Magister Scientiae Dentium - MSc(Dent) / Betel nut/quid chewing is a habit that is commonly practiced in the Indian subcontinent. This age-old social habit is still practiced by Indians in Durban, Kwazulu Natal (South Africa). The betel nut/quid is prepared in a variety of ways. The quid may be prepared with or without tobacco. This habit is said to be associated with the development of premalignant lesions,namely, Oral Submucous Fibrosis (OSF) which increases the susceptibility for malignancy of the oral mucosa and the foregut. The aim of this study was to investigate the prevalence of betel nut/quid chewing (with or without tobacco), the associated habits (smoking and alcohol consumption) and awareness of the harmful effects of the chewing habit among Indians in Durban, KwaZulu-Natal.A cross-sectional study design was chosen utilising a self-administered questionnaire and semi-structured interviews to collect data. Consenting participants were requested to complete a self-administered, structured questionnaire. The study population included any person in the Durban area who chewed betel nut/quid/tobacco. Only persons willingly and who consented to be part of the study, were included. The sample size was based on convenience. People were approached at the pan shops, leisure markets, traditional functions and at the dental practice the researcher operated at. A total of 101 respondents were interviewed.A significantly higher proportion of females chewed betel nut/quid from the total of the respondents. The results showed that the habit is increasingly practiced in the younger age group (20-39 years). There was evidence to show that the chewing habit is used more by the employed than the unemployed (p=0.055). Of the sample population, 78% were born in South Africa and the rest were immigrants from Pakistan, India and Dubai. All respondents from the migrant community were males. The most important reasons for chewing betel nut were for enjoyment and at special functions. More than two third indicated family members (aunts,uncles and cousins) influence as a reason for chewing, in comparison to influences by parents or grandparents. The study also indicated that parents were far more likely to influence betel nut chewing if grandparents did so (p-value= 0.000). In addition, the study revealed that family members (aunts, uncles and cousins) were far more likely to influence betel nut chewing if parents did so (p=0.000).The most popular ingredients chewed were betel nut, betel leaf, lime and pan masala and the most popular combinations were betel nut/lime/betel leaf quid preparation, betel nut alone,betel nut/betel leaf/lime/tobacco/pan masala and betel nut/betel leaf/lime/pan masala. Two thirds of the respondents do not know that betel nut chewing is harmful to their health, thus indicating a lack of awareness on the risks associated with the chewing habit, and the majority have not attempted to give up the habit. Most of the respondents retained their chewing habits after being informed about the risks. A little more than half the study population reported neither smoking nor drinking.The present study found that betel nut/quid chewing habits continue to be enjoyed by many people and most are unaware of the hazardous effects of the habit. More younger people are using the habit as compared to previous studies. This is probably because it is an affordable and easily accessible habit. It is recommended that aggressive awareness programmes on the harmful effects of betel nut/quid chewing be developed, similar to that for smoking cessation.Government health warnings need to be instituted, for example, by having written warnings on packagings. Taxes need to be imposed on the betel nut and condiments thereby reducing access to most people. Age restrictions need to be imposed on purchasing of the betel nut/quid thus making access difficult for the children.

La Critique de la raison pure est traversée de part en part par une analogie juridique dont l’étude peut enrichir la compréhension de l’œuvre. Il est ainsi question, dès la préface, d’une raison qui se juge elle-même devant son propre tribunal, ce qui constituera le point de départ de notre analyse. Or, ce tribunal très particulier doit se fonder sur une connaissance de soi approfondie de la raison. Cette entreprise est de fait réalisée au fil des développements de la Critique. Le rôle bien particulier joué à cet égard par les trois déductions présentes dans l’œuvre sera dûment examiné. On verra par ailleurs que la déduction doit elle-même être considérée plutôt comme procédure d’inspiration juridique que comme inférence, tout en conservant pourtant un statut de preuve philosophique. Les nombreuses allusions juridiques effectuées par Kant au fil de l’œuvre seront ainsi mises à profit dans le cadre de cette interprétation. / A legal analogy runs through the Critique of Pure Reason, and studying it can shed light on the work. The metaphor of the “tribunal of reason”, first introduced in the Preface, will thus be the starting-point for our analysis. Due to its very nature, this tribunal must be based upon reason’s in-depth self-knowledge – a task to be accomplished over the course of the Critique. The special part played in this regard by the book’s three deductions will be thoroughly examined. In addition, we will see that a deduction itself has more to do with a legally inspired procedure than with an inference, while it nevertheless remains a legitimate philosophical proof. Kant’s frequent legal allusions throughout the text will therefore constitute the basis for our interpretation.

Most oral squamous cell carcinoma (OSCC) is believed to develop via a multistep process of cumulative gene damage in epithelial cells. Increasing incidence of OSCC and evidence that traditional risk factors may not be responsible directed us to investigate the prevalence of virus in pre- and malignant samples.The integration of the DNA from human papillomavirus (HPV), Epstein-Barr virus (EBV), and Herpes simplex (HSV) into the human genome is associated with the expression of oncogenes and the down-regulation of tumor-suppressor genes in OSCC carcinogenesis. This thesis compared samples from India and Sudan, two countries on two continents having a documented high incidence of oral cancer, with specimens from Sweden, with its known low incidence of oral cancer. Each region has, in addition to smoking, a unique non-smoked tobacco habits with documented carcinogenic effects. These countries also typify areas of low and high socioeconomic living conditions with their expected impact on disease development. The study populations were selected from tobacco users and nonusers with OSCC, oral sub-mucous fibrosis (India), oral lichen planus (Sweden), oral leukoplakia with and without dysplasia and snuff-induced lesions (Sweden and Sudan). An expedient method was developed for extracting DNA from old formalin-fixed and paraffin-embedded biopsies. The prevalence of HPV, EBV, and HSV was investigated using PCR/DNA sequencing and southern blot hybridization analysis. We found HPV and EBV to be most prevalent in samples of tissue characterized as normal, with decreasing prevalence in dysplastic and malignant lesions. This intriguing finding that prevalence decreases as neoplastic development proceeds warrants further investigation. Our data do not at first sight support the conclusion that viruses and tobacco use jointly interact with cell mechanisms in the development of oral cancer.

Thesis (LLM. (Labour Law)) -- University of Limpopo, 2022 / Sexual harassment remains an issue in the workplace as result of ineffective legislative and other measures that fail to recognise sexual harassment as a form of discrimination that is gender orientated. Gender inequality is credited as one of the contributors of sexual harassment, as more women than men suffer sexual harassment in the workplace. Moreover, sexual harassment has adverse effects on the individual who is on the receiving end of it, which are psychological in nature. This alone may lead to the abuse of substances as a form of coping mechanism, to arriving late to work or quitting which also affects productivity. In an attempt to confront the issue of sexual harassment, laws were created over the years, both at national and international level. Although some countries show efficiency in the creation of these laws by responding with urgency, some countries have had a more difficult time formulating appropriate and effective laws, with some countries having very little laws aimed at combatting sexual harassment in the workplace. At the same time workplace sexual harassment policies have proven to be an effective weapon against the gendered inequality that is sexual harassment if implemented effectively.

Deux questions largement discutées par les médiévistes concernant Boèce de Dacie consistent à savoir quels sont les enjeux de la censure dont ce philosophe fut l'une des principales cibles lors de la condamnation promulguée à Paris en 1277 par l'évêque Étienne Tempier et s'il a effectivement défendu, dans son De aeternitate mundi, une doctrine qualifiée par ces mêmes historiens de « double vérité ». Si cette expression n'a pas été forgée par Étienne Tempier lui-même, on retrouve néanmoins, dans le prologue de la condamnation de 1277, une formulation qui traduit l'esprit de cette expression en affirmant que certains enseignants disaient qu'une même chose est vraie selon la philosophie, mais fausse selon la foi catholique, de sorte que nous sommes en présence de deux vérités contraires. Malgré le consensus établi chez les historiens du XXe siècle voulant que Boèce de Dacie n'ait jamais défendu une telle doctrine, nous pensons que cette question reste d’actualité dans la mesure où le texte lui-même ne semble pas totalement clair en affirmant que si la foi dit vrai absolument, le philosophe dit également vrai, mais de manière relative à ses principes. Or, une telle conception ne va pas sans problème au regard de l’interprétation des principes régissant l’épistémologie de Boèce. Notre recherche a donc pour unique question d'éclaircir et d'élucider cette mise en accusation de « double vérité » au vu de ses différents textes ainsi que les différentes interprétations que son modèle a reçu. / There are two questions widely discussed by the medievalists about Boethius of Dacia. The first consist in knowing what are the stakes of the censorship of which this philosopher was one of the main targets during the condemnation promulgated in Paris in 1277 by the bishop Etienne Tempier. The second ask if Boethius actually uphold, in his De aeternitate mundi, a doctrine qualified by these same historians as ‘‘double truth’’. If this expression was not coined by Etienne Tempier himself, we nevertheless find, in the prologue to the condemnation of 1277, a formulation which translates the spirit of this expression by affirming that certain teachers said that the same thing is true according to philosophy, but false according to the Catholic faith, so that we are in the presence of two contradictory truths. Despite the consensus, established among historians of the twentieth-century, that Boethius of Dacia never defended such a doctrine, we believe that this question remains topical insofar as the text itself does not seem completely clear when it states that if faith absolutely says the truth, the philosopher also says the truth, but in a manner relative to his principles. However, such a conception is not without problems in regard to the interpretation of the principles governing the epistemology of Boethius. The sole question of our research is therefore to clarify and elucidate this indictment of ‘‘double truth’’ in view of its different texts as well as the different interpretations that his model received.

From time to time the court delivers a judgment that has a ripple effect beyond what was expected, resulting in estate planners reconsidering their planning strategies. Such a judgment was the judgment delivered by the Supreme Court of Appeal (SCA) in the case of the Commissioner for the South African Revenue Services v Brummeria Renaissance 2007 6 SA 601 (SCA) (Brummeria case). In this case the interest-free loan and the right to use loan capital free of any interest obligation were under scrutiny. The SCA had to rule on whether or not this right had a determinable value and whether or not this value could be taxable in the hands of the borrower. The SCA ruled that the right under an interest-free loan should be included in the gross income of the borrower. Since estate planning often involves the use of an interest-free loan, as estate planning tool, to remove a growth asset from the estate of a planner, it could not be generally accepted any more that the granting of such loan would not have any tax implications. Although the interest-free loans used in the Brummeria case, did not relate to an estate planning exercise, the ruling resulted in much speculation regarding the future of the interest-free loan as estate planning tool. SARS tried to ease the uncertainty by issuing Interpretation Note 58, but there is still uncertainty to some extent. The focus of this mini-dissertation is to explain when and to what extend the provisions of the Income Tax Act 58 of 1962 (ITA) as well as the Estate Duty Act 45 of 1955 (EDA) will apply to the granting of an interest-free loan as part of an estate planning exercise. The provisions of the gross income definition, sections 7 and 64E, the provisions of donations tax as well as paragraph 12(5) and 12A of the Eighth Schedule to the ITA, were explored. Sections 3(3) and 3(5) of the EDA are discussed with the use of these loans for estate planning in mind. The question whether or not the interest-free loan is still a useful estate planning tool is also answered. / LLM (Estate Law), North-West University, Potchefstroom Campus, 2015

From time to time the court delivers a judgment that has a ripple effect beyond what was expected, resulting in estate planners reconsidering their planning strategies. Such a judgment was the judgment delivered by the Supreme Court of Appeal (SCA) in the case of the Commissioner for the South African Revenue Services v Brummeria Renaissance 2007 6 SA 601 (SCA) (Brummeria case). In this case the interest-free loan and the right to use loan capital free of any interest obligation were under scrutiny. The SCA had to rule on whether or not this right had a determinable value and whether or not this value could be taxable in the hands of the borrower. The SCA ruled that the right under an interest-free loan should be included in the gross income of the borrower. Since estate planning often involves the use of an interest-free loan, as estate planning tool, to remove a growth asset from the estate of a planner, it could not be generally accepted any more that the granting of such loan would not have any tax implications. Although the interest-free loans used in the Brummeria case, did not relate to an estate planning exercise, the ruling resulted in much speculation regarding the future of the interest-free loan as estate planning tool. SARS tried to ease the uncertainty by issuing Interpretation Note 58, but there is still uncertainty to some extent. The focus of this mini-dissertation is to explain when and to what extend the provisions of the Income Tax Act 58 of 1962 (ITA) as well as the Estate Duty Act 45 of 1955 (EDA) will apply to the granting of an interest-free loan as part of an estate planning exercise. The provisions of the gross income definition, sections 7 and 64E, the provisions of donations tax as well as paragraph 12(5) and 12A of the Eighth Schedule to the ITA, were explored. Sections 3(3) and 3(5) of the EDA are discussed with the use of these loans for estate planning in mind. The question whether or not the interest-free loan is still a useful estate planning tool is also answered. / LLM (Estate Law), North-West University, Potchefstroom Campus, 2015

A patent is often characterized as a bargain between an inventor and society. Generally, for a patent to be considered valid, an invention must satisfy three broad criteria: it must be new, useful, and non-obvious. This paper focuses on the requirement of non-obviousness. It explores the criterion from inception to its current state and suggests a potential refinement. A multi-jurisdictional snap-shot is presented focusing on the United Kingdom, Australia, the United States, and Canada. It is submitted that the non-obvious prerequisite contains a problematic level of uncertainty. The law of obviousness lacks a baseline standard. To achieve certainty, it is suggested that the law adopt the principles pertaining to patenting combinations and aggregates. Ultimately the law of patents, inclusive of the doctrine of obviousness, must be fashioned and administered in a manner that respects the quid pro quo that has guided the law for many years.

A patent is often characterized as a bargain between an inventor and society. Generally, for a patent to be considered valid, an invention must satisfy three broad criteria: it must be new, useful, and non-obvious. This paper focuses on the requirement of non-obviousness. It explores the criterion from inception to its current state and suggests a potential refinement. A multi-jurisdictional snap-shot is presented focusing on the United Kingdom, Australia, the United States, and Canada. It is submitted that the non-obvious prerequisite contains a problematic level of uncertainty. The law of obviousness lacks a baseline standard. To achieve certainty, it is suggested that the law adopt the principles pertaining to patenting combinations and aggregates. Ultimately the law of patents, inclusive of the doctrine of obviousness, must be fashioned and administered in a manner that respects the quid pro quo that has guided the law for many years.

Made available in DSpace on 2014-06-11T19:24:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-03-12Bitstream added on 2014-06-13T18:52:40Z : No. of bitstreams: 1 montezuma_r_me_rcla.pdf: 2261471 bytes, checksum: e8de3c70b94bdde4b8cd09e24247eaf2 (MD5) / O objetivo desta pesquisa foi determinar o Perfil de Textura (TPA) em formulações comerciais de “carne bovina em conserva” (corned beef) enlatada processada termicamente e avaliar sua relação com os valores de esterilização (F0), com a Concentração da Proteína do Tecido Conjuntivo Colagenoso (CCTP) e com a Concentração da Proteína do Tecido Muscular (MTP). Foram selecionados 14 lotes de produção de corned beef em latas tronco trapezoidais de 340 g correspondentes ao padrão continental Campden A e destes foram retiradas 24 latas do produto dos sub lotes submetidos ao processamento térmico. Destas latas foram retiradas seis amostras aleatórias para determinação do TPA e para análise da composição visando determinação da Proteína do Tecido Conjuntivo Colagenoso (CCTP), da Proteína do Tecido Muscular (MTP) e do Conteúdo Carne Magra (LMC). As latas de corned beef analisadas foram submetidas a tratamentos térmicos de 75,0 a 76,7 minutos, com a temperatura da autoclave a 121o C e resfriamento a 35o C durante 60 minutos, obtendo-se valores de F0 no centro de massa do produto variando de 14,8 a 20 minutos. Os parâmetros de TPA dureza, fraturabilidade, coesividade, elasticidade, adesividade, mastigabilidade, gomosidade e resiliência foram determinados no bloco integral do produto bloco resfriado a 4ºC em oito pontos na superfície. Os mesmos blocos do produto utilizados para determinação do TPA foram analisados quanto à composição média, apresentando concentração de 0,4 a 2,5% para CCTP, de 21,7 a 25,3% para MTP e de 102,79 a 107,95% para LMC. Os tratamentos de corned beef avaliados apresentaram diferenças significativas pelo teste de Tukey nas médias dos parâmetros dureza, gomosidade, mastigabilidade, adesividade e elasticidade. Os três primeiros parâmetros apresentaram correlações significativas fortemente negativas com o valor... / The objectives of this research were the determination of the texture profile of canned corned beef thermally processed and to evaluate its relationship with the sterilization value (F0) and the composition. Fourteen production batches of Campden A grade 340-g corned beef cans were selected, from which twenty-four cans of the thermal process sub-batches were retrieved. From the sub-batches, six random sample cans were taken and its content submitted to the Texture Profile Analysis (TPA) and to the composition analysis to determine the concentration of the Collagenous Connective Tissue Protein (CCTP), the Muscular Tissue Protein (MTP) concentration and the Lean Meat Content (LMC). The corned beef samples analyzed were submitted to thermal treatments at 121o C (retort steam temperature) for varying heating times, from 75 to 76 minutes and cooled at 35o C (retort water temperature) during 35 minutes, to obtain F0 values at the product center point varying from 14.8 to 20 minutes. The TPA parameters were determined in 8 points of the whole corned beef loaf of each sample, previously chilled and stabilized at 4o C temperature, to obtain hardness, fracturability, cohesiveness, elasticity, adhesiveness, springiness, gumminess, chewiness and resilience. The same sample material were then analyzed in terms of average composition of the product, resulting in concentrations in the range of 0.4 to 2.5% for CCTP, 21.7 to 25.3% for MTP and content from 102.8% to 108.0% for LMC. The treated corned beef samples analyzed showed significant differences in the means for hardness, adhesiveness, chewiness and elasticity. These parameters showed dependence with the sterilization value (F0), revealing negative strong significant correlation for F0 with hardness, gumminess and chewiness. The MTP and LMC values showed a high positive significant correlation with cohesiveness. It was observed a high... (Complete abstract click electronic access below)