis is described as very close to African American in a population based study in Martinique and Guadeloupe. We finally show that the rare ENT involvement of idiopathic inflammatory myositis is frequent in our population, associated with poor outcome, and surprisingly frequently related to systemic lupus and necrotizing myositis associated to SRP antibody but not to inclusion body myositis. To conclude, we allow an amount of description of these diseases in our region, including pioneer studies. This works tends to be the basis for studies to be continued in a more fundamental way in our countries.

Dans cette thèse , nous proposons d’étudier des questions sur le parallélism de tâche avec dépendance de données dans le cadre de machines multicoeur avec des accélérateurs. La solution proposée a été développée en utilisant l’interface de programmation haute niveau XKaapi du projet MOAIS de l’INRIA Rhône-Alpes. D’abord nous avons étudié des questions liés à une approche d’exécution totalement asyncrone et l’ordonnancement par vol de travail sur des architectures multi-GPU. Le vol de travail avec localité de données a montré des résultats significatifs, mais il ne prend pas en compte des différents ressources de calcul. Ensuite nous avons conçu une interface et une modèle de coût qui permettent d’écrire des politiques d’ordonnancement sur XKaapi. Finalement on a évalué XKaapi sur un coprocesseur Intel Xeon Phi en mode natif. Notre conclusion est double. D’abord nous avons montré que le modèle de programmation data-flow peut être efficace sur des accélérateurs tels que des GPUs ou des coprocesseurs Intel Xeon Phi. Ensuite, le support à des différents politiques d’ordonnancement est indispensable. Les modèles de coût permettent d’obtenir de performance significatifs sur des calculs très réguliers, tandis que le vol de travail permet de redistribuer la charge en cours d’exécution. / Esta tese investiga os desafios no uso de paralelismo de tarefas com dependências de dados em arquiteturas multi-CPU com aceleradores. Para tanto, o XKaapi, desenvolvido no grupo de pesquisa MOAIS (INRIA Rhône-Alpes), é a ferramenta de programação base deste trabalho. Em um primeiro momento, este trabalho propôs extensões ao XKaapi a fim de sobrepor transferência de dados com execução através de operações concorrentes em GPU, em conjunto com escalonamento por roubo de tarefas em multi-GPU. Os resultados experimentais sugerem que o suporte a asincronismo é importante à escalabilidade e desempenho em multi-GPU. Apesar da localidade de dados, o roubo de tarefas não pondera a capacidade de processamento das unidades de processamento disponíveis. Nós estudamos estratégias de escalonamento com predição de desempenho em tempo de execução através de modelos de custo de execução. Desenvolveu-se um framework sobre o XKaapi de escalonamento que proporciona a implementação de diferentes algoritmos de escalonamento. Esta tese também avaliou o XKaapi em coprocessodores Intel Xeon Phi para execução nativa. A conclusão desta tese é dupla. Primeiramente, nós concluímos que um modelo de programação com dependências de dados pode ser eficiente em aceleradores, tais como GPUs e coprocessadores Intel Xeon Phi. Não obstante, uma ferramenta de programação com suporte a diferentes estratégias de escalonamento é essencial. Modelos de custo podem ser usados no contexto de algoritmos paralelos regulares, enquanto que o roubo de tarefas poder reagir a desbalanceamentos em tempo de execução. / In this thesis, we propose to study the issues of task parallelism with data dependencies on multicore architectures with accelerators. We target those architectures with the XKaapi runtime system developed by the MOAIS team (INRIA Rhône-Alpes). We first studied the issues on multi-GPU architectures for asynchronous execution and scheduling. Work stealing with heuristics showed significant performance results, but did not consider the computing power of different resources. Next, we designed a scheduling framework and a performance model to support scheduling strategies over XKaapi runtime. Finally, we performed experimental evaluations over the Intel Xeon Phi coprocessor in native execution. Our conclusion is twofold. First we concluded that data-flow task programming can be efficient on accelerators, which may be GPUs or Intel Xeon Phi coprocessors. Second, the runtime support of different scheduling strategies is essential. Cost models provide significant performance results over very regular computations, while work stealing can react to imbalances at runtime.

Thesis Abstract Akshay Aggarwal July 2020 This thesis attempts at correction of some errors and inconsistencies in dif- ferent treebanks. The inconsistencies can be related to linguistic constructions, failure of the guidelines of annotation, failure to understand the guidelines on annotator's part, or random errors caused by annotators, among others. We propose a metric to attest the POS annotation consistency of different tree- banks in the same language, when the annotation guidelines remain the same. We offer solutions to some previously identified inconsistencies in the scope of the Universal Dependencies Project, and check the viability of a proposed in- consistency detection tool in a low-resource setting. The solutions discussed in the thesis are language-neutral, intended to work with multiple languages with efficiency. 1

We present results of an experimental and theoretical study of the magnetic properties of soft magnetic gels consisting of micron-sized magnetizable particles embedded in a polymer matrix. Experiments demonstrate hysteretic dependences of composite magnetization on an applied magnetic field and non-monotonic, with maximum, dependence of the sample susceptibilities on the field. We propose a theoretical approach which describes the main physical features of these experimental results.

Russia’s invasion of Ukraine in 2022 has once again demonstrated that the European Union does not have a common external energy policy since it has struggled to take on a common energy position towards Russia. Prior research has stated that this can mainly be attributed to member states' divergent energy supply objectives towards Russia, which can be divided into two groups. One group comprises Central and East European member states who want to reduce their import dependencies on Russia. The other group, mainly composed of Western member states, seek to maintain their relations with Russia. This paper analyzes how these two groups' divergent energy supply objectives have changed and how these objectives can explain the lack of consensus regarding an external energy policy of the EU. Three hypotheses are constructed on rational choice and sociological institutionalism. The main findings are that member states' energy supply objectives towards Russia have changed. Both groups of member states have attempted to reduce their import dependencies on Russia. At the same time, the countries continue to pursue their energy supply objectives at the bilateral level, which can be explained by member states' divergent perceptions of solidarity.

Floodplains represent a global hotspot of sensitive socioenvironmental changes and early human forcing mechanisms. In this review, we focus on the environmental conditions of preindustrial floodplains in Central Europe and the fluvial societies that operated there. Due to their high land-use capacity and the simultaneous necessity of land reclamation and risk minimisation, societies have radically restructured the Central European floodplains. According to the current scientific consensus, up to 95% of Central European floodplains have been extensively restructured or destroyed. Therefore, question arises as to whether or when it is justified to understand Central European floodplains as a ‘Fluvial Anthroposphere’. The case studies available to date show that human-induced impacts on floodplain morphologies and environments and the formation of specific fluvial societies reveal fundamental changes in the medieval and preindustrial modern periods. We aim to contribute to disentangling the questions of when and why humans became a significant controlling factor in Central European floodplain formation, and how humans in interaction with natural processes and other chains of effects have modified floodplains. As a conclusion, we superimpose emerging fields of research concerning the onset of the Fluvial Anthroposphere and provide 10 specific thematic objectives for future multidisciplinary work.

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The regular behavior of sound sources helps us to make sense of the auditory environment. Regular patterns may, for instance, convey information on the identity of a sound source (such as the acoustic signature of a train moving on the rails). Yet typically, this signature overlaps in time with signals emitted from other sound sources. It is generally assumed that auditory regularity extraction cannot operate upon this mixture of signals because it only finds regularities between adjacent sounds. In this view, the auditory environment would be grouped into separate entities by means of readily available acoustic cues such as separation in frequency and location. Regularity extraction processes would then operate upon the resulting groups. Our new experimental evidence challenges this view. We presented two interleaved sound sequences which overlapped in frequency range and shared all acoustic parameters. The sequences only differed in their underlying regular patterns. We inserted deviants into one of the sequences to probe whether the regularity was extracted. In the first experiment, we found that these deviants elicited the mismatch negativity (MMN) component. Thus the auditory system was able to find the regularity between the non-adjacent sounds. Regularity extraction was not influenced by sequence cohesiveness as manipulated by the relative duration of tones and silent inter-tone-intervals. In the second experiment, we showed that a regularity connecting non-adjacent sounds was discovered only when the intervening sequence also contained a regular pattern, but not when the intervening sounds were randomly varying. This suggests that separate regular patterns are available to the auditory system as a cue for identifying signals coming from distinct sound sources. Thus auditory regularity extraction is not necessarily confined to a processing stage after initial sound grouping, but may precede grouping when other acoustic cues are unavailable.

Visualization of software systems is mainly used for understanding and modeling software architecture. Examples of what can be visualized are source code, systems during execution together with manipulated data or system architecture on either a detailed or a general level. The connection between all of these types of visualization is that they help computer engineers maintain or develop software systems. The largest challenge with visualizing software systems is when the systems in question are exceedingly large and containing an abundance of relations. A problem of this kind arise at the company DGC, where this study is performed. The company manages at present more than a couple hundred systems with over ten thousand relations between each other. The problem with the company’s existing visualization is that they are very difficult to follow and understand, since they mainly present raw data in the form of tables that do not show all relations optimally, and which can also easily distract the company stakeholders from their intended task. The aim of this study is to find a visualization method where a system and its underlying parts are shown together with their relations to other systems. The created visualization will be able to be used by several different stakeholders and will as clearly as possible present relevant information to them. Furthermore, it should also aim to contribute to a better understanding of the complex software systems and their relations. After the implementation of the chosen visualization method, a time-based study is performed to determine whether it poses an improvement of perception among the stakeholders or not. An interview is also conducted where these stakeholders provide their opinion on the created visualization and if they think it presents the necessary information in a pedagogical way. Analysis of the result of the timekeeping and the interview answers indicate that the aim of the study is met. The majority of the resulting times show that the created visualization is more efficient than the original ones, and the interview answers furthermore show how different stakeholders all together agree that the visualization can be used in both future development and maintenance. / Visualisering av mjukvarusystem används i stor utsträckning för att förstå och modellera mjukvaruarkitektur. Ett par exempel på vad som kan visualiseras är: källkod, system under exekvering tillsammans med manipulerat data eller systemarkitektur på detaljerad eller övergripande nivå. Sambandet mellan alla dessa typer av visualiseringar är att de hjälper dataingenjörer att underhålla och utveckla mjukvarusystem. Den största utmaningen i att visualisera mjukvarusystem är när systemen i fråga är väldigt stora och har många beroenden. Ett sådant problem uppstår på företaget DGC där denna undersökning utförs. Företaget hanterar i dagsläge mer än hundratals mjukvarusystem med över tiotusentals beroenden sinsemellan. Problemet med företagets befintliga visualiseringar är att dessa är väldigt svåra att följa eftersom de oftast presenterar rådata i form av tabeller som inte visar alla relationer på ett optimalt sätt och distraherar lätt intressenter på företaget från sin avsedda uppgift. Undersökningen syftar på att finna en visualiseringsmetod där ett system och dess underliggande systemdelar visas tillsammans med deras beroenden till andra. Den framtagna visualiseringen skall kunna användas av flera olika intressenter, och i högsta möjliga mån presentera relevant information för dem på ett tydligt sätt. Vidare ska den skapade visualiseringen också bidra till bättre förståelse för komplexa mjukvarusystem och deras beroenden. Efter framtagandet av visualiseringen utförs en tidsundersökning, för att avgöra huruvida den skapade visualiseringen stimulerar förståelse hos de olika intressenterna på företaget. Det utförs även en intervju där intressenterna på företaget lämnar sina synpunkter angående den skapade visualiseringen och om den kan presentera nödvändig information på ett pedagogiskt sätt. Analys av resultaten av tidtagningarna och svaren på intervjuerna visar tydligt att undersökningens syften nåtts. Majoriteten av tidtagningarna visade att den skapade visualiseringen är effektivare än de ursprungliga och intervjusvaren uppvisar hur olika intressenter ser att den kan användas vid vidareutvecklingen eller underhåll, vilket alla intressenter höll med om.

Nous étudions les réponses proches à des requêtes OLAP sur les entrepôts de données. Nous considérons les réponses relatives aux requêtes OLAP sur un schéma, comme les distributions avec la distance L1 et rapprocher les réponses sans stocker totalement l'entrepôt de données. Nous présentons d'abord trois méthodes spécifiques: l'échantillonnage uniforme, l'échantillonnage basé sur la mesure et le modèle statistique. Nous introduisons également une distance d'édition entre les entrepôts de données avec des opérations d'édition adaptées aux entrepôts de données. Puis, dans l'échange de données OLAP, nous étudions comment échantillonner chaque source et combiner les échantillons pour rapprocher toutes requêtes OLAP. Nous examinons ensuite un contexte streaming, où un entrepôt de données est construit par les flux de différentes sources. Nous montrons une borne inférieure de la taille de la mémoire nécessaire aux requêtes approximatives. Dans ce cas, nous avons les réponses pour les requêtes OLAP avec une mémoire finie. Nous décrivons également une méthode pour découvrir les dépendances statistique, une nouvelle notion que nous introduisons. Nous recherchons ces dépendances en basant sur l'arbre de décision. Nous appliquons la méthode à deux entrepôts de données. Le premier simule les données de capteurs, qui fournissent des paramètres météorologiques au fil du temps et de l'emplacement à partir de différentes sources. Le deuxième est la collecte de RSS à partir des sites web sur Internet. / We study the approximate answers to OLAP queries on data warehouses. We consider the relative answers to OLAP queries on a schema, as distributions with the L1 distance and approximate the answers without storing the entire data warehouse. We first introduce three specific methods: the uniform sampling, the measure-based sampling and the statistical model. We introduce also an edit distance between data warehouses with edit operations adapted for data warehouses. Then, in the OLAP data exchange, we study how to sample each source and combine the samples to approximate any OLAP query. We next consider a streaming context, where a data warehouse is built by streams of different sources. We show a lower bound on the size of the memory necessary to approximate queries. In this case, we approximate OLAP queries with a finite memory. We describe also a method to discover the statistical dependencies, a new notion we introduce. We are looking for them based on the decision tree. We apply the method to two data warehouses. The first one simulates the data of sensors, which provide weather parameters over time and location from different sources. The second one is the collection of RSS from the web sites on Internet.