Essa dissertação possui um caráter exploratório, em que o delineamento metodológico é dado pelo estudo de caso que investiga os mecanismos sociocognitivos dos estudantes em interação com o laptop educacional. Os estudantes, com idade de 13 anos, frequentavam o sétimo ano do ensino fundamental, de uma escola pública municipal, que participa da etapa dois do projeto Um computador por aluno (UCA) do Governo Federal. Esse estudo buscou compreender os mecanismos sociocognitivos presentes nas trocas interindividuais dos estudantes nos diferentes contextos de aprendizagem em que faziam uso do laptop educacional na disciplina de história. Para a análise dos mecanismos sociocognitivos dos estudantes, nesse contexto, foi utilizado o referencial piagetiano. Com base na organização dos dados, as categorias de análise foram os contextos de aprendizagem e os mecanismos sociocognitivos. Concluímos que as possibilidades da interface física e digital nos contextos de aprendizagem, considerando a mobilidade do laptop na modalidade 1:1, podem configurar novas relações e desafios no processo de ensino e aprendizagem. Com relação aos mecanismos sociocognitivos, evidenciamos uma tendência de relações de conformismo e de coação nas trocas interindividuais e um falso equilíbrio de cooperação. / Submitted by Marcelo Teixeira (mvteixeira@ucs.br) on 2014-06-06T15:44:35Z No. of bitstreams: 1 Dissertacao Dirce Rigoni.pdf: 1213768 bytes, checksum: 80653838764b7f30f53e7182e920c963 (MD5) / Made available in DSpace on 2014-06-06T15:44:35Z (GMT). No. of bitstreams: 1 Dissertacao Dirce Rigoni.pdf: 1213768 bytes, checksum: 80653838764b7f30f53e7182e920c963 (MD5) / This paper has an exploratory character, which the research design is a study that investigates the socio-cognitive mechanisms of students interaction with educational laptop. Students in the age of 13 years old, in seventh grade of an elementary public school, that participates in second level of the Federal Government project Um computador por aluno (UCA). This study attempted to understand the present sociocognitive mechanisms in the interindividual exchanges of students in different learning contexts that made use of education laptop in the history subject. For the analysis of students' socio-cognitive mechanisms in this context, we used the Piaget theory. Based on data organization, the categories of analysis were the contexts of learning and social cognitive mechanisms. We conclude that the possibilities of physical and digital interface in Learning Contexts, considering the mobility of the laptop in mode 1:1, can set up new relationships and challenges in the teaching and learning. Regarding the socio-cognitive mechanisms, we noted a trend of conformity relations and coercion in exchanges interindividual and a false balance of cooperation.

Les cellules Natural Killer (NK) sont non, seulement de précieux effecteurs cytotoxiques de la réponse immunitaire innée dirigée contre les tumeurs et les infections, mais aussi d’importants immunorégulateurs. Leur activation dépend d’une balance complexe entre des signaux émanant de multiples récepteurs, tantôt inhibiteurs, tantôt activateurs. Parmi les récepteurs activateurs, NCR3 représente un acteur important de la lyse tumorale et de l’interaction avec les cellules dendritiques. Dans le but de caractériser la variabilité interindividuelle de la réponse NK et d’établir une référence pour des études ultérieures dans un contexte pathologique, nous avons examiné, dans un échantillon de 43 donneurs sains, les corrélations entre la variabilité fonctionnelle des cellules NK en réponse à la stimulation de leur récepteur NKp30 et le niveau d’expression des transcrits de NCR3 ainsi que celui de la protéine correspondante, au regard du polymorphisme génomique. Nous avons mis en évidence une étroite corrélation entre l’expression membranaire de NKp30 et NKp46 et la fonction cytotoxique NK, mais pas avec la sécrétion de cytokines. Nous avons retrouvé l’effet déjà connu du variant rs986475 sur l’expression de l’un des transcrits alternatifs de NCR3, T3. Nous avons également identifié un autre variant, rs11575836, influençant le niveau de transcrits T1, en relation avec la cytotoxicité induite par la signalisation NKp30. Cette étude pointe le doigt sur la spécificité des voies de signalisation des fonctions NK et le réseau complexe de gènes impliqués dans leur régulation. Nous avons par ailleurs évalué la variabilité génétique de NCR3 dans la myasthénie auto-immune où les cellules NK pourraient jouer un rôle. Le re-séquençage du gène NCR3 n’a pas révélé d’association avec un polymorphisme commun mais a permis d’identifier deux mutations rares, « faux-sens », retrouvées uniquement chez des patients myasthéniques. L’une d’elle, L19R, est non-conservative et représente un candidat particulièrement intéressant à examiner en détail du fait de sa localisation dans une région très conservée dans la phylogénie. Même si de nombreux points restent à élucider, ces résultats indiquent qu’il devrait être possible de relier de façon globale et intégrative le polymorphisme de l’ADN, ainsi que l’expression des transcrits et des protéines, à la réponse fonctionnelle des cellules NK / Natural Killer (NK) cells are not just invaluable cytotoxic effectors of innate immune response against tumors and infections but also important immunoregulators. They are activated by an intricate balance between signals provided by their inhibitory and activating receptors. Among activating receptors, NCR3 can mediate tumor lysis and dendritic cell maturation making it a crucial receptor in NK cell function. Furthermore, a recent study showed that alternative splicing of NCR3 can affect NK cell function and patient responses to treatment. In order to characterize interindividual variability of NK cell response and to set up a reference for future investigations in pathologies, we investigated 43 healthy donors and studied correlations between NK cell functional variability in response to NKp30 triggering with NKp30 transcript and membrane expression in light of genomic polymorphism. We showed a tight correlation between membrane expression of NKp30 and NKp46 with the cytotoxic NK cell response but not with cytokine secretion. In addtion, we identified a new variant influencing T1 NCR3 transcripts, rs11575836, which is associated with NKp30-induced cytotoxicity. This study pointed out the specifity of pathways underlying NK cell function and the complexity of gene networks involved in their regulation. NCR3 genetic variability was also assessed in myasthenia gravis, an autoimmune disease where NK cells seem to be implicated. NCR3 re-sequencing did not shown any association with common polymorphisms but disclosed two rare nonsense mutations that were found only in patients. One of them, L19R, a non-conservative amino acid change, is of particular interest because it is located in a highly-conserved region across phylogeny. Although numerous issues remain to be clarified, our results indicate that it should be possible to integrate information of DNA polymorphism, with that of transcript and membrane protein expression to identify functional patterns in NK cell response

Red deer males aggregate for a major part of a year to bachelor groups. Social position - Rank - is unstable in these groups. Previous experiments revealed that rank modulated by agonistic behaviour influences antler growth and antler cycle timing. Antlers are secondary sexual characteristics of the deer family and one of the fastest growing tissue in the vertebrate taxa. Their development is modulated by androgenic hormone, testosterone. In our experiment, we observed agonistic behaviour of 19 males. They were equipped with GPS collars and regularly handled for blood samples and downloading of telemetrical data. Based on statistical analysis, we found that in our bachelor group 13 stags kept similar interindividual distances which did not exceed 22 metres ("Closest associates"), whereas the rest of the group moved tens of metres away ("Wanderers"). In regard to the number of agonistic interactions and the interindividual relationship, which arose from that, we divided the bachelor group on "Friends" (˂9 interactions) and "Rivals" (≥9). We found that the number of interactions depended on average distance among males in groups divided by dyadic relationship ("Friends" and "Rivals"). With increasing distance, "Rivals" increased the number of interactions, while "Friends" did not show this trend....

L’étude de la complexité de l’anatomie du cerveau humain nécessite la caractérisation des paramètres multimodaux et multi-échelle obtenus par des techniques de neuroimagerie récentes. Pour ce travail de thèse nous avons tiré profit d’un logiciel automatique actuel d’analyse surfacique d’images cérébrales afin d’extraire les phénotypes structuraux du cortex cérébral humain, c’est-à-dire l’épaisseur corticale, l’aire de la surface, la profondeur sulcale, la courbure et le contenu en myéline intracorticale. L’objectif principal de ce travail a été de caractériser des variables structurales multimodales sur une large base de données de plus de 450 adultes sains âgés de 18 à 57 ans (base de données BIL&GIN) dans le but de décrire la variabilité interindividuelle de l’organisation structurale du cerveau et notamment la recherche de marqueurs de la maturation cérébrale et de la latéralisation. Nous avons tout d’abord pris l’exemple du gyrus de Heschl, support anatomique du cortex auditif primaire, qui possède une grande variabilité en lien avec l’existence de différents profils de duplication du gyrus couplée à de fortes différences interhémisphériques. Nous avons montré qu’une duplication partielle ou complète du gyrus de Heschl était associée à des modifications locorégionales d’épaisseur corticale, d’aire de la surface et de myéline localisée postérieurement à ce gyrus et dans le planum temporale, ces deux régions étant impliquées dans le traitement du langage. Dans une deuxième étude, nous avons recherché les modifications structurales du cortex associées à la maturation tardive (entre 18 et 30 ans) et à l’atrophie corticale liée au vieillissement. Nous avons montré que l’établissement d’un index de maturation basé sur l’intégration de l’épaisseur corticale et de la myéline intracorticale améliorait la discrimination entre les 2 profils de modifications de la substance grise pendant ces deux périodes de la vie. Finalement, nous avons caractérisé les asymétries corticales en utilisant un recalage surfacique des hémisphères qui s’affranchit des différences de morphologie sulcale et de position entre les deux hémisphères. Nous avons mis en évidence des régions pour lesquelles les asymétries d’épaisseur et de surface étaient concordantes (asymétrie gauche ou droite pour les deux variables anatomiques) et des régions pour lesquelles les asymétries étaient opposées (gauche pour l’une des variables et droite pour l’autre). Environ 20% des régions qui montraient une asymétrie d’épaisseur et d’aire présentaient des corrélations négatives entre ces variables. Il est frappant de constater que les deux régions ayant les asymétries les plus fortes, le planum temporale et le sillon temporal supérieur, ont des corrélations positives entre leurs asymétries d’épaisseur et d’aire. Le planum temporale possède une asymétrie gauche à la fois pour l’épaisseur et l’aire alors que le sillon temporal supérieur a une asymétrie droite pour les deux variables. Cette étude démontre qu’il existe des corrélations entre les asymétries d’épaisseur et d’aire qui sont caractéristiques de l’organisation du cortex. Ces régions sont des sites clé pour lesquels il reste maintenant à étudier la pertinence en tant que marqueurs de la latéralisation cérébrale et leurs corrélats fonctionnels. / Studying the complexity of the human brain anatomy requires the characterization of multimodal and multiscale features obtained by recent in vivo neuroimaging techniques. In the present thesis, we benefited from up to date automated surface-based brain image analysis software to extract structural phenotypes of the human cerebral cortex, namely the cortical thickness, the surface area, the sulcal depth, the curvature and the intracortical myelin content. The principal aim of this work was to characterize multimodal structural variables on a large database of 450 healthy adults aged from 18 to 57 years (the BIL&GIN database) in order to describe the inter-individual variability of brain structural organization and notably the research of candidate markers for brain maturation and lateralization. We first took the example of the Heschl’s gyrus hosting the primary auditory cortex and having high variability due to the presence of different pattern of gyrus duplication coupled with strong interhemispheric differences. We showed that the partial or complete duplication of the Heschl’s gyrus was associated to loco-regional modifications in terms of cortical thickness, surface area and myelin located posteriorly to this gyrus and in the planum temporale, this two regions being implied in language processing. In a second study, we investigated the cortical structural modifications associated to late maturation (between 18 and 30 years) and cortical atrophy linked to aging. We revealed that the computation of a maturation index based on an integration of cortical thickness and intracortical myelin improved the discrimination of two different patterns of grey matter changes during these different stages of life. Finally, we characterized cortical asymmetries using a specific hemisphere surface matching which removed differences in sulcal morphology and position between both hemispheres. We highlighted regions where thickness and surface area asymmetries were concordant (leftward or rightward asymmetry for both anatomical variables) and regions of opposite asymmetries (leftward for one and rightward for the other). About 20% of regions that showed cortical thickness and surface area asymmetries presented negative correlation between these variables. It is striking that the two regions with the strongest anatomical asymmetries; the planum temporale and the superior temporal sulcus had rather positive asymmetry correlations. The planum temporale presented a leftward asymmetry of both cortical thickness and area while the superior temporal sulcus showed a right asymmetry of the two variables. This study demonstrated that there were correlations between thickness and surface area asymmetries, characteristics of the cortex organization. These areas are key sites for which it now remains to study the anatomical relevance as markers of brain lateralization and its functional correlates.

Essa dissertação possui um caráter exploratório, em que o delineamento metodológico é dado pelo estudo de caso que investiga os mecanismos sociocognitivos dos estudantes em interação com o laptop educacional. Os estudantes, com idade de 13 anos, frequentavam o sétimo ano do ensino fundamental, de uma escola pública municipal, que participa da etapa dois do projeto Um computador por aluno (UCA) do Governo Federal. Esse estudo buscou compreender os mecanismos sociocognitivos presentes nas trocas interindividuais dos estudantes nos diferentes contextos de aprendizagem em que faziam uso do laptop educacional na disciplina de história. Para a análise dos mecanismos sociocognitivos dos estudantes, nesse contexto, foi utilizado o referencial piagetiano. Com base na organização dos dados, as categorias de análise foram os contextos de aprendizagem e os mecanismos sociocognitivos. Concluímos que as possibilidades da interface física e digital nos contextos de aprendizagem, considerando a mobilidade do laptop na modalidade 1:1, podem configurar novas relações e desafios no processo de ensino e aprendizagem. Com relação aos mecanismos sociocognitivos, evidenciamos uma tendência de relações de conformismo e de coação nas trocas interindividuais e um falso equilíbrio de cooperação. / This paper has an exploratory character, which the research design is a study that investigates the socio-cognitive mechanisms of students interaction with educational laptop. Students in the age of 13 years old, in seventh grade of an elementary public school, that participates in second level of the Federal Government project Um computador por aluno (UCA). This study attempted to understand the present sociocognitive mechanisms in the interindividual exchanges of students in different learning contexts that made use of education laptop in the history subject. For the analysis of students' socio-cognitive mechanisms in this context, we used the Piaget theory. Based on data organization, the categories of analysis were the contexts of learning and social cognitive mechanisms. We conclude that the possibilities of physical and digital interface in Learning Contexts, considering the mobility of the laptop in mode 1:1, can set up new relationships and challenges in the teaching and learning. Regarding the socio-cognitive mechanisms, we noted a trend of conformity relations and coercion in exchanges interindividual and a false balance of cooperation.

Several studies reported training-induced improvements in executive function tasks and also observed transfer to untrained tasks. However, the results are mixed and there is a large interindividual variability within and across studies. Given that training-related performance changes would require modification, growth or differentiation at the cellular and synaptic level in the brain, research on critical moderators of brain plasticity potentially explaining such changes is needed. In the present study, a pre-post-follow-up design (N = 122) and a 3-weeks training of two response inhibition tasks (Go/NoGo and Stop-Signal) was employed and genetic variation (Val66Met) in the brain-derived neurotrophic factor (BDNF) promoting differentiation and activity-dependent synaptic plasticity was examined. Because Serotonin (5-HT) signaling and the interplay of BDNF and 5-HT are known to critically mediate brain plasticity, genetic variation in the 5-HTT gene-linked polymorphic region (5-HTTLPR) was also addressed. The overall results show that the kind of training (i.e., adaptive vs. non-adaptive) did not evoke genotype-dependent differences. However, in the Go/NoGo task, better inhibition performance (lower commission errors) were observed for BDNF Val/Val genotype carriers compared to Met-allele ones supporting similar findings from other cognitive tasks. Additionally, a gene-gene interaction suggests a more impulsive response pattern (faster responses accompanied by higher commission error rates) in homozygous l-allele carriers relative to those with the s-allele of 5-HTTLPR. This, however, is true only in the presence of the Met-allele of BDNF, while the Val/Val genotype seems to compensate for such non-adaptive responding. Intriguingly, similar results were obtained for the Stop-Signal task. Here, differences emerged at post-testing, while no differences were observed at T1. In sum, although no genotype-dependent differences between the relevant training groups emerged suggesting no changes in the trained inhibition function, the observed genotype-dependent performance changes from pre- to post measurement may reflect rapid learning or memory effects linked to BDNF and 5-HTTLPR. In line with ample evidence on BDNF and BDNF-5-HT system interactions to induce (rapid) plasticity especially in hippocampal regions and in response to environmental demands, the findings may reflect genotype-dependent differences in the acquisition and consolidation of task-relevant information, thereby facilitating a more adaptive responding to task-specific requirements.

No description available.

Le bison est un taxon couramment représenté dans les gisements archéologiques du Pléistocène récent européen. Il est omniprésent dans les assemblages paléolithiques des plaines méridionales d’Europe orientale où les économies préhistoriques sont généralement considérées comme spécialisées dans l’acquisition de ce boviné. La « spécialisation économique » implique l’acquisition et la consommation quasi-exclusive d’un taxon au sein des populations animales disponibles. Le complexe de sites épigravettien ancien d’Amvrosievka, particulièrement riche en vestiges osseux de bisons, permet de vérifier si cette notion est ou non applicable aux populations épigravettiennes des steppes du nord de la mer Noire. La synthèse des travaux éthologiques modernes montre que les bisons présentent une grande diversité comportementale, principalement liée à l’environnement, aux conditions climatiques locales et à la densité des populations. La caractérisation du comportement des bisons des steppes chassés par les Préhistoriques d’Amvrosievka s’est donc imposée afin de pouvoir déterminer les modalités d’acquisition de ce taxon. Deux volets ont ainsi été documentés à travers l’analyse des vestiges osseux : l’étude intra et interindividuelle des signatures isotopiques – teneurs isotopiques en carbone, oxygène et strontium de la bioapatite de l’émail dentaire ; composition isotopique en azote et en carbone du collagène de la dentine et de l’os – et l’analyse palethnographique basée sur une étude archéozoologique. Cela nous a permis de restituer certains aspects de la paléoéthologie du bison des steppes – particulièrement son caractère non migrateur – ayant eu des répercussions directes sur les comportements cynégétiques et les économies des chasseurs d’Amvrosievka. En comparant ces résultats avec les données connues pour d’autres gisements contemporains ainsi que pour d’autres sociétés de chasseurs dans lesquelles le bison est particulièrement bien représenté dans les assemblages fauniques, nous avons discuté des modalités de chasse et des économies préhistoriques en lien avec cet animal emblématique. / Bison are one of the most abundant and widely distributed large mammals during the Late Pleistocene and are commonly found in archaeological sites. This large bovid is omnipresent in Palaeolithic faunal assemblages from the Southern Plains of Eastern Europe, where Palaeolithic economies are considered to specialise in bison hunting. Amvrosievka is a complex of Epigravettian sites, particularly rich in bison remains; thus, it provides a good context for verifying the applicability of this notion to the northern Black sea economies. A synthesis of recent ethological analyses demonstrates the behavioural diversity of bison, linked mainly to local environmental variability, climatic conditions and population density. It was therefore necessary to reconstruct the behaviour of the steppe bison hunted at Amvrosievka before attempting to identify the acquisition strategies used. There are two distinct aspects to this research: an intra- and interindividual study of isotopic signatures – carbon, oxygen and strontium isotope ratios from enamel bioapatite; nitrogen and carbon isotope ratios from bone and dentin collagen –, and a palethnological analysis, based on the zooarchaeological study of the faunal remains. Aspects of steppe bison palaeoethology are identified that had a direct impact on the choice of hunting strategy and subsistence economy of the Epigravettian occupants of Amvrosievka: in particular, the non migratory behaviour of steppe bison is shown to have affected the seasonality of acquisition as well as hunting and butchering strategies developed by the Epigravettians. Finally, through a comparison of the faunal data from Amvrosievka with published records from other sites where bison is well represented in the archaeofaunal material, we discuss Prehistoric acquisition strategies and subsistence economies related to this emblematic species. / Réalisé en cotutelle avec le Département de Préhistoire du Muséum national d’Histoire naturelle (Paris, France), École doctorale « Sciences de la nature et de l’Homme » (ED 227)

No description available.

Les pays africains de la zone CFA ont connu ces dernières années de multiples transformations économiques d'une part à travers les mesures initiées par les bailleurs de fonds bilatéraux et multilatéraux et d'autre part à travers les politiques d'intégration économique et monétaire. Ainsi, en partant de l'hypothèse selon laquelle du fait de ces nombreuses interventions, ces systèmes économiques incorporent divers phénomènes tels que les changements structurels et les dépendances inter-économies, nous avons étudié leurs principales implications sur la croissance, la convergence et la prévisibilité du taux de croissance. L'accent est d'abord mis sur les traits majeurs des politiques d'intégration dans le cadre d'une union monétaire tout en soulignant les éventuelles incidences de telles politiques sur la dynamique économique des pays membres principalement en termes de modélisation économétrique de la croissance et de la convergence. Les différentes études réalisées sur la base d'outils économétriques adaptés ont permis d'aboutir à des résultats nouveaux relatifs au processus de croissance et de convergence de ces économies comparativement à ceux basés sur les outils classiques de modélisation économétrique. Il ressort également de cette étude que la présence de facteurs communs et de ruptures structurelles est fortement liée aux politiques d'intégration mises en oeuvre au sein de la zone CFA. Ces résultats révèlent aussi que les chocs produisent des effets hétérogènes et ont généralement des dates d'occurrence différentes selon les pays et qu'il est nécessaire de faire varier les réponses de politique économique d'un pays à l'autre pour une croissance durable et mieux partagée. / During the recent years, african countries in the CFA zone have experienced many economic changes on the one hand through the measures initiated by bilateral and multilateral donors and on the other hand through the economic and monetary integration policies. Thus, relying on the assumption that because of these interventions, the economic systems incorporate various phenomena such as structural change and economic interdependencies, we studied their major implications on growth, convergence and growth predictability. Emphasis is first placed on the major features of integration policies in a monetary union, while stressing the possible implications of such policies on the economic dynamics of member countries mainly in terms of econometric modelling of growth and convergence. The different studies conducted on the basis of appropriate econometric tools led to new results concerning the process of growth and convergence of these economies compared to those based on standard tools of econometric modelling. It is also clear from this study that the presence of common factors and structural breaks is strongly linked to integration policies implemented in the CFA zone. These results also indicate that shocks produce heterogeneous effects on economies with various dates of occurrence and that it is necessary to vary the policy responses from one country to another for sustainable and shared growth.