In manufacturing systems subject to machine and operator resource constraints the effects of rework can be profound. High levels of rework burden the resources unnecessarily and as the utilization of these resources increases the expected queuing time of work in process increases exponentially. Queuing models can help managers to understand and control the effects of rework, but often this tool is overlooked in part because of concerns over accuracy in complex environments and/or the need for limiting assumptions. One aim of this work is to increase understanding of system variables on the accuracy of simple queuing models. A queuing model is proposed that combines G/G/1 modeling techniques for rework with effective processing time techniques for machine availability and the accuracy of this model is tested under varying levels of rework, external arrival variability, and machine availability. Results show that the model performs best under exponential arrival patterns and can perform well even under high rework conditions. Generalizations are made with regards to the use of this tool for allocation of jobs to specific workers and/or machines based on known rework rates with the ultimate aim of queue time minimization.

No description available.

The advent of prostate-specific antigen (PSA) testing and increased patient awareness has led to patients being diagnosed with prostate cancer at an earlier stage and a younger age than previously. Adjuvant hormonal therapy to radiotherapy or prostatectomy has been shown to reduce the risk of tumour progression, and in some studies survival benefits have been demonstrated. The non-steroidal antiandrogen bicalutamide (‘Casodex’) has undergone extensive evaluation and is currently undergoing clinical trials as immediate therapy, either alone or as adjuvant to treatment of curative intent in patients with localized or locally advanced disease. Data from the first analysis of one of the studies in the Early Prostate Cancer (EPC) programme involving 3,603 patients have shown that, after a median follow-up of 2.6 years, the risk of prostate cancer progression was significantly reduced (by 43%) in patients receiving bicalutamide 150 mg compared with those receiving standard care alone (HR 0.57; 95% CI 0.48, 0.69; p ≪ 0.0001). The risk of PSA progression was also significantly reduced (by 63%). At this stage the survival data are still immature. Side effects of bicalutamide were mostly gynaecomastia and breast pain, which is consistent with its pharmacology. Overall withdrawal rates were similar in the bicalutamide 150 mg and standard care alone groups. In the bicalutamide 150 mg group, withdrawals were mainly due to side effects, whereas in the group receiving standard care alone, withdrawals were mainly due to disease progression. The programme is ongoing, and survival data are awaited. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

Absicht: Ziel dieser retrospektiven Arbeit war es den Erfolg des Behandlungskonzeptes der Sofortversorgung von oberen Frontzahnimplantaten unter Anwendung palatinaler kortikaler Satellitenimplantate zu überprüfen. Material und Methode: An der Befragung zur Erfassung der Überlebensrate und der Patientenzufriedenheit nahmen 44 Patienten teil (29 w, 15 m, Durchschnittsalter 58 Jahre), die in der oberen Frontzahnregion mit Implantaten unter Anwendung der palatinalen kortikalen Mikrofixation versorgt wurden. Eine klinische Untersuchung zur Erfassung des Knochenabbaus, der Periotestwerte, der Sondierungstiefen sowie des Papilla Presence Indizes erfolgte bei 35 der befragten Patienten. Ergebnisse: Die Gesamtüberlebensrate der Implantate betrug 98 % (mittlerer Beobachtungszeitraum 46 Monate). Ein mittlerer Knochenverlust von 0,87 mm und ein mittlerer Periotestwert von -0,02 konnten ermittelt werden. Mittlere Sondierungstiefen betrugen 1,72 bis 2,3 mm. Bei der Befragung der Patienten konnte eine hohe Patientenzufriedenheit mit dem Behandlungsergebnis der Implantation festgestellt werden. Fazit: Die Ergebnisse dieser Arbeit zeigen, dass das Konzept der implantologischen Sofortversorgung mit palatinaler subgingivaler kortikaler Mikrofixation in der oberen Frontzahnregion positive Ergebnisse liefert.

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.

Magister Commercii (Information Management) - MCom(IM) / At public sector health facilities in Cape Town, South Africa, patients experience very high waiting times, with a medium waiting time of 3 hours which prevailed at the study facility being common. So the question arose as to why waiting times are so very high and what could be done to reduce them? While for the facility under investigation the immediate causes of the high waiting times were known, the underlying causes were quite opaque. A concern expressed therefore, was that if the underlying causes were not uncovered then efforts to reduce waiting times might not be successful, as they would just address the immediate causes. The legitimacy of the concern derives from the view that if underlying causes are not addressed, then they will continue to exert an influence on the immediate causes, and therefore perpetuate the environment which creates fertile ground for immediate causes to arise and persist, with resultant persistence of high waiting times. Hence, my interest to undertake research to explore the underlying causes of high waiting times. / 2018-12-14

The proper maintenance of the pathways governing cell growth is critical to ensure cell survival and DNA fidelity. Much of our understanding of how the cell cycle is regulated comes from studies examining the relationship between DNA viruses and the mechanisms of cell proliferation control. There are numerous examples demonstrating that viruses can alter the host cell environment to their advantage. In particular, the small DNA tumor viruses, which include adenovirus, simian-virus 40 (SV-40), and human papillomavirus (HPV), can modulate the host cell cycle to facilitate viral DNA replication. Due to the fact that these viruses infect quiescent, non-cycling cells and lack the necessary enzymes and resources to replicate their DNA (e.g. DNA polymerase), the small DNA tumor viruses must activate the host cell replication machinery in order to expedite viral DNA replication. The capacity of these viruses to perturb normal cell proliferation control is dependent upon their oncogene products, which target p53 and members of the Retinoblastoma (RB) family of proteins and inactivate their respective functions. By targeting these key cell cycle regulatory proteins, the small DNA tumor viruses induce the infected host cells to enter S-phase and activate the components involved with host cell DNA synthesis thereby generating an environment that is conducive to viral DNA replication. In contrast, the larger, nuclear-replicating DNA viruses such as those from the family Herpesviridae, do not share the same stringent requirement as the small DNA viruses to induce the infected host cell to enter S-phase. The herpesviruses encode many of the components to stimulate nucleotide biosynthesis and the necessary factors to facilitate virus DNA replication including a viral DNA polymerase and other accessory factors. Additionally, many herpesviruses encode gene products that arrest the host cell cycle, in most instances, prior to the G1/S transition point. Inducing cells to growth arrest appears to be a prerequisite for the replication of most herpesviruses. However, in addition to encoding factors that inhibit the cell cycle, many herpesviruses encode proteins that can promote cell cycle progression in a manner similar to the small DNA tumor virus oncoproteins. By targeting members of the RB family and p53 protein, the herpesvirus proteins induce S-phase and activate S-phase associated factors that playa role in DNA replication. In this manner, the herpesviruses may promote an environment that is favorable for DNA replication. Consistent with the other herpesviruses, human cytomegalovirus (HCMV)induces human fibroblasts to growth arrest. However, in other cell types, virus infection causes cells to enter S-phase. In addition, HCMV replication requires several cellular factors that are present only during S-phase. Furthermore, HCMV induces the activation of S-phase-associated events as well as the increased expression of numerous S-phase genes following infection. HCMV encodes two immediate early (IE) gene products, IE1-72 and IE2-86, which can interact with members of the RB family of proteins. Additionally, the IE2-86 protein can bind to and inhibit p53 protein function. Given the functional resemblance between the HCMV IE proteins and the oncoproteins of the small DNA tumor viruses, we hypothesized that expression of the HCMV IE proteins could modulate cell cycle control. Specifically, we determined that expression of either IE1-72 or IE2-86 can induce quiescent cells to enter S-phase and delay cell cycle exit following serum withdrawal. Moreover, IE2-86 mediates this effect in the presence or absence of p53, whereas IE1-72 fails to do so in p53-expressing cells. Furthermore, both IE1-72 and IE2-86 induce p53 protein accumulation that is nuclear localized. Because IE1-72 fails to promote S-phase entry in cells expressing p53 and induces p53 protein levels, the mechanism by which IE1-72 alters p53 levels was examined. IE1-72 elevates p53 protein levels by inducing both p19ARF protein and an ATM-dependent phosphorylation of p53 at Ser15. IE1-72 also promotes p53 nuclear accumulation by abrogating p53 nuclear shuttling. As consequence of this IE1-72-mediated increase in p53 levels, p21 protein is induced leading to a p21-dependent growth arrest in cells expressing IE1-72. These findings demonstrate that the HCMV IE proteins can alter cell proliferation control and provide further support to the notion that HCMV, through the expression of its IE proteins, induces S-phase and factors associated with S-phase while blocking cell DNA synthesis, to possibly generate an environment that is suitable for viral DNA replication.

Resumo: Um estudo clínico e radiográfico foi realizado para analisar o resultado do tratamento com implantes unitários e unidos (prótese protocolo), instalados e imediatamente carregados. O estudo inclui 10 pacientes que receberam 10 implantes e próteses provisórias unitárias e 5 pacientes que receberam 25 implantes, 5 implantes cada paciente entre os foramens mentoniano, estes foram unidos e receberam uma prótese tipo protocolo. Todas as próteses foram instaladas imediatamente após a cirurgia. Em um intervalo de 6 e 12 meses todos os pacientes foram radiografados e avaliados clinicamente. Não foram registradas perdas no grupo de implantes unitários e o grupo de implantes que recebeu prótese protocolo perdeu 2 implantes. Não houve alterações nos parâmetros periodontais (clínicos e radiográficos) entre os períodos de 6 e 12 meses, e as diferenças encontradas entre os implantes unitários e unidos, parecem estar mais relacionados ao local de inserção (maxila - mandíbula). Podemos concluir que a carga imediata é um procedimento previsível tanto para implantes unitários como em implantes unidos. / Abstract: The study includes 10 patient that received 10 implants and unitary temporary prostheses and 5 patient that received 25 implants, 5 implants each patient one in the area previous of jawbone, these were united and they received a prosthesis type protocol. All of the prostheses were installed immediately after the surgery. In an interval of 6 and 12 months all the patients were x-rayed and evaluated clinically. Losses were not registered in the group of unitary implants and the group of implants that it received prosthesis protocol lost 2 implants. There were not alterations in the periodontal parameters (clinical and radiographic) among the periods of 6 and 12 months, and the differences found among the unitary and united implants, they seem to be more related to the insert place (jawbone - jaw). We can conclude that the immediate load is a previsible procedure so much for unitary implants as in united implants. / Orientador: Elcio Marcantonio / Coorientador: Elcio Marcantonio Junior / Banca: Roberto Henrique Barbeiro / Banca: Wilson Trevisan Junior / Mestre

A presente pesquisa investiga uma modalidade de prática estética no campo das artes cênicas, desenvolvida com a participação de artistas e outros interessados. Fundada em uma perspectiva existencial da experiência estética, tal modalidade baseia-se em pressupostos elaborados a partir do estudo de aspectos da obra do autor dinamarquês Søren Kierkegaard (1813-1855) e apresenta uma dupla problemática: a singeleza do desejo de expressar a existência poética e a ambiguidade contida em um tema kierkegaardiano por excelência: a vontade de tornar-se si mesmo. A noção de estética existencial é abordada no plano dessa modalidade de prática que, situada filosoficamente no contexto da obra A Doença para a Morte (1849), no âmbito do chamado \"desespero-desafio\" e da \"existência poética orientada ao religioso\", tateia os limites da linguagem verbal, compreendida como \"espaço de possibilidade\", a fim de facultar uma interlocução sui generis entre pontos específicos da rota de leitura perscrutada e os efeitos estéticos de sua recepção. Assim, paralelamente às questões focalizadas em A Doença para a Morte, a escrita trilha a via da participante em primeira pessoa, procurando se acercar da problematização suscitada pela prática proposta, mediante um itinerário peculiar de leitura de alguns tópicos presentes na produção pseudonímica de Kierkegaard, particularizados em capítulos selecionados das obras: Ou-Ou. Um Fragmento de Vida (1843); Temor e Tremor. Lírica Dialética (1843); A Repetição. Um ensaio em Psicologia Experimental (1843); Estádios no Caminho da Vida. Estudos por pessoas diversas (1845). Por meio dessa rota de leitura buscamos circunscrever, fundamentalmente, as vias e os limites da idealidade estética pela afirmação de duas instâncias existenciais que escapam à linguagem verbal e, portanto, resistem à representação: o erótico imediato e a fé. Com esse escopo, a tese se compõe de três partes: Ato I: apresentação do princípio e dos limites da noção de estética existencial no campo problematizado por nossa prática, a partir da relação entre estética e existência; Ato II: exposição das vias da prática estética em seus pressupostos, com a identificação dos artistas e participantes na pesquisa na qualidade de coautores, e do Livro de Cultivo, método-objeto criado para abrigar as proposições estéticas associadas ao Stemning, título do primeiro capítulo da obra Temor e Tremor, eixo central da nossa prática. Em acréscimo, investigação conceitual acerca da própria noção de stemning (do dinamarquês: \"atmosfera\", \"disposição\", \"afinação\", \"tonalidade afetiva\", \"estado de espírito\", \"ambiência\"), vinculada à instância do erótico imediato; Ato III: reconhecimento do ato de assistir e de ser assistido como finalidade da recordação pelo entendimento de que recordar a obra é assisti-la; exame da idealidade estética da recordação como poder poético. Com isso, articulamos nossa própria recordação da prática realizada por meio daquilo que consideramos o princípio formal da problematização: uma recordação filmada, que consiste no \"processo de produção\" [making of] da coleta ou colheita das resultantes estéticas geradas pelo envolvimento dos participantes, na posição tanto de produtores como de espectadores. / The present research looks into a modality of aesthetic practice within the field of performing arts, and it was developed with the participation of artists and other interested parties. This modality, based on assumptions put forth from the study of aspects of the works of the Danish author Søren Kierkegaard (1813-1855), is founded in an existential perspective of the aesthetic experience and it introduces a double problematic: the simplicity of the desire to express poetic existence and the ambiguity in a kierkegaardian theme par excellence: the willingness to become oneself. The notion of existential aesthetics is approached within this modality of practice, which is philosophically situated in the context of the book The Sickness Unto Death (1849) as well as within the scope of the so-called \"defiant despair\" and the \"poet-existence inclined towards the religion\". This modality of practice probes the limits of verbal language, understood as \"space of possibility\", in order to allow for a sui generis dialog between specific spots in the examined reading itinerary and the aesthetic effects of its reception. Thus, alongside the issues focused on The Sickness Unto Death, the text follows the path of the participant in first person and seeks to encompass the problematization raised by the proposed practice, which is assisted by a peculiar reading itinerary of some topics included within the pseudonymous production of Kierkegaard, particularized in selected chapters of the works: Either/Or. A Fragment of Life (1843); Fear and Trembling. Dialectical Lyric (1843); Repetition. A Venture in Experimenting Psychology (1843); Stages on Life\"s way. Studies by Various Persons (1845). Through this reading itinerary, we fundamentally seek to circumscribe the avenues and limits of the aesthetic ideality by showcasing two existential instances that evade verbal language and, therefore, resist representation: the immediate eroticism and the faith. Within this scope, this thesis consists of three parts: Act I: presentation of the principle and limits of the notion of existential aesthetics within the field problematized by our practice, based on the relationship between aesthetics and existence; Act II: exposition of the avenues of the aesthetic practice within its assumptions, with the identification of the artists and participants in the research as coauthors, and of the Book of Cultivation, a method-object that was conceived to contain the aesthetic propositions associated with Stemning, title of the first section of Fear and Trembling and central axis of our practice. In addition, act II brings the conceptual investigation about the notion of stemning itself (Danish for: \"mood\", \"tuning up\", \"attunement\" \"atmosphere\") linked to the instance of the immediate eroticism; Act III: recognition of the act of watching/assisting and being watched/assisted as the goal of the recollection through the understanding that to recollect the work means to watch/assist it; examination of the aesthetic ideality of recollection as poetic power. With this, we articulate our own recollection of the practice performed by that which we consider the formal beginning of the problematization: a filmed recollection consisting in the making-of of the collection or harvest of the resulting aesthetics generated by the involvement of the participants in the position of producers as well as that of spectators.

Made available in DSpace on 2017-07-10T17:56:19Z (GMT). No. of bitstreams: 1 Lucas Patschiki_parte1.pdf: 3784874 bytes, checksum: ff646a9f25e7c4f7022c0a280c29048a (MD5) Previous issue date: 2012-03-29 / Fundação Araucária / In this dissertation we investigated the performance of the partisan group organized around the website Maskless Media (Mídia Sem Máscara, www.midiasemmascara.org) between the years 2002 and 2011. The website was founded in the year of 2002 in the context of presidential elections to elect Luiz Inácio Lula da Silva of the Workers Party (Partido dos Trabalhadores), presenting itself as an observatory of the press, under the responsibility of the main organizer Olavo de Carvalho. He proposed through the Mídia Sem Máscara group a series of right-wing intellectuals around an ideological component: the anticommunism. After this election there is a fast rise on anticommunism in Brazilian media as an element of pressure on the Labor Party to fulfill the commitments made with the bourgeoisie and imperialism. Explanation that is not sufficient to characterize the progress of an organized movement of fascist type, which we´ll analyze through the limits of ultra-liberalism as a social-historical project, unable to resolve the crisis of capital-imperialism. In this conjuncture its anticommunism served as common ideological basis for the fascist spectrum of society, organizing a movement aiming the intensification of class struggle. Starting from this bases, the group Mídia sem Máscara began their militating for a fascist project - not yet fully developed, given the circumstances. Fascism is here understood as a phenomenon born with imperialism, which first political and social function is to rearrange the block in the power in a brutal manner during the open crisis, for the maintenance and reproduction of class society which indicates its character of constant struggle against the working class and generally against any democratic advance. This does not mean that any crisis gives way to an alternative fascist, but is by the perspective of institutional breakdown that contemporary fascist movements are organized. It is one of the prerogatives of what we might call the third fascist wave , ideologically distinct from the previous by the acceptance of the ultra-liberal economic presuppositions and organizationally by the emphasis on the formation of networks around the party. We investigate in this dissertation: the approaches to the immediate history in academy; the production of historical knowledge and the question of historical truth; the qualitative developments of capitalism in the last century; the development of the internet as part of the expansion of forms of reproduction of capital; the installation of Internet in Brazil; fascist movements in its transformations; the public career of Olavo de Carvalho; the formation of the Mídia Sem Máscara and its affirmation; its organization; discursive peculiarity; ways of activity for propaganda, cooptation and training of their readers-militants over the internet; the social groups which are aimed; its network around the party; and their ideological assumptions, emphasizing the specificity of their anticommunism (the anticommunism against Gramsci). / Investigamos nesta dissertação a atuação partidária do grupo organizado em torno do website Mídia Sem Máscara (www.midiasemmascara.org) entre os anos de 2002 e 2011. Ele se constitui em 2002, no contexto das eleições presidenciais que elegeram Luiz Inácio Lula da Silva, do Partido dos Trabalhadores, apresentando-se como um observatório de imprensa, sob a responsabilidade de seu principal organizador Olavo de Carvalho. Este propunha através do Mídia Sem Máscara agrupar uma série de intelectuais de direita em torno de um componente ideológico: o anticomunismo. Após aquela eleição houve rápida ascensão anticomunista na mídia brasileira, elemento de pressão sobre o Partido dos Trabalhadores para que cumprisse os compromissos assumidos com a burguesia e o imperialismo. Explicação que não é suficiente para caracterizar o avanço de um movimento organizado de tipo fascista, que iremos analisar através dos limites do ultraliberalismo como projeto histórico-social, incapaz de solucionar as crises do capital-imperialismo. Nesta conjuntura o anticomunismo serviu como base ideológica comum para o espectro fascista da sociedade, um movimento organizador visando o acirramento da luta de classes. O Mídia Sem Máscara partiu destas bases militando por um projeto fascista ainda não plenamente desenvolvido, já que determinado pela conjuntura. O fascismo é compreendido aqui como um fenômeno nascido com o imperialismo, cuja função política e social primária é o de reorganizar o bloco no poder de maneira brutal durante a crise aberta, para a manutenção e reprodução da sociedade de classes o que denota seu caráter de luta aberta contra a classe trabalhadora e suas organizações, de maneira geral contra qualquer avanço conquistado pelas classes exploradas. Isto não significa que qualquer crise abre caminho para a alternativa fascista, mas é pela perspectiva de ruptura institucional que os movimentos fascistas contemporâneos organizam-se. Esta é uma das prerrogativas do que podemos chamar de terceira onda fascista, ideologicamente distinta das anteriores pela aceitação dos pressupostos econômicos ultraliberais e organizativamente pela ênfase na formação de redes extrapartidárias. Iremos abordar nesta dissertação: a relação da história imediata com a academia; a produção do conhecimento histórico e a questão da verdade histórica; os desenvolvimentos qualitativos do capitalismo no século passado; o desenvolvimento da internet como parte da ampliação das formas de reprodução do capital; a instalação da internet no Brasil; os movimentos fascistas em suas transformações; a trajetória pública de Olavo de Carvalho; a constituição e afirmação do Mídia Sem Máscara; sua organização; peculiaridade discursiva; formas de atuação para propaganda, cooptação e formação de seus leitores-militantes através da internet; os grupos sociais aos quais dirigem-se; sua rede extrapartidária; e suas premissas ideológicas, enfatizando a especificidade de seu anticomunismo (o anticomunismo contra Gramsci).