Os mecanismos fisiológicos de detecção e controle da sede no paciente cirúrgico idoso ocorrem de forma diferenciada do que em adultos e crianças o que justifica o investimento na condução de estudos sobre estratégias que podem proporcionar alívio deste sintoma com o uso de temperatura fria e volume pequeno. O objetivo do estudo foi comparar a intensidade e o desconforto da sede de pacientes idosos que degustaram o picolé mentolado com a sede de pacientes idosos que receberam o cuidado usual, no pós-operatório imediato. Trata-se de ensaio clínico randomizado em paralelo com dois grupos, realizado em sala de recuperação pós-anestésica de hospital público de ensino no sul do Brasil. A amostra foi composta de 50 pacientes idosos em pós-operatório imediato, os quais foram alocados em dois grupos, sendo 25 no grupo controle e 25 no grupo experimental, sem perda de seguimento. Os critérios de inclusão foram: pacientes com idade >= 60 anos; estar em jejum; verbalizar sede e ter sido aprovado na avaliação do Protocolo de Segurança no Manejo da Sede. Os pacientes com restrições à ingesta ou deglutição, bem como os que autorreferiram alergia à menta, foram excluídos. Os pacientes alocados no grupo controle receberam o cuidado usual de rotina da instituição, onde o estudo foi conduzido, que consiste na manutenção do jejum. Já os pacientes alocados no grupo experimental receberam um picolé mentolado de 20 ml. Os desfechos primários de interesse foram a intensidade e o desconforto da sede, sendo que ambos foram avaliados inicialmente (T0) e novamente (T1) após 20 minutos da intervenção ou cuidado usual. A intensidade da sede foi mensurada por meio da Escala Numérica (zero significa nenhuma sede e 10 a maior sede já vivenciada pelo paciente), e o desconforto da sede pela Escala de Desconforto da Sede Perioperatória (pontuação de zero a 14 pontos, sendo zero a ausência de desconforto e 14 corresponde ao desconforto mais intenso relacionado à sede). A mediana da intensidade e do desconforto da sede inicial (T0) foi de 6,0 para os participantes alocados no grupo experimental, e 5,0 para a intensidade e 6,0 para o desconforto da sede para os participantes alocados no grupo controle. Para a comparação das mudanças nos escores da Escala Numérica e da Escala de Desconforto da Sede Perioperatória entre o grupo experimental e o grupo controle (valor final menos valor inicial), o teste de Mann-Whitney foi empregado para diferenças de medianas. Os resultados do ensaio clínico randomizado demonstraram que houve diminuição estatisticamente significante na intensidade (p<0,001) e no desconforto da sede (p<0,001) dos pacientes cirúrgicos idosos, após vinte minutos da degustação do picolé mentolado quando comparados à intensidade e desconforto da sede dos pacientes que receberam o cuidado usual, no pósoperatório imediato. Considerando a escassez de evidências sobre estratégias para manejo da sede do paciente cirúrgico idoso, o picolé mentolado é uma estratégia inovadora e segura, podendo se tornar método de escolha para uso na prática clínica / Physiological mechanisms of detection and control of thirst in the elderly surgical patient occur differently than in adults and children, which justifies the investment in conducting studies on strategies that can provide relief of this symptom with use of cold temperature and small volume. The aim of the study was to compare thirst intensity and discomfort of elderly patients who savoured mentholated popsicle with thirst of elderly patients who received the usual care in the immediate postoperative period. This is a randomized controlled clinical trial in parallel with two groups, conducted in a post anesthesia care unit of a public teaching hospital in southern Brazil. The sample consisted of 50 elderly patients in the immediate postoperative period, who were allocated in two groups, 25 in the control and 25 in the experimental group, without follow-up losses. Inclusion criteria were: patients aged >= 60 years; being fasting; verbalize thirst and having been approved in the assessment of Safety Protocol of Thirst Management. Patients with restrictions to ingestion or swallowing, as well as those who self-referred peppermint allergy, were excluded. Patients assigned to the control group received usual routine care of the institution where the study was conducted, which consists in maintenance of fasting. Patients assigned to the experimental group received a 20 ml mentholated popsicle. Primary outcomes of interest were thirst intensity and discomfort, both of which were assessed initially (T0) and again (T1) after 20 minutes of the intervention or usual care. Thirst intensity was measured using a Numerical Scale (zero means no thirst and 10 the greatest thirst ever experienced by patient), and thirst discomfort by Perioperative Thirst Discomfort Scale (score of zero to 14 points, being zero the absence of discomfort and 14 corresponds to the most intense discomfort related to thirst). Median of initial thirst intensity and discomfort (T0) was 6.0 for the participants assigned to the experimental group, 5.0 for thirst intensity and 6.0 for thirst discomfort for the participants assigned to the control group. Mann-Whitney test was used evaluating differences in medians, comparing changes in Numerical Scale and in Perioperative Thirst Discomfort Scale between the experimental group and the control group (final value minus initial value). Results of the randomized clinical trial demonstrated that there was a statistically significant decrease in thirst intensity (p <0.001) and discomfort (p <0.001) of elderly surgical patients, after twenty minutes of tasting the mentholated popsicle when compared to thirst intensity and discomfort of the patients who received the usual care, in the immediate postoperative period. Considering the shortage of evidence on strategies for thirst management of elderly surgical patient, mentholated popsicle is an innovative and safe strategy, and may become a method of choice for use in clinical practice

<p>En operationssjuksköterska kan under sin yrkesverksamma tid förväntas att ansvara vid en operation där patienten konstaterats hjärndöd och det beslutats att organdonation ska genomföras. Syftet med denna studie var att beskriva operationssjuksköterskors erfarenheter vid organdonation när donatorn är hjärndöd. Studien har en kvalitativ ansats, där forskarna strävar efter en helhetsförståelse av det studerade intresseområdet. Datainsamling utfördes via ostrukturerade intervjuer med öppna frågor. Sju intervjuer genomfördes med operationssjuksköterskor som medverkat vid organdonation när donatorn var hjärndöd. Innehållsanalys genomfördes och fyra huvudkategorier framträdde: <em>Inför donation, Genomförande av donation, Efter donation </em>och<em> Etiska aspekter vid donation</em>. Resultatet visade att operationssjuksköterskorna hade liknande erfarenheter vid organdonation när donatorn var hjärndöd som vid andra operationer angående arbetsuppgifter och ansvarsområden. Teamarbete hade en central roll och vikten av värdighet i vården framträdde tydligt. Många olika tankar och känslor väcktes hos operationssjuksköterskorna i samband med en organdonation. En operationssjuksköterska kan under sin yrkesverksamma tid förväntas att ansvara vid en operation där patienten konstaterats hjärndöd och det beslutats att organdonation ska genomföras. Syftet med denna studie var att beskriva operationssjuksköterskors erfarenheter vid organdonation när donatorn är hjärndöd. Studien har en kvalitativ ansats, där forskarna strävar efter en helhetsförståelse av det studerade intresseområdet. Datainsamling utfördes via ostrukturerade intervjuer med öppna frågor. Sju intervjuer genomfördes med operationssjuksköterskor som medverkat vid organdonation när donatorn var hjärndöd. Innehållsanalys genomfördes och fyra huvudkategorier framträdde: <em>Inför donation, Genomförande av donation, Efter donation </em>och<em> Etiska aspekter vid donation</em>. Resultatet visade att operationssjuksköterskorna hade liknande erfarenheter vid organdonation när donatorn var hjärndöd som vid andra operationer angående arbetsuppgifter och ansvarsområden. Teamarbete hade en central roll och vikten av värdighet i vården framträdde tydligt. Många olika tankar och känslor väcktes hos operationssjuksköterskorna i samband med en organdonation.</p>

<p>The aims of this project were to investigate the impact of perioperative myocardial damage on morbidity and mortality after coronary artery bypass grafting (CABG), to determine whether biochemical marker levels after CABG correlate to perioperative myocardial infarct size, and to assess the long-term morbidity after CABG, in particular to determine whether women do worse.</p><p>The studies were conducted in patients who had undergone isolated, primary CABG. The correlation of postoperative cardiac marker levels to early and late survival was evaluated in 4,911 consecutive patients; this showed that elevated cardiac markers implied a highly increased risk of both early cardiac death and late death. Hospital readmission for any cause and effect of gender on the readmission rate were analysed in 7,493 patients; it was found that the risk of readmission was higher in women than in men, because of greater co-morbidity and higher age. In the same patient cohort, it was clearly demonstrated that perioperative myocardial damage increased the risk of heart failure independently, and that late mortality was greatly increased in patients readmitted for heart failure. Finally, in a prospective, clinical trial, creatine kinase MB (CK-MB) and troponin I and T levels were found to correlate to infarction mass, as quantified by magnetic resonance imaging postoperatively. The findings strongly suggested that CK-MB above five times the upper normal limit was the result of perioperative myocardial infarction.</p><p>In conclusion, perioperative myocardial damage is an important adverse event with a highly negative effect on early and late survival after CABG, and also entails an increased risk of subsequent heart failure, which markedly impairs long-term survival. Gender differences may be explained by patient characteristics and risk factors and not by female sex per se. Increases in biochemical markers after CABG correspond to the amount of perioperatively infarcted myocardium. </p>

This thesis describes the management of patients treated with mechanical circulatory support devices for short- or long-term use. Twenty-four patients suffering from postcardiotomy heart failure were treated with a minimally invasive axial flow pump. The device was effective in unloading the failing left ventricle and in maintaining an adequate systemic circulation. The principles of perioperative monitoring, and pharmacological therapy are outlined. The pump was also used as an alternative to the heart-lung machine in conjunction with coronary artery bypass surgery. Together with a short-acting β-blocker, esmolol, the heart was decompressed and heart motion was reduced, facilitating bypass surgery on the beating heart. The anesthesiological considerations using this method are described. An implantable left ventricular assist device was used as a bridge to heart transplantation in 10 patients. We were interested in assessing the possibility to establish such a treatment program at a non-transplanting center. A multidisciplinary approach was enabled thanks to the organization of our Heart Center and due the close collaboration with our transplant center at Lund University. As one of the first centers in Europe, we established a well-functioning program with good results. Nine out of 10 of the bridge patients, with treatment times varying between 53 to 873 days, survived pump treatment and were eventually transplanted. The device proved to be powerful enough to support the failing heart and enable rehabilitation of the patients. Outpatient management became simpler when using the electrical device with belt-worn batteries. The uncertain durability and the high risk of device-related complications are shortcomings that limit its potential for more permanent treatment of heart failure. A new generation of small implantable axial blood flow pumps has therefore been developed. The principles of these pumps are based on the first generation axial flow pumps evaluated in this thesis. After several years of basic research and experimental studies, the first human implants have been performed. In the thesis, the hemodynamic effects of such a novel axial flow pump have been evaluated in an acute heart failure model. This technology holds great promise, both as a bridge to heart transplantation, and as a permanent circulatory support system. / On the day of the public defence the status of the article IV was: Submitted for publication.

The aims of this project were to investigate the impact of perioperative myocardial damage on morbidity and mortality after coronary artery bypass grafting (CABG), to determine whether biochemical marker levels after CABG correlate to perioperative myocardial infarct size, and to assess the long-term morbidity after CABG, in particular to determine whether women do worse. The studies were conducted in patients who had undergone isolated, primary CABG. The correlation of postoperative cardiac marker levels to early and late survival was evaluated in 4,911 consecutive patients; this showed that elevated cardiac markers implied a highly increased risk of both early cardiac death and late death. Hospital readmission for any cause and effect of gender on the readmission rate were analysed in 7,493 patients; it was found that the risk of readmission was higher in women than in men, because of greater co-morbidity and higher age. In the same patient cohort, it was clearly demonstrated that perioperative myocardial damage increased the risk of heart failure independently, and that late mortality was greatly increased in patients readmitted for heart failure. Finally, in a prospective, clinical trial, creatine kinase MB (CK-MB) and troponin I and T levels were found to correlate to infarction mass, as quantified by magnetic resonance imaging postoperatively. The findings strongly suggested that CK-MB above five times the upper normal limit was the result of perioperative myocardial infarction. In conclusion, perioperative myocardial damage is an important adverse event with a highly negative effect on early and late survival after CABG, and also entails an increased risk of subsequent heart failure, which markedly impairs long-term survival. Gender differences may be explained by patient characteristics and risk factors and not by female sex per se. Increases in biochemical markers after CABG correspond to the amount of perioperatively infarcted myocardium.

En operationssjuksköterska kan under sin yrkesverksamma tid förväntas att ansvara vid en operation där patienten konstaterats hjärndöd och det beslutats att organdonation ska genomföras. Syftet med denna studie var att beskriva operationssjuksköterskors erfarenheter vid organdonation när donatorn är hjärndöd. Studien har en kvalitativ ansats, där forskarna strävar efter en helhetsförståelse av det studerade intresseområdet. Datainsamling utfördes via ostrukturerade intervjuer med öppna frågor. Sju intervjuer genomfördes med operationssjuksköterskor som medverkat vid organdonation när donatorn var hjärndöd. Innehållsanalys genomfördes och fyra huvudkategorier framträdde: Inför donation, Genomförande av donation, Efter donation och Etiska aspekter vid donation. Resultatet visade att operationssjuksköterskorna hade liknande erfarenheter vid organdonation när donatorn var hjärndöd som vid andra operationer angående arbetsuppgifter och ansvarsområden. Teamarbete hade en central roll och vikten av värdighet i vården framträdde tydligt. Många olika tankar och känslor väcktes hos operationssjuksköterskorna i samband med en organdonation. En operationssjuksköterska kan under sin yrkesverksamma tid förväntas att ansvara vid en operation där patienten konstaterats hjärndöd och det beslutats att organdonation ska genomföras. Syftet med denna studie var att beskriva operationssjuksköterskors erfarenheter vid organdonation när donatorn är hjärndöd. Studien har en kvalitativ ansats, där forskarna strävar efter en helhetsförståelse av det studerade intresseområdet. Datainsamling utfördes via ostrukturerade intervjuer med öppna frågor. Sju intervjuer genomfördes med operationssjuksköterskor som medverkat vid organdonation när donatorn var hjärndöd. Innehållsanalys genomfördes och fyra huvudkategorier framträdde: Inför donation, Genomförande av donation, Efter donation och Etiska aspekter vid donation. Resultatet visade att operationssjuksköterskorna hade liknande erfarenheter vid organdonation när donatorn var hjärndöd som vid andra operationer angående arbetsuppgifter och ansvarsområden. Teamarbete hade en central roll och vikten av värdighet i vården framträdde tydligt. Många olika tankar och känslor väcktes hos operationssjuksköterskorna i samband med en organdonation.

Background: Patients who waiting for a surgery can feel fear, which increases the risk of more concern and anxiety. Patients need a clear information and communication that includes openness and hope in the preoperative care. Aim: The aims of this study are to investigate patients' experiences of the perioperative care in connection with an operation and with questions about the patients experience regarding information, communication, satisfaction and anxiety. Method: A quantitative descriptive study in the form of questionnaires conducted. The study participants were all patients who had undergone elective surgery at a hospital in central Sweden during week 10-11 in 2015. It was attended 50 patients, 30 men and 20 women between 20-86 years from five different surgical divisions. Results: The patient has high confidence of nurses and doctors professional competence, however more than half of the patients reported that the experienced anxiety before surgery. The preoperative meeting with the anesthesiologist experienced positive without reducing their anxiety. Patients felt that communication with a nurse anesthetist is easier compared to an anesthesia doctor, according to descriptive data. The majority of patients that the experienced unexpected situations in the operating room, and 28% wanted more information on how the surgery would go to. Conclusion; Lack of information is extensive in the preoperative care of patients who waiting for an operation. Most patients felt unexpected situations during the hospital stay, spite that the 100% of patients had high confidence in the nurse anesthesia and anesthesia doctor’s professional competence. / Bakgrund: Patienter som väntar på en operation kan uppleva rädsla vilket ökar risken för oro och ångest. Det önskas av patienter tydlig information och kommunikation som innehåller öppenhet och hopp i den preoperativa vården. Syfte: Syften med denna studie är att undersöka patienters upplevelse av den perioperativa vården i samband med en operation med frågeställningar om patienters upplevelse angående information, kommunikation, tillfredställelse och oro/ångest. Metod: En kvantitativ deskriptiv studie i form av enkäter utfördes. Studiedeltagarna var alla patienter som hade genomgått en elektiv operation vid ett sjukhus i Mellansverige under vecka 10-11 år 2015. Det deltog 50 patienter, 30 män och 20 kvinnor mellan 20-86 år från fem olika kirurgiska verksamheter. Resultat: Patienter har högt förtroende på sjuksköterskan och läkarens yrkeskompetens. Däremot angav mer än hälften av patienterna att de upplevde oro eller ångest inför operationen. Den preoperativa mötet med anestesiologen upplevdes positivt utan att minska deras oro och ångest. Patienter upplever att kommunikation med en anestesisjuksköterska är lättare jämfört med en anestesiolog enligt beskrivande data. En Majoritet av patienterna angav att de upplevde oförutsedda situationer i operationssalen och 28 % önskade mer information om hur operationen skulle gå till. Slutsats: Brist på information är omfattande i den preoperativa vården för patienter som väntar på en operation. De flesta patienter kände oberäknade situationer under sin sjukhusvistelse trots det hade 100 % av patienter högt förtroende för anestesisjuksköterskan och anestesiologens yrkeskompetens.

No description available.

Background: In morbidly obese individuals (MO) cardiorespiratory comorbidities and body habitus challenge the perioperative management of anesthesia. To implement safe and reproducible routines for anesthesia and fluid therapy is the cornerstone in order to minimize anesthesia-related complications and to meet individual variability in rehydration needs. Methods: Paper I: Impact of rapid-weight-loss preparation prior to bariatric surgery was investigated. Prevalence of preoperative dehydration and cardiac function were assessed with transthoracic echocardiography (TTE). Paper II: The anesthetic technique for rapid sequence induction (RSI) in MO based on a combination of volatile and i.v. anesthetics was developed. Pre- and post-induction oxygenation, blood pressure levels and feasibility of the method was evaluated. Paper III: The preoperative ideal body weight based rehydration regime was evaluated by TTE. Paper IV: Need of rehydration during bariatric surgery was evaluated by comparing conventional monitoring to a more advanced approach (i.e. preoperative TTE and arterial pulse wave analysis). Results: Rapid-weight-loss preparation prior to bariatric surgery may expose MO to dehydration. TTE was shown to be a robust modality for preoperative screening of the level of venous return, assessment of filling pressures and biventricular function of the heart in MO. The combination of sevoflurane, propofol, alfentanil and suxamethonium was demonstrated to be a safe method for RSI regardless of BMI. The preoperative rehydration regime implemented by colloids 6 ml/kg IBW was an adequate treatment to obtain euvolemia. In addition, preoperative rehydration seems to increase hemodynamic stability during intravenous induction of anesthesia and even intraoperatively. Conclusion: This thesis describes a safe and comprehensive perioperative management of morbidly obese individuals scheduled for bariatric surgery. Hemodynamic and respiratory stability can be achieved by implementation of strict and proven methods of anesthesia and fluid therapy. Much focus should be placed on feasible monitoring and preoperative optimization in morbidly obese individuals for increased perioperative safety.

Objective: The primary aim of this study was to assess patients’ preferences between radiofrequency ablation (RFA) versus hepatic resection (HR) for the treatment of small hepatocellular carcinomas (HCC). Methods: Decision analysis was performed by using probability trade-off (PTO) technique to elicit patients’ preferences and the strength of their decisions. Results: The vast majority of the study population preferred RFA over HR (70% vs. 30%, p=0.001). Their initial choice changed if 5-year survival benefit after surgery was at least 14% superior to RFA and if the 3-year disease-free survival advantage was at least 13% better than ablation. Conclusions: The results of this study suggest that fully informed cirrhotic patients would prefer RFA if diagnosed with early stage HCC even if able to undergo surgery.