Background: Myrmecia pilosula (the jack jumper ant, JJA) is the principal cause of ant venom anaphylaxis in Australia. Whereas honeybee and wasp venom allergy can be treated by venom immunotherapy (VIT), no such treatment is available for ant sting allergy. In addition, information on the natural history of JJA sting allergy is required to identify those most likely to benefit from immunotherapy. The main objectives of this research were to establish: (i) the prevalence, natural history and determinants of reaction severity for JJA allergy, and; (ii) the efficacy and tolerability of JJA VIT. Methods: A search of the Royal Hobart Hospital (RHH) forensic register, a random telephone survey, and a review of emergency department (ED) presentations were performed. Three hundred eighty-eight JJA allergic volunteers were assessed, including serum venom-specific IgE RAST, and then followed up for accidental stings over a 4-year period. Finally, a randomised double-blind, placebo-controlled, crossover trial of JJA VIT was performed. Laboratory parameters measured during the trial were; leukocyte stimulation index (SI), IL-4 production, IgE RAST, histamine release test (HRT), leukotriene release test (LRT) and basophil activation test (BAT). Intradermal venom skin testing (VST) was also performed at trial entry. Findings: The prevalence of JJA sting allergy was 2.7% in the Tasmanian population, compared to 1.4% for honeybee. People aged 35 or older had a greater risk of both sting allergy and hypotensive reactions. Four deaths were identified, all in adults with significant comorbidities. During follow-up, 79 (70%) of 113 accidental jack jumper stings caused systemic reactions. Only prior worst reaction severity predicted the severity of follow-up reactions, with the majority of people experiencing similar or less severe reactions when stung again. Sixty-eight otherwise healthy JJA allergic adult volunteers were enrolled in the clinical trial. Systemic reactions to therapy were recorded in 34% during VIT. Objectively defined systemic reactions to sting challenges arose in 1/35 after VIT (mild self-limiting urticaria only) versus 21/29 in the placebo group. Treatment with oxygen, intravenous adrenaline infusion and volume resuscitation was effective and well tolerated. Hypotension was always accompanied by a relative bradycardia, which was severe and treated with atropine in two patients. In the placebo group, only VST and HRT were predictive of sting challenge results. Although IgE RAST, leukocyte SI and IL-4 production, LRT and BAT all correlated well with VST, they did not predict sting challenge outcome. After successful VIT, venom-induced leukocyte IL-4 production tended to fall, whereas IgE RAST increased and a natural decline in HRT reactivity was reversed. Interpretation: VIT is highly effective in prevention of JJA sting anaphylaxis and is likely to be of most benefit to people with a history of severe systemic reactions, which usually occur in people aged over 35. Neurocardiogenic mechanisms &/or direct cardiac effects may be important factors in some anaphylaxis deaths. Systemic reactions to immunotherapy are common and require immediate access to resuscitation facilities. The HRT warrants further investigation as a test for selecting those most likely to benefit from VIT. None of the tests evaluated appear to be reliable markers of successful VIT.

Submitted by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-09-21T13:18:33Z No. of bitstreams: 2 Dissertação - Gilmara S. Forte.pdf: 4193962 bytes, checksum: b3e3892e84e4cce73be4a728d86abc99 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-09-21T13:18:45Z (GMT) No. of bitstreams: 2 Dissertação - Gilmara S. Forte.pdf: 4193962 bytes, checksum: b3e3892e84e4cce73be4a728d86abc99 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-09-21T13:18:45Z (GMT). No. of bitstreams: 2 Dissertação - Gilmara S. Forte.pdf: 4193962 bytes, checksum: b3e3892e84e4cce73be4a728d86abc99 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-04-07 / This scientific research if based in the case study, applied in assembly line of air conditioners type window, a company in Manaus industrial pole (PIM), with targets of reducing operational costs, based on their internal indicators of year 2016: zero base budget (OBZ), where identified a potential source to reduce operational costs in your assembly line the welding of parts, the welders were the bigger salaries because they are more qualified. The general objective of this dissertation was the understanding of how the interaction between Lean Manufacturing and Six Sigma could contribute to the company reduce your assembly costs and increase your productivity. Their methodology was an experimental case study, applied nature, quantitative and qualitative approach, with descriptive purposes and experimental procedures, general features to verify the relationship between the variables, in which the experiment was a planning type with Six Sigma tools. The results achieved, for this research, was ratified how the interaction of Lean Manufacturing and Six Sigma can help to become an assembly line more productive with stable results in terms of cost and quality. Intending this research to be the basis for applying these methods in small companies as the future research work of other researchers. / Esta pesquisa cientifica se estruturou em estudo de caso, aplicado em uma linha de produtos de eletrodomésticos de condicionadores de ar tipo janela, de uma empresa do polo industrial de Manaus (PIM), na busca por redução dos seus custos operacionais, baseados em seus indicadores internos do ano de 2016: orçamento base zero (OBZ), que identificou uma fonte potencial para redução de custos operacionais em sua linha de montagem, a parte de soldagem de peças, apontado como sendo os maiores salários dos soldadores por serem profissionais mais qualificados. O objetivo geral desta dissertação foi o entendimento de como a interação entre o Lean Manufacturing e Seis Sigma poderiam contribuir para a empresa reduzir seus custos operacionais e aumentar sua produtividade. Sua metodologia foi um estudo de caso experimental, de natureza aplicada, abordagem quantitativa e qualitativa, com fins descritivos e procedimentos experimentais, de características gerais para verificar a relação entre as variáveis, em que o tipo de instrumento foi um planejamento com ferramentas Seis Sigma. Os resultados alcançados, por esta pesquisa, foi ratificar como a interação do Lean Manufacturing e Seis Sigma podem contribuir para tornar uma linha de montagem mais produtiva com resultados estáveis em termos de custos e qualidade. Deixando esta pesquisa como base para aplicação destes métodos para empresas de menores porte à trabalhos futuros de outros pesquisadores.

Bakgrund: Patellar tendinopati (PT) är framförallt en vanlig diagnos bland aktiva inom idrotter där hopprörelser ofta förekommer. Diagnosen innebär ofta överbelastning av knäskålsenan, vilket leder till smärta och nedsatt funktionsförmåga. Fysioterapeutisk behandling syftar till att minska smärtan och återställa funktionsförmågan. Infrapatellara remmar (IPR) har använts sedan många år för symptomlindring vid idrottsaktiviteter men det saknas forskning som har sammanställt effekter av användning, vilket föranleder behovet av en systematisk litteraturöversikt. Syftet var att genom en systematisk litteraturstudie beskriva hur IPR används och utvärderas i studier vid PT, rapporterade effekter samt studiekvalitet och preliminär evidensstyrka. Metod: Artikelsökning genomfördes i databaserna PubMed och PEDro. Fem studier analyserades utifrån litteraturstudiens syfte och frågeställningar samt kvalitetsgranskades enligt SBU:s granskningsmallar. Resultat: Av studierna undersökte tre IPR:s effekt på smärtintensitet, två proprioception och två indirekt uppmätt senbelastning. Endast kortsiktiga utfall mättes och när dessa var statistiskt signifikanta var kliniska relevansen ofta oklar. Sammantagen preliminär evidensstyrka bedömdes som måttligt stark. Slutsatser: Studierna visade på varierande effekt av att använda IPR avseende förbättring av proprioception, smärtintensitet och indirekt uppmätt senbelastning. Fler högkvalitativa randomiserade studier behövs och framtida forskning bör undersöka långsiktiga effekter vid användning av IPR. / Background: Patellar tendinopathy (PT) is common in jumping athletes. It’s mostly related to excessive loading of the patellar tendon, which leads to pain and decreased functional capacity. Physiotherapy treatment aims to reduce pain and restore functional capacity. Infrapatellar straps (IPS) have been utilized for many years to alleviate symptoms during sports activities but there is a lack of research that has compiled reports on effects of usage, which leads to the need of a systematic review. Objective: To describe use and evaluation of IPS in studies on patients with PT and describe reported effects, study quality and preliminary strength of evidence. Method: The PubMed and PEDro databases were searched for articles. Five studies were analyzed considering the review’s objective. Study quality was assessed according to SBU’s checklists. Results: Among the studies three investigated the effect of IPS on pain intensity, two on proprioception and two on indirectly measured tendon load. Short-term outcomes were investigated and the clinical relevance was often unclear when outcomes were statistically significant. Total preliminary strength of evidence was assessed as moderate. Conclusion: Variable effects are shown from IPS usage regarding pain intensity, proprioception and indirectly measured tendon load. More high-quality randomized trials and investigations of long-term effects are needed.

Dissertation of Chief Fire Officer Dipl.-Ing. M. Sc. Dirk Schneider for achieving the academic degree of Dr.-Ing. of the Faculty of Forestry, Geo and Hydro Sciences of the Technical University of Dresden with the title: “Early Detection of Fires in Areas of Forests and other Vegetation” Fires threaten and destroy extensive forest and vegetation areas every year, endangering people and its settlements, leading to significant pressures on the environment and destroying considerable high value resources. The expenditures in manpower, logistics and finance for safety in general and fire suppression in particular are considerable. To minimize these varied and extensive consequences of fires, early detection is desirable, making an effective firefighting strategy possible. This early detection is particularly of importance in remote, large-scale areas and territories not under observation by the population, especially if they are subject to an increased or high vulnerability. After investigating and considering the causes, that repeatedly lead to forest fires not only in the Federal Republic of Germany but worldwide, the author describes different traditional and modern methods for early detection of fires in areas of forests and other vegetation. Furthermore the author develops a performance item catalog, basing on practical and economic experience, by which not only novel early warning systems can be developed, but the systems and methods described in the present study also are assessed and compared. The comparison of various early warning systems is guided not only by means of technical features, but also from an economic perspective. Financial calculation methods, staff costs and the peculiarities in public administration are particularly noted. The author also shows the different parameters that influence the selection of an appropriate early warning system for the detection of forest and vegetation areas. It becomes clear that it is the scene of the incident with its specific parameters that determines the most useful early warning system.

Dissertation of Chief Fire Officer Dipl.-Ing. M. Sc. Dirk Schneider for achieving the academic degree of Dr.-Ing. of the Faculty of Forestry, Geo and Hydro Sciences of the Technical University of Dresden with the title: “Early Detection of Fires in Areas of Forests and other Vegetation” Fires threaten and destroy extensive forest and vegetation areas every year, endangering people and its settlements, leading to significant pressures on the environment and destroying considerable high value resources. The expenditures in manpower, logistics and finance for safety in general and fire suppression in particular are considerable. To minimize these varied and extensive consequences of fires, early detection is desirable, making an effective firefighting strategy possible. This early detection is particularly of importance in remote, large-scale areas and territories not under observation by the population, especially if they are subject to an increased or high vulnerability. After investigating and considering the causes, that repeatedly lead to forest fires not only in the Federal Republic of Germany but worldwide, the author describes different traditional and modern methods for early detection of fires in areas of forests and other vegetation. Furthermore the author develops a performance item catalog, basing on practical and economic experience, by which not only novel early warning systems can be developed, but the systems and methods described in the present study also are assessed and compared. The comparison of various early warning systems is guided not only by means of technical features, but also from an economic perspective. Financial calculation methods, staff costs and the peculiarities in public administration are particularly noted. The author also shows the different parameters that influence the selection of an appropriate early warning system for the detection of forest and vegetation areas. It becomes clear that it is the scene of the incident with its specific parameters that determines the most useful early warning system.:Vorwort 3 Abstract 6 Inhaltsverzeichnis 7 1 Einleitung 12 2 Ziel- und Aufgabenstellung 17 3 Vorbetrachtungen und Stand des Wissens 18 3.1 Die Waldbrandsituation 18 3.2 Brandursachen in Wäldern und Vegetationsgebieten 21 3.3 Methoden der Waldbrandfrüherkennung 27 3.3.1 Herkömmliche Methoden der Waldbrandfrüherkennung 27 3.3.1.1 Notrufmeldung durch die Öffentlichkeit 27 3.3.1.2 Feuerwachtürme 29 3.3.1.3 Luftbeobachtung 35 3.3.1.3.1 Feuerwehrflugdienst Niedersachsen 39 3.3.1.3.2 Luftrettungsstaffel Bayern 44 3.3.1.3.3 Avialesookhrana 47 3.3.2 Moderne Systeme 50 3.3.2.1 Terrestrische Systeme 51 3.3.2.1.1 Firewatch 53 3.3.2.1.2 Firehawk Forestwatch 69 3.3.2.1.3 Integriertes Waldbrand-Beobachtungssystem (IPNAS) 72 3.3.2.1.4 FireALERT 76 3.3.2.1.5 Fire Wall 83 3.3.2.1.6 Radio-Akustisches-Sondierungssystem (RASS) 87 3.3.2.1.7 Mobile Biological Sensors (MBS) 93 3.3.2.1.8 Light Detection And Ranging (LIDAR) 101 3.3.2.1.9 Golden Eye 104 3.3.2.2 Aeronautische Systeme 108 3.3.2.2.1 National Infrared Operations Program (NIROPS) 108 3.3.2.2.2 Wildfire Airborne Sensor Program (WASP) 116 3.3.2.2.3 Unmanned Aerial Vehicles (UAV) 121 3.3.2.2.4 Luftschiffe 130 3.3.2.3 Orbitale Systeme 135 3.3.2.3.1 Nomos 137 3.3.2.3.2 Bispectral Infrared Detection (BIRD) 141 3.3.2.3.3 Moderate Resolution Imaging Spectroradiometer (MODIS) 146 3.3.2.3.4 Polar Operational Environmental Satellite Project (POES) 151 4 Material und Methoden 154 4.1 Material 155 4.1.1 Fachliteratur und Forschungsberichte 155 4.1.2 Fachberichte internationaler staatlicher Dienststellen 155 4.1.3 Technische Betriebsunterlagen von Herstellern 155 4.2 Methoden 156 4.2.1 Gespräche und Interviews 156 4.2.2 Praxisorientiertes Erfahrungs- und Anwenderwissen 156 4.2.3 Vergleich zur Bewertung der technischen Leistungsfähigkeit 157 4.2.4 Wirtschaftlichkeit 159 4.2.4.1 Wirtschaftlichkeit unter betriebs- und finanzwirtschaftlicher Betrachtung 160 4.2.4.1.1 Die Wirtschaftlichkeitsanalyse 161 4.2.4.1.1.1 Wirtschaftlichkeitsrechnung 161 4.2.4.1.1.1.1 Statische Verfahren 161 4.2.4.1.1.1.1.1 Kosten- und Gewinnvergleichsrechnung 162 4.2.4.1.1.1.1.2 Rentabilitätsvergleichsrechnung 162 4.2.4.1.1.1.1.3 Amortisationsvergleichsrechnung 162 4.2.4.1.1.1.2 Dynamische Verfahren 163 4.2.4.1.1.1.2.1 Kapitalwertmethode 163 4.2.4.1.1.1.2.2 Internal Rate of Return 164 4.2.4.1.1.1.2.3 Annuitätenmethode 164 4.2.4.1.1.2 Kosten-Nutzen-Analyse 165 4.2.4.1.1.3 Nutzwertanalyse 165 4.2.4.2 Wirtschaftlichkeit in der öffentlichen Verwaltung 166 4.2.4.3 Personalkosten 170 4.2.4.4 Kostenvergleich verschiedener Früherkennungssysteme 172 5 Entwicklung eines Leistungspositionskataloges 174 5.1 Funktionale Anforderungen 176 5.1.1 Melde- und Dispositionszeiten 176 5.1.1.1 Frühzeitige Branderkennung 176 5.1.1.2 Schnelle Meldewege 177 5.1.1.3 Automatisierte Ortsbestimmung 177 5.1.2 Einsatzbereitschaft 177 5.2 Nicht-Funktionale Anforderungen 178 5.2.1 Zuverlässigkeit 178 5.2.1.1 Geringe Fehlalarm- und Detektionsverlustrate 178 5.2.1.2 Wetterunabhängigkeit 179 5.2.1.3 Temperaturunabhängigkeit 179 5.2.1.4 UV-Beständigkeit 179 5.2.1.5 Elektromagnetische Verträglichkeit 179 5.2.1.6 Reduktion von Täuschungsalarmen 180 5.2.1.7 Zwei-Linien-Abhängigkeit 180 5.2.2 Leistungsvermögen 181 5.2.2.1 Automatisches Wirken 181 5.2.2.2 Einsatzinformationsprojektion 181 5.2.3 Benutzbarkeit 181 5.2.3.1 Bedienbarkeit 181 5.2.3.2 Intuitive Erfassbarkeit 182 5.2.4 Portierung und Übertragung 182 5.2.4.1 Leitstellenaufschaltung 182 5.2.4.2 Geoinformationssystem 182 5.2.4.3 Schnittstelle für Wetterinformationen 183 5.2.4.4 Kommunikationsredundanz 183 5.2.4.5 Kompatibilität 183 5.2.4.6 Ergonomie, Design und Ästhetik 183 5.3 Sicherheitsanforderungen 184 5.3.1 Umweltsicherheit 184 5.3.1.1 Gesundheitsschutz 184 5.3.1.2 Umweltverträglichkeit 184 5.3.2 Technische Betriebssicherheit 185 5.3.2.1 Systemstabilität 185 5.3.2.2 Unabhängigkeit von Dritten 185 5.3.2.3 Zwei-Wege-Energieversorgung 185 5.3.2.4 Umweltresistenz 186 5.4 Wirtschaftlichkeit 186 5.4.1 Wartung und Instandsetzung 186 5.4.2 Erweiterbarkeit 186 5.5 Der Leistungspositionskatalog 187 6 Ergebnisse 188 6.1 Die Notwendigkeit des Einsatzes von Früherkennungssystemen 189 6.2 Grundlegende Bewertung der Leistungsfähigkeit 190 6.2.1 Public Report (Notrufmeldung durch die Öffentlichkeit) 192 6.2.2 Feuerwachtürme 193 6.2.3 Luftbeobachtung 193 6.2.4 Unmanned Aerial Vehicles (UAV) 194 6.2.5 Luftschiffe 195 6.2.6 Terrestrische CCTV-Technik 196 6.2.7 Terrestrische OSS-Videotechnik 196 6.2.8 Erdgebundene Infrarotsysteme 197 6.2.9 Erdgebundene Temperatursensoren 197 6.2.10 Light Detection And Ranging (LIDAR) 198 6.2.11 Sonic Detection and Ranging (SODAR) und Radio-Akustische-Sondierungssysteme (RASS) 199 6.2.12 Mobile biologische Sensoren (MBS) 200 6.2.13 Satellitentechnologie 201 6.2.14 Zusammenfassung der grundlegenden Bewertung 201 6.3 Bewertung nach dem Leistungspositionskatalog 204 6.3.1 Erfüllung der funktionalen Anforderungen 205 6.3.2 Erfüllung der nicht-funktionalen Anforderungen 206 6.3.3 Erfüllung der Sicherheitsanforderungen 206 6.3.4 Betrachtung der Wirtschaftlichkeit 207 6.3.5 Public Report (Notrufmeldung durch die Öffentlichkeit) 207 6.3.6 Feuerwachturm 209 6.3.7 Luftbeobachtung 212 6.3.8 Unmanned Aerial Vehicles (UAV) 213 6.3.9 Luftschiffe 216 6.3.10 CCTV-Technik 218 6.3.11 OSS-Videotechnik 220 6.3.12 Erdgebundene Infrarotsysteme 222 6.3.13 Erdgebundene Temperatursysteme 224 6.3.14 Light Detection And Ranging (LIDAR) 226 6.3.15 Sonic Detection and Ranging (SODAR) und Radio-Akustische-Sondierungssysteme (RASS) 228 6.3.16 Mobile biologische Sensoren (MBS) 229 6.3.17 Satellitentechnologie 232 6.3.18 Zusammenfassung der Bewertung nach dem Leistungspositionskatalog 235 6.4 Bewertung anhand komplexer Kriterien 243 6.5 Die Vulnerabilität von Ökosystemen 244 6.6 Kostenvergleich ausgewählter Früherkennungssysteme 246 6.7 Bewertung der betriebs- und finanzwirtschaftlichen Methoden 257 6.8 Wirtschaftlichkeit und beeinflussende Nebenaspekte 258 6.9 Die Anwendung von Analysemethoden 261 7 Diskussion 263 7.1 Grundlagen und Methoden der Waldbrandfrüherkennung 263 7.2 Die Komplexität der Findung eines geeigneten Früherkennungssystems 276 7.3 Der Kostenvergleich von Früherkennungssystemen 276 7.4 Allgemeine Wirtschaftlichkeit 278 7.5 Technische Wirtschaftlichkeit 278 7.6 Finanz- und betriebswirtschaftliche Methoden 279 8 Schlussfolgerungen 280 8.1 Lehre zur Bedeutung von Wald- und Vegetationsgebieten 280 8.2 Prävention und Aufklärung 281 8.3 Schutzbedarf feuerunabhängiger Ökosysteme 282 8.4 Notwendigkeit des Einsatzes von Früherkennungssystemen 282 8.5 Der Einfluss der Empfindlichkeit eines Ökosystems 283 8.6 Technische Weiterentwicklung des Systems Feuerwachturm 284 8.7 Erfüllung funktionaler und nicht-funktionaler Anforderungen 285 8.8 Die Gewährleistung der Umweltsicherheit 286 8.9 Unzulässigkeit der Verwendung von Tieren als Früherkennungssystem 286 8.10 Die Wirtschaftlichkeit von Früherkennungssystemen 287 8.11 Die interdisziplinäre Nutzung zur Senkung von Kosten 288 8.12 Der Leistungspositionskatalog als Werkzeug 288 8.13 Orbitaler Systemverbund für den globalen Umweltschutz 289 8.14 Minimierung von Fehlalarmen durch Zwei-Linien-Abhängigkeit 290 8.15 Kombination unterschiedlicher Methoden zum Erhalt eines Idealsystems 291 8.16 Örtliche Bedingungen bestimmen das Früherkennungssystem 292 9 Zusammenfassung 293 10 Quellen- und Literaturverzeichnis (numerisch) 296 11 Quellen- und Literaturverzeichnis (alphabetisch) 338 Anhang I: Abkürzungsverzeichnis 344 Anhang II: Bilderverzeichnis 348 Anhang III: Tabellenverzeichnis 353 Anhang IV: Index 354