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Techninės analizės taikymas Lietuvos vertybinių popierių rinkoje spekuliaciniai tikslais / Usage of technical analysis for speculative purposes in lithuanian stock marketPekšys, Darius 26 June 2014 (has links)
Lietuvoje privatūs asmenys (spekuliantai) vis dažniau pasirenka įvairesnes investicijos formas. Viena iš sparčiai populiarėjančių investicijos formų – prekyba akcijomis Lietuvos vertybinių popierių biržoje tarpininkaujant finansų maklerių įmonėms. Investuotojai/spekuliantai norėtų žinoti, ar teorijoje aprašyta techninė analizė gali suteikti pakankamai informacijos, kad būtų galima apsispręsti, pirkti ar parduoti akcijas. Darbo tikslas yra nustatyti ar taikytini yra techninės analizės matematiniai modeliai Lietuvos vertybinių popierių rinkoje. Buvo taikomi penki pagrindiniai techninės analizės matematiniai modeliai: - paprastąjį slankųjį vidurkį (SMA); - eksponentinį slankųjį vidurkį (EMA); - slankaus vidurkio konvergencijos ir divergencijos indikatorių (MACD); - santykinio stiprumo indeksą (RSI); - stochastinį indikatorių; Buvo sukurta programinė įranga kuri, analizuodama pagal statistinius duomenis matematinių modelių generuojamus pirkimo pardavimo signalus, skaičiavo prekybos rezultatus. Tyrimo rezultatai parodė, kad krypties indikatorių SMA, EMA bei MACD naudojimas Lietuvos vertybinių popierių rinkoje pasitvirtino. Osciliatorių naudojimas Lietuvos vertybinių popierių rinkoje davė arba prastus arba neigiamus rezultatus. / There are more and more private persons (speculators) who a choosing different types of investment in Lithuania. More people are willing to participate in the stock trade in the Lithuanian stock market with brokers mediation. Investors/speculators are willing to know if technical analysis, that is well described in the theory, can give enough information that could lead to decision to buy or sell the stock. The goal of this study is to identify if the mathematical models, that are described by technical analysis, are possible to use in Lithuanian stock market. The mathematical models are: - simple moving average, SMA; - exponential moving average, EMA; - moving average convergence and divergence, MACD; - relative strength indicator, RSI; - Stochastic oscillator. The software was developed to calculate the result of all possible trades. All trades were made after receiving the signals according to mathematical calculations when statistic data where entered. The result of the study proved with positive results the use of trend indicators like SMA, EMA and MACD in Lithuanian stock market. The use of oscillators is not offered to use in Lithuanian stock market according to study results.
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Energia metabolizável aparente para poedeiras Isa Label mantidas em ambiente de alta temperatura / Apparent metabolizable energy for Isa Label laying kept in high temperature environmentMacchi, Paloma de Matos 16 July 2015 (has links)
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Previous issue date: 2015-07-16 / Brazil stands out in poultry production as the largest exporter and third largest producer of chicken, and among the ten largest producers of eggs. The demand for food and population growth make the poultry production chain essential to agribusiness, regional economy and strengthening family agriculture, providing highly nutritious affordable food. Genetic improvements and research in pet nutrition favored the success of the poultry industry in the country, however, there is little research on nutritional requirements for slow growth bloodlines in hot climate regions. The Isa Label is a strain with naked neck, slow growth bloodlines with two option for products, which has been widely used by farmers for being good producer of eggs and meat have with appreciable flavor. The amount of metabolizable energy used in feed is conditional factor for productivity of laying in high temperature conditions, and has considerable weight in food costs. The aim of this study was to determine the requirement of apparent metabolizable energy (AME) to Isa Label bird dual purpose in laying phase, 52 weeks old, under high temperature conditions, by evaluating performance, quality eggs and economic viability. They were distributed at random 90 laying in five treatments with nine replicates of two birds each. The treatments were 2,600; 2,675; 2,750; 2,825 and 2,900 kcal / kg of EMA in the feed. We evaluated: feed intake and EMA, laying rate, egg weight, egg mass, feed conversion and energy per mass and dozen eggs; and quality characteristics of eggs. The economic analysis was performed with the number of eggs produced, feed consumption and price per kilogram of feed. The results were productive performance and egg quality were statistically analyzed by polynomial regression with probability <5% significance level. The results of the economic analysis were submitted to descriptive statistics. Increasing the EMA level in poultry feed Isa Label in laying phase, not compromise performance between 52 and 64 weeks of age. The level 2,778 kcal / kg of EMA in the ration showed lower feed intake, while the 2,638 kcal / kg EMA level in the diet had lower power consumption under high temperature environment conditions. Internal and external quality of the eggs was not affected by EMA level in feed, but increased EMA in diets increased the width of the albumen and egg. The use level of 2,675 kcal / kg of EMA is economically viable for poultry Isa Label in stance phase, from 52 to 64 weeks of age under high temperature conditions / O Brasil se destaca na produção avícola como maior exportador e terceiro produtor mundial de frango, e entre os dez maiores produtores de ovos. A demanda por alimentos e o crescimento populacional tornam a cadeia produtiva avícola essencial ao agronegócio, economia regional e fortalecimento da agricultura familiar, fornecendo alimento de alto valor nutritivo a preço acessível. Melhorias genéticas e pesquisas em nutrição animal favoreceram o sucesso da avicultura no país, contudo, existem poucas pesquisas em exigências nutricionais para linhagens de crescimento lento em regiões de clima quente. A Isa Label é uma linhagem com pescoço pelado, crescimento lento e dupla aptidão, que vem sendo muito utilizada pelos criadores por ser boa produtora de ovos e possuir carne com sabor apreciável. A quantidade de energia metabolizável utilizada nas rações é fator condicional para produtividade de poedeiras em condições de altas temperaturas, e tem peso considerável nos custos com alimentação. O objetivo com este trabalho foi determinar a exigência de energia metabolizável aparente (EMA) para aves Isa Label de dupla aptidão em fase de postura, com 52 semanas de idade, sob condições de alta temperatura, por meio da avaliação de desempenho, qualidade de ovos e viabilidade econômica. Distribuíram-se ao acaso 90 poedeiras em cinco tratamentos, com nove repetições de duas aves, por unidade experimental. Os tratamentos foram: 2.600; 2.675; 2.750; 2.825 e 2.900 kcal/kg de EMA na ração. Avaliou-se: consumo de ração e de EMA, taxa de postura, peso do ovo, massa de ovo, conversão alimentar e energética por massa e dúzia de ovos; e características de qualidade de ovos. A análise econômica foi realizada com número de ovos produzidos, consumo de ração e preço por quilograma da ração. Os resultados foram de desempenho produtivo e qualidade de ovos foram submetidos à análise estatística por regressão polinomial com probabilidade < 5% de significância. Os resultados da análise econômica foram submetidos à estatística descritiva. O aumento do nível EMA na ração para aves Isa Label, em fase de postura, não comprometeu desempenho entre 52 e 64 semanas de idade. O nível 2.778 kcal/kg de EMA na ração apresentou menor consumo de ração, enquanto o nível 2.638 kcal/kg de EMA na ração apresentou menor consumo de energia, sob condições de alta temperatura ambiente. A qualidade interna e externa dos ovos não foi afetada pelo nível de EMA nas rações, porém o aumento de EMA nas rações aumentou a largura do albúmen e do ovo. A utilização do nível 2.675 kcal/kg de EMA é economicamente viável para aves Isa Label, em fase postura, entre 52 a 64 semanas de idade, sob condições de alta temperatura
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A educação mediada por animais como atividade desenvolvente no processo de aprendizagem de estudantes com deficiências / Animals-mediated education (cinotherapy) as a developmental activity in the learning process of disabled studentsFidler, Denise Medina 14 October 2016 (has links)
Nowadays the special education is gaining increasing prominence in the educational and political scenario, consolidating itself as a profitable field of research and bringing to discussion numerous issues that point out its potentiality. Among those issues, the matter of learning alternatives and new approaches is brought up, a complex notion that involves a multiplicity of conceptions and functions, specially within the ambit of the multifunctional-feature classroom. That being said, the present dissertation research is bound to the Special Education Line of Research of the Program of Post-Graduate Studies in Education and to the Group of Studies and Research in Educational Psychology and Inclusive Education (GEPEIN) and its purpose is to investigate and analyse, through the eyes of the teachers, parents and/or legal guardian, how the AME (Cinotherapy) can develop a student‟s cognitive functions as a mediator feature for support in the multifunctional classroom, involving the learning process in multiple areas of development. Aiming to comprehend the nature of this field of research in a historical and theoretical perspective, we based our research on the studies of Vygotsky (1991, 1993, 1997,1998, 2007), Baptista (2011), Becker (2002), Bardin (2011), Gatti (2006), Costas (2012), Dotti (2014) and others. The methodological basis adopted for this study is guided by a qualitative approach, using as research technique the Analysis of Content and as a collecting instrument for semi-instructed interviews along with teachers and parents and/or legal guardians. The investigation field was a public school in Santa Maria/RS and another public school in the city of Itaara/RS. Thereby, six categories were stablished: attention, memory, perception, language, logic and autonomy, which were indicated during the analysis and conducted this study, therefore, they are relevant and potent for making us realise the relevance of exchanging and the work developed and mediated in collectivity, mainly with the AME (Cinotherapy) diferential, in which this activity was interacting in a motivating way with students and leading to the exercise of interaction and the experience of new things in the classroom environment. / A educação especial vem se destacando cada vez mais no cenário educacional e político, consolidando-se como um profícuo campo investigativo e trazendo para a pauta inúmeras questões que revelam a sua potencialidade. Dentre estas, emerge a temática de conceito que envolvem uma multiplicidade de concepções e finalidades, especialmente no âmbito da sala de recursos multifuncional. Assim, esta pesquisa de dissertação está vinculada à Linha de Pesquisa em Educação Especial do Programa de Pós-Graduação em Educação e ao Grupo de Estudos e Pesquisas em Psicologia da Educação e Educação Inclusiva – GEPEIN e pretendeu investigar e analisar por meio do olhar dos professores, pais e/ou responsáveis como a Educação Mediada por Animais (EMA), especificamente com a Cinoterapia pode desenvolver as funções cognitivas dos estudantes com deficiência, sendo um recurso mediador para o atendimento na sala de recursos e envolvendo aprendizagem em diversas áreas do desenvolvimento. Na busca por compreender a constituição do campo de pesquisa em perspectiva histórica e teórica, a pesquisa apoiou-se nos estudos de Vygotsky (1991, 1993, 1997,1998, 2007), Baptista (2011), Becker (2002), Bardin (2011), Gatti (2006), Costas (2012), Dotti (2014), dentre outros. A base metodológica adotada para este estudo pauta-se em uma abordagem qualitativa, utilizando como técnica de pesquisa a Análise de Conteúdo e como instrumento para coleta a entrevista semiestruturada junto a professores e pais e/ou responsáveis. O espaço de investigação constitui-se de uma escola municipal de Santa Maria-RS e de outra escola municipal no município de Itaara-Rs. Desse modo, foram estabelecidas seis categorias de análise: atenção, memória, percepção, linguagem, raciocínio e autonomia, que foram indicadas durante a análise e que conduziram este estudo. Portanto, foram relevantes e potentes para que se percebesse a pertinência das trocas e o trabalho desenvolvido e mediado na coletividade, principalmente com o diferencial da EMA (Cinoterapia), onde essa atividade estava a todo o momento interagindo envolventemente de maneira motivadora com os estudantes, provocando o exercício de interagir e experienciar novidades no ambiente e sala de aula.
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DESENVOLVIMENTO DE EMBUTIDO CURADO FERMENTADO DE CARNE DE EMA (Rhea americana) ASSOCIADA À DE SUÍNO / DEVELOPMENT OF THE CURED FERMENTED SAUSAGE OF GREATER RHEA MEAT (Rhea americana) ASSOCIETED TO THE PORKToneto, Edsom Roberto Lorenci 16 February 2007 (has links)
The wild fauna represent an option of protein source to Brazil and others countries of Latina America, Europe and Asia. In this context, the greater rhea and others ratites are very valorized in the market, because of the healthy read meat that is introduced what is similar to others sorts of slaughter. This work had the objective to develop and to characterize a cured fermented sausage with rhea meat (Rhea Americana)
and the pork meat in the Brazilian market. In the formulations of the cured fermented sausage used five meat combinations (90% rhea, 67,5% rhea / 22,5% pork, 45% rhea / 45% pork, 22,5% rhea / 67,5% pork, 90% pork). The products elaborated were appraised for analysis physicochemical, microbiologics, and sensorials. The results of phisicochemical analyzes sowed that the proctucts elaboreteds were in the vigor law to the salami, therefore water activity varieted from 0,88 to 0,90 (maximum 0,92), umided varieted from 35,93% to 41,07% (maximum 40%), fat varieted from 29,89 from 31,03 (maximum 35%) and protein variated from 29,89% to 31,03% (minimum 20%). The results indicated that all products developed showed secure to the microbiologic seen. The sensorial analyze revealed bigger preference to the cured
sausages that contains elevated percentage of the pork meat in relation to the rhea meat, therefore the cured sausages that contains 22,5% of rhea meat and 67,5% of pork meat obtained the best valuation of the colour, smell, texture and savour. The products developed with more proportion of rhea meat in relation to the pork obtained the minor preference for the provers panel, moreover the formulated cured sausages
with 90% of rhea meat received undervaluation. Is follow that, in the present work, the cured fermented sausages that have a formulation of 22,5% of rhea meat and 67,5% of pork meat reunited characteristics to be framed into the vigor law of salami and are the most appropriate to be into the Brazilian market as a alternative font of proteins to the human consumption. / A fauna silvestre representa uma opção de fonte protéica para o Brasil e outros países da América Latina, Europa e Ásia. Nesse contexto, a ema e outras ratitas, são muito valorizadas no mercado pela carne vermelha saudável que apresentam,
que é similar a outras espécies de abate. Este trabalho teve como objetivo desenvolver e caracterizar um embutido curado fermentado contendo carne de ema (Rhea americana) e carne de suíno, no mercado brasileiro. Nas formulações dos
embutidos, utilizou-se cinco combinações cárneas (90% ema, 67,5% ema / 22,5% suíno, 45% ema / 45% suíno, 22,5% ema / 67,5% suíno, 90% suíno). Os produtos elaborados foram avaliados por análise físico-químicas, microbiológicas e sensoriais. Os resultados das análises físico-químicas mostraram que os produtos elaborados estavam dentro da legislação vigente para salame, sendo que a atividade de água
variou de 0,88 a 0,90 (máximo 0,92), umidade variou de 35,93% a 41,07% (máximo 40%), gordura variou de 19,67% a 23,53% (máximo 35%) e proteína variou de 29,89% a 31,03% (mínimo 20%). Os produtos desenvolvidos apresentaram-se
seguros sob o ponto de vista microbiológico. A análise sensorial revelou maior preferência pelos embutidos contendo percentagem mais elevada de carne de suíno em relação à carne de ema, sendo que os embutidos contendo 22,5% de carne de ema e 67,5% de carne de suíno obtiveram as melhores avaliações da cor, odor, textura e sabor. Os produtos desenvolvidos com maior proporção de carne de ema
em relação ao suíno tiveram a menor preferência pelo painel de avaliadores, sendo que os embutidos formulados com 90% de carne de ema receberam as menores avaliações. Conclui-se que no presente trabalho, os embutidos curados fermentados que possuem uma formulação de 22,5% de carne de ema e 67,5% de carne de suíno reuniram características para serem enquadrados na legislação vigente de salame e são os mais adequados para serem lançados no mercado brasileiro como uma fonte alternativa de proteínas para o consumo humano.
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Analytical tool for electromechanical actuators for primary and secondary flight control systems : Optimization of the initial design of the EMA using parametric sizing models / Analytiskt verktyg för elektromekaniska aktuatorer för primära och sekundära styrsystem för flygplan : Optimering av den initiala designen av EMA genom användandet av parametriska dimensioneringsmodellerLinderstam, Albin January 2019 (has links)
The number of flights have increased by 80% between 1990 and 2014, and the demand for air travel continues to increase. Even though the aviation sector contributes to economical and social benefits, it still affects the climate change [1]. A first step to minimize the environmental impact is to develop more electric aircraft (MEA), where the idea is to maximize the use of electricity and improve the overall energy effciency [2]. In most of today's aircraft, large mechanical transmission shafts with a lot of components are driven by central power units, termed centralized drive systems. By the use of electromechanical actuators (EMAs), a distributed drive systems can be used instead, which increases functionality, reduces mass, maintenance and energy consumption, as well as improves manufacturing and assembly [3]. When designing electromechanical actuators, one must take into account a lot of parameters that affect each other in various ways. It is often a time-consuming job to find the most optimal choice of architecture. Parameters such as temperature, load, lifetime and effciency to mention a few. This master thesis offers a new analytical tool for EMAs of primary and secondary flight control systems for Saab Avionics Systems. The aim of the analytical tool is to characterize the parts of the system and identify important parameters in order to find the most optimal choice of architecture. The tool focus on the main mechanical components such as the three-phase synchronous permanent magnet motor, power-off brake, two-stage planetary gearbox and ball screw. The tool developed in this project generates an initial design of the EMA with optimized dimensions in order to minimize both mass and energy consumption. It functions by identifying three main groups of parameters: The input parameters: fixed values defined by the customer demands The design parameters: variables that the user can change to find the optimal choice of architecture The output parameters: resulting values of either performance or dimensions By defining few design parameters for each component, and implementing multidisciplinary design optimization (MDO), the analytical tool can find an optimized solution for each specific project in a time-efficient way. The final values of the parameters characterize the performance of the EMA.
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Návrh automatického obchodního systému pro obchodování na forexu / Design of an Automatic Trading System For Forex TradingPoláchová, Zuzana January 2018 (has links)
This diploma thesis deals with the design of automated trading system for trading the currency market. On the basis of technical indicators is created a trading system in MQL4 for the MetaTrader4 platform. Part of the thesis is optimization of the proposed system and testing on historical data in order to increase stability and maximize profit.
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Propriedades funcionais da carne de ratitas : ema (Rhea americana) e avestruz (Struthio camellus) comparadas com a carne de frango (Gallus domesticus) /Silva, Letícia Cristina Costa e. January 2009 (has links)
Orientador: Pedro Fernando Romanelli / Banca: José Francisco Lopes Filho / Banca: Expedito Tadeu Facco Silveira / Resumo: O objetivo deste trabalho é avaliar as propriedades funcionais da carne de Ema (Rhea americana) e de Avestruz (Struthio camellus) por meio de um estudo comparativo com a carne de Frango (Gallus domesticus). Para tanto, analisaram-se a solubilidade das proteínas miofibrilares, a capacidade de retenção de água, a capacidade de emulsificação das proteínas totais, a estabilidade da emulsão e as perdas por cocção, por evaporação e por gotejamento. Obtiveram-se os seguintes resultados por meio das análises da composição nutricional do músculo Iliotibialis lateralis das aves: avestruz: 19,59 % de proteínas, 75,53 % de umidades, 1,37 % de lipídeos, 1,13 % de cinzas e 2,38 % de carboidratos; ema: 23,50 % de proteínas, 74,19 % de umidades, 1,11 % de lipídeos, 1,13 % de cinzas e 0,07 % de carboidratos e frango: 18,35 % de proteínas, 73,30 % de umidades, 5,92 % de lipídeos, 1,03 % de cinzas e 1,40 % de carboidratos. Por meio da análise das propriedades funcionais observou-se que as proteínas solúveis no NaCl (PS) e as proteínas extraídas com NaCl das proteínas totais (PT) apresentaram, respectivamente, os seguintes resultados: pH 7.0: avestruz (7,40 % e 38,06 %), ema (8,52 % e 36,11 %) e frango (7,68 % e 41,88 %); pH 5.5: avestruz (5,87 % e 30,18 %), ema (6,53 % e 28,54 %) e frango (5,65 % e 29,97 %) e pH 3.0: avestruz (3,04 % e 15,64%), ema (3,29 % e 13,97 %) e frango (2,85 % e 15,52 %). Na análise da capacidade de retenção de água obteve-se para avestruz (73,19 %), ema (66,25 %) e frango (67,13 %). Com relação à capacidade de emulsificação no pH 7.0 foram obtidos estes resultados: avestruz (21,42 mL óleo/ 100 mg de proteína), ema (18,98 mL óleo/ 100 mg de proteína) e frango (31,87 mL óleo/ 100 mg de proteína). Para a estabilidade da emulsão (pH 7.0) obteve-se: para avestruz (36,33 mL liberado (água e óleo)/ 100 g de emulsão)... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: This study aims to assess the functional properties of both Rhea (Rhea americana) and Ostrich meat (Struthio camellus) through a comparive study to chicken meat (Gallus domesticus). For that, myofibrillar proteins solubility, water retention capacity, total proteins emulsifying capacity, emulsion stability and losses due to cooking, evaporation and meat proteins drip loss were analyzed. This results obtained through the nutritional composition analysis of the muscle Iliotibialis lateralis of poultry: to ostrich 19,59 % proteins, 75,53 % humidity, 1,37 % fat, 1,13 % ash and 2,38 % carbohydrate; to rhea 23,50 % proteins, 74,19 % humidity, 1,11 % fat, 1,13 % ash and 0,07 % carbohydrate and to chicken 18,35 % proteins, 73,30 % humidity, 5,92 % fat, 1,03 % ash and 1,40 % carbohydrate. Through the functional properties analysis we observed that the soluble proteins in NaCl (PS) and the extracted proteins with NaCl from total proteins (PT) presented, respectively, the following results: pH 7.0: to ostrich (7,40 % and 38,06 %), rhea (8,52 % and 36,11 %) and chicken (7,68 % and 41,88 %), pH 5.5: to ostrich (5,87 % and 30,18 %), rhea (6,53 % and 28,54 %) and chicken (5,65 % and 29,97 %) and pH 3.0: to ostrich (3,04 % and 15,64 %), rhea (3,29 % and 13,97 %) and chicken (2,85 % and 15,52 %). Analysing water retention capacity we obtained to ostrich (73,19 %), rhea (66,25 %) and chicken (67,13 %). Regarding the emulsifying capacity in pH 7.0 these results were obtained: ostrich (21,42 mL oil/ 100 mg proteins), rhea (18,98 mL oil/ 100 mg proteins) and chicken (31,87 mL oil/ 100 mg proteins). For the emulsion stability (pH 7.0) we obtained: to ostrich (36,33 mL released (water and oil)/ 100 g emulsion), rhea (81,00 mL released (water and oil)/ 100 g emulsion) and chicken (0,66 mL released (water and oil)/ 100 g emulsion). The values found to cooking losses were: ostrich (21,77 g/ 100 g sample)... (Complete abstract click electronic access below) / Mestre
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An evasive manoeuvre assist function for over-reactive driversKittane, Santusht Vasuki, Harinath, Preetham January 2018 (has links)
Previous studies have shown that many drivers are unable to provide the right amount of steering torque when facing an imminent collision with an upcoming obstacle. In some cases, drivers under-react i.e., they provide too low steering inputs and thus collide with the obstacle in front; in other cases, drivers might apply a higher steering input than necessary, potentially resulting in the vehicle leaving the road or losing stability. The EMA function is an active safety feature which has the sole objective of providing steering torque interference when performing such a manoeuvre. The motivation for the thesis work is to overcome some limitations of the existing MA function which does not incorporate the ability to differentiate driver reactions. In this thesis, an Evasive Manoeuvre Assist (EMA) function is designed to adapt to both types of the drivers, by an optimised steering torque overlay. The existing current EMA function is always amplifying the driver steering inputs using a feed-forward controller. The focus of this thesis work is to identify and dene a proper steering sequence reference model for closed-loop feedback control design. A simple single-point preview model is designed first to calculate the reference steering angle. A few test scenarios are set-up using the IPG CarMakerTMsimulation tool. The reference model is then tuned with respect to the amplitude and frequency by batch simulations to obtain the optimal steering prole. A feedback controller is then designed using this reference model. The controller is implemented in a real-time environment, using a Volvo rapid-prototype test vehicle. Preliminary variation tests have shown that the developed controller can enhance both an over-reacting and under-reacting driver's performance during an evasive manoeuvre, by applying assistance/resistance EPAS torque timely. The designed EMA function is shown to accommodate different driver reactions and provide intuitive torque interference. As opposed to the earlier notion that the EMA function only assists the driver with an additional steering wheel torque, it was shown that the optimal steering torque overlay might be in the form of assistance or resistance.
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FDA and EMA Approvals of New Breast Cancer Drugs—A Comparative Regulatory AnalysisLeo, Chandra P., Hentschel, Bettina, Szucs, Thomas D., Leo, Cornelia 13 April 2023 (has links)
Breast cancer is the most common cancer in women worldwide and the solid tumor type for which the highest number of drugs have been approved to date. This study examines new drug approvals for breast cancer by the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA), based on an analysis of regulatory documents from both agencies for the period from 1995 to 2018. Of the 29 breast cancer drugs approved over this time span, 17 received positive decisions from both the FDA and EMA, including all drugs licensed after 2008. Nineteen of the 25 FDA-approved drugs, but none of the EMA approvals, benefited from special regulatory pathways (such as fast track, breakthrough therapy, or priority review). In the U.S.A., four accelerated approvals were granted (of which one, for bevacizumab, was later revoked), while only two drugs received provisional approvals following EMA review. New breast cancer drugs were approved approximately twelve months earlier in the United States than in Europe. These results suggest that a broader use of special regulatory pathways by EMA could help to accelerate access to novel drugs for European breast cancer patients.
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Force Fight Study in a Dual Electromechanical Actuator ConfigurationWroble, Daniel G. January 2017 (has links)
No description available.
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