What were Mary-Russell Ferrell Colton’s contributions to the progressive education movement and the Indian arts and crafts movement in the Southwestern United States at a time when the region was still very remote? Artist, author, amateur ethnographer, educator, and curator; these were but a few of the talents of Mary-Russell Ferrell Colton, co-founder of the Museum of Northern Arizona and early art advocate on the Colorado Plateau. This study investigates how Colton contributed to the progressive education movement and the Indian arts and crafts movement through the work that she did at the museum. There, she labored to increase public awareness of the importance of art education and to revive Native American arts on the Colorado Plateau. Using an extensive collection of archival material in the Colton Collection at the Museum of Northern Arizona, as well as oral history interviews, this historical study provides a nuanced analysis of Colton’s life as an educator. Colton’s influence is not well known today, but her professional contributions merit recognition, giving her a place in the history of American education. This study reveals how Colton’s efforts fit within the context of the work of her contemporaries in Santa Fe and Taos, and within the progressive education movement, from the then relatively remote outpost of Flagstaff. Much can be learned from Colton’s work that is relevant to the field of education today. Her ideals and writings about art education will resonate with opponents of No Child Left Behind. Colton’s work as one of northern Arizona’s earliest art educators contributed to a better understanding of the culture of the various peoples of the Colorado Plateau and to the preservation of Navajo and Hopi traditions through education. Colton made notable contributions to the Indian arts and crafts movement, museum education, and the progressive education movement. A woman of firm convictions and ideals, Colton was strong-willed, and complex, a multi-faceted person with a broad range of interests which she pursued with passion and commitment. This study crosses the boundaries of several disciplines, including educational history, museum studies, women’s studies, educational biography, Native American studies, and art education.

By considering San Francisco’s legal, social, and cultural history during the late 19th and early 20th centuries in relation to American law, missionary women, and Chinese American prostitutes, this thesis argues that by aggressively trying to control Chinese sexuality through laws, “yellow slave” narratives, Christianizing, and the immigration process, the American government and missionaries created an atmosphere ripe for Chinese prostitutes in America with varying degrees of sexual freedoms.

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by loss of renal function within days to weeks and by glomerular crescents on biopsy. The pathogenesis of this disease is unclear, but circulating factors such as antineutrophil cytoplasmic antibodies (ANCA) are believed to play a major role. In this thesis, we show that deletion of the Von Hippel-Lindau gene (Vhlh) from intrinsic glomerular cells of mice is sufficient to initiate a necrotizing crescentic glomerulonephritis and the clinical features that accompany RPGN. Loss of Vhlh leads to stabilization of hypoxia-inducible factor alpha subunits (HIFαs). Using gene expression profiling, we identified de novo expression of the HIFα target gene Cxcr4. In glomeruli from mice with RPGN, the course of RPGN is markedly improved in mice treated with a blocking antibody to Cxcr4, whereas overexpression of Cxcr4 alone in podocytes of transgenic mice is sufficient to cause glomerular disease. Despite the development of glomerular disease in mice that overexpress Cxcr4, their disease was milder and lacked features of full-blown RPGN. The Vhlh gene encodes VHL protein (pVHL, product of the Von Hippel-Lindau gene) that functions as the substrate recognition component of an E3 ubiquitin ligase. Although HIFα subunits are the best characterized substrates for pVHL, additional non-HIF mediated targets have been identified. To determine the role of HIF stabilization in this RPGN model, we generated double mutants that lack aryl hydrocarbon receptor nuclear translocator gene (Arnt, also called HIF1beta), an obligate dimerization partner for HIFα subunit function. Podocyte-selective deletion of Arnt in Vhlh mutant mice completely rescued the RPGN phenotype and mice survived longer than 8 months of age. Furthermore, stabilization of HIF2α alone led to glomerular disease characterized by crescentic transformation. Collectively, these results indicate an alternative mechanism for the pathogenesis of RPGN and glomerular disease in an animal model and suggest novel molecular pathways for intervention in this disease. In addition, we demonstrate a key role for VHL-HIF-Cxcr4 molecular pathway for the integrity of the glomerular barrier.

Darbo problema – vis dar lieka neaiškus PRR efektyvumas ir jos sąsajos su amžiumi, lytimi, išsilavinimu, IŠL forma, subjektyvia savijauta, subjektyviu sveikatos vertinimu bei organizmo raumenų įtampa, sergantiems IŠL. Todėl šio tyrimo tikslas - nustatyti progresuojančios raumenų relaksacijos taikymo efektyvumą AKS reguliavimui, atsižvelgiant į lytį, amžių, ligos formą, subjektyvų sveikatos vertinimą, išsilavinimą, raumenų įtampą ir subjektyvią savijautos įtampą, sergantiems IŠL, stacionarinės reabilitacijos etape. Tyrime buvo pakviesti dalyvauti 204 Abromiškių reabilitacinės ligoninės, kardiologinio skyriaus pacientai, tačiau į 1 užsiėmimą atėjo 53 (48,18 %) vyrai ir 40 (42,55 %) moterų, į 2 – 20 (18,18 %) vyrų ir 14 (14,89 %) moterų, į 3 – 15 (13,63 %) vyrų ir 12 (12,76 %) moterų ir į 4 – 12 (10,9 %) vyrų ir 8 (8,51 %) moterys. Tiriamieji dalyvavo 4 vienos valandos užsiėmimuose, kurie vyko 4 kartus per savaitę. Siekiant įvertinti PRR efektyvumą AKS mažinimui ir efektyvumo sąsajas su prieš tai išvardintais faktoriais, tiriamiesiems buvo pateikiamos anketos, vedami relaksaciniai užsiėmimai. Kiekvieno užsiėmimo pradžioje ir pabaigoje buvo matuojamas AKS ir duodamas užpildyti manekenas (raumenų įtampai įvertinti) bei subjektyvios savijautos skalė. Tyrimo rezultatai parodė, kad po relaksacijos AKS statistiškai reikšmingi sumažėjimai buvo tik vyrų tarpe, taip pat tarp jaunesnių pacientų, žmonėms sergantiems lengvesne IŠL forma, pacientams su aukštuoju išsilavinimu ir blogesniu... [toliau žr. visą tekstą] / It is still unclear if effectiveness of PMR is related with age, gender, education, IHD form, subjective health status, subjective tension and muscle tension for ischemic heart disease patients. So the aim of this survey is to analize how effectiveness of progressive muscle relaxation in blood pressure regulation is related with these factors for ischemic heart disease in-patients at their rehabilitation period. 204 patients from Abromiškės rehabilitation hospital, cardiac department were invited to participate in relaxation groups, but in the first group participated only 53 (48,18%) men and 40 (42,55%) women, in the second - 20 (18,18%) men and 14 (14,89%) women, in the third - 15 (13,63%) men and 12 (12,76%) women and in fourth - 12 (10,9%) men and 8 (8,51%) women. Participants attended in four hourly relaxation groups which were four times per week. With the purpose to evaluate PMR effectiveness for blood pressure regulation and its’ relation with factors, participants were given questionnaires also relaxation groups were provided. At the beginning and at the end of each session blood pressure was measured also muscle tension was evaluated with the given model and 10 score scale was given for subjective feeling evaluation. The results of this study showed that the statistically significant reductions of blood pressure were only for men also for younger patients and patients with higher education, for patients with easier IHD form and for patients with worse... [to full text]

This thesis assesses the current status of Canadian prescription drug regulation and the policy drivers that guide this process. This analysis is accomplished by first providing a general survey of the steps, law, and institutional players involved in the full life-cycle of a drug. Next the evolution of current clinical trials and the gaps that the present legal regime creates in the scientific standards employed in clinical research is reviewed. This is followed by a discussion of how commercialization (innovation) and speed of approval (market access) are slowly becoming the dominant policy drivers for the Canadian regime. Finally a discussion of the proposed Progressive Licensing model, and Bill C-51-An Act to Amend the Food and Drug Act, raises the concerns with a shift to a system largely based on risk assessment and post-market monitoring (pharmacovigilence).

This design-based research study investigates the development of progressive discourse among participants (n=15, n=17, n=20) in three online graduate course contexts. Progressive discourse is a kind of discourse for inquiry in which participants share, question, and revise their ideas to deepen understanding and build knowledge. Although progressive discourse is central to knowledge building pedagogy, it is not known whether it is possible to detect its emergence in the patterns of participation in asynchronous conferencing environments or what kinds of instructional scaffolding are most effective to support its development. This study offers a unique perspective by characterizing episodes of discourse where participants honor the commitments for progressive discourse and by refining designs of peer and software-based scaffolding for progressive discourse. Results showed that measures such as note count, replies, and thread sizes can determine some qualities of online discourse but do not shed light on the development of progressive discourse. Thus an in-depth analysis of discourse for groups was developed to trace the interdependent individual contributions to the group discourse. Peer scaffolding that made norms for progressive discourse explicit was introduced to encourage participants to engage in sustained student-centered discourse for inquiry. Findings show that this intervention was most effective at the beginning of a course for newer online learners and newer graduate students, and least effective for students who were practicing K-12 teachers. A significant barrier to fostering progressive discourse is the tendency for teachers to reject these norms and revert to belief-mode thinking and devotional discourse typical of traditional schooling. Additionally, findings suggest that software-based scaffolding (as found in Knowledge Forum’s scaffold support feature) is a promising avenue for future design innovations to encourage progressive discourse. Although the results of this study are only suggestive, the findings do illustrate ways in which graduate students can uphold the commitments to move beyond expressions of socio- affective connection and opinion to discuss ideas in ways that lead to more useful explanations. The implications for these results for analyzing the quality of online discourse and the designs of instructional scaffolding in online learning environments are discussed.

This dissertation investigates the development of progressive Christianity. It explores the ways in which progressive Christian churches in Canada adopt biblical criticism and popular theology. Contributing to the anthropology of Christianity, this study is primarily an ethnographic and linguistic analysis that juxtaposes contemporary conflicts over notions of the Christian self into the intersecting contexts of public discourse, contending notions of the secular and congregational dynamics. Methodologically, it is based upon two-and-a-half years of in-depth participant observation research at five churches and distinguishes itself as the first scholarly study of progressive Christianity in North America. I begin this study by outlining the historical context of skepticism in Canadian Protestantism and arguing that skepticism and doubt serve as profoundly religious experiences, which provide a fuller framework than secularization in understanding the experiences of Canadian Protestants in the nineteenth and twentieth centuries. In doing so, I draw parallels between the ways that historical and contemporary North American Christians negotiate the tensions between their faith and biblical criticism, scientific empiricism and liberal morality. Chapter Two seeks to describe the religious, cultural and socio-economic worlds inhabited by the progressive Christians featured in this study. It focuses on the worldviews that emerge out of participation in what are primarily white, middle-class, liberal communities and considers how these identity-markers affect the development and lived experiences of progressive Christians. My next three chapters explore the ways that certain engagements with text and the performance or ritualization of language enable the development of a distinctly progressive Christian modality. Chapter Three investigates progressive Christian textual ideologies and argues that the form of biblical criticism that they employ, along with entrenched concerns about the origins of the Christian faith ultimately, leads to a rejection of the biblical narrative. Chapter Four examines the ways in which progressive Christians understand individual 'deconversion' narratives as contributing to a shared experience or way of being Christian that purposefully departs from evangelical Christianity. The final chapter analyses rhetoric of the future and argues that progressive Christians employ eschatological language that directs progressive Christians towards an ultimate dissolution.

This dissertation investigates the development of progressive Christianity. It explores the ways in which progressive Christian churches in Canada adopt biblical criticism and popular theology. Contributing to the anthropology of Christianity, this study is primarily an ethnographic and linguistic analysis that juxtaposes contemporary conflicts over notions of the Christian self into the intersecting contexts of public discourse, contending notions of the secular and congregational dynamics. Methodologically, it is based upon two-and-a-half years of in-depth participant observation research at five churches and distinguishes itself as the first scholarly study of progressive Christianity in North America. I begin this study by outlining the historical context of skepticism in Canadian Protestantism and arguing that skepticism and doubt serve as profoundly religious experiences, which provide a fuller framework than secularization in understanding the experiences of Canadian Protestants in the nineteenth and twentieth centuries. In doing so, I draw parallels between the ways that historical and contemporary North American Christians negotiate the tensions between their faith and biblical criticism, scientific empiricism and liberal morality. Chapter Two seeks to describe the religious, cultural and socio-economic worlds inhabited by the progressive Christians featured in this study. It focuses on the worldviews that emerge out of participation in what are primarily white, middle-class, liberal communities and considers how these identity-markers affect the development and lived experiences of progressive Christians. My next three chapters explore the ways that certain engagements with text and the performance or ritualization of language enable the development of a distinctly progressive Christian modality. Chapter Three investigates progressive Christian textual ideologies and argues that the form of biblical criticism that they employ, along with entrenched concerns about the origins of the Christian faith ultimately, leads to a rejection of the biblical narrative. Chapter Four examines the ways in which progressive Christians understand individual 'deconversion' narratives as contributing to a shared experience or way of being Christian that purposefully departs from evangelical Christianity. The final chapter analyses rhetoric of the future and argues that progressive Christians employ eschatological language that directs progressive Christians towards an ultimate dissolution.

Le traitement de signaux multidimensionnels reste un problème délicat lorsqu'il s'agit d'utiliser des méthodes conçues pour traiter des signaux monodimensionnels. Il faut alors étendre les méthodes monodimensionnelles à plusieurs dimensions, ce qui n'est pas toujours possible, ou bien convertir les signaux multidimensionnels en signaux 1D. Dans ce cas, l'objectif est de conserver le maximum des propriétés du signal original. Dans ce contexte, le théorème de superposition de Kolmogorov fournit un cadre théorique prometteur pour la conversion de signaux multidimensionnels. En effet, en 1957, Kolmogorov a démontré que toute fonction multivariée pouvait s'écrire comme sommes et compositions de fonctions monovariées. Notre travail s'est focalisé sur la décomposition d'images suivant le schéma proposé par le théorème de superposition, afin d''etudier les applications possibles de cette d'ecomposition au traitement d'image. Pour cela, nous avons tout d'abord 'etudi'e la construction des fonctions monovari'ees. Ce probl'eme a fait l'objet de nombreuses 'etudes, et r'ecemment, deux algorithmes ont 'et'e propos'es. Sprecher a propos'e dans [Sprecher, 1996; Sprecher, 1997] un algorithme dans lequel il d'ecrit explicitement la m'ethode pour construire exactement les fonctions monovari'ees, tout en introduisant des notions fondamentales 'a la compr'ehension du th'eor'eme. Par ailleurs, Igelnik et Parikh ont propos'e dans [Igelnik and Parikh, 2003; Igelnik, 2009] un algorithme pour approximer les fonctions monovariéees par un réseau de splines. Nous avons appliqué ces deux algorithmes à la décomposition d'images. Nous nous sommes ensuite focalisés sur l'étude de l'algorithme d'Igelnik, qui est plus facilement modifiable et offre une repréesentation analytique des fonctions, pour proposer deux applications originales répondant à des problématiques classiques de traitement de l'image : pour la compression : nous avons étudié la qualité de l'image reconstruite par un réseau de splines généré avec seulement une partie des pixels de l'image originale. Pour améliorer cette reconstruction, nous avons proposé d'effectuer cette décomposition sur des images de détails issues d'une transformée en ondelettes. Nous avons ensuite combiné cette méthode à JPEG 2000, et nous montrons que nous améliorons ainsi le schéma de compression JPEG 2000, même à bas bitrates. Pour la transmission progressive : en modifiant la génération du réseau de splines, l'image peut être décomposée en une seule fonction monovariée. Cette fonction peut être transmise progressivement, ce qui permet de reconstruire l'image en augmentant progressivement sa résolution. De plus, nous montrons qu'une telle transmission est résistante à la perte d'information.

Bakgrund: Den senaste tiden har en debatt blossat upp i media om huruvida det är rimligt att bostadsrättsföreningar får tillämpa progressiva avskrivningar och om raka avskrivningar är ett bättre alternativ. Bokföringsnämnden beslöt under våren år 2014 att progressiva avskrivningar inte är en tillämplig avskrivningsmetod för byggnader. I media har många uttalat sig om vad detta kommer få för effekt på marknaden för bostadsrätter, men det har ännu inte utretts ur ett vetenskapligt perspektiv. Syfte: Uppsatsen syftar till att bidra med detta vetenskapliga perspektiv genom att analysera huruvida progressiva avskrivningar är en förutsättning för nyproduktion. I uppsatsen ämnas även undersöka om detta skiljer mellan olika regioner i Sverige. Metod: För att besvara de i syftet ställda problemformuleringarna har en teoretisk modell utvecklats med grundantagandet att köpare av bostadsrätter ska vara indifferenta till vilken avskrivningsmetod som används. Regler och praxis kring avskrivningar i bostadsrättsföreningar har kartlagts för att kunna ge modellen adekvat utformning. Modellens slutresultat visar hur en övergång från progressiva till raka avskrivningar påverkar lönsamheten i nyproduktion av bostadsrätter. En diskussion har förts kring rimligheten i de antaganden som gjorts i modellen och det framtagna resultatet, med utgångspunkt i mikroekonomisk teori och en generell analys av bostadsmarknaden. Slutsats: Enligt de antaganden som gjorts i denna studie och den modell som tagits fram har slutsatsen dragits att de progressiva avskrivningarna på kort sikt är en förutsättning för nyproduktion. Det finns dock ett antal omständigheter som tyder på att reaktionen i verkligheten blir något mildare än vad resultatet från modellen visar. Vidare tycks effektens storlek minska ju högre marknadspriset för bostadsrätter var innan övergången till raka avskrivningar. På lång sikt är inte progressiva avskrivningar en förutsättning för nyproduktion av bostadsrätter. / Background: In Sweden, there has been a recent debate about the reasonability of the use of progressive depreciations by housing cooperatives and if straight line depreciations is a better alternative. The Swedish Accounting Standards Board decided during the spring of 2014 that progressive depreciation is not an applicable depreciation method for buildings. In media, many have discussed the effect on the market for housing cooperative shares but it has not yet been investigated with a scientific perspective. Purpose: The aim of the thesis is to contribute with this scientific perspective by analyzing if progressive depreciations is a prerequisite for production of new dwellings. The thesis is also meant to look into regional differences of this matter. Method: To answer the two problem formulations above, a theoretical model has been developed with the basic assumption that buyers of housing cooperative shares should be indifferent to which depreciation method is applied. Rules and practices of housing cooperative depreciations have been charted in order to make the model adequate. The end result of the model shows how a transition from progressive to straight line depreciation affects the profitability of production of new dwellings. With respect to microeconomic theory and a general analysis of the housing market, a discussion has been carried out about the model assumptions and the model results. Conclusions: According to the used model and its assumptions, the conclusion has been made that progressive depreciations is a short term prerequisite for production of new dwellings. Although, there are circumstances that indicate that the market reaction would be milder than what the model results show. Furthermore, the effect of the depreciation method transition seems to decrease with higher market prices for the housing cooperative shares. In the long term, progressive depreciations is not a prerequisite for production of new dwellings.