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Les pansements dits " hydrocolloïdes " sont très couramment utilisés dans le traitement des plaies à forte exsudation. Ils permettent de réguler l'hygrométrie au sein d'une plaie tout en évitant une accumulation d'eau susceptible d'entrainer la prolifération de bactéries entre le pansement et la peau. Deux propriétés antagonistes apparaissent alors nécessaires : une fonction d'adhésion pour assurer le maintien du pansement sur la peau, et de fortes propriétés d'absorption et de perméabilité à l'eau pour réguler l'humidité et favoriser la cicatrisation de la plaie. Pour satisfaire ces deux fonctions, des systèmes hétérogènes sont utilisés : l’adhésion est apportée par une matrice adhésive hydrophobe, composée d’un élastomère modifié par un plastifiant et des résines tackifiantes, la régulation de l’humidité est assurée par de fines particules hydrophiles sèches de carboxymethylcellulose (CMC), dispersées dans la matrice adhésive. Un enjeu majeur de ces pansements est le maintien de l’adhésion cutanée dans le temps. Or une perte de l’adhésion est souvent observée après un long contact avec l’eau. Ces travaux de thèse visent à mieux comprendre l’origine de cette perte d’adhésion, à travers l’étude des propriétés mécaniques de la matrice hydrophobe, de ses interactions avec les particules hydrophiles et des mécanismes de transport d’eau. La substitution de la CMC par des particules d’hydrogels synthétisés au laboratoire a permis l’étude plus systématique de l’effet des propriétés physico-chimiques de la phase hydrophile sur l’absorption, la perméabilité et l’adhésion des pansements hydrocolloïdes ainsi mis en œuvre. / Hydrocolloid wound dressings are commonly used for the care of highly exuding wounds. They allow to control the wound moisture, while avoiding the water accumulation which could lead to bacterial proliferation between the dressing and the skin. Two antagonist properties appear to be required: an adhesive function to maintain the dressing on the skin, and high water absorption and permeability to control the humidity level and promote healing. To achieve both properties, heterogeneous systems are used : the adhesion is ensured by an hydrophobic adhesive matrix, made of an elastomer modified by plasticizers and tackifying resins, the regulation of the humidity relies on fine dry hydrophilic particles, made of carboxymethylcellulose (CMC), dispersed within the matrix. A major issue of these wound dressings is to maintain a long term skin adhesion. However a loss of adhesion is often observed after a long contact with water. This PhD work aims at a better understanding the origin of this loss of adhesion through the study of the hydrophobic matrix mechanical properties, its interactions with the hydrophilic particles and water transport. Replacing the CMC by tailor-made hydrogel particles allowed to a systematic study of the impact of the physico-chemical properties of the hydrophilic phase on the absorption, the permeability and the adhesion of the hydrocolloid-based adhesives.

Wound care is a difficult process in the healthcare sector, especially the problem with chronic and infected wounds. There are a lot of patients suffering from these wounds and it is both painful and time consuming for nurses and patients. A wound on the verge of slowing down in the healing process has a shift in its pH value from acidic to neutral and alkaline. If healthcare staff could easily identify this change the chances of treating the wound in time increases, which could stop the developing of a chronic wound. This report aims to research the possibilities of textile materials that can respond to pH changes and be used in the healthcare sector as a wound dressing. If this becomes a reality, it can both reduce the number of patients suffering from infected and chronic wounds and facilitate the efficiency of healthcare workers' work. Through interviews and a selective reading into the subjects of: pH, chronic wounds and wound dressings, textile materials and healthcare requirements sketches and ideas were created on how to incorporate a pH indicator into a textile material and through this: into a wound dressing. What was found was that the technique of electrospun polyamide together with bromocresol purple (pH indicator) in the solution creates a highly suitable fiber for use in pH monitoring wound care. The fiber provides the possibility to construct a fabric, that have the application of detecting and changing color between the pH values in the range between 5.2-6.8, which is the critical pH range for healing wounds. Wound dressing that's interacting with healthcare staff and provides clues on how the wound is evolving could be the future of wound dressings. Not just to create the perfect environment for the wound but actively analyzing on how it is healing.

Boli pripravené kryty rán na bázi prírodných látok polyvinyl alcohol/ hyaluronan/ strieborné nanočastice (PVA/ HA/ Ag-NPs). Hyaluronan bol použitý ako redukčné a stabilizačné činidlo pre syntézu nanočastíc striebra. Pri príprave Ag-NPs boli testované viaceré parametre ako koncentrácia dusičnanu strieborného ako zdroja Ag-NPs (0,01; 0,1;0,5;1 M), koncentrácia kyseliny hyalurónovej (1,2 %) a jej rozdielna molekulová hmotnosť. Kryty rán z nanovlákien boli pripravené pomocou techniky electro-spinning z roztokov líšiacich sa pomerom PVA a HA/Ag-NPs (100; 90/10; 80/20; 60/40; 50/50). Vlastnosti nanokompozitu HA/Ag-NPs boli hodnotené pomocou TEM, reológie, DLS, XRD, UV/Vis spektroskopie a kryty rán boli charakterizované pomocou SEM, TGA, FTIR a ťahovej skúšky.

Syftet med denna litteraturstudie var att undersöka om nutritionstillskott, tryckavlastning och typ av förband har någon påvisad effekt på läkningen av trycksår. Litteraturstudien grundar sig på Goodmans systematiska tillvägagångssätt. Litteratursökningen gjordes i CINAHL, PubMed och The Cochrane Library samt att artiklar som inte var tillgängliga i fulltext via någon av databaserna söktes via Samsök. Granskning och kvalitetsbedömning av artiklarna gjordes individuellt utav författarna oberoende av varandra utefter ett modifierat granskningsprotokoll. Elva artiklar av varierande kvalitet inkluderades i litteraturstudien. Resultatet tyder på en förbättrad läkning vid användande av tryckavlastande madrasser och dynor, vid tillskott av protein, vitamin C och zink samt att kollagena förband är ekvivalenta med hydrokolloida . Med otillräckligt vetenskapligt underlag kan det sägas att fuktighetsbevarande förband, såsom hydrokolloida, är att föredra framför torra förband vid behandling av trycksår. Behandling med noncontact normothermic wound therapy eller en kombination av alginat och hydrokolloida förband är att rekommendera framför enbart fuktigthetsbevarande förband, såsom hydrokolloida. Fler studier behövs för att slutsatser med hög evidens skall kunna dras. / The aim of this study was to investigate whether nutritional support, pressure relieve and type of dressing have any proved effect on pressure ulcer healing. The review is based on Goodman´s systematic procedure. The searches of litterature were made in CINAHL, PubMed and The Cochrane Library. Articles that weren’t available in fulltext in any of the three databases were further searched in Samsök. The analyse and the assessment of quality of the articles were made by the authors individually with a modified assessment-protocol. Eleven articles of varying qualities were included in this review. The result indicates on an improved rate of healing when pressure relieving mattresses and cushions were used, with an increased intake of protein, vitamin C and zinc and that collagen dressings are equivalent with hydrocolloids. There are no conclusive evidence that moist dressings, such as hydrocolloids, is to prefer comparing to dry dressings in pressure ulcer treatment. Treatment with noncontact normothermic wound therapy or a combination with alginate dressings and hydrocolloids are recommended in front of only moist dressings, such as hydrocolloids. Further studies needs to make conclusions with high evidence.

Alfresco LLC is a startup business based in Managua, Nicaragua. The aim of Alfresco is to help create healthy nutrition habits in Central America’s homes by providing fresh, organic, high quality products with no sugar added and free of lactose and gluten. The salad dressing industry in Nicaragua is relatively mature and it’s characterized by a medium level of fragmentation. However, organic salad dressings are currently inexistent, therefore, this would be a disruption in the lifecycle of the industry. Moreover, since there are no competitors in the organic segment, there is a market gap that has not been covered yet; that is exactly the segment that Alfresco will target. An initial investment of $4,362 is required to start the business. As shown in the financial section, we forecast to recover the investment in year 3. One important risk is the fact that there are a lot of substitutes for salad dressings. However, the busy consumers’ lifestyle backed with the heavy advertising efforts and the high quality of our product, will help us overcome this obstacle and succeed in the industry. Overall, we believe that there is a big opportunity in this industry and we expect to break even before the forecasted time.

O Transplante de Células-Tronco Hematopoéticas (TCTH) é uma terapia complexa que expõe o paciente a inúmeras vulnerabilidades, das quais se destaca a infecção relacionada ao Cateter Venoso Central (CVC). Entre as coberturas oclusivas, o Curativo Impregnado com Gel de Clorexidina (CIGCHX) é uma tecnologia promissora que tem demonstrado eficácia superior na prevenção dessas infecções. Uma característica inovadora é a presença da almofada gel de clorexidina, que mantém ação antimicrobiana, a despeito da presença de matéria orgânica, permitindo permanência de sete dias por propiciar controle do crescimento da microbiota local. Diante disto, propôs-se descrever o uso do CIGCHX como cobertura do CVC inserido em adultos e crianças submetidos ao TCTH e a ocorrência de infecção relacionada ao cateter na vigência deste curativo. Foi conduzido um estudo quantitativo, observacional, descritivo com corte transversal. A casuística compôs-se de 25 pacientes que se submeteram a observações diárias de aspectos relacionados ao CIGCHX até 45 dias após a inserção do primeiro CVC, ou antes, caso este curativo tenha sido suspenso ou o cateter removido, entre setembro de 2013 a fevereiro de 2014. As variáveis foram analisadas por meio de estatística descritiva. O CIGCHX teve permanência média de 4,62 dias, variando entre 0,5 e sete dias. A remoção programada do mesmo ocorreu em 43 dos 104 curativos acompanhados. A presença de sangue foi o principal motivo para remoção não programada do CIGCHX. A presença de bolha de ar sob a almofada gel de clorexidina foi a observação mais frequente sobre o aspecto diário do curativo, presente em 56,7% das avaliações realizadas. O CVC teve permanência média de 14,73 dias, variando entre cinco e 33 dias, com DP 6,78 dias. A infecção relacionada ao cateter foi o principal motivo para sua remoção. Nas culturas de sangue e ponta de cateter, os microrganismos isolados foram todos bactérias gram negativas. Os sinais e sintomas de irritação cutânea na região do CIGCHX ocorreram em cinco pacientes. Os achados relacionados à irritação cutânea podem apontar que o uso do CIGCHX exige cautela na população estudada. A presença de sangue como principal motivo para remoção não programada do curativo revela a especificidade dos pacientes e indica que os fatores relacionados devem ser considerados para o uso do CIGCHX nesta população. O desenvolvimento de estudos experimentais que investiguem as causas e implicações da presença da bolha de ar, bem como dos outros aspectos observados no curativo, é essencial para certificar a eficácia do uso do CIGCHX sob essas condições e propor medidas para manejo, se necessário, para que seja implementado em sua maior potencialidade. Ademais, tais resultados contribuirão para centros de transplante gerenciar o uso do CIGCHX e desenvolver protocolos para sua utilização, com atenção às diversas nuances que seu uso implica. / Hematopoietic Stem-Cell Transplantation (HSCT) is a complex treatment that exposes patients to uncountable vulnerabilities, particularly central venous catheter (CVC) infections. Among the many occlusive dressings, the chlorhexidine-gel-impregnated dressing (CHXGID) is a promising technology that has proven superior effectiveness in preventing CVC infections. One innovative feature of CHXGID is the presence of a chlorhexidine-gel pad that maintains an antimicrobial action despite of the presence of organic material. The dressing can remain on the patient for seven days, thus controlling local microbiota growth. Therefore, it was proposed to describe the use of CHXGID as a dressing of the CVC of adult and child patients undergoing HSTC and the occurrence of catheter-related infections while using that dressing. A quantitative, observational, descriptive and cross-sectional study was conducted. The study sample consisted of 25 patients who agreed to daily observations of aspects related to the CHXGID for 45 days after first CVC insertion, or less in case the dressing or catheter were removed, from September of 2013 to February of 2014. The variables were analyzed using descriptive statistics. The mean CHXGID permanence was 4.62 days, ranging between 0.5 and seven days. Scheduled removal occurred in 39 of the 104 studied dressings. The presence of blood was the main reason for unscheduled CIGCHX removal. The presence of air bubbles under the chlorhexidine-gel pad was the most frequent observation regarding the daily aspect of the dressing, observed in 56.7% of the assessments. The mean CVC permanence was 14.73 days, ranging between five and 33 days, with a SD of 6.78 days. Catheter-related infection was the main reason for its removal. The microorganisms isolated in the blood and catheter tip cultures were all gram negative bacteria. Five patients showed signs and symptoms of skin irritations in the CHXGID area. The findings related to skin irritations suggest that special care is required when using CHXGID in the studied population. The presence of blood as the main reason for unscheduled removing the dressing reveals the specificity of the patients and indicates that the associated factors must be considered for using CHXGID in this specific population. Further experimental studies that investigate the causes and implications of air bubbles, as well as other aspects observed on the dressings, are essential to verify the effectiveness of CHGID under these conditions and to propose any necessary handling measures, so the highest effectiveness of CHGID use can be achieved. Furthermore, such results will help transplant centers manage the utilization of CHXGID and develop specific utilization protocols, with particular care to the diverse levels of implications involved.

Desde o início da espécie humana, houve quem procurasse auxiliar o corpo na tentativa natural de restaurar suas partes injuriadas. Um dos grandes desafios atuais é a substituição de tecidos do organismo, inclusive em áreas de lesão cutânea. Um biomaterial pode ser utilizado para melhorar, aumentar ou substituir, parcial ou inteiramente tecidos ou órgãos. A membrana de celulose bacteriana (CB) possui moldabilidade, boas propriedades mecânicas, permeabilidade seletiva, permitindo a passagem de vapor d\'água, mas impedindo a passagem de microrganismos. O colágeno (COL) vem sendo amplamente usado como material na fabricação de biomateriais. Neste trabalho obteve-se membrana e hidrogel de CB-COL, caracterizados de diferentes maneiras. Foram realizados, estudos in vivo, análises macroscópica e histológica de coberturas de CB-COL, comparando com os controles (coágulo e a pomada de colagenase), após a aplicação sobre as feridas confeccionadas no dorso de ratos. Os animais foram sacrificados depois de 3, 7, 15 e 30 dias, e os dorsos processados segundo rotina histológica para coloração em HE. As caracterizações realizadas neste trabalho (microscopia eletrônica de varredura (MEV), análise termogravimétrica (TG), espectroscopia no infravermelho com transformada de Fourier (FT-IR) e difratometria de raios-X (DRX)) confirmaram a incorporação do COL às matrizes de CB. A avaliação macroscópica somente demonstrou diferença estatisticamente significante da reparação tecidual entre os tratamentos aos sete dias de pós-operatório, sendo que o hidrogel apresentou uma tendência para uma reparação mais rápida. Os resultados da avaliação histológica demonstraram diferença estatisticamente significante para reação inflamatória tecidual entre os tratamentos em todos os períodos estudados. Na avaliação da qualidade, quantidade e orientação das fibras colágenas, somente o período de três dias que não apresentou diferença estatisticamente significante entre os tratamentos. Conclui-se com esses resultados que as duas coberturas são biocompatíveis. / Since the beginning of the human race, there was those who sought to assist the body in a natural attempt to restore yours injured parts. One of the main current challenges is the replacement of body tissues, including areas of skin lesion. A biomaterial can be used to improve, enhance or replace, partially or fully tissues or organs. The membrane of bacterial cellulose (BC) has moldability, good mechanical properties, selective permeability, allowing the passage of water vapor but preventing the passage of microorganisms. The collagen (COL) has been widely used as material in the manufacture of biomaterials. In this study was obtained hydrogel and membrane BC-COL, characterized in different ways. Were realized in vivo studies, macroscopic and histological analyzes from dressings of BC-COL, comparing with controls (clot and collagenase ointment), after applying in wounds on the backs of rats. The animals were sacrificed after 3, 7, 15 and 30 days, and the scars were processed according to histological routine to HE staining. The characterizations performed in this study (scanning electron microscopy (SEM), thermogravimetric analysis (TGA), infrared spectroscopy with Fourier transform (FT-IR) and X-ray diffraction (XRD)) confirmed the incorporation of the COL to matrices BC. The macroscopic evaluation only demonstrated statistically significant difference of tissue repair between treatments at seven days postoperative, and the hydrogel showed a trend for a faster repair. The results of the histological evaluation showed statistically significant difference in inflammatory tissue reaction between treatments in all periods studied. In quality evaluation, quantity and orientation of collagen fibers, only three days period didnt show statistically significant difference between treatments. We conclude from these results that the two dressings are biocompatible.

Made available in DSpace on 2016-08-10T10:57:42Z (GMT). No. of bitstreams: 1 ANA VITORIA ROSA.pdf: 683707 bytes, checksum: d00aaedc3b15de8284e163af46cf4542 (MD5) Previous issue date: 2015-06-29 / Central venous catheters are very important devices in critically ill patients care. However, this device can become a threat to the health of patients, as commonly causes bloodstream infections, especially those most vulnerable. The aim of the study was to evaluate the effectiveness of chlorhexidine-impregnated coatings in central venous catheter ostium in reducing the incidence of catheter-related bloodstream infection. The method used was a systematic review study in a timeframe of eleven years, including the research published in the period from 2004 to 2014, including publications on coatings of central venous catheter ostium in the perspective of the prevention and control of infection, in search of evidences about the effectiveness of using chlorhexidine-impregnated coatings when compared to others coatings in reducing rates of catheter-related bloodstream infection. The search for articles was made through the CINAHL databases, Web of Science, EMBASE, LILACS, MEDLINE and PubMed, using the descriptors and relevant terms to each one. Seventy six publications were identified and eight fulfilled the eligibility criteria. Participants in the studies ranged from 85 to 2302 patients. The use of chlorhexidine-impregnated coating was related to the reduction of the catheterrelated infection rates and catheter-related bloodstream infection rates. The coating with chlorhexidine was well tolerated by participants, however, local reactions such as hyperemia, dermatitis and skin maceration were reported, especially in patients with multiple organ failure, subcutaneous edema or skin integrity impaired, and when remained without dressing change for more than three days. The chlorhexidineimpregnated coating presented advantages and reduction in catheter-related infection rates and in catheter-related bloodstream infection rates when compared to coating without antiseptics, besides representing a best cost-benefit ratio and reduction in mortality rate. / Cateteres venosos centrais são dispositivos de grande relevância no cuidado ao paciente crítico. Entretanto esse artefato poderá se tornar uma ameaça à saúde dos pacientes, já que comumente ocasiona infecções de corrente sanguínea, principalmente naqueles mais vulneráveis. Objetivou-se avaliar a eficácia das coberturas impregnadas com clorexidina em óstio de cateter venoso central na redução da incidência de infecção de corrente sanguínea relacionada a cateter venoso central. Foi realizado um estudo de revisão sistemática, num recorte temporal de onze anos, incluindo as pesquisas publicadas no período de 2004 a 2014, compreendendo as publicações sobre coberturas de óstio de cateter venoso central na perspectiva da prevenção e controle de infecção, em busca de evidências acerca da eficácia do uso da cobertura impregnada com clorexidina quando comparada a outras coberturas na redução das taxas de infecção da corrente sanguínea, relacionada a cateter venoso central. A busca dos artigos se deu por meio das bases de dados CINAHL, Web of Science, EMBASE, LILACS, MEDLINE e PUBMED, utilizando-se os descritores e termos pertinentes a cada uma. Identificouse 76 publicações e foram inclusas oito na revisão, por atenderem aos critérios de elegibilidade. O uso da cobertura impregnada com clorexidina apresentou vantagens e queda nas taxas de infecções quando comparada a outros curativos, estando relacionado a redução das taxas de infecção associada a cateter e das taxas de infecção da corrente sanguínea. A cobertura com clorexidina foi bem tolerada pelos participantes, no entanto, reações locais como hiperemia, dermatites e maceração da pele foram notificadas, principalmente em pacientes com falência múltipla de órgãos, edema subcutâneo e ou com a integridade da pele prejudicada, e quando o curativo permaneceu sem troca por mais de três dias. A cobertura impregnada com clorexidina apresentou vantagens e redução nas taxas de infecção relacionada a cateter e nas taxas de infecção da corrente sanguínea relacionada a cateter quando comparada as coberturas sem antissépticos, além de representar um melhor custo benefício e redução na taxa de mortalidade.

Hidrogéis compreendem uma importante classe de materiais poliméricos adequados à aplicação como curativos de feridas e queimaduras. A estrutura tridimensional hidrofílica dos hidrogéis permite que estes mantenham a umidade ideal no leito das feridas, absorvam o exsudato e não causem danos ao novo tecido durante as trocas dos curativos. No caso dos hidrogéis, essas trocas podem ser menos frequentes. Além disso, curativos que auxiliem na remoção de tecidos necrosados e ainda sejam capazes de oferecer tratamentos extras que acelerem o processo de cicatrização são desejáveis. Este trabalho apresenta a produção de materiais à base de hidrogel capazes de auxiliar neste processo de diferentes maneiras. Primeiramente, são apresentados hidrogéis formados a partir de nanofibras de poli(N-vinil-2-pirrolidona) (PVP) produzidas por eletrofiação, seguido da reticulação através da utilização de radiação UV-C ou reação de Fenton. A utilização da eletrofiação como técnica auxiliar na formação dos hidrogéis permitiu o controle da porosidade através da formação de fibras de diferentes diâmetros. A evidência de tal propriedade foi constatada através da produção de materiais que apresentam diferentes perfis de liberação da proteína modelo albumina de soro bovino (BSA). O hidrogel de PVP nanoestruturado foi capaz de liberar e manter a atividade da colagenase, uma importante enzima aplicada no tratamento de feridas via desbridamento enzimático, durante as 48 horas em que foi avaliado. Além disso, hidrogéis bactericidas nanoestruturados foram produzidos a partir de nanocompósitos de PVP e nanopartículas de prata (AgNP) produzidos por eletrofiação. Esses hidrogéis apresentaram propriedades térmicas semelhantes aos hidrogéis sem AgNP, diminuindo, contudo, a sua capacidade de intumescimento. Esses hidrogéis mostraram-se ativos contra bactérias gram-positivas e gram-negativas a partir de 100 ppm de AgNPs. Adicionalmente, foi estudada a formação de um hidrogel modelo composto PVP/AgNP/Imidazol, almejando-se a produção de um material bactericida-fungicida a base de hidrogel. Este hidrogel apresentou atividade conta três espécies de Candida a partir de 500 ppm de imidazol no material. Embora exista a formação de um complexo estável entre AgNP e Imidazol, cálculos teóricos e a constatação da atividade fungicida corroboram com o fato de que derivados imidazólicos podem ser liberados a partir deste hidrogel híbrido. A produção de hidrogéis físicos compostos por blendas de PVP/Polianidridos sintetizados a partir de derivados de hidroxicinamatos e ácido salicílico, capazes de liberar moléculas de interesse biológico quando parcialmente degradados hidroliticamente, também é descrita neste trabalho. Os resultados indicam que interações hidrofóbicas entre a PVP e os polianidridos sintetizados podem ser responsáveis pela formação dos hidrogéis físicos e pela miscibilidade das blendas produzidas. Os hidrogéis físicos de PVP/Polianidridos foram obtidos na forma de filmes por evaporação do solvente. Micro- e nanofibras também foram obtidas por eletrofiação. Desta maneira, o presente trabalho contribui com o desenvolvimento de uma geração de curativos multifuncionais aplicados no tratamento de feridas crônicas e queimaduras. / Hydrogels comprise an important class of polymeric materials that finds application as wound and burn dressings. The hydrophilic three-dimensional structure of hydrogels helps to provide the ideal humidity at the wound bed, to remove exsudates and to prevent damages to the new tissue during dressing substitution. Furthermore, these wound dressings are able to remove necrotic tissues and, therefore, capable to offer extra treatments that would benefit the healing processes. This work describes the production of hydrogel based materials that are able to act in wound healing by different ways. First, it is presented hydrogels composed of poly(N-vinyl-2-pyrrolidone) (PVP) nanofibers produced by electrospinning, followed by its crosslinking using UV-C radiation or Fenton reaction. The use of electrospinning in the hydrogel formation allowed porosity control by obtaining fibers of different diameters. This was evidenced by achieving materials that present different release profiles of the model protein bovine serum albumin (BSA). The nanostructured PVP hydrogel was capable of releasing and maintaining collagenase activity during 48 hour of evaluation. This is an important enzyme that find application in wound healing based on enzymatic debridement. Moreover, nanostructured bactericidal hydrogels were produced from PVP and silver nanoparticles (AgNP) composite through electrospinning, resulting in hydrogels with thermal properties similar to those hydrogels without AgNP, decreasing its swelling ability. These hydrogels were active against gram-positives and gram-negatives bacteria starting from 100 ppm of AgNP. In addition, the production of a model hydrogel composed by PVP/AgNP/Imidazole was investigated, aiming at a bactericidal-fungicidal hydrogel based material. This hydrogel was active against three Candida having 500 ppm of imidazole into the structure. In spite of the formation of a stable complex between AgNP and imidazole, theoretic calculations and the observed fungicidal activity corroborate with the fact that imidazoles derivatives can be released from this hybrid hydrogel. Physical hydrogels composed of PVP/Polyanhydrides blends were synthesized from hydroxycinammates derivatives and salicylic acid. These materials which were capable of releasing molecules with biological potential upon hydrolysis, are also described in this work. The results indicate that hydrophobic interactions between PVP and the synthesized polyanhydrides could be responsible for the hydrogel formation and blend miscibility as well. PVP/Polyanhydride physical hydrogels were obtained from cast films. Micro- and nanofibers were also obtained by electrospinning. Thus, the present work contributes with the development of the new generation of smart dressings for wound and burn healing.