D.Phil. (Biokinetics) / Please refer to full text to view abstract

Physical inactivity and obesity in adolescence are associated with an increased risk of cardiovascular disease (CVD). Although exercise is recommended for the management of obesity, we know little about which types of exercise training are the most effective in reducing excess body fat and improving CVD risk in obese adolescents. This dissertation examined the effects of aerobic training, resistance training and their combination on the cardiometabolic health (body composition, CVD risk markers, resting metabolic rate (RMR), and fitness) of obese adolescents who participated in the Healthy Eating Aerobic and Resistance Training in Youth (HEARTY) trial. After a 4-week supervised moderate-intensity exercise run-in period, 304 overweight and obese adolescents were randomized to 4 groups for 22 weeks: Aerobic training, Resistance training, Combined aerobic and resistance exercise training, or a non-exercising Control. All four groups received dietary counseling designed to promote healthy eating with a maximum daily energy deficit of 250 kcal. Participants were assessed at baseline and after 3 and 6 months. Body composition was assessed using magnetic resonance imaging. Blood tests for traditional and non-traditional CVD risk markers were measured after a 12-hour fast. RMR and cardiorespiratory fitness were assessed using indirect calorimetry at rest and during a maximal treadmill test respectively. Musculoskeletal fitness (muscular strength, endurance, flexibility) was assessed using eight repetition maximum tests (8-RM) on the leg press, chest press and upright row machines and using the Canadian Society for Exercise Physiology- Canadian Physical Activity Fitness and Lifestyle Appraisal (CSEP-CPAFLA) tests for grip strength, push-ups, sit-ups, sit and reach and vertical jump. Decreases in percent body fat and abdominal fat were greatest in the combined training group. Although body weight, RMR and traditional CVD risk markers did not improve following the exercise intervention, the combined training group showed improvements in cardiorespiratory and musculoskeletal fitness and some non-traditional CVD risk markers. Cumulatively, combined aerobic and resistance exercise training showed the greatest improvements in cardiometabolic health in overweight and obese adolescents. This thesis concludes with a knowledge translation article detailing the practical lessons learned from exercise interventions with obese youth with hopes of increasing adherence to future exercise programs and improving the overall health of children and adolescents with obesity.

The proportion of HIV-positive people over the age of 50 is increasing rapidly in New York City. An estimated half of those living with HIV are over 50. While many are long-term survivors, reflecting the transformation of HIV from a life-threatening illness to a chronic disease—due to the advent of highly active antiretroviral therapy (HAART) in 1996—others are newly diagnosed or newly infected. However, relatively few studies have examined how older adults with HIV/AIDS are aging well, and whether these strategies are associated with a reduction in risk behaviors. To address these gaps, paper one, using a basic qualitative research methodology and constructivist grounded theory analysis approach, had two related objectives: (1) to explore the lived experience of men over 50 with HIV/AIDS in New York City; (2) to examine the ways in which individuals have aged successfully. Based on the findings of the aforementioned paper, paper two and paper three, using the Research on Older Adults with HIV/AIDS (ROAH) data set, determined if loneliness predicted condomless sex in the past three months and chemsex (paper 2) and if loneliness predicted a reduced CD4 count and substance use in the past three months. Using the three-paper model, the following dissertation sheds new insight into how older adults age well with HIV/AIDS but finds that loneliness does not predict negative health and risk behaviors in this group. The dissertation does, however, highlight other avenues for research, policy and practice based on the results.

The outbreak of the Ebola virus was declared a Public Health Emergency of International Concern by the World Health Organisation (WHO). Due to the complex nature of the outbreak, the Centers for Disease Control and Prevention (CDC) had created interim guidance for monitoring people potentially exposed to Ebola and for evaluating their intended travel and restricting the movements of carriers when needed. Tools to evaluate the risk of individuals and groups of individuals contracting the disease could mitigate the growing anxiety and fear. The goal is to understand and analyze the nature of risk an individual would face when he/she comes in contact with a carrier. This thesis presents a tool that makes use of contextual data intelligence to predict the risk factor of individuals who come in contact with the carrier.

The study sought to identify reasons for non-compliance among a particular medical aid scheme's members and their dependants registered for the asthma disease risk management (DRM) programme. A quantitative descriptive study was undertaken, using postal questionnaires. The research results indicated that most asthma patients were not compliant with the DRM programme because they lacked knowledge about the programme. Asthma patients' compliance with the DRM programme can be enhanced by health providers' and case managers' positive attitudes, better promotion of the programme, and by involving the patients in managing their illnesses. Asthma patients require education about healthy lifestyles, empowering them to successfully manage their condition, preventing asthma attacks and/or hospital admissions. When asthma is well-managed the patients' quality of life and general wellbeing will improve and the medical aid scheme's costs will be contained. / HEALTH STUDIES / MA (HEALTH STUDIES)

Thesis (MCur)--Stellenbosch University, 2015. / ENGLISH ABSTRACT: Background: Coronary artery disease is a form of cardiovascular disease (CVD) which manifests itself in three ways: angina pectoris, acute coronary syndrome and cardiac death. Thirty-three people die daily of a myocardial infarction (cardiac death) and 7.5 million deaths annually are caused by CVD (51% from strokes and 45% from coronary artery disease) worldwide. Globally, the CVD death rate is a mere 4% compared to South Africa which has a 42% death rate. It is predicted that by the year 2030 there will be 25 million deaths annually from CVD, mainly in the form of strokes and heart disease. The WHO compared the death rates of high-income countries to those of low- and middle-income countries, like South Africa, and the results show that CVD deaths are declining in high-income countries but rapidly increasing in low- and middle-income countries. Although there are several risk prediction tools in use worldwide, to predict ischemic risk, South Africa does not use any of these tools. Current practice in South Africa to diagnose acute coronary syndrome is the use of a physical examination, ECG changes and positive serum cardiac maker levels. Internationally the same practice is used to diagnose acute coronary syndrome but risk assessment tools are used additionally to this practise because of limitations of the ECG and serum cardiac markers when it comes to NSTE-ACS. Objective: The aim of this study was to systematically appraise evidence on the accuracy of acute coronary syndrome risk prediction tools in adults. Methods: An extensive literature search of studies published in English was undertaken. Electronic databases searched were Cochrane Library, MEDLINE, Embase and CINAHL. Other sources were also searched, and cross-sectional studies, cohort studies and randomised controlled trials were reviewed. All articles were screened for methodological quality by two reviewers independently with the QUADAS-2 tool which is a standardised instrument. Data was extracted using an adapted Cochrane data extraction tool. Data was entered in Review Manager 5.2 software for analysis. Sensitivity and specificity was calculated for each risk score and an SROC curve was created. This curve was used to evaluate and compare the prediction accuracy of each test. Results: A total of five studies met the inclusion criteria of this review. Two HEART studies and three GRACE studies were included. In all, 9 092 patients participated in the selected studies. Estimates of sensitivity for the HEART risks score (two studies, 3268 participants) were 0,51 (95% CI 0,46 to 0,56) and 0,68 (95% CI 0,60 to 0,75); specificity for the HEART risks score was 0,90 (95% CI 0,88 to 0,91) and 0,92 (95% CI 0,90 to 0,94). Estimates of sensitivity for the GRACE risk score (three studies, 5824 participants) were 0,03 (95% CI0,01 to 0,05); 0,20 (95% CI 0,14 to 0,29) and 0,79 (95% CI 0,58 to 0,93). The specificity was 1,00 (95% CI 0,99 to 1,00); 0,97 (95% CI 0,95 to 0,98) and 0,78 (95% CI 0,73 to 0,82). On the SROC curve analysis, there was a trend for the GRACE risk score to perform better than the HEART risk score in predicting acute coronary syndrome in adults. Conclusion: Both risk scores showed that they had value in accurately predicting the presence of acute coronary syndrome in adults. The GRACE showed a positive trend towards better prediction ability than the HEART risk score. / AFRIKAANSE OPSOMMING: Agtergrond: Koronêre bloedvatsiekte is ‘n vorm van kardiovaskulêre siekte. Koronêre hartsiekte manifesteer in drie maniere: angina pectoris, akute koronêre sindroom en hartdood. Drie-en-dertig mense sterf daagliks aan ‘n miokardiale infarksie (hartdood). Daar is 7,5 miljoen sterftes jaarliks as gevolg van kardiovaskulêre siektes (51% deur beroertes en 45% as gevolg van koronêre hartsiektes) wêreldwyd. Globaal is die sterfte syfer as gevolg van koronêre vaskulêre siekte net 4% in vergelyking met Suid Afrika, wat ‘n 42% sterfte syfer het. Dit word voorspel dat teen die jaar 2030 daar 25 miljoen sterfgevalle jaarliks sal wees, meestal toegeskryf aan kardiovaskulêre siektes. Die hoof oorsaak van sterfgevalle sal toegeskryf word aan beroertes en hart siektes. Die WHO het die sterf gevalle van hoeinkoms lande vergelyk met die van lae- en middel-inkoms lande, soos Suid Afrika, en die resultate het bewys dat sterf gevalle as gevolg van kardiovaskulêre siekte is besig om te daal in hoe-inkoms lande maar dit is besig om skerp te styg in lae- en middel-inkoms lande. Daar is verskeie risiko-voorspelling instrumente wat wêreldwyd gebruik word om isgemiese risiko te voorspel, maar Suid Afrika gebruik geen van die risiko-voorspelling instrumente nie. Huidiglik word akute koronêre sindroom gediagnoseer met die gebruik van n fisiese ondersoek, EKG verandering en positiewe serum kardiale merkers. Internationaal word die selfde gebruik maar risiko-voorspelling instrumente word aditioneel by gebruik omdat daar limitasies is met EKG en serum kardiale merkers as dit by NSTE-ACS kom. Doelwit: Die doel van hierdie sisematiese literatuuroorsig was om stelselmatig die bewyse te evalueer oor die akkuraatheid van akute koronêre sindroom risiko-voorspelling instrumente vir volwassenes. Metodes: 'n Uitgebreide literatuursoektog van studies wat in Engels gepubliseer is was onderneem. Cochrane biblioteek, MEDLINE, Embase en CINAHL databases was deursoek. Ander bronne is ook deursoek. Die tiepe studies ingesluit was deurnsee-studies, kohortstudies en verewekansigde gekontroleerde studies. Alle artikels is onafhanklik vir die metodologiese kwaliteit gekeur deur twee beoordeelaars met die gebruik van die QUADAS-2 instrument, ‘n gestandaardiseerde instrument. ‘n Aangepaste Cochrane data instrument is gebruik om data te onttrek. Data is opgeneem in Review Manager 5.2 sagteware vir ontleding. Sensitiwiteit en spesifisiteit is bereken vir elke risiko instrument en ‘n SROC kurwe is geskep. Die SROC kurwe is gebruik om die akkuraatheid van voorspelling van elke instrument te evalueer en te toets. Resultate: Twee HEART studies en drie GRACE studies is ingesluit. In total was daar 9 092 patiente wat deelgeneeem het in die gekose studies. Skattings van sensitiwiteit vir die HEART risiko instrument (twee studies, 3268 deelnemers) was 0,51 (95% CI 0,47 to 0,56) en 0,68 (95% CI 0,60 to 0,75) spesifisiteit vir die HEART risiko instrument was 0,89 (95% CI 0,88 to 0,91) en 0,92 (95% CI 0,90 to 0,94). Skattings van sensitiwiteit vir die GRACE risiko instrument (drie studies, 5824 deelnemers) was 0,28 (95% CI 0,13 to 0,53); 0,20 (95% CI 0,14 to 0,29) en 0,79 (95% CI 0,58 to 0,93). Die spesifisiteit vir die GRACE risiko instrument was 0,97 (95% CI 0,95 to 0,99); 0,97 (95% CI 0,95 to 0,98) en 0,78 (95% CI 0,73 to 0,82). Met die SROC kurwe ontleding was daar ‘n tendens vir die GRACE risiko instrument om beter te vaar as die HEART risiko instrument in die voorspelling van akute koronêre sindroom in volwassenes. Gevolgtrekking: Altwee risiko instrumente toon aan dat albei instrumente van waarde is. Albei het die vermoë om die teenwoordigheid van akute koronêre sindroom in volwassenes te voorspel. Die GRACE toon ‘n positiewe tendens teenoor beter voorspelling vermoë as die HEART risiko instrument.

Thesis (MScSportSc)--University of Stellenbosch, 2002. / ENGLISH ABSTRACT: Numerous studies have shown that coronary artery disease (CAD) has its origin in childhood. Several risk factors that increase a person's risk for the development of CAD are prevalent amongst children. South African statistics concerning the prevalence of these risk factors are limited. Research has shown that early intervention to eliminate risk factors can decrease the risk for the development of CAD. The purpose of this study was to determine the prevalence of certain coronary risk factors amongst children aged 11 to 13 years in certain Western Cape schools. Certain selected factors were tested. These included obesity, lack of physical activity, hypertension, low physical fitness (V02max), a family history associated with an increased risk, exposure to cigarette smoke, prevalence of diabetes mellitus and an unhealthy diet. The sample consisted out of 288 children and was made up by 154 boys and 134 girls. Certain anthropometrical measurements (stature, weight, skinfoids, waist and hip circumferences) were taken. Activity levels, family history, exposure to cigarette smoke, prevalence of diabetes mellitus and diet, were measured by means of questionnaires. Physical fitness (V02max) was tested with a three-minute step-test. A sphygmomanometer was used to measure blood pressure. Depending on the circumference of the child's arm, a paediatric or adult size cuff was used. The results of the study showed that 22.01% of the boys and 59.7% of the girls had a percentage body fat so high that it was considered a coronary risk factor. Physical fitness levels were considered risk factors in 2.6% of the boys and 9% of the girls. A very high percentage of the children tested had a family history associated with an increased risk for the development of CAD (73.38% of the boys and 78.36% of the girls). Systolic hypertension was prevalent among 22.01% of the boys and 23.13% of the girls. Diastolic hypertension was only prevalent among 5.19% of the boys and 5.97% of the girls. Low activity levels were considered a risk factor in 31.17% of the boys and 39.55% of the girls. Out of all the subjects, 32.47% of the boys and 37.31% of the girls were exposed to cigarette smoke on a daily basis. The results of this study shows that certain coronary risk factors are quite common amongst children. Prevention programmes that focuses on elimination of coronary risk factors, such as hypertension, inactivity and obesity, is essential for the prevention of subsequent coronary artery disease in adults. / AFRIKAANSE OPSOMMING: Verskeie studies het al bewys dat koronêre hartvatsiekte (KHS) reeds sy ontstaan het in kinders van baie jong ouderdomme. Verskeie risikofaktore wat tot die latere ontstaan van KHS lei kom ook onder jong kinders voor. Statistiek ten opsigte van die voorkoms van hierdie risikofaktore onder kinders in Suid-Afrika is egter baie beperk. Verskeie navorsing toon dat vroeë intervensie kan lei tot "n verlaging in risiko vir die ontwikkeling van KHS op "n latere stadium. Die doel van die studie was om die voorkoms van sekere koronêre risikofaktore in kinders in Suid-Afrika te ondersoek. Sekere risikofaktore is ondersoek, dit het ingesluit, obesiteit, lae fisieke aktiwitietsvlakke, hipertensie, lae fisieke fiksheid (V02maks), 'n familie geskiedenis wat geassosieer word met "n verhoogte risiko, blootstelling aan sigaret rook, die voorkoms van diabetes mellitus en "n swak dieet. Die steekproef het bestaan uit 288 kinders waarvan 134 meisies en 154 seuns was. Verskeie antropometriese meetings (lengte, massa, velvoue, middel- en heup omtrekmates) is geneem. Aktiwiteitsvlakke, familiegeskiedenis, blootstelling aan sigarette rook, voorkoms van diabetes mellitus en dieet is deur middel van vraelyste vasgestel. Fisieke fiksheid (V02maks) is deur middel van "n drie-minuut-opstaptoets vasgestel. Bloeddruk is met "n sfigmomanometer gemeet. Afhangend van die omtrek van die kind se arm is "n pediatries- of volwasse-grootte drukband gebruik. Persentasie liggaamsvet was by 22.01% van die seuns en 59.7% van die meisies so hoog dat dit as "n risikofaktor beskou kan word. Fisieke fiksheidsvlakke kan by 2.6% van die seuns en 9% van die meisies as "n risikofaktor beskou word. "n Baie hoë persentasie van die kinders het "n familiegeskiedenis gehad wat geassosieer word met "n verhoogde risiko vir die ontwikkeling van KHS (73.38% van die seuns en 78.36% van die meisies). Sistoliese hipertensie het onder 22.01% van die seuns en 23.13% van die meisies voorgekom. Diastoliese hipertensie het baie minder voorgekom as sistoliese hipertensie (5.19% van die seuns en 5.97% van die meisies). Lae aktiwiteitsvlakke het onder 31.17% van die seuns en 39.55% van die meisies voorgekom. 'n Redelike hoë persentasie van die kinders word daagliks aan sigaretrook van hulouers of oppassers blootgestel (32.47% van die seuns en 37.31% van die meisies.) Die resultate van die studie dui aan dat daar 'n redelike hoë voorkoms van sekere koronêre risikofaktore onder kinders is. Ondersoek moet ingestel word na moontlike, goed gestruktureerde intervensieprogramme.

Each year approximately 600 000 infants, most of them in Sub-Saharan Africa are born with HIV infection as a result of mother to child transmission of HIV. Whereas significant progress has been made in reduction of mother to child transmission of HIV in developed countries, the situation remains desperate in developing countries. Progress has been hampered by shortage of staff, facilities, limited access to voluntary counselling and testing and lack of support for women by their partners and communities. The challenge is to increase voluntary counselling and testing uptake during antenatal care. Onandjokwe district in Northern Namibia is currently introducing the Prevention of Mother to Child Transmission Program (PMTCT). It has been found the previous PMTCT programs have failed because they adopted a top down approach where there was no community consultation. This study was conducted to explore the community perceptions, knowledge and attitudes regarding mother to child transmission of HIV through focus group discussions and in-depth interviews of key community members.

PhD, Faculty of Health Sciences, University of the Witwatersrand / Background: In low- to middle-income countries, rising levels of overweight and obesity are a result of multiple transitions, in particular, a nutrition transition. Consequently, in these countries, metabolic diseases are contributing increasingly to disease burden, despite the persisting burden of undernutrition and infectious diseases. Understanding the patterns and factors associated with persistent undernutrition and emerging obesity in children and adolescents, and concomitant risk for metabolic disease, is therefore of criticial importance. This should contribute to public health policy on interventions to prevent adult disease. Aims: To better understand the double burden of malnutrition in a poor, high HIV prevalent, transitional society in a middle-income country; In so doing, to inform policies and interventions to address the double burden of malnutrition. Methods: A cross-sectional growth survey was conducted in 2007 targeting 4000 children and adolescents 1-20 years of age living in rural South Africa. The survey was nested within the ongoing Agincourt Health and Socio-demographic Surveillance System, which acted as the sampling frame and also provided data for explanatory variables. Anthropometric measurements were performed on all participants using standard procedures. In addition, HIV testing was done on children aged 1 to 5 years and Tanner pubertal assessment was conducted among adolescents 9-20 years. A one-year follow-up of HIV positive children included a matched control group of HIV negative counterparts. Data collection involved both quantitative and qualitative methods. Growth z-scores were used to determine stunting, underweight and wasting and were generated using the 2006 WHO growth standards for children up to five years and the 1977 NCHS/WHO reference for older children. Overweight and obesity were determined using the International Obesity Task Force cut-offs for BMI for children aged up to 17 years and adult cut offs of BMI =25 and =30 kg/m2 for overweight and obesity respectively for adolescents 18 to 20 years. Waist circumference cut-offs of =94cm for males and =80cm for females, and waist-to-height ratio of 0.5 for both sexes, were used to determine central obesity and hence metabolic disease risk in ix adolescents. Descriptive analysis described patterns of nutritional status by age, sex, pubertal stage and HIV status. Linear and logistic regression was done to determine predictors of nutrional outcomes. A p-value of <0.05 was considered statistically significant. Results: Prevalence of undernutrition, particularly stunting, was substantial: 18% among children aged 1-4 years, with a peak of 32% in children at one year of age. Stunting and underweight were also substantial in adolescent boys, with underweight reaching a peak of 19% at 14 years of age. Concurrently, the prevalence of combined overweight and obesity, almost non-existent in boys, was prominent among adolescent girls, increasing with age, and reaching a peak of 25% at 18 years. Risk for metabolic disease using waist circumference cut-offs was substantial among adolescents, particularly girls, increasing with sexual maturation, and reaching a peak of 35% at Tanner stage 5. Prevalence of HIV in children aged 1-4 years was 4.4%. HIV positive children had poorer nutritional outcomes than that of HIV negative children in 2007. The impact of paediatric HIV on nutritional status at community level was, however, not significant. Significant predictors of undernutrition in children aged 1-4 years, documented at child, maternal, household and community levels, included child’s HIV status, age and birth weight; maternal age; age of household head; and area of residence. Significant predictors of overweight/obesity and risk for metabolic disease in adolescents aged 10-20 years, documented at individual/child and household levels included child’s age, sex and pubertal development; and household-level food security, socio-economic status, and household head’s highest education level. There was a high acceptance rate for the HIV test (95%). One year following the test, almost all caregivers had accepted and valued knowing their child’s HIV status, indicating that it enhanced their competency in caregiving. Additionally, nutritional status of HIV positive children had improved significantly within a year of follow-up. Conclusions: The study describes co-existing child stunting and adolescent overweight/obesity and risk for metabolic disease in a society undergoing nutrition transition. While likely that this profile reflects changes in nutrition and diet, variation in infectious disease burden, physical activity patterns, and social influences need to be investigated. The findings are critical in the wake of the rising public health importance of metabolic diseases in low- to middle-income countries, despite the unfinished agenda of undernutrition and infectious diseases. Clearly, policies and interventions to address malnutrition in this and other transitional societies need to be double-pronged. In addition, gender-biased nutritional patterns call for gender-sensitive policies and interventions. The study further documents a significant role of paediatric HIV on nutritional status, and the potential for community-based paediatic HIV testing to ameliorate this. Targeted early paediatric HIV testing of exposed or at risk children, followed by appropriate health care for infected children, may improve their nutritional status and survival.

O uso das águas costeiras para fins recreacionais está associado com benefícios à saúde e bem-estar, todavia eventuais impactos negativos podem diminuir estes benefícios. Esses usos variam de acordo com o tipo de atividade desenvolvida, sendo que a recreação de contato primário requer contato direto e prolongado com a água, durante a qual pode ocorrer ingestão acidental. A Resolução CONAMA nº 274/2000 dispõe sobre os critérios de balneabilidade e reza que as condições da qualidade das águas recreacionais devem ser avaliadas através de indicadores microbiológicos de contaminação fecal, e ainda recomenda que seja realizada pesquisa de organismos patogênicos em praias sistematicamente impróprias. Dada a escassez de dados da ocorrência de patógenos em águas costeiras, no período de 2010 a 2012, a CETESB realizou o Estudo de microrganismos patogênicos nas praias do Litoral Paulista pesquisando enterovírus, adenovírus, vírus da hepatite A, Cryptosporidium sp e Giardia sp, no intuito de preencher esta lacuna e gerar dados primários. Assim, o objetivo deste trabalho foi estimar a probabilidade de infecção por Cryptosporidium sp e Giardia sp após exposição a águas recreacionais costeiras usando como ferramenta a Avaliação Quantitativa de Risco Microbiológico (AQRM), como também o risco de doença. As concentrações de (oo)cistos nas águas das praias são oriundas dos relatórios de Qualidade das Praias Litorâneas no Estado de São Paulo da CETESB dos anos de 2011 e 2012. Nesse período foram analisadas 203 amostras coletadas de 12 praias na 1ª fase e de cinco praias na 2ª fase para a pesquisa de ocorrência de (oo)cistos. As amostras de água foram coletadas na isóbata de um metro, com frequência mensal. Giardia sp foi o microrganismo mais frequente, presente em 43 por cento das amostras e Cryptosporidium sp em 13 por cento . O cenário de exposição considerou tipos de atividade, tipos de usuários (crianças, adultos e esportistas), concentração de (oo)cistos, volume de ingestão, duração e frequência da exposição. A probabilidade de infecção foi maior em praias com mais amostras positivas para oocistos e cistos, no grupo dos esportistas e para Giardia sp. Em alguns casos os valores de risco de doença ultrapassaram o risco tolerável pela U.S. EPA (2012) de 3,6 por cento casos de gastroenterite, assim como ultrapassaram os resultados de incidência acumulada encontradas por LAMPARELLI et al. (2015). Os resultados apontaram a necessidade de melhoria nos sistemas de tratamento de efluentes no Litoral Paulista. A AQRM é uma ferramenta capaz de estimar a probabilidade de infecção no cenário das águas recreacionais e pode auxiliar no gerenciamento dos riscos. / The use of coastal water for recreational purposes has been associated with benefits to health and well-being; however some negative impacts can diminish such benefits. The usages can vary according to the type of activity but the primary contact demands physical contact resulting in a high probability in accidental ingestion of water. Brazilian legislation for coastal recreational waters CONAMA 274/2000 establishes criteria for fecal indicator bacteria and furthermore recommends investigation of pathogenic organisms for beaches which classification is systematically as improper. Given the scarcity of data referring to pathogenic presence in beaches´ waters, CETESB carried out a study, in 2010 and 2012, for quantifying enterovirus, adenovirus, hepatitis A virus, Cryptosporidium sp and Giardia sp in coastal waters of São Paulo state in order to obtain data about their occurrence of these pathogens in coastal waters. The objective of this study was to estimate the annual risk of infection and disease for Giardia sp and Cryptosporidium sp by ingestion of water during primary contact recreation using QMRA approach. Concentrations of both parasites were taken from the annual report entitled Quality of coastal beaches in São Paulo state by CETESB (2011 and 2012). In these years were analyzed 203 samples of water for quantifying (oo)cysts of Giardia and Cryptosporidium from 12 beaches in the first year and five beaches in the second year of research. The samples were collected at one meter isobaths, with monthly frequency. Giardia was the most frequent parasite present in 43 per cent of samples and Cryptosporidium sp in 13 per cent . Exposure scenario was built considering types of activity, beach goers (children, adults and athletes), concentration of parasites, ingestion rate, duration and frequency of exposure. The probability of annual infection was higher in beaches in which there were more positive results for parasites for athletes and for Giardia infection. The tolerable risk for gastroenteritis by USEPA, which is 3.6 per cent , was overpassed in some cases. Though the results found in this study overpassed the cumulative incidence reported by LAMPARELLI et al. (2015). The results indicate the need for improvements in wastewater treatment systems in the coastal area of São Paulo. As QMRA is a tool capable in estimating the probability of infection it can help to highlight crucial issues in risk management.