In November 1558, Elizabeth I ascended the throne of England as a single Queen with Protestant tendencies in a male-dominated Catholic world. Her council believed it was imperative that she marry immediately, and the rest of Western Europe agreed. Catholic suitors sought to bring England back under Catholic control. Protestant suitors hoped for an ally in the religious wars that were ravaging Europe. Even Englishmen sought to become king. Ambassadors from the Spanish Empire, the Holy Roman Empire, and the Baltics and Scotland came to negotiate the suits of their monarchs. Ambassadorial correspondences are often used as primary source material for historians, yet few rarely recognize the importance of the ambassador and his role in the court, especially during the marriage negotiations of Elizabeth I. Ambassadors left their home to live in a foreign country, often for long periods of time. The ambassadors were the embodiment of their sovereigns during the negotiations, and often success or failure rested on their abilities. An ambassador was the eyes and ears of the Elizabethan court for his sovereign in a foreign country. They wrote minutely detailed letters that included basic facts and information along with court gossip and personal opinions and recommendations. Their intimate relationship with the Queen and her court made their recommendations invaluable to their monarch. They were far more than mere note takers and should be recognized as such. The focus of this thesis deals primarily with the ambassadorial reports of the Spanish and Hapsburg ambassadors as they participated in the negotiations in one form or another during the time frame discussed, 1558-1560. They also not only wrote about their own negotiations but the negotiations involving Protestant and English suitors. Their reports are full of pertinent information that, without, their monarchs would have been blind to the goings on of the English court. The marriage of Elizabeth I was seen as a priority by all except her. During the first two years of her reign, more than a half dozen suits were pursued, not just by kings and dukes, earls and knights, but, more importantly, by their ambassadors.

Schilddrüsenhormone benötigen als geladene Proteine Transporter um Zellmembranen zu durchqueren. Ein sehr spezifisches Transportprotein ist der Monocarboxylattransporter 8 (Mct8). Mutationen in MCT8 führen beim Menschen zu einer schweren X-gekoppelten mentalen Retardierung, die mit sehr speziellen Veränderungen der Schilddrüsenhormonwerte im Serum einher geht. Zur genaueren Untersuchung der Funktion von Mct8 sowie Mechanismen der Erkrankung wurde ein Knock-out Mausmodell für Mct8 generiert und mit dem menschlichen Phänotyp verglichen. Mct8-defiziente Mäuse replizieren den humanen Phänotyp in Hinsicht auf veränderte Schilddrüsenhormonparameter im Serum. Dennoch weisen diese Mäuse keine morphologischen Veränderungen des Gehirns auf. Ein in dieser Arbeit erstmalig nachgewiesenes ähnlich einer Hyperthyreose verändertes Angstverhalten sowie ein ähnlich einer Hypothyreose verändertes Putzverhalten führte zu der Hypothese, dass es andere Transporter gibt, die den Verlust von Mct8 kompensieren. Ein Kandidat mit einem ähnlichen Expressionsmuster in verschiedenen Geweben und auch in Zelltypen des Gehirns ist der L-Typ Aminosäuretransporter 2 (Lat2). Mct8 ist bei der Maus und beim Menschen während der Entwicklung stark in Neuronen und anderen Zelltypen des Gehirns exprimiert. LAT2 ist jedoch anders als bei der Maus beim Menschen während der Entwicklung in Neuronen nicht nachweisbar. Lat2 könnte also bei der Maus, jedoch nicht beim Menschen den Verlust von Mct8 während der Gehirnentwicklung kompensieren und somit den Unterschied zwischen beiden Phänotypen erklären. Die Untersuchung von Mct8-defizienten Mäusen konnte jedoch auch einen neuen Phänotyp aufdecken: das Fehlen von Mct8 führt bei Mäusen mit zunehmendem Alter zu Hyperplasien der Schilddrüse, die als papilläre Schilddrüsenkarzinome klassifiziert wurden. Bei einem Patienten mit Allan-Herndon-Dudley-Syndrom konnten hierauf ebenfalls hyperplastische Veränderungen der Schilddrüse gefunden werden. / Thyroid hormones are charged molecules and therefore need transporters to cross the cell membrane. One very specific transport protein is the monocarboxylatetransporter 8 (Mct8). Mutations in MCT8 lead to a severe form of X-linked mental retardation in humans in combination with very specific changes in thyroid hormone serum parameters. A mouse model of Mct8-deficiency was generated and compared to the human phenotype to be able to precisely analyze functions of Mct8 and mechanisms of the disease. Mct8-deficient mice do replicate the human phenotype concerning changes of thyroid hormones in serum. However, these mice did not show any morphological changes in the brain. This work could show for the first time changes in anxiety-related behaviour indicative of hyperthyroidism as well as changes in grooming behaviour indicative of hypothyroidism. This led to the hypothesis that other transporters exist that can compensate for the loss of Mct8. One candidate that has a similar expression pattern in different tissues and cell types of the brain is the L-type amino acid transporter 2 (Lat2). Mct8 is highly expressed in neurons and other cell types of mice and humans during development. LAT2 is in contrast to the mouse not detectable in human developing neurons. Therefore, Lat2 could compensate in the mouse but not in the human for the loss of Mct8 during brain development. This could explain the differences between both phenotypes. Nevertheless, the analysis of Mct8-deficient mice could also disclose a new phenotype: the loss of Mct8 leads to thyroid hyperplasia in mice that increases with age and could be classified as papillary thyroid carcinoma. Thereupon, hyperplastic changes of the thyroid could also be detected in a patient with Allan-Herndon-Dudley syndrome.

Thesis (Ph.D.) -- University of Western Sydney, 2004. / "A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy" Bibliography : leaves [361]-388.

Speech work, as it relates to actor training, has undergone many important changes since its formal introduction to the field over a century ago by Edith Skinner. Unfortunately, there are many who hold on to antiquated, misinformed and often harmful approaches to this kind of training. This thesis questioned the traditional models of speech pedagogy by creating a narrative for its development, questioning its efficacy, and exploring the alternatives that have developed over the years. I looked at the texts and approaches of Edith Skinner, Patricia Fletcher, Louis Coliaini, and Dudley Knight/Phil Thompson. I acknowledge that each practitioner has made a substantial contribution to the field. In this thesis I question what place each has in the future of speech pedagogy in America. I gathered opinions from both critics and proponents of each work in the hopes of creating a more cohesive understanding of how speech pedagogy should be handled in the future according to those who will be teaching it. This thesis includes considerable usage of phonetic symbols found on the International Phonetic Alphabet establish by the International Phonetic Association.

No description available.

No description available.

Between 1960 and 1992, American artist George Tsutakawa (1910 – 1997) created more than sixty fountain sculptures for publicly accessible sites in the U.S., Canada, and Japan. The vast majority were made by shaping sheet bronze into geometric and organically inspired abstract forms, often arranged around a vertical axis. Though postwar modernist artistic production and the issues it raises have been widely interrogated since the 1970s, and public art has been a major area of study since about 1980, Tsutakawa's fountains present a major intervention in North America's urban fabric that is not well-documented and remains almost completely untheorized. In addition to playing a key role in Seattle's development as an internationally recognized leader in public art, my dissertation argues that these works provide early evidence of a linked concern with nature and spirituality that has come to be understood as characteristic of the Pacific Northwest. Tsutakawa was born in Seattle, but raised and educated primarily in Japan prior to training as an artist at the University of Washington, then teaching in UW's Schools of Art and Architecture. His complicated personal history, which in World War II included being drafted into the U.S. army, while family members were interned and their property confiscated, led art historian Gervais Reed to declare that Tsutakawa was aligned with neither Japan nor America – that he and his art existed somewhere in-between. There is much truth in Reed's statement; however, artistically, such dualistic assessments deny the rich interplay of cultural allusions in Tsutakawa's fountains. Major inspirations included the Cubist sculpture of Alexander Archipenko, Himalayan stone cairns, Japanese heraldic emblems, First Nations carvings, and Bauhaus theory. Focusing on the early commissions, completed during the 1960s, my study examines the artist's debts to intercultural networks of artistic exchange – between North America, Asia, and Europe – operative in the early and mid-twentieth century, and in some cases before. I argue that, with his fountain sculptures, this Japanese American artist sought to integrate and balance such binaries as nature/culture, intuition/reason, and spiritual/material, which have long served to support the construction of East and West as opposed conceptual categories. / Graduate