京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第20294号 / 人健博第42号 / 新制||人健||4(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 二木 淑子, 教授 精山 明敏, 教授 村井 俊哉 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM

In recent years, wind energy technology has become one of the top areas of interest for energy harvesting in the power electronics world. This interest has especially peaked recently due to the increasing demand for a reliable source of renewable energy. In a recent study, the American Wind Energy Association (AWEA) ranked the U.S as the leading competitor in wind energy harvesting followed by Germany and Spain. Although the United States is the leading competitor in this area, no one has been able successfully develop an efficient, low-cost AC/DC convertor for low power turbines to be used by the average American consumer. There has been very little research in low power AC/DC converters for low to medium power wind energy turbines for battery charging applications. Due to the low power coefficient of wind turbines, power converters are required to transfer the maximum available power at the highest efficiency. Power factor correction (PFC) and maximum power point tracking (MPPT) algorithms have been proposed for high power wind turbines. These turbines are out of the price range of what a common household can afford. They also occupy a large amount of space, which is not practical for use in one's home. A low cost AC/DC converter with efficient power transfer is needed in order to promote the use of cheaper low power wind turbines. Only MPPT is implemented in most of these low power wind turbine power converters. The concept of power factor correction with MPPT has not been completely adapted just yet. The research conducted involved analyzing the effect of power factor correction and maximum power point tracking algorithm in AC/DC converters for wind turbine applications. Although maximum power to the load is always desired, most converters only take electrical efficiency into consideration. However, not only the electrical efficiency must be considered, but the mechanical energy as well. If the converter is designed to look like a purely resistive load and not a switched load, a wind turbine is able to supply the maximum power with lower conduction loss at the input side due to high current spikes. Two power converters, VIENNA with buck converter and a Buck-boost converter, were designed and experimentally analyzed. A unique approach of controlling the MPPT algorithm through a conductance G for PFC is proposed and applied in the VIENNA topology. On the other hand, the Buck-boost only operates MPPT. With the same wind profile applied for both converters, an increase in power drawn from the input increased when PFC was used even when the power level was low. Both topologies present their own unique advantages. The main advantage for the VIENNA converter is that PFC allowed more power extraction from the turbine, increasing both electrical and mechanical efficiency. The buck-boost converter, on the other hand, presents a very low component count which decreases the overall cost and volume. Therefore, a small, cost-effective converter that maximizes the power transfer from a small power wind turbine to a DC load, can motivate consumers to utilize the power available from the wind.

Electrical activity is omnipresent throughout the brain, and it varies dependant on the brain region. Areal hierarchy has been suggested to be one of the main principles of the organization of the brain, but there is not a lot of evidence available related to the specialization of the brain’s regions in the temporal domain, that is, how the activity evolves over time. It has been suggested that there is a relationship between spatial location and timescale [1] and that the timescales of neuronal activity in rodents change according to the hierarchical position (derived from anatomical connectivity measurements) of the brain region [2]. Timescale is related to to the capability of a neuron to maintain the same firing rate over a time period. This firing rate can be measured as decay time constant of an auto-correlation matrix of spiking activity, referred to as the timescale of a single neuron [3]. In this thesis, timescales of spontaneous brain activity were measured in eight regions of the mouse prefrontal cortex (PFC) (data obtained in the Carlén Laboratory) and compared to the timescales of eight visual areas (Neuropixels Visual Coding dataset, Allen Institute for Brain Science) [4]. The results showed that cortical regions hold varying timescales, but that there is no clear correspondence of the timescales of spontaneous activity to the anatomical hierarchies. Instead, we show that the PFC regions have a greater variability in their respective timescales compared to visual cortical regions. The analysis was done using two different approaches, where for some regions the measured timescales significantly differs, due to the difference in the use of the magnitudes of the correlation. This work highlights how neuronal timescales measurements can be approached in cortical regions and used for the future work investigating their functional role and the mechanisms of generation of distinct neuronal timescales in the brain. / Elektrisk aktivitet är allestädes närvarande i hela hjärnan, och den varierar beroende på hjärnregionen. Arealhierarki har föreslagits vara en av huvudprinciperna för hjärnans organisation, men det finns inte mycket bevis tillgängligt relaterat till specialiseringen av hjärnans regioner i den temporala domänen, det vill säga hur aktiviteten utvecklas över tiden . Det har föreslagits att det finns ett samband mellan rumslig plats och tidsskala [1] och att tidsskalorna för neuronal aktivitet hos gnagare ändras beroende på den hierarkiska positionen (härledd från anatomiska anslutningsmätningar) i hjärnregionen [2]. Tidsskala är relaterat till förmågan hos ett neuron att bibehålla samma fyrningshastighet under en tidsperiod. Denna avfyrningshastighet kan mätas som fallstidskonstant för en autokorrelationsmatris av spikaktivitet, kallad tidsskalan för en enda neuron [3]. I denna avhandling mättes tidsskalor för spontan hjärnaktivitet i åtta regioner i musens prefrontala kortex (PFC) (data erhållen av Carlén Laboratory) och jämfört med tidsskalorna för åtta visuella områden (Neuropixels Visual Coding dataset, Allen Institute for Brain Science) [4]. Resultaten visade att kortikala regioner har olika tidsskalor, men att det inte finns någon tydlig överensstämmelse mellan tidsskalorna för spontan aktivitet med de anatomiska hierarkierna. Istället visar vi att PFC-regionerna har större variation i sina respektive tidsskalor jämfört med visuella kortikala regioner. Analysen gjordes med hjälp av två olika tillvägagångssätt, där de uppmätta tidsskalorna för vissa regioner skiljer sig avsevärt på grund av skillnaden i användning av storleken på korrelationen. Detta arbete belyser hur neuronala tidsskalemätningar kan beaktas i kortikala regioner och användas för det framtida arbetet med att undersöka deras funktionella roll och mekanismerna för generering av distinkta neuronala tidsskalor i hjärnan.

Tuberculosis (TB) is a respiratory disease caused by Mycobacterium tuberculosis (Mtb) that kills around 1.3 million people annually. Multi-drug resistant TB (MDR-TB) strains are increasingly encountered, in part resulting from shortcomings of current TB drug regimens that last between six to nine months. Patients may stop taking the antibiotics during their allotted regimen, leading to drug resistant TB strains. Novel drug screening platforms are therefore necessary to find drugs effective against MDR-TB. In order to discover compounds that target under-exploited pathways that may be essential only in vivo, the proposed screening platform will use a novel approach to drug discovery by blocking essential protein-protein interactions (PPI). In Mtb, PPI can be monitored by mycobacterial protein fragment complementation (M-PFC). This project will re-engineer the M-PFC assay to include the red fluorescent mCherry reporter for increased efficiency and sensitivity in high-throughput screening applications. To optimize the mCherry assay, we have developed fluorescent M-PFC reporter strains to monitor distinct PPI required for Mtb virulence: homodimerization of the dormancy regulator DosR. A drug screen will then identify novel compounds that inhibit this essential PPI. The screen will involve positional-scanning combinatorial synthetic libraries, which are made up of chemical compounds with varying side chains. This work will develop novel tools for TB drug discovery that could identify new treatments for the emerging world threat of MDR-TB.

In category learning, explicit processes function through the prefrontal cortex (PFC) and implicit processes function through the basal ganglia. Research suggested that these two systems compete with each other. The goal of this study was to shed light on this theory. 15 undergraduate subjects took part in an event-related experiment that required them to categorize computer-generated line-stimuli, which varied in length and/or angle depending on condition. Subjects participated in an explicit "rule-based" (RB) condition and an implicit "information-integration" (II) condition while connected to a functional near-infrared spectroscopy (fNIRS) apparatus, which measured the hemodynamic response (HR) in their PFC. Each condition contained 2 blocks. We hypothesized that the competition between explicit and implicit systems (COVIS) would be demonstrated if, by block 2, task-accuracy was approximately equal across conditions with PFC activity being comparatively higher in the II condition. This would indicate that subjects could learn the categorization task in both conditions but were only able to decipher an explicit rule in the RB condition; their PFC would struggle to do so in the II condition, resulting in perpetually high activation. In accordance with predictions, results revealed no difference in accuracy across conditions with significant difference in channel activation. There were channel trends (p < .1) which showed PFC activation decrease in the RB condition and increase in the II condition by block 2. While these results support our predictions, they are largely nonsignificant, which could be attributed to the event-related design. Future research should utilize a larger samples size for improved statistical power.

In this work, a modeling approach is delineated and described in detail; predominantly done in the time domain from low frequency, DC, to high frequencies, 100 MHz. Commercially available computer aided design tools will be used to determine the propagation path in a given structure. Next, an integrated transmission-line filter — fabricated using planar processing technologies — is modeled to accurately predict the EMI characteristics of the system. A method was derived to model the filter's performance in the time-domain while accurately depicting the highly frequency dependant transmission-line properties. A system model of a power factor correction (PFC) boost converter was completed by using active device models for diodes, MOSFETs, and the gate driver. In addition, equivalent circuits were used to characterize high frequency impedances of the passive components. A PFC boost converter was built and used to validate the model. The PFC operated at a peak output power of 1 kW, switching at 400 kHz, with a universal input ranging from 90-270 VRMS with unity power factor. The time-domain and EMI frequency spectrum waveforms are experimentally measured and agree very well with the simulated values; within 5 dB for EMI. The transmission-line filter was also manufactured for model verification, and it is tested for the first time with an operating converter: a PFC at 50 W output and 50 VDC input. The small signal characteristics match the model very well. In addition, impedance interactions between the filter, the converter, and the EMI measurement set-up are discussed, evaluated, measured, and improved to minimize undesired resonances and increase low-frequency EMI attenuation. Experimentally measured attenuation provided by the filter in the range from 100 kHz to 100 MHz was 20-50 dBμV. The simulation also shows a similar attenuation, with the exception of one key resonance not seen in the simulation. / Master of Science

With the development of information technology, the market for power management of telecom and computing equipment keeps increasing. Distributed power systems are widely adopted in the telecom and computing applications for the reason of high performance and high reliability. Recently industry brought out aggressively high efficiency requirements for a wide load range for power management in telecom and computing equipment. High efficiency over a wide load range is now a requirement. On the other hand, power density is still a big challenge for front-end AC/DC converters. For DPS systems, front-end AC/DC converters are under the pressure of continuous increasing power density requirement. Although increasing switching frequency can dramatically reduce the passive component size, its effectiveness is limited by the converter efficiency and thermal management. Technologies to further increase the power density without compromising the efficiency need to be studied. The industry today is also at the beginning of transferring their design from analog control to full digital control strategy. Although issues are still exist, reducing components count, reducing the development cycle time, increasing the reliability, enhancing the circuit noise immunity and reducing the cost, all of these benefits indicate a great potential of the digital control. This thesis is focusing on how to improve the efficiency and power density by taking the advantages of the digital control. A novel Ï /2 phase shift two Channel interleaving PFC is developed to shrink the EMI filter size while maintain a good efficiency. A sophisticated power management strategy that associates with phase shedding and adaptive phase angle control is also discussed to increase the efficient for the entire load range without compromising the EMI filter size. The method of current sampling is proposed for Ï /2 phase shift two Channel interleaving PFC and multi-channel adaptive phase angle shift PFC is proposed to accurately extract the average total current information. A noise free current sampling strategy is also proposed that adjusting the sampling edge according to duty cycle information. An isolated ZVS dual boost converter is proposed to be the DC/DC stage of the front-end converter. This PWM converter has similar performance as the LLC resonant converter. It has hold up time extension capability without compromising the normal operation efficiency. It can achieve ZVS for all the switches. The current limit and SR implementation is much easier than LLC. State plane method, which potentially can be extent to other complex topologies, is used to fully study this circuit. All the operation modes are understood through the state plane method. The best operation mode is discovered for the front end applications. Light load efficiency is improved by the proposed pulse skipping method to guarantee the ZVS operation meanwhile reduce the switching frequency. Current limit operation is also proposed to restrict a best operation mode by fully taking the advantage of digital control that precisely control the circuit under the over current condition. High efficiency high power density is achieved by new topology, innovative interleaving, and the sophisticated digital control method. / Master of Science

The number of plug-in electric vehicles (PEVs) is likely to increase in the near future and these vehicles will probably be connected to the electric grid most of the day time. PEVs are interesting options to provide a wide variety of services such as primary frequency control (PFC), because they are able to quickly control their active power using electronic power converters. However, to evaluate the impact of PEVs on PFC, one should either carry out complex and time consuming simulation involving a large number of PEVs or formulate and develop aggregate models which could efficiently reduce simulation complexity and time while maintaining accuracy. This thesis proposes aggregate models of PEVs for PFC. The final aggregate model has been developed gradually through the following steps. First of all, an aggregate model of PEVs for the PFC has been developed where various technical characteristics of PEVs such as operating modes (i.e., idle, disconnected, and charging) and PEV’s state of charge have been formulated and incorporated. Secondly, some technical characteristics of distribution networks have been added to the previous aggregate model of PEVs for the PFC. For this purpose, the power consumed in the network during PFC as well as the maximum allowed current of the lines and transformers have been taken into account. Thirdly, the frequency stability margins of power systems including PEVs have been evaluated and a strategy to design the frequency-droop controller of PEVs for PFC has been described. The controller designed guaranties similar stability margins, in the worst case scenario, to those of the system without PEVs. Finally, a method to evaluate the positive economic impact of PEVs participation in PFC has been proposed. / En el futuro cercano se espera un notable incremento en el número de vehículos eléctricos enchufables (PEVs), los cuales están conectados a la red eléctrica durante la mayor parte del día. Los PEVs constituyen una opción interesante a la hora de proporcionar una amplia variedad de servicios, tales como el control primario de frecuencia (PFC), dado que tienen la capacidad de controlar rápidamente el flujo de potencia activa a través de convertidores electrónicos de potencia. Sin embargo, para evaluar el impacto de los PEVs sobre el PFC se debe llevar a cabo una simulación computacionalmente compleja y con un largo tiempo de simulación en la que se considere un gran número de PEVs. Otra opción sería la formulación y desarrollo de modelos agregados, los cuales podrían reducer eficazmente la complejidad y tiempo de simulación manteniendo una alta precisión. Esta tesis propone modelos agregados de PEVs para PFC. El modelo agregado definitivo ha sido desarrollado de manera gradual a través de los siguientes pasos. En primer lugar, se ha desarrollado un modelo agregado de PEVs para PFC en el cual son incorporadas varias características técnicas de los PEVs, tales como los modos de operación (inactivo, desconectado y cargando), y la formulación del estado de carga de los PEVs. En segundo lugar, ciertas características técnicas de las redes de distribución han sido consideradas en el modelo agregado de PEVs para PFC previamente propuesto. Para este fin, la potencia consumida por la red durante el PFC, así como la corriente máxima permitida en las líneas y transformadores han sido consideradas. En tercer lugar, se han evaluado los márgenes de estabilidad en la frecuencia de los sistemas de potencia que incluyen PEVs y se ha descrito una estrategia para diseñar un control de frecuencia-droop de PEVs para PFC. El controlador diseñado garantiza márgenes de estabilidad similares, en el peor de los casos, a aquellos de un sistema sin PEVs. Finalmente, se ha propuesto un método para evaluar el impacto económico positivo de la participación de los PEVs en el PFC. / Inom en snar framtid förväntas antalet laddbara bilar (laddbilar) öka kraftig, vilka tidvis kommer att vara anslutna till elnätet. Då laddbilar snabbt kan styra och variera sin aktiva laddningseffekt med hjälp av kraftelektroniken i omriktaren kan dessa fordon erbjuda en rad systemtjänster, såsom primär frekvensregleringen. Att utvärdera hur laddbilarna kan påverka den primära frekvensreglering är utmanande då en stor mängd laddbilar måste beaktas vilket kräver komplexa och tidskrävande simuleringar. Ett effektivt sätt att minska komplexiteten men bibehålla noggrannheten är genom att utforma och använda aggregerade modeller. Syftet med denna avhandling är att ta fram aggregerade modeller för laddbilars påverkan på primär frekvensreglering. Modellen har gradvis utvecklats genom följande steg. I första steget har en aggregerad modell av hur laddbilar kan användas för primär frekvensreglering utvecklats där olika tekniska detaljer så som laddbilars tillstånd (d.v.s. inkopplade, urkopplade eller laddas) och laddningnivån beaktats. I andra steget har en modell av distributionsnätet integrerats i den aggregerade modellen. Här tas hänsyn till effektflöden i elnätet samt begränsningar i överföringskapacitet i transformatorer och ledningar i distributionsnätet. I ett tredje steg har frekvensstabiliteten i ett elnät med laddbilar utvärderats och en strategi för hur en frekvensregulator kan designas för att tillhandahålla primär frekvensreglering med hjälp av laddbilar har utvecklats. Designen garanterar samma stabilitetsmarginal för styrsystemet både med och utan laddbilar. Dessutom föreslås en metod för att utvärdera de ekonomiska effekterna av att använda laddbilar för primär frekvensreglering. / Het aantal elektrische voertuigen (EV’s) zal zeer waarschijnlijk toenemen in de nabije toekomst en deze voertuigen zullen vermoedelijk gedurende het grootste deel van de dag aan het elektriciteitsnetwerk aangesloten zijn. EV’s zijn interessante opties om een grote verscheidenheid van diensten te leveren, zoals bijvoorbeeld primaire frequentieregeling, omdat ze snel hun actieve vermogen kunnen aanpassen met behulp van elektronische vermogensomvormers. Echter, om de invloed van EV’s en primaire frequentieregeling te kunnen evalueren, moet men complexe en tijdrovende simulaties met een groot aantal EVs uitvoeren of verzamelmodellen formuleren en ontwikkelen die de complexiteit en duur van de simulaties kunnen reduceren zonder nauwkeurigheid te verliezen. Dit onderzoek presenteert verzamelmodellen voor EV’s en primaire frequentieregeling. Het uiteindelijke verzamelmodel is geleidelijk ontwikkeld door de volgende stappen te nemen. Ten eerste is een verzamelmodel voor EV’s en primaire frequentieregeling ontwikkeld waar verscheidene technische karakteristieken van EV’s, zoals bedieningsmodi (bijv. Inactief, losgekoppeld en ladend) en de actuele laadtoestand in zijn geformuleerd en geïntegreerd. Ten tweede zijn enkele technische karakteristieken van distributienetwerken toegevoegd aan het eerdere verzamelmodel van EV’s voor primaire frequentieregeling. Hiervoor zijn de vermogensconsumptie in het network gedurende primaire frequentieregeling en de maximaal toegestane stroomsterkte van de kabels meegerekend. Ten derde zijn de marges voor de frequentiestabiliteit van elektriciteitssystemen met EV’s geëvalueerd en is een strategie voor het ontwerpen van de frequentie-droop regeling van de EV’s voor primaire frequentieregeling beschreven. De ontworpen controller garandeert soortgelijke stabiliteitsmarges in het slechtste scenario, als voor het systeem zonder EV’s. Ten slotte is er een methode voorgesteld om de positieve economische invloed van EV-participatie in primaire frequentieregeling te evaluëren. / <p>“SETS Joint Doctorate Programme</p><p>The Erasmus Mundus Joint Doctorate in Sustainable Energy Technologies and Strategies (SETS), the SETS Joint Doctorate, is an international programme run by six institutions in cooperation:</p><p>• Comillas Pontifical University, Madrid, Spain</p><p>• Delft University of Technology, Delft, the Netherlands</p><p>• Florence School of Regulation, Florence, Italy</p><p>• Johns Hopkins University, Baltimore, USA</p><p>• KTH Royal Institute of Technology, Stockholm, Sweden</p><p>• University Paris-Sud 11, Paris, France</p><p>The Doctoral Degrees provided upon completion of the programme are issued by Comillas Pontifical University, Delft University of Technology, and KTH Royal Institute of Technology.</p><p>The Degree Certificates are giving reference to the joint programme. The doctoral candidates are jointly supervised, and must pass a joint examination procedure set up by the three institutions issuing the degrees.</p><p>This Thesis is a part of the examination for the doctoral degree.</p><p>The invested degrees are official in Spain, the Netherlands and Sweden respectively.</p><p>SETS Joint Doctorate was awarded the Erasmus Mundus excellence label by the European Commission in year 2010, and the European Commission’s Education, Audiovisual and Culture Executive Agency, EACEA, has supported the funding of this programme</p><p>The EACEA is not to be held responsible for contents of the Thesis.”  QC 20170412</p>

Ce mémoire traite de la commande aléatoire du convertisseur Buck-Boost triphasé à prélèvement sinusoïdal du courant. Cette famille de convertisseurs est peu maîtrisée, et ce malgré le grand avantage qu'elle apporte par rapport à la structure Boost. L'objectif de ce travail est de développer une commande adaptée à cette structure améliorant la fiabilité et la qualité du convertisseur tout en réduisant le coût de réalisation. L'objectif étant d'aboutir à un convertisseur plus compétitif par rapport au convertisseur Boost. Après une présentation du contexte de l'étude dans le premier chapitre, le second chapitre est consacré au dimensionnement et à la mise en oeuvre de la commande du convertisseur. Le troisième chapitre décrit la modulation à fréquence aléatoire RCFM, permettant d'atténuer la densité spectrale des courants de ligne tout en conservant l'amplitude de la composante fondamentale. Le quatrième chapitre porte sur l'amélioration de la fiabilité et la réduction du coût du convertisseur. Qui consiste en l'élaboration d'une architecture de commande s'affranchissant des capteurs de courant alternatif, et réduisant le nombre des capteurs utilisés ce qui améliore sa fiabilité. Enfin, le dernier chapitre est consacré à l'étude expérimentale et aux simulations. L'étude expérimentale de la modulation a permis de valider les résultats théoriques de l'analyse de la RCFM. De plus, les simulations (intégrant des contraintes expérimentales) ont permis de valider le dimensionnement du convertisseur, sa dynamique ainsi que la reconstruction des différents signaux

This work presents the direct torque control (DTC) techniques, implemented in four- and six-switch inverter, for brushless dc (BLDC) motors with non-sinusoidal back- EMF using two and three-phase conduction modes. First of all, the classical direct torque control of permanent magnet synchronous motor (PMSM) with sinusoidal back-EMF is discussed in detail. Secondly, the proposed two-phase conduction mode for DTC of BLDC motors is introduced in the constant torque region. In this control scheme, only two phases conduct at any instant of time using a six-switch inverter. By properly selecting the inverter voltage space vectors of the two-phase conduction mode from a simple look-up table the desired quasi-square wave current is obtained. Therefore, it is possible to achieve DTC of a BLDC motor drive with faster torque response while the stator flux linkage amplitude is deliberately kept almost constant by ignoring the flux control in the constant torque region. Third, the avarege current controlled boost power factor correction (PFC) method is applied to the previously discussed proposed DTC of BLDC motor drive in the constant torque region. The test results verify that the proposed PFC for DTC of BLDC motor drive improves the power factor from 0.77 to about 0.9997 irrespective of the load. Fourth, the DTC technique for BLDC motor using four-switch inverter in the constant torque region is studied. For effective torque control in two phase conduction mode, a novel switching pattern incorporating the voltage vector look-up table is designed and implemented for four-switch inverter to produce the desired torque characteristics. As a result, it is possible to achieve two-phase conduction DTC of a BLDC motor drive using four-switch inverter with faster torque response due to the fact that the voltage space vectors are directly controlled.. Finally, the position sensorless direct torque and indirect flux control (DTIFC) of BLDC motor with non-sinusoidal back-EMF has been extensively investigated using three-phase conduction scheme with six-switch inverter. In this work, a novel and simple approach to achieve a low-frequency torque ripple-free direct torque control with maximum efficiency based on dq reference frame similar to permanent magnet synchronous motor (PMSM) drives is presented.