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Untersuchungen zum Einfluss von Elektrodenkennwerten auf die Performance kommerzieller graphitischer Anoden in Lithium-Ionen-BatterienZier, Martin 20 January 2015 (has links) (PDF)
Die vorliegende Arbeit liefert einen Beitrag zum Verständnis der elektrochemischen Prozesse an der Elektrodengrenzfläche und im Festkörper graphitischer Anoden für Lithium-Ionen-Batterien. Der Zusammenhang zwischen den intrinsischen Eigenschaften des Aktivmaterials und den resultierenden Eigenschaften von Kompositelektroden stand dabei im Fokus der Untersuchungen.
Die Temperaturabhängigkeit von Materialeigenschaften (Diffusionskoeffizient, Austauschstromdichte) und Elektrodeneigenschaften (Verhalten unter Strombelastung) wurde in einem Bereich von 40 °C bis -10 °C erfasst. Dazu werden elektrochemische Charakterisierungsmethoden aus der Literatur vorgestellt und hinsichtlich ihrer Gültigkeit für die Anwendung an realen Elektroden evaluiert. Die elektrochemisch aktive Oberfläche wurde bestimmt und stellte sich als ausschlaggebender Parameter für die Bewertung der Elektrodenprozesse heraus.
Auf Basis korrigierter Elektrodenoberflächen konnten Austauschstromdichten für die konkurrierenden Prozesse Lithium-Interkalation und -Abscheidung ermittelt werden. Zusammen mit Kennwerten zur Keimbildungsüberspannung für Lithium-Abscheidung flossen die ermittelten Kennwerte in eine theoretische Berechnung des Zellstroms ein. Es konnte gezeigt werden, dass die Lithium-Abscheidung kinetisch deutlich gegenüber der Lithium-Interkalation bevorzugt ist, nicht nur bei niedriger Temperatur.
Die Übertragbarkeit wissenschaftlicher Grundlagenexperimente auf kommerzielle Systeme war bei allen Versuchen Gegenstand der Untersuchungen. In einem separaten Beispiel einer Oberflächenmodifikation mit Zinn wurde diese Problematik besonders verdeutlicht.
Zusätzlich wurde die parasitäre Abscheidung von Lithium auf graphitischen Anoden hinsichtlich der Nachweisbarkeit und Quantifizierung evaluiert. Hierfür wurde eine neue Untersuchungsmethode im Bereich der Lithium-Ionen-Batterie zur besseren Detektion von Lithium-Abscheidung und Grenzflächen-Morphologie mittels Elektronenmikroskopie entwickelt.
Die Osmiumtetroxid (OsO4) Färbung ermöglichte eine deutliche Verbesserung des Materialkontrasts und erlaubte somit eine gezielte Untersuchung von graphitischen Anoden nach erfolgter Lithium-Abscheidung. Darüber hinaus konnte die selektive Reaktion des OsO4 für eine genauere Betrachtung der Solid Electrolyte Interphase genutzt werden. Eine Stabilisierung der Proben an Luft und im Elektronenstrahl konnte erreicht werden. / This work sheds light on the electrochemical processes occurring at commercially processed graphitic anodes. It raises the question whether values published in literature for mostly ideal electrode systems can be readily taken for simulation and design of real electrodes in high-energy cells. A multiple step approach is given, evaluating different methods to determine electrode and material properties independently. The electrochemically active surface area was shown to be a crucial parameter for the calculation of electrode kinetics. Using exchange current densities corrected for the electrode surface area, the overall charging current in a cell could be calculated. The resulting part of lithium deposition in the charging process is strikingly high, not only at low temperatures.
To further investigate lithium deposition in terms of morphology and quantity, a method was developed for graphitic anodes. Osmium tetroxide (OsO4) staining serves well as a tool to strongly increase material contrast in electron microscopy. Thus lithium dendrites could be made visible in an unprecedented manner. Furthermore, the selective chemical reaction of osmium tetroxide allows for a better investigation of the multi-layer solid electrolyte interphase as was shown in transmission electron microscopy. Using the staining method, a stabilization of the sample under air and in the electron beam could be achieved.
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Metal-loaded graphitic carbon nitride for photocatalytic hydrogen production and the development of an innovative photo-thermal reactorCaux, Marine January 2018 (has links)
The path towards mitigation of anthropogenic greenhouse gas emissions lies in the transition from conventional to sustainable energy resources. The Hydrogen Economy, a cyclic economy based on hydrogen as a fuel, is suggested as a tool in the necessary energy transition. Photocatalysis makes use of sunlight to promote thermodynamically non-favoured reactions such as water splitting, allowing for sustainable hydrogen production. Harvesting thermal energy along with photonic energy is an interesting concept to decrease the activation energy of water splitting (i.e. ΔG = + 237.2 kJ∙mol−1). This work aims to confront this hypothesis in a gas phase photo-thermal reactor designed specifically for this study. The photocatalyst chosen is graphitic carbon nitride (g-C3N4), an organic semiconductor possessing a narrow band gap (i.e. 2.7 eV) as well as a band structure which theoretically permits water splitting. The photocatalytic performance of Pt/g-C3N4 for hydrogen evolution was tuned by altering its synthetic temperature. Electron paramagnetic resonance was used to gain insight on the evolution of the photocatalyst activity with synthesis temperature. Then, gold nanoparticles were deposited on g-C3N4 surface. Localized surface plasmon resonance properties of gold nanoparticles are reported in the literature to be influenced by temperature. Therefore Au/g-C3N4 appeared as a promising candidate for photo-thermal water splitting. X-ray spectroscopy unveiled interesting observations on the gold oxidation state. Moreover, under specific reduction conditions, gold nanoparticles with a wide variety of shapes characterized by sharp edges were formed. Finally, the development of the photo-thermal reactor is presented. The design process and the implementation of this innovative reactor are discussed. The reactor was successfully utilized to probe photoreactions. Then, the highly energy-demanding photocatalytic water splitting was proven not to be activated by temperature in the photo-thermal apparatus.
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Highly selective mesoporous sorbents for mercury removal from industrial wastewaterGodongwana, Ziboneni Governor January 2011 (has links)
Philosophiae Doctor - PhD / The results of this study show that novel mesoporous carbons were obtained as inverse replica of SBA-15, HMS and MCM-41 silica templates, with a large pore diameter (2-4 nm), a BET surface area of 1867, 874 and 910 m2g–1 respectively for CA_SBA-15_LPG_105, CA_HMS_LPG_80 and CA_MCM- 41_LPG_80 with bimodal pore size distribution (PSD) in the mesopores range. The results obtained show that mesoporous carbon with graphitic structures can be synthesized via the LPG route. / South Africa
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Development of a sensitive electrochemical sensor based on carbon dots and graphitic carbon nitride for the detection of 2-chlorophenol and arsenic (III) in waterMoundzounga, Theo Herman Gael 02 1900 (has links)
M. Tech. (Department of Chemistry, Faculty of Applied and Computer Sciences), Vaal University of Technology. / The presence of organic and inorganic pollutants in aqueous environments is one of the major challenges confronting man. It is therefore important to develop sensitive, versatile and cheap techniques for their detection. Arsenic (III), 2-chlorophenol (2-CP) and sulfamethoxazole (SMX) are priority pollutants that pose health threats to humans and animals. This study was thus aimed at exploring two promising carbon nanomaterials as electrode modifiers for the electrochemical sensing of arsenic (III), 2-CP and SMX in water. Glassy carbon electrode (GCE) was modified with a nanocomposite of carbon dots (CDs) and graphitic carbon nitride (g-C3N4) and used as a sensor for the analytes in aqueous media. The CDs was prepared by a facile one-pot hydrothermal method using pine cone as the carbon source; g-C3N4 and g-C3N4/CDs nanocomposite were prepared via the microwave irradiation heating method. CDs, g-C3N4 and g-C3N4/CDs were dropped-dried on the surface of bare GCE. Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were used to characterize the prepared materials. GCE, g-C3N4/GCE, CDs/GCE and g-C3N4/CDs/GCE electrodes were electrochemically investigated by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) using a ferrocyanide [Fe (CN) 6]3-/4- redox probe. The current and the reversibility of the redox probes were enhanced in the presence of modifiers. The electrochemical behavior of arsenic (III), 2-CP and SMX on different electrodes (GCE, CDs/GCE, g-C3N4/GCE and g-C3N4/CDs/GCE) were investigated by differential pulse voltammetry (DPV) under optimized conditions in a phosphate buffer solution (pH 7.6, 6 and 5 for 2-CP, As (III) and SMX respectively). The results demonstrated that the g-C3N4/CDs/GCE electrode significantly enhanced the oxidation peak current of all three analytes. The detection sensitivity of the analytes was greatly improved, suggesting that this new modified electrode has great potential in the determination of trace level of arsenic (III), 2-CP and SMX in water. The oxidation peak currents displayed a linear relationship to concentrations for 2-CP (0.5 - 2.5 μM, R2=0.958, n=5), arsenic (III) (2 - 10 μM R2=0.978, n=5) and SMX (0.3 - 1.3 μM R2=0.9906, n=5). The detection limits of 0.62 μM, 1.64 μM and 0.10 μM were obtained for 2-CP, arsenic and SMX, respectively. Phenol and 4-chloro-3-methyl-phenol were found to interfere with the detection of 2-CP, while, Cu2+, Zn2+, Pb2+ and Cd2+ were the only significant ions that interfered with the electrochemical detection of arsenic (III). EDTA was used as a ligand to mask the interference effects of copper, cadmium, lead and zinc on arsenic sensing. The modified electrode (g-C3N4/CDs/GCE) was used to determine arsenic, 2-CP and SMX in spiked tap and effluent water samples by the standard addition method and the results showed percentage recoveries varying from 93-118% for 2-CP, 98-100% for arsenic and 80-105% for SMX. The outcomes of this study established that the nanocomposite material represents an easy and sensitive sensing platform for the monitoring of arsenic (III), 2-CP and SMX in aqueous media.
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Структурные и оптические свойства графитоподобного нитрида углерода : магистерская диссертация / Structural and optical properties of graphitic carbon nitrideИльяшенко, И. Н., Ilyashenko, I. N. January 2023 (has links)
В работе проведено исследование структурных, оптических и электронных свойств графитоподобного нитрида углерода (g-C3N4), синтезированных методом пиролиза мочевины при температурах 450–600°С. Метод функционала плотности использован для подтверждения выводов, основанных на экспериментальных данных. Был выполнен анализ литературных данных по g-C3N4, были рассмотрены структурные особенности получаемого материала и их оптическое поглощение. Также приведено описание используемых экспериментальных методов и математическое описание используемого метода моделирования – теории функционала плотности. Структура синтезированных образцов g-C3N4 определена по спектрам рентгеновской дифракции и ИК поглощения. Оптическое поглощение образцов исследованы по спектрам диффузного отражения, преобразованным в соответствии с теорией Кубелки-Мунка, оценка ширины энергетической щели для прямых и непрямых оптических переходов проводилась по методу Тауца. Была установлена линейная зависимость параметров кристаллической решетки и ширины щели от температуры синтеза. Для подтверждения экспериментальных результатов было проведено моделирование возможных структур g-C3N4 методом функционала плотности в пакете Quantum ESPRESSO. Была проведена оптимизация положений атомов для различных модельных структур, рассчитаны ИК спектры и зонные структуры электронных состояний. / In this work we investigated structural, optical and electrical properties of graphitic carbon nitride (g-C3N4) synthesized by thermal treatment of urea at 450– 600°C. Density functional theory calculations were performed to support suggestions based on experimental data. Available research data for g-C3N4 was studied, with interest in structural and absorption properties of the material. Additionally, the experimental methods and theory behind DFT-calculations were described. We determined the structure of g-C3N4 samples based on XRD and IR spectra. Optical absorption was investigated using diffuse reflectance spectra transformed with Kubelka-Munk function. Energy band gap was evaluated with Tauc plot for direct and indirect optical transitions. We show that crystal lattice parameters and band gap linearly depend on the synthesis temperature. To further prove our assumptions based on experimental data we also performed DFT-calculations for g-C3N4 in Quantum ESPRESSO software package. We calculated IR spectra and electronic band structures for models of each sample.
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Exploring graphitic carbon nitrides for (opto)electronic applicationsBurmeister, David 04 December 2023 (has links)
Graphitische Karbonitride sind organische, kovalent gebundene, geschichtete und
kristalline Halbleiter mit einer hohen thermischen und chemischen Stabilität. Diese
Eigenschaften machen 2D Schichten der graphitischen Kristalle potentiell nützlich
für das Ziel, Limitationen von organischen 0D Molekularen und 1D polymerischen
Halbleitern zu überwinden. Trotz dieser interessanten Eigenschaften haben nur
wenige Publikationen erfolgreich graphitische Karbonitride in optoelektronischen
Bauteilen eingesetzt. Um die Vorteile dieser Materialien nutzbar zu machen, wurden
bessere Synthesebedingungen gesucht. Die Verwendung von einem Iod-Eutektikum
zeigt, dass Anionen mit einem größeren Radius als Bromid nicht für die Stabilisation
von graphitischen Karbonitriden geeignet sind. Das Optimieren der
Synthesebedingungen von Poly(triazin-imid)-LiBr resultiert in der Reduzierung
von einem kohlenstoffreichen Zersetzungsprodukt bei vollständiger Kondensation.
Das Untersuchen der elektronischen Struktur mit ab initio Berechnungen ergibt,
dass der elektronische VB-CB-Übergang verboten ist. Dies resultiert daraus, dass die
Zustände des obersten Valenzbandes nichtbindender Natur sind. Ein Band aus
nichtbindenden Elektronen als oberstes Valenzband ist vor allem aus „lone-pair
semiconductors“ aus der sechsten Hauptgruppe bekannt. In der Welt organischer
Halbleiter wurde dieses Phänomen bisher nicht beobachtet. Die geringe
makroskopische elektrische Leitfähigkeit der PTI-Filme wurde
mit der Leitfähigkeit auf Nanoebene verglichen, woraus gefolgert
werden kann, dass der Ladungsträgertransport durch den nanokristallinen
Charakter an den Kristall-Kristall Übergängen gestört wird. Die elektronische Leitfähigkeit, Mobilität der Ladungsträger sowie die Ladungsträgerdichte wurden untersucht. Die Energie Niveaus legen nahe das Elektronentransport in der Präsenz von Sauerstoff möglich ist. Die erste Applikation eines kovalenten organischen Netzwerks in
einer organischen lichtemittierenden Diode ist gezeigt worden. / Graphitic carbon nitrides are organic covalently-bonded, layered, and crystalline
semiconductors with high thermal and oxidative stability. These properties make
2D layers of graphitic carbon nitrides potentially useful in overcoming the
limitations of 0D molecular and 1D polymer semiconductors. Only few
reports have shown them being employed in optoelectronic applications. With the
goal to find better reaction conditions that enable higher product quality from the
ionothermal synthesis the size effect of anions is studied by using an iodide eutectic
instead of bromide or chloride eutectic. The highest crystalline condensation
product obtained is melem, revealing that the large iodide anion is not capable of
stabilizing a graphitic structure. Studying the synthesis conditions of poly(triazine
imide) (PTI), the best characterized graphitic carbon nitride in literature, it is
revealed that the brown discoloration of the product is due to a carbon rich side
product. Reduction of reaction temperature and increase of reaction time allows
omittance of carbonisation. Analyzing the electronic structure with ab initio
calculations one finds that the lowest energy electronic transition in PTI is forbidden
due to a non-bonding uppermost valence band. A uppermost non-bonding valence
band is most reminiscent of lone-pair semiconductors and unknown in the world of
organic semiconductors making PTI the first organic lone-pair semiconductor. The
low electrical conductivity of PTI derivatives is compared to
nanoscale conductivity values. The results indicate that macroscopic conductivity is
hampered by the nano-crystalline character due to charge carrier trapping at crystal
interfaces. The effective mobility is in the range of amorphous organic
semiconductors with an unexpectedly high carrier density. The energy levels in PTI-LiBr potentially
enable environmentally stable n-transport. The first successful Application of a covalent organic framework in a
organic light emitting diode is presented.
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Pétrologie, géochimie et genèse des gisements de tsavorite associés aux gneiss et roches calco-silicatées graphiteux de Lemshuku et Namalulu, Tanzanie / Petrology, geochemistry and genesis of tsavorite deposits associated with graphitic gneiss and calc-silicates rocks from Lemshuku and Namalulu, TanzaniaFeneyrol, Julien 16 February 2012 (has links)
La tsavorite, grossulaire vert à V-Cr-Mn, est contenue dans des gneiss et roches calco-silicatées graphiteux, souvent associés à des marbres dolomitiques, et appartenant à la ceinture métamorphique néoprotérozoïque mozambicaine. La tsavorite se trouve soit dans des nodules ou des veines de quartz (gisements primaires), soit dans des placers (gisements secondaires). L'étude minéralogique des tsavorites propose un nouveau protocole de certification de leur origine géographique, à partir du rapport V/Cr, de la teneur en Mn et du [delta]18 O. L'étude des gisements de Lemshuku et Namalulu en Tanzanie montre que le métamorphisme des protolithes sédimentaires riches en matière organique et évaporites s'est effectué à P = 7,0 ± 0,4 kbar et T = 677 ± 14°C, à 634 ± 22 Ma (datation U-Th-Pb sur monazite). Le bâti métamorphique s'est refroidi vers 500 Ma (datation 40Ar-39Ar sur muscovite). Deux stades de métasomatose sont reliés à la formation de la tsavorite : (i) une métasomatose de diffusion formant les nodules à P = 5,0-7,4 kbar et T = 580-691°C; (ii) une métasomatose calcique d'infiltration contemporaine de la formation des veines de quartz à P = 3,6-4,9 kbar et T = 505-587°C. Ces dernières sont datées in situ par la méthode Sm-Nd à 606 ± 36 Ma. Les évaporites continentales, déposées dans une sabkha de côte marine avec des sédiments silico-calcaires, sont transformées en tsavorite dans le cas des nodules, alors que les sels fondus sont associés à la formation des veines de quartz. Les minéralisations sont contrôlées par la lithostratigraphie et la tectonique / Tsavorite, a (V, Cr, Mn)-bearing green grossular, is hosted by graphitic gneisses or calc-silicates, often asssociated with dolomitic marbles, and belonging to the Metamorphic Neoproterozoic Mozambique Belt. Tsavorite is found either as nodules or in quartz veins (primary deposits), or in placers (secondary deposits). The mineralogical study of tsavorites suggests a new protocol to certificate their geographical origin, based on the V/Cr ratio, Mn content and delta18O. The study of the Lemshuku and Namalulu deposits in Tanzania has shown that the metamorphism of organic matter-rich and evaporites-rich sedimentary protoliths occurred at P = 7.0 ± 0.4 kbar and T = 677 ± 14°C, at 634 ± 22 Ma (U-Th-Pb dating on monazite). The metamorphic series cooled down at around 500 Ma (40Ar-39Ar dating on muscovite). Two metasomatic stages are linked to the formation of tsavorite : (i) diffusion metasomatism forming nodules at P = 5.0-7.4 kbar and T = 580-691°C; (ii) calcitic infiltration metasomatism forming quartz veins at P = 3.6-4.9 kbar and T = 505-587°C. These last have been dated in situ with Sm-Nd dating at 606 ± 36 Ma. Continental evaporites, deposited in a coastal marine sabkha with (Si, Ca)-bearing sediments, transformed into tsavorite in the case of the nodules, while the molten salts are associated with the formation of the quartz veins. The mineralisations are controlled by lithostratigraphy and structure
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Stratégie analytique des tradimédicaments : établissement de profils chromatographiques des métabolites phytochimiques apolaires / Analytical strategy of traditional herbal medicines : establishing chromatographic profiles of non-polar phytochemical metabolitesBony, Nicaise françois 26 September 2013 (has links)
Les médicaments traditionnels à base de plantes (tradimédicaments) sont très utilisés par les populations africaines. Mais leur qualité est difficile à maîtriser, car ce sont des mélanges complexes de plusieurs drogues végétales ou des préparations à base de drogues végétales d’origine souvent inconnue et/ou très variable. Le profil chromatographique des métabolites phytochimiques constitue un outil important pour l’évaluation de la qualité de ces produits.L'objectif de ce travail est de proposer un protocole de préparation des échantillons et d’établissement de profil par chromatographie liquide et chromatographie en phase gazeuse des métabolites apolaires, pour l’évaluation de la qualité des médicaments traditionnels à base de plantes.La méthodologie est basée sur le traitement chimiométrique des profils chromatographiques des métabolites apolaires issus de différents lots de feuilles de Combretum micranthum et Mitracarpus scaber.Le profilage métabolique s’est effectué par chromatographie liquide sur Carbone Graphite Poreux en milieu non-aqueux et par chromatographie en phase gazeuse à haute température, couplées à la spectrométrie de masse, après extraction au dichlorométhane et élimination de la chlorophylle adsorbée sur charbon actif.L'analyse chimiométrique des données utilisant l’analyse PLS-discriminante avec ou sans correction orthogonale du signal, appliquée aux profils chromatographiques des feuilles de Combretum micranthum et Mitracarpus scaber, a montré de faibles différences entre les lots de chaque drogue végétale, et une différenciation claire des deux drogues végétales.Les deux méthodes d'analyse par chromatographie liquide et chromatographie en phase gazeuse permettent de détecter la plupart des métabolites secondaires apolaires bioactifs ou non déjà identifiés dans les feuilles des deux espèces. / The traditional herbal medicines are widely used by African people. But their quality control is difficult, because they are complex mixtures of several herbal drugs or herbal drugs preparations. Their origin is often unknown and/or highly variable. The chromatographic profile of phytochemical metabolites is an important tool for quality assessment of these products.The objective of this work is to propose a protocol for sample preparation and liquid chromatographic and gas chromatographic profiling of non-polar metabolites for quality assessment of africain traditional herbal medicinal products.The methodology is based on the chemometric treatment of chromatographic profiles of non-polar metabolites from different batches of leaves of Combretum micranthum and Mitracarpus scaber.Metabolic profiling is carried out by non-aqueous liquid chromatography on Porous Graphitic Carbon and by high temperature gas chromatography, coupled with mass spectrometry, after extraction with dichloromethane and removal of chlorophyll adsorbed on activated charcoal.The chemometric data analysis using PLS-discriminant analysis with or without orthogonal signal correction applied to the chromatographic profiles of leaves of Combretum micranthum and Mitracarpus scaber showed small differences between batches of each herbal drug, and a clear differentiation two herbal drugs.Both analyses by liquid chromatography and gas chromatography methods detect most non-polar metabolites bioactive or/not already identified in the leaves of both species.
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Aspects of Porous Graphitic Carbon as Packing Material in Capillary Liquid ChromatographyTörnkvist, Anna January 2003 (has links)
<p>In this thesis, porous graphitic carbon (PGC) has been used as packing material in packed capillary liquid chromatography. The unique chromatographic properties of PGC has been studied in some detail and applied to different analytical challenges using both electrospray ionization-mass spectrometry (ESI-MS) and ultra violet (UV) absorbance detection. </p><p>The crucial importance of disengaging the conductive PGC chromatographic separation media from the high voltage mass spectrometric interface has been shown. In the absence of a grounded point between the column and ESI emitter, a current through the column was present, and changed retention behaviors for 3-O-methyl-DOPA and tyrosine were observed. An alteration of the chromatographic properties was also seen when PGC was chemically oxidized with permanganate, possibly due to an oxidation of the few surface groups present on the PGC material. </p><p>The dynamic adsorption of the chiral selector lasalocid onto the PGC support resulted in a useful and stable chiral stationary phase. Extraordinary enantioselectivity was observed for 1-(1-naphthyl)ethylamine, and enantioseparation was also achieved for other amines, amino acids, acids and alcohols. </p><p>Finally, a new strategy for separation of small biologically active compounds in plasma and brain tissue has been developed. With PGC as stationary phase it was possible to utilize a mobile phase of high content of organic modifier, without the addition of ion-pairing agents, and still selectively separate the analytes. </p>
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Aspects of Porous Graphitic Carbon as Packing Material in Capillary Liquid ChromatographyTörnkvist, Anna January 2003 (has links)
In this thesis, porous graphitic carbon (PGC) has been used as packing material in packed capillary liquid chromatography. The unique chromatographic properties of PGC has been studied in some detail and applied to different analytical challenges using both electrospray ionization-mass spectrometry (ESI-MS) and ultra violet (UV) absorbance detection. The crucial importance of disengaging the conductive PGC chromatographic separation media from the high voltage mass spectrometric interface has been shown. In the absence of a grounded point between the column and ESI emitter, a current through the column was present, and changed retention behaviors for 3-O-methyl-DOPA and tyrosine were observed. An alteration of the chromatographic properties was also seen when PGC was chemically oxidized with permanganate, possibly due to an oxidation of the few surface groups present on the PGC material. The dynamic adsorption of the chiral selector lasalocid onto the PGC support resulted in a useful and stable chiral stationary phase. Extraordinary enantioselectivity was observed for 1-(1-naphthyl)ethylamine, and enantioseparation was also achieved for other amines, amino acids, acids and alcohols. Finally, a new strategy for separation of small biologically active compounds in plasma and brain tissue has been developed. With PGC as stationary phase it was possible to utilize a mobile phase of high content of organic modifier, without the addition of ion-pairing agents, and still selectively separate the analytes.
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