Målet med projektet var att skapa en applikation för Ericsson AB R&D som kan hjälpa till att analysera datatrafiken i deras nätverk (ECN). Det finns tre stycken accesspunkter till ECN som skyddas av brandväggar. Alla datauppkopplingar genom brandväggarna lagras dygnvis i loggar. Genom loggarna kan obehörig trafik upptäckas. Ett verktyg som analyserar brandväggsloggarna underlättar arbetet. Resultatet av mitt examensarbete är en applikation som är skriven i Perl. Programmeringsspråket Perl valdes för dess effektiva texthantering. Programmet exekveras genom terminalen (Solaris) / kommandoraden (Windows). De två viktigaste funktionerna är Searchlog och Check. Searchlog hanterar sökning av IP-adresser och Check kontrollerar att det inte finns några säkerhetsöverträdelser i brandväggsloggarna. Funktionerna har konstruerats så att största vikt är lagd på exekveringstiden och korrekt utdata. Slutsatsen av arbetet med brandväggsloggar är att det kräver testning för att få programmet att uppnå optimalt resultat. Perls reguljära uttryck var till stor hjälp i mitt arbete. De är bra vid behandling av stora mängder text. Minnesanvändningen kanske kan göras effektivare. Eftersom att exekveringstiden prioriterades kom det i andra hand. / The goal of this project was to construct an application that can analyze the traffic through the network (ECN) at Ericsson. There are three accesspoints to ECN protected by firewalls. The connections through the firewalls are logged daily. With the help from firewall logs unauthorized access can be found. A tool which analyzes the logs is therefore needed. The program is made in the computer language Perl. Perl was chosen because of its superior text handling capabilities. The application is executed through the terminal/command line. The two most important functions are Searchlog and Check. Searchlog handles the IP-searching and the Check function searches for unauthorized connections in the firewall logs. Execution time and data integrity were the main goals that were strived for. My conclusion is that working with firewall logs requires a lot of testing to achieve the best result. I realized that regular expressions is the easiest and most powerful tool to use when working with large amounts of text. Since the speed was prioritized and not memory usage there is room for memory improvement.

Introduction: Bacteria are the most common pathogens responsible for pulpal necrosis and periapical disease conditions. The importance of eradicating bacteria and their endotoxic by-products has been highlighted in numerous studies. Aim: The aim of this in vitro study was to establish the efficacy of six endodontic disinfection protocols in eradicating Enterococcus faecalis from single root canals of human teeth. Materials and Methods: Endodontic access cavities were prepared on 86, extracted, single rooted, human teeth. Root canal preparation was done using nickel titanium rotary files. Each tooth was sterilised, inoculated with E. faecalis and randomly allocated to one of seven groups (n = 12). The six disinfection protocols were 3% sodium hypochlorite solution (NaOCl), 2% chlorhexidine digluconate solution (CHX), Chlor-XTRA, 3% NaOCl combined with 2% CHX, 3% NaOCl followed by photo-activated disinfection (PAD) and PAD alone. The seventh group was irrigated with sterile water (control). The roots were fractured longitudinally. Dentine samples from coronal, middle and apical sections of one half of each root were plated onto brain heart infusion (BHI) plates. These were incubated anaerobically at 37⁰C for five days. The colony-forming units (cfu) were counted. The second half of each root was prepared for Scanning Electron Microscopy. The Pairwise Wilcoxon Rank Sum test and the Kruskal-Wallis test were used to compare the cfu counts of the seven groups to one another. Results: Two per cent CHX, Chlor-XTRA, combination of 3% NaOCl and 2% CHX and irrigation with 3% NaOCl followed by PAD were able to eradicate E. faecalis from the coronal levels of the root canals. A combination of 3% NaOCl and 2% CHX and irrigation with 3% NaOCl followed by PAD were able to eradicate E. faecalis from the middle levels of the root canals. None of the disinfection protocols were able to eradicate E. faecalis from the apical levels of all root canals. The regimen of 3% NaOCl followed by 2% CHX was slightly more efficient in eradicating E. faecalis from the root canals than the other disinfection regimens. Dentine erosion and precipitate formation were two incidental observations in some of the samples upon SEM examination. / Dissertation (MSc)--University of Pretoria, 2013. / Odontology / unrestricted

Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-08-04T13:34:48Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE - Waleska de Araújo Siqueira Bento - Versão final.pdf: 3392903 bytes, checksum: 633a749c72e4eb3f1d0e4f6b0f0c0b83 (MD5) / Made available in DSpace on 2017-08-04T13:34:48Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE - Waleska de Araújo Siqueira Bento - Versão final.pdf: 3392903 bytes, checksum: 633a749c72e4eb3f1d0e4f6b0f0c0b83 (MD5) Previous issue date: 2016-03-11 / O desenvolvimento de métodos de preparo de amostras é de suma importância para a análise química. Ao longo dos anos, cada vez mais os cientistas buscam técnicas para aprimorar metodologias e ferramentas matemáticas para a validação dos métodos desenvolvidos. No presente trabalho foram desenvolvidos dois diferentes métodos de preparo de amostras: um para a análise de corantes artificiais em iogurtes e posterior análise por HPLC-PAD e outro método utilizando a técnica de CE-UV/Vis para separar e fracionar amostras padrões de misturas de proteínas, seguido de um método para digestão destas e análise por LC-ESI-MS para posterior mapeamento dos peptídeos. O primeiro trabalho foi realizado para determinar a concentração de corantes artificiais em iogurtes e bebidas lácteas que são alimentos produzidos a partir da fermentação do leite sendo um alimento importante e indispensável a dieta de adultos e crianças. Para tanto foi desenvolvido um método de extração e determinação de corantes artificiais em iogurtes e bebidas lácteas por HPLC-PAD. O método foi devidamente validado e as amostras comerciais analisadas estavam de acordo com a legislação. Já o segundo trabalho visa o estudo da proteômica através do mapeamento de peptídeos. A eletroforese capilar (CE) por ser uma técnica de separação muito eficiente para a análise de proteínas e peptídeos foi utilizada na etapa inicial de preparo da amostra. A separação inicial foi seguida do fracionamento da amostra que é uma etapa muito importante e que a CE pode proporcionar, minimizando a complexidade da amostra. Posteriormente foi desenvolvido um método para a digestão das proteínas contidas em cada fração e o mapeamento dos peptídeos foi realizado com auxílio do LC-ESI-MS. Os resultados obtidos são animadores, visto que foi possível digerir as proteínas com quimotripsina em até duas horas. O que é um tempo curto se comparado a trabalhos da literatura que necessitaram de 12 a 24 horas para digestão de proteínas quando utilizadas enzimas livres em solução. / The development of sample preparation methods is of paramount importance for analytical chemistry. Over the years, more and more scientists are seeking techniques to improve methodologies and mathematical tools for the validation of the methods they have developed. In this study two different methods of sample preparation were developed: one for analysis of artificial colorants in yogurts and subsequent analysis by HPLC-PAD; and another method using the CE-UV/Vis technique to separate and fractionate standard samples of protein mixtures, followed by a digestion method for these and analysis by LCESI-MS for subsequent peptides mapping. The first study was conducted to determine the concentration of artificial colorant in yoghurts and milk drinks, foods produced from the fermentation of milk that are an important and indispensable part of the food diet for adults and children. To this end, a method was developed for the extraction and determination of artificial colorant in HPLC-PAD yoghurts and milk drinks. The method was validated and commercial samples were analyzed according to the legislation. The second work is aimed at the study of proteomics by peptide mapping. Capillary electrophoresis (CE) as an effective separation technique was used in the initial stage of sample preparation for the anaysis of proteins and peptides. The initial separation was followed by fractionation of the sample which is a very important step enabled by CE, thus minimizing sample complexity. Then, a method was developed to digest the proteins contained in each fraction and the mapping of the peptides was carried out with the aid of LC-ESI-MS. The results obtained are encouraging, since the study showed that it was possible to digest proteins with free chymotrypsin within two hours. This is a short time compared to that found in the published papers requiring 12 to 24 hours for protein digestion when free enzymes in solution are used.

Background: Over 100 million people in the United States (U.S.) have diagnosed diabetes or pre-diabetes. People with this condition are at an increased risk of Peripheral Arterial Disease (PAD). There is a high prevalence of people with risk factors of diabetes especially in the rural Central Appalachia region. People with diabetes are at a higher risk of developing atherosclerosis, which is the most common cause of PAD. Although about 20–30% of 12 million people affected with PAD in the U.S. have diabetes, little is known about diabetes in PAD patients in Central Appalachia. Therefore, this study aimed to examine the risk factors of diabetes in patients with PAD within the Central Appalachian region. Methods: The study population consisted of patients with PAD with medical comorbidities of Cardiovascular disease (CVD). All patients were admitted to a large health system in Central Appalachia between 2008 and 2018. 13,455 index cases were extracted from the Electronic Medical Records (EMR) using the ICD-9 and ICD-10 codes. With diabetes as the outcome variable under study, the risk factors included Myocardial Infarction (MI) history, hypertension, smoking status and hypercholesterolemia. Socio-demographic variables considered in the study included gender, age, ethnicity and marital status and the covariates were Body Mass Index (BMI), Low density lipoproteins (LDL), High density lipoproteins (HDL), Total Cholesterol, and Triglycerides (TG). Multivariable logistic regression was performed to examine potential risk factors of diabetes in PAD patients. Results: The results showed that BMI {OR =1.056 (CI: 1.039, 1.073)}, HDL {OR =0.980 (CI: 0.965, 0.995)}, TG {OR=1.003 (CI: 1.001, 1.005)}, MI history {OR= 1.375 (CI: 1.111, 1.703)}, hypertension {OR=2.822 (CI: 1.804, 4.415)} and smoking {OR =0.802(CI: 0.641, 1.003)} were significant for diabetes in known PAD. To control for potential confounders, Stratification was used. Among males and females with PAD, diabetes was associated with last BMI, MI, hypertension and TG. HDL seemed to be negatively associated with hypertension and female diabetics while smoking seemed to be negatively associated in males. Upon stratification with hypertension, diabetes in PAD patients was significant with BMI, TG, MI history and HDL. After stratification with MI, diabetes in PAD female patients was associated with BMI, and previous MI history. On the other hand, patients without MI had an elevated TG level and an increased risk of hypertension. Conclusion: CVD risk factors are strongly associated with PAD comorbidities, which are worsened in the presence of diabetes. We suggest that hospitals and health care systems should strongly control for the risk factors of diabetes and adopt a multi-risk-factor approach for improving health outcomes for PAD patients.

The Diploma Thesis presents a draft of designated automatic apparatus for cutting out and assembling pads for pressure control valve (DRV2). The theoretical chapter of the Thesis contains selected findings from theory and technology for material cutting. The next chapter contains design solutions for a designated apparatus for cutting and assembling pressure control valves. The pads are etched from 0,08 mm steel plates X2CrNi Mol7-12-2. The shape of the pads is etched on a 35mm-wide belt that is wound up onto a drum. The draft of this new technological facility has been elaborated in accordance with the most suitable technological variant. The cutting tool is made of steel 19 437 that is thermally processed at HRC 62-4. Estimated annual volume of production series is 2 mil. pcs. The cutting and assembly processes are executed with the aid of this designated automatic apparatus.

This master´s thesis solves the problem of stationary viscous flow of incompressible fluids in thin layers of fluid film lubrication in fixed pad thrust bearings. The parametric computational model of oil domain was created for investigation the distribution of pressure, velocity and thermal fields together with the determination of the basic parameters as axial force, heating up and friction loss. Subsequently this model was applied for investigation influence of uneven bearing clearance. The problem task was solved by final volume method in Ansys CFX 12.0 software.

The U.S. transportation sector represented about 28% of all energy consumption in 2018. Petroleum products accounted for 92% of this total energy. Light-duty vehicles are the largest energy consumers in the transportation sector. The high amount of petroleum used by light-duty vehicles creates significant economic and environmental challenges. Electric Vehicles (EVs) have a higher fuel economy and can be emission-free; they are therefore an alternative solution for minimizing the negative environmental impact of internal combustion engine vehicles. However, the adoption of EVs has been limited by their limited driving range, long recharging time, and comparatively higher price. Dynamic wireless charging technology allows for charging the EV battery in motion. Charging pads are embedded in the road and the EV battery is charged while the vehicle is passing over them. This technology not only extends the EV range but also results in a considerable reduction in battery size and capacity. Therefore, dynamic wireless charging solves one of the major issues of EVs, leading to their large-scale adoption. In the first part of this dissertation, a pad optimization methodology is presented to minimize system cost and losses. Using this method, two pads are optimized, built and tested for charging the EV. In the next section, two methods are presented to estimate how much the EV is laterally misaligned with respect to the center of the charging pads. This helps to increase system efficiency and power transfer capability. Finally, new concrete-based material is presented and studied to reduce the charging pad cost and increase their durability.

Interactive product visualisation (IPV) addresses the shortcomings of product visualisation on e-commerce sites, such as the absence of tactile information and the inability to directly examine products. Previous research has not addressed the influence of IPV on customer satisfaction. Therefore, the objective of this study was to address this gap by investigating factors that may influence customer satisfaction. The Stimulus-Organism-Response (SOR) model was used as a lens to further investigate the effect of stimuli of an IPV environment on the affective states of users as well as satisfaction as a response to stimuli. The furniture e-commerce industry and IKEA’s IPV tool were selected as the basis for this research. To gather data, an online survey with 5-point Likert scales was created based on previous research to discover the relationships between these factors. A total of 115 questionnaire responses were validated and analysed using multiple regression analysis. The results of the analysis indicated that interactivity, perceived ease of use, and entertainment had a positive influence on customer satisfaction as mediated by pleasure and dominance. Practical implications are presented to guide businesses that seek to implement IPV effectively.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24128号 / 医博第4868号 / 新制||医||1059(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 松田 秀一, 教授 杉田 昌彦, 教授 金子 新 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

AstraZeneca är en av världens främsta tillverkare av läkemedel. Agenda 2030 ställer höga krav på läkemedelsföretagen vad gäller att höja den globala folkhälsan och samtidigt bidra till en hållbar produktion. På PET Respules i Södertälje tillverkas flytande astmamedicin i plastampuller med steril BFS-teknik. Dessa plastampuller ges tilltryck genom tampontryckteknik. Tilltrycket innehåller batchunik information som utgångsdatum, produkt och dos och är en viktig process för patientsäkerhet och spårbarhet. För att säkra denna process är tryckmaskinerna utrustade med kalibrerad visionteknik som ställer krav på tryckprocessen. Tryckfärgen som används blandas med lösningsmedel för att sänka viskositeten och påverka färgens egenskaper. Viskositet har inte tidigare använts som parameter vid felsökning av färgblandningen vilket har resulterat i att bedömningen av huruvida färgblandningen varit lös (låg viskositet) eller tjock (hög viskositet) varit subjektiv. Genom experimentella försök och stickprov undersöktes sambandet mellan färgens viskositet och kassation från tryckmaskin. Detta genom att testa flera olika förhållanden mellan tryckfärg och lösningsmedel samtidigt och övervaka hur viskositeten betedde sig över tid. Testerna visade att det finns ett spann på viskositet mellan 350-622,4 mPa·s där ingen kassation kopplat till tryckfärgen förekommer. Det gick även konstatera att färgblandning med för lös viskositet genererar problem med övriga komponenter och att resultaten möjliggör standardisering av arbetssätt kopplat till hantering av tryckfärg. / AstraZeneca is one of the world's leading pharmaceutical manufacturers. Agenda 2030 places high demands on pharmaceutical companies regarding improving global public health while contributing to sustainable production. At PET Respules in Södertälje, liquid asthma medication is manufactured and packed in plastic ampoules using sterile BFS technology. These plastic ampoules are printed using pad printing technology. The print contains batch-specific information such as expiration date, product, dose, and is an important process for patient safety and traceability. To ensure this process, the printing machines are equipped with calibrated vision control system that sets requirements for the printing process. The printing ink used is mixed with a solvent to reduce viscosity and affect the properties of the color. Viscosity has not previously been used as a parameter in troubleshooting the color mixture, resulting in the assessment of whether the color mixture has been loose (low viscosity) or thick (high viscosity) being subjective. Through experimental trials and random sampling, the correlation between color viscosity and rejection from the printing machine was examined. This was done by testing several different ratios between printing ink and solvent simultaneously and monitoring how viscosity behaved over time. The tests showed that there is a range of viscosity between 350-622,4 mPa·s where no rejection related to the printing ink occurs. It was also found that a color mixture with excessively low viscosity generates problems with other components, and the results enable the standardization of work processes related to handling the printing ink.