The Material is a line of physical events structured into the form of the magazine. Each event is an attempt to move in the same area in which similar conditions are given, but every time among different range of people. The self-destructive principle of the Material magazine is to return to the same thing and deal with it again and again. It means not to do anything new, do the same all the time as long as all possibilities are exhausted. To exhaust what is given, to squeeze it like a lemon, to resign on the open end. I think of Věra Linhartová, who ehxausted the Czech language by continual experiments. Every new event – a variation better than an issue – returns back to the previous variantions and tries to work with them again. This progression, teamwork, dealing with someone else´s texts and pictures and the object of the printed issue keep the context of the magazine. The Material is the grey area between the psysical thing-object and the event.

IN ENGLISH Trade mark law and the issues of parallel imports under Czech law The purpose of the thesis is to analyze the trade mark law and the issues of parallel imports under Czech law. The thesis describes the present situation in the Czech Republic, points out the influence of the European Union and considers the impact of the current regulation of parallel imports concerning trademarked goods. The paper also focuses on the court decisions of the Court of Justice of the European Union which have great effect on the law effective in the Czech Republic. The reason for my research is the ongoing international discussion on that topic and the necessity to find balance among contrary interests of trademark owners, parallel importers and consumers. The aim of the thesis is presented at the beginning. The next chapter of the thesis is introductory and defines basic terminology in general. The third chapter looks at the Czech legislation connected to the topic and highlights its connection to the European law. The next section analyzes the law of the European Union and is subdivided into three parts. The first part outlines the historical context and sets out the basic facts. The next part is concerned with a leading principle used in the European Union - the principle of community exhaustion. The last...

Syftet med litteraturstudien var att undersöka när arbetsterapeuten blir involverad i den arbetslivsinriktade rehabiliteringen för individer som är sjukskrivna till följd av utmattningssyndrom och stressrelaterad psykisk ohälsa, hur arbetsterapi tillämpassamt vilken effekt arbetsterapeutiska insatser har på klientens återgång i arbete. Insamlingen av data gjordes genom sökningar databaserna CINAHL, PsycINFO, Cochrane, PubMed, SveMed+ samt Amed via Luleå tekniska universitetsbibliotek under perioden februari till mars 2019. Totalt valdes tio artiklar ut för att ingå i studien. Resultatet visar att ingen av studierna med tydlighet när arbetsterapeuten blev involverad i klientens arbetslivsinriktade rehabilitering. Resultatet gällande hur arbetsterapi tillämpasför klientgruppen visade generellt att arbetsterapeuten själv eller i multidisciplinära team utför interventioner riktade mot aktivitetsbalans och att det sker främst i kontexten svensk primärvård och rehabiliteringskliniker. Effekterna av de arbetsterapeutiska insatserna på klientens återgång i arbete presenteras endast i tre studier och sammantaget visade resultaten på små effekter, samtatt evidensen som presenterades var låg eller måttlig. Författarnas slutsatser är att det saknas studier av högre evidensstyrka på området samt att den evidens som presenteras i studierna är bristfällig. Författarna konstaterar att det behövs mer forskning på ämnet och klientgruppen samt att de olika professionernas del i insatserna behöver tydliggöras för att det skall vara möjligt att urskilja betydelsen av arbetsterapi för återgång i arbete. / The aim of the literature study was to investigate when the occupational therapist becomes involved in the work rehabilitation of individuals who are sick-listed as a result of exhaustion disorder and stress-related mental health, how occupational therapy is applied and what effect occupational therapy interventions have on the client's return to work. The collection of data was done by searching the databases CINAHL, PsycINFO, Cochrane, PubMed, SveMed + and Amed via Luleå technical university library during the period February to March 2019. A total of ten articles were selected for inclusion in the study. The result show thatnone of the studies describes with clarity when the occupational therapist becomes involved in the work rehabilitation. The results regarding how occupational therapy is being used for the client group generally shows that the occupational therapist alone or in multidisciplinary teams perform interventions directed toward activity balance, primarily in the context of swedish primary care and rehabilitation clinics. The effects of the interventions on the client's return towork were presented in only three of the studies and the overall results show small effects, and the evidence presented is of low or moderate quality. The author ́s states that more research is needed on the subject and the client group, and that in future studies each professions part of the efforts need to be elucidated so that it is possible to distinguish the importance of occupational therapy for return to work.

Made available in DSpace on 2016-08-10T10:53:41Z (GMT). No. of bitstreams: 1 ROGERIO SANTOS MARQUES.pdf: 1002304 bytes, checksum: 86b50a322dcbe63ce2b5e3e6208ddd3a (MD5) Previous issue date: 2012-08-27 / Stress is defined as a bodily reaction, with physical and psychological components, and psycho-physiological causes. Stress can affect professional performance and quality of service. The aim of this study is to investigate the existence, and the degree of stress experienced by the physicians at the Hospital Municipal Esau Matos (HMEM) in Vitoria da Conquista in the Brazilian state of Bahia. The method is transversal. The research took place at the HMEM which is considered a reference in infant maternal care, attending the population of Vitória da Conquista and its surrounding micro region. The population studied included all specialties and sectors: physicians working in neonatal ICU, Obstetrics, Delivery Room, Ambulatory, Surgical Center, Emergency Department and other physicians who are part of the staff of HMEM. 78 physicians work at the hospital, 65 agreed to participate and 52 answered the questionnaires. Demographic and professional data, as well as level of stress were checked through questionnaires. The results showed that a small number of the physicians is stress-free 11,5%, a large number 84,6% of report moderate levels of stress and a small number experiences severe stress 3,8% , nearing exhaustion. Some risk factors showed significant differences in statistical tests. The vast majority of respondents that felt lower back pain, were women aged 30-40 years. Work at the obstetric ward was significantly related to lower back pain. The connection of stressful situations with the demands of medical work is discussed as well as the need of health professionals to rethink attitudes about work and life, in order to reduce the possible damage related to stress, and increase the quality of life of the professionals. / O estresse é definido como uma reação do organismo, com componentes físicos e ou psicológicos, causada pelas alterações psicofisiológicas. O estresse pode prejudicar o desempenho profissional e a qualidade do trabalho. O objetivo da pesquisa é investigar o ambiente de trabalho, estresse e saúde em médicos do hospital municipal Esaú Matos em Vitória da Conquista Bahia. A metodologia desta pesquisa trata-se de um estudo transversal. A pesquisa foi realizada no HMEM, onde o mesmo é considerado de referência materno infantil, atendendo a população do município de Vitória da Conquista e micro região. A população estudada foi a de médicos que trabalham no Hospital Municipal Esaú Matos-HMEM em Vitória da Conquista BA. O critério de escolha considerou todas as categorias e especialidades: médicos que trabalham na UTI Neonatal, Obstetrícia, Sala de Parto, Ambulatórios, Centro Cirúrgico, Pronto Atendimento e outros médicos que fazem parte do quadro de pessoal do HMEM. O universo foi de 78 médicos que trabalham neste hospital em todos os setores, sendo que 65 concordaram em participar do desenvolvimento desta pesquisa, e efetivamente participaram, respondendo os questionários um total de 52 médicos. Dados sócios demográficos e nível de estresse foram levantados por questionários. O resultado em relação ao estresse de todos os sujeitos entrevistados ficou constatado, que uma parcela pequena dos participantes está sem estresse 11,5%, trabalhando de forma saudável e, a grande maioria dos pesquisados 84,6% está com o grau de estresse chamado moderado, o que se pode perceber que os participantes estão na fase de resistência do estresse, também foi verificado que um pequeno grupo dos participantes 3,8% está com um estresse intenso, chegando à exaustão, nenhum dos entrevistados se encontrava com o grau de estresse considerado muito intenso. Analisando os resultados, foi percebido que alguns fatores de risco mostraram diferenças significativas nos testes estatísticos, onde a maioria dos pesquisados sentiam dores lombares, sendo as mulheres com idade de 30 a 40 anos, em quase totalidade são as que mais sentiam as dores lombares. Concluindo o trabalho, perceberam-se possíveis situações estressoras, ligadas às demandas do trabalho e às peculiaridades iminentes do trabalho médico. Considerou-se a necessidade dos profissionais da saúde, especificamente os médicos, repensem as atitudes no trabalho, com o intuito de diminuir ou cessar os possíveis danos relacionados ao estresse, e aumentar a qualidade de vida dos profissionais.

Este estudo teve como objetivo analisar a produção científica relacionada ao estresse ocupacional que a equipe de enfermagem de urgência e/ou emergência está exposta. Para isto realizou-se uma revisão integrativa da literatura nas bases de dados Lilacs e Scielo. Os critérios de inclusão para a seleção da amostra foram: artigos em português que retratassem a temática em estudo, publicados nos últimos cinco anos. Com a busca foram encontrados vinte e quatro artigos, dos quais foram selecionados sete. A análise destes artigos gerou três categorias para discussão – carga horária excessiva, síndrome de Burnout e satisfação profissional. Apesar das poucas publicações no período estudado, seus dados reforçam que a atividade de enfermagem em emergência intrahospitalar se mostra sensível quando relacionada às doenças que o ambiente laboral pode desencadear. Além disto, os estudos selecionados indicam a importância da atuação do gestor priorizando ações, que minimizem o esgotamento dos profissionais e promovam sua motivação, reduzindo a possibilidade de doença relacionada ao trabalho. / This study aimed to analyze the scientific production related to occupational stress that the emergency and / or emergency nursing team is exposed. For this, an integrative review of the literature in the Lilacs and Scielo databases was carried out. The inclusion criteria for the sample selection were: articles published in Portuguese that portrayed the subject under study, published in the last five years. In view of the seven articles selected, 3 categories were chosen for discussion - excessive hours, Burnout syndrome and professional satisfaction. Despite the few publications during the period studied, their data reinforce that the activity of nursing in hospital emergency is sensitive when related to the diseases that the work environment can trigger. In addition, the selected studies indicate the importance of the manager's actions prioritizing actions that minimize the exhaustion of professionals and promote their motivation, reducing the possibility of work-related illness.

L’immunothérapie se présente aujourd’hui comme une alternative de choix dans le traitement des cancers. Son objectif est d’amplifier la réponse immunitaire contre les cellules tumorales tout en préservant les cellules normales. Les travaux antérieurs de mon équipe ont démontré qu'une réponse immunitaire antitumorale a lieu dans les carcinomes bronchiques non à petites cellules (CBNPC) et que des lymphocytes T cytotoxiques (CTL) spécifiques peuvent contribuer à la régression de la tumeur. Les travaux de mon équipe ont démontré aussi que l’interaction de l’intégrine CD103, souvent exprimée sur les lymphocytes infiltrant la tumeur (TIL), avec son ligand, le marqueur des cellules épithéliales E-Cadhérine, à la surface des cellules tumorales, est nécessaire à la polarisation des granules cytotoxiques et leur exocytose pour déclencher la lyse de la cellule cible. L’objectif principal de mon projet de thèse est de déterminer la contribution réelle des lymphocytes T CD8+/CD103+ infiltrant les tumeurs épithéliales dans la réponse CTL antitumorale et le rôle de CD103 dans la régulation de leurs fonctions effectrices in situ. Dans un premier temps, j’ai caractérisé, sur le plan transcriptionel et phénotypique, les TIL de CBNPC humains. Mes résultats ont montré que les lymphocytes T CD8+/CD103+ présentent une signature moléculaire caractéristique des cellules T mémoires résidentes dans les tissues (TRM), avec une expression des récepteurs CD69 et CD45RO. Mes résultats ont montré aussi que cette population lymphocytaire co-Exprime les récepteurs inhibiteurs PD-1 et Tim-3. Dans un deuxième temps, j’ai étudié la fonctionnalité des TIL CD8+/CD103+ et le rôle de CD103 dans leur activité cytotoxique anti-Tumorale. Mes résultats ont d’abord indiqué que les lymphocytes T CD103+ sont plus sensibles à la mort cellulaire induite par activation (AICD) que les TIL CD103-, et qu’ils expriment le granzyme B et CD107a suite à une activation spécifique. De plus, ils sont capables d’exercer une activité cytotoxique spécifique à l’encontre des cellules tumorales autologues suite à la neutralisation de l’interaction de PD-1 avec son PD-L1, et que des anticorps anti-CD103 bloquants inhibe cette fonction. Ensuite, j’ai analysé l’impact de l’expression de CD103 à la surface des TIL sur la survie de patients atteints de CBNPC de stade 1. Mes résultats ont révélé que cette intégrine favorise l’infiltration des TIL dans les régions tumorales épithéliales et qu’une forte expression de CD103 sur les TIL corrèle avec une amélioration de la survie des patients. Enfin, J’ai examiné le rôle de CD103 dans cette fonction et dans la réponse immunitaire antitumorale in vivo. Mes résultats préliminaires ont montré une croissance tumorale retardée des tumeurs LL2 transfectées avec l’E-Cadhérine et CCL5 greffées dans les souris CD103-WT. De plus l’inhibition de cette croissance corrèle avec une infiltration plus importante des tumeurs avec des lymphocytes T CD8+/CD103+. Ces résultats suggèrent un rôle important de la coexpression de CCL5 et d’E-Cadhérine par la tumeur dans le recrutement et la rétention des CTL au site tumoral. L’ensemble de ces travaux est en faveur du rôle important de CD103 dans la régulation de l’immunité T CD8 dans les tumeurs épithéliales et de l’utilité des anticorps neutralisants anti-PD-1 et anti-Tim-3 pour inverser l'épuisement de cette population lymphocytaires CD8+/CD103+. / Today Immunotherapy is clearly an alternative choice in the treatment of cancers. Its main objective is to enhance the cytotoxic immune response against tumor cells while preserving normal cells. We have previously demonstrated that there is an antitumor immune response in the Non-Small-Cell lung carcinoma (NSCLC) and cytotoxic T lymphocytes (CTL) contribute to NSCLC tumor regression. We further showed that the CD103 integrin interaction (oftenly expressed on tumor infiltrating lymphocytes (TIL)) with its ligand, the epithelial cell marker E-Cadherin, expressed at the surface of tumor cells, is necessary for the polarization and exocytosis of TIL cytotoxic granules and to trigger the lysis of the tumor target cells. The main purpose of my thesis project is to determine the actual role/ contribution of CD8+/CD103+ T lymphocytes (infiltrating the epithelial tumors) in the regulation of antitumor CTL response and to study the role of CD103 in the regulation of their in situ effector functions. Firstly, TIL infiltrating human NSCLC were characterized at transcriptional and phenotypic level. My results show that CD8+/CD103+ T lymphocytes have a molecular signature characteristic of memory T cells resident in tissues (MRT), with expression of CD69 receptors and CD45RO. My results also showed that this cell population co-Expresses the inhibitory receptors, PD-1 and Tim-3.In a second step, I studied the functionality of CD8+/CD103+ TIL and the role of CD103 in the regulation of anti-Tumor cytotoxic activity. My results have first indicated that CD103+ TIL are more sensitive to activation induced cell death (AICD) than TIL-CD103- and CD103+ TIL express granzyme B and CD107a after specific activation. Furthermore, CD103+ TIL are able to exert a specific cytotoxic activity against autologous tumor cells following the neutralization of PD-1- PD-L1 interaction, and that of anti-CD103 antibody inhibits this blocking function. After, I analyzed the impact of the expression of CD103 on the surface of TIL on the survival of patients with NSCLC stage 1. My results revealed that this integrin promotes the infiltration of TIL in epithelial tumor regions and a strong expression of CD103 on TIL correlates with improved patient survival. Finally, I examined the role of CD103 in this function and the antitumor immune response in vivo. My preliminary results showed a tumor growth delay of LL2 tumors transfected with E-Cadherin and CCL5 grafted in CD103-WT mice. Furthermore inhibition of growth correlates with a higher tumor infiltrating with CD8+/CD103+ T lymphocytes. These results suggest an important role of the coexpression of CCL5 and E-Cadherin by the tumor in the recruitment and retention of CTL at the tumor site. The whole work supports the role of CD103 in regulating the CD8 T cells-Mediated immune response in epithelial tumors and the usefulness of anti-PD-1 neutralizing and anti-Tim-3 for reversing the depletion of this lymphocyte population CD8+ / CD103+.

Submitted by Suzana Dias (suzana.dias@famerp.br) on 2018-10-24T19:17:06Z No. of bitstreams: 1 EduardoMiyazaki_dissert.pdf: 639516 bytes, checksum: 6cf34731b8387cb3a3a35f3a3f74aabe (MD5) / Made available in DSpace on 2018-10-24T19:17:06Z (GMT). No. of bitstreams: 1 EduardoMiyazaki_dissert.pdf: 639516 bytes, checksum: 6cf34731b8387cb3a3a35f3a3f74aabe (MD5) Previous issue date: 2015-09-18 / To work in health care settings, especially in Intensive Care Unities (ICUs), has been associated with high levels of stress and burnout. Objective: to assess burnout, physical activity practice, and quality of life in professionals working in ICUs in a high complexity hospital. Method: descriptive cross-sectional study performed at the following ICUs: SUS (Unified Health System), Health Insurance, Emergency and Cardiology, with nursing, medical and physical therapy professionals. Participants (n=141) filled an identification questionnaire, the International Physical Activity Questionnaire (IPAC), the Maslach Burnout Inventory (MBI) and the WHOQOL-Bref, World Health Organization instrument (brief) to asses quality of life. Results : Participants mean age was 34,55 ± 8,74, 70% were female and 47,1% were single. Professionals reported working from 20 to 120 hours a week ( mean 48,97 ± 17,4), 53 (38,1%) had more than one job and 46 (35,9%) worked on call. IPAC results indicated that 30,7% (N=43) reported low levels of physical activity, 35% (N=49) reported moderate levels, and 34,3 (N=48) reported high levels. None of the pawrticipants presented burnout although burnout symptoms were presente. Significant diferences were observed between groups: a) despersonalization was lower for the Ucor group when compared to the SUS group (p=0,021); b) the Emergency group reported higher levels of physical activity when compared to the SUS group (p=0,03); c) despersonalization was lower for the Emergency group when compared to the SUS group (p=0,039). Ucor professinals presented higher quality of life scores when compared with professional from other ICUs. Conclusions: participants reported higher levels of physical activity practice when compared to the literature. None of the participants presented burnout, although they had burnout symptoms. There was a difference between professional from diferente concerning despersonalization and quality of life. / Trabalhar na saúde, inclusive em Unidades de Terapia Intensiva (UTIs), tem sido associado a altos níveis de estresse e burnout. Objetivo: Avaliar burnout, prática de atividade física e qualidade de vida entre profissionais que trabalham em UTIS de um hospital de alta complexidade. Método: estudo descritivo, transversal, realizado nas UTIs do SUS, do Convênio, da Emergência e da Cardiologia (UCor) com profissionais das áreas de enfermagem, medicina e fisioterapia. Os participantes responderam individualmente a um Questionário de identificação, ao Questionário Internacional de Atividade Física (IPAQ), ao Maslach Burnout Inventory (MBI) e ao WHOQOL-Bref , instrumento da Organização Mundial de Saúde para avaliar qualidade de vida. Resultados: Dos 251 questionários entregues, 142 foram devolvidos e seus dados incluídos estudo. A média de idade foi 34,55 ± 8,74 anos, 70% dos participantes eram do sexo feminino e 47,1% eram solteiros. Os profissionais relataram trabalhar de 30 a 120 horas por semana (média: 48,97 ± 17,4), 53 (38,1%) tinham mais que um emprego e 46 (35,9%) eram plantonistas. Os resultados do IPAQ indicaram que 30,7% (N=43) realizavam nível baixo de atividade física, 35% (N=49) nível moderado e 34,3% (N=48) nível alto. Nenhum dos participantes do estudo apresentou burnout, apesar de sintomas estarem presentes. Diferenças significantes foram encontradas entre os grupos: a) o índice de despersonalização no grupo Ucor foi menor que o encontrado no grupo SUS (p=0,021); b) o grupo da Emergência relatou uma prática de atividade física mais intensa quando comparada ao grupo do SUS (p=0,03); c) o índice de despersonalização do grupo Emergência foi menor que o do grupo SUS (p=0,039). Profissionais da Ucor apresentaram melhores índices de qualidade de vida em relação aos funcionários das outras unidades. Conclusões: a prática de atividade física relatada pelos participantes foi superior à encontrada na literatura. Não foram identificados profissionais com burnout, embora sintomas estivessem presentes. Houve diferença entre profissionais de diferentes UTIs em relação a despersonalização e qualidade de vida.

This thesis attempted to examine stressors associated with the psychiatric technician profession and levels of burnout amongst them. This was accomplished through the use of a survey which included demographic data, the Maslach Burnout Inventory Human Services Survey (MBI‑HSS), an adaptation of the Nursing Stress Scale (NSS) and a self‑care assessment tool. A total of three research questions were examined statistically including levels of burnout on subcategories (personal accomplishment, emotional exhaustion and depersonalization), most common stressors identified by psychiatric technicians and percentage of participants who utilized therapy to cope with work related stress. The survey was made available via survey monkey and posted on the website for the California Association of Psychiatric Technicians website and via links posted on Union Chapter social media pages. A total of 123 Psychiatric Technicians participated in the study. Results indicated high levels of emotional exhaustion, depersonalization and personal accomplishment among psychiatric technicians. Results indicate that extended work hours and staffing minimums were significant issues impacting union members. Also significant among participants, was high level of difficulty attending work due to work related stress during the last three months. For future research, it is recommended that similar studies of psychiatric technicians be conducted to provide further insight into burnout, how it happens and how to avoid it.

A significant amount of previous research has addressed burnout among mental health professionals who work with individuals with severe and persistent mental disorders. Multiple issues can contribute to burnout including organizational factors, severity of client diagnosis, and low quality supervision (Lasalvia et al., 2009, Ballenger-Browning et al., 2011, Kozlawska, Nunn, & Cousens, 1997). The purpose of this study is to identify the most critical elements of burnout among public mental health professionals. This study is a systematic review, using 10 key articles, of existing literature on elements of burnout and contributing factors to developing burnout in public mental health professionals. The search yielded three major categories of dynamics: client specific characteristics, individual worker characteristics, and organizational/environmental characteristics. Identifying the red flag contributors to burnout in this segment of social work will be essential informing clinician’s practice in public mental health. Additionally, the findings from this study may be effective in macro practice in informing large-scale trainings for social workers as well as policy and legislation.

Burnout syndrome has recently been a frequently discussed term. Burnout is a state of emotional, mental and physical exhaustion as a result of excessive chronic stress. Burnout syndrome affects all people regardless of their age and occupation. The thesis is divided into a theoretical and a practical part. The theoretical part of this thesis defines burnout syndrome, explains its causes of origin and describes its phases, symptoms and risk factors for its occurrence. Furthermore, the thesis deals with prevention of burnout and distinguishes burnout from other negative phenomena. The practical part is realized through a quantitative research method - a questionnaire. The main objective was to find out The survey was performed out by using a quantitative research method - a questionnaire. The main objective was to find out final-year pupils' knowledge (number of correct answers) of burnout syndrome in selected high schools in the district Česká Lípa. The results have shown that knowledge differs depending on high schools pupils study in. The best results were achieved by pupils from Gymnázium ČL and the worst results were achieved by pupils from SOŠ and SOU ČL. In general, pupils have been making mistakes mostly in the areas of physical and mental symptoms of burnout syndrome and prevention of this...