abstract: In situ remediation of contaminated aquifers, specifically in situ bioremediation (ISB), has gained popularity over pump-and-treat operations. It represents a more sustainable approach that can also achieve complete mineralization of contaminants in the subsurface. However, the subsurface reality is very complex, characterized by hydrodynamic groundwater movement, geological heterogeneity, and mass-transfer phenomena governing contaminant transport and bioavailability. These phenomena cannot be properly studied using commonly conducted laboratory batch microcosms lacking realistic representation of the processes named above. Instead, relevant processes are better understood by using flow-through systems (sediment columns). However, flow-through column studies are typically conducted without replicates. Due to additional sources of variability (e.g., flow rate variation between columns and over time), column studies are expected to be less reproducible than simple batch microcosms. This was assessed through a comprehensive statistical analysis of results from multiple batch and column studies. Anaerobic microbial biotransformations of trichloroethene and of perchlorate were chosen as case studies. Results revealed that no statistically significant differences were found between reproducibility of batch and column studies. It has further been recognized that laboratory studies cannot accurately reproduce many phenomena encountered in the field. To overcome this limitation, a down-hole diagnostic device (in situ microcosm array - ISMA) was developed, that enables the autonomous operation of replicate flow-through sediment columns in a realistic aquifer setting. Computer-aided design (CAD), rapid prototyping, and computer numerical control (CNC) machining were used to create a tubular device enabling practitioners to conduct conventional sediment column studies in situ. A case study where two remediation strategies, monitored natural attenuation and bioaugmentation with concomitant biostimulation, were evaluated in the laboratory and in situ at a perchlorate-contaminated site. Findings demonstrate the feasibility of evaluating anaerobic bioremediation in a moderately aerobic aquifer. They further highlight the possibility of mimicking in situ remediation strategies on the small-scale in situ. The ISMA is the first device offering autonomous in situ operation of conventional flow-through sediment microcosms and producing statistically significant data through the use of multiple replicates. With its sustainable approach to treatability testing and data gathering, the ISMA represents a versatile addition to the toolbox of scientists and engineers. / Dissertation/Thesis / Ph.D. Civil and Environmental Engineering 2013

Orientador: Edineis de Brito Guirardello / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-11T15:08:10Z (GMT). No. of bitstreams: 1 Reis_CarlaKlavados_M.pdf: 2891097 bytes, checksum: 7c63fc2d21f82331f58cce8ec7d2b283 (MD5) Previous issue date: 2007 / Resumo: Este estudo teve como propósito realizar a adaptação cultural e validação do instrumento Attentional Function Index para a cultura brasileira. O processo de adaptação cultural foi baseado em uma metodologia reconhecida internacionalmente, a qual envolve as etapas de: tradução do instrumento para o idioma alvo, tradução do instrumento de volta para o idioma de origem, avaliação das equivalências semântica, idiomática, conceitual e cultural por um grupo de juízes e realização do pré-teste. A versão final do instrumento adaptado foi denominada versão brasileira do Attentional Function Index e foi submetida a um processo de validação com determinação de sua confiabilidade e validade entre uma amostra de estudantes de graduação em enfermagem de uma universidade pública no interior do estado de São Paulo. Para a confiabilidade analisou-se a homogeneidade por meio da consistência interna, e a estabilidade por meio do teste-reste, expressos pelo Coeficiente Alfa de Cronbach (a= 0,89) e pelo Coeficiente de Correlação Intraclasse (CCI= 0,81), respectivamente. Para avaliação da validade de construto do tipo convergente, utilizou-se a versão em português do instrumento Profile of Mood States (POMS) e para avaliação da validade relacionada com critério, utilizou-se a Medida de Sobrecarga Mental, ambas expressas pelo Coeficiente de Correlação de Pearson. Obteve-se correlação significativa negativa de moderada magnitude (r= -0,64; p-valor <0,0001) para validade convergente e correlação negativa de fraca magnitude para validade relacionada com critério (r= -0,40; p-valor <0,0001). Os resultados evidenciaram que a adaptação cultural e o processo de validação foram satisfatórios, demonstrando a viabilidade da utilização da versão brasileira do Attentional Function Index na prática e no desenvolvimento de novas pesquisas. Palavras-chave: atenção; tradução; validade dos resultados. Linha de Pesquisa: Processo de Cuidar em Saúde e Enfermagem / Abstract: The purpose of this study was to fulfill the cross cultural adaptation and to validate the instrument Attentional Function Index into the Brazilian culture. The process of cultural adaptation was based on a standardized guideline internationally recognized, which involves the following steps: translation of the instrument into the target language; translation of the instrument into the original language; evaluation of semantic, idiomatic, conceptual and cultural equivalences, by a group of judges; and the pre-test of the instrument¿s final version. The final version of the suitable instrument was called the Brazilian version of the Attentional Function Index and was submitted to a validation process, with determination of its reliability and validity in a sample of graduation students in nursing of a public university in the inner part of the state of São Paulo. Reliability was analyzed through its internal consistency and the stability by means of test-retest, expressed by the Cronbach¿s alpha coefficient (a= 0.89) and intraclass correlation coefficient (ICC= 0.81), respectively. For evaluation of the construct validity, especially convergent validity, the portuguese version of the Profile of Mood States (POMS) was used, and for the evaluation of the criteria validity, a Measure of mental overload was used, both expressed by the Pearson correlation coefficient. One got a negative significant of moderate magnitude correlation (r= -0.64; p< 0.0001) for convergent validity and a weak magnitude negative correlation for criteria validity (r = -0.40; p<0.0001). Of this form, the results had pointed that the cross cultural adaptation and the validation process had been satisfactory, demonstrating the viability of the use of the Brazilian version of the Attentional Function Index in the practical one and the development of new research. Key-words: attention; translating; validity of results / Mestrado / Enfermagem e Trabalho / Mestre em Enfermagem

A fim de avaliar a confiabilidade de alguns dos testes que avaliam o Processamento Auditivo (PA), foi realizado um estudo do tipo teste-reteste desta avaliação, em um intervalo de uma semana e um mês entre as duas situações. O desempenho de 40 indivíduos foi analisado em relação à situação de teste e reteste, normalidade versus alteração e orelha testada. Verificou-se que os testes do PA, utilizados neste estudo, demonstraram sua confiabilidade por meio do teste-reteste / In order to verify the reliability of some Auditory Processing (AP) tests was carried out a test-retest study in a break of a week and a month between the two situations. The performance of 40 individuals was analyzed regarding the situation (test-retest), normality versus alteration and tested ear. It was confirmed that the AP tests used in this study indicated their reliability through the test-retest

O propósito deste trabalho foi verificar a reprodutibilidade bem como a repetibilidade do método de avaliação postural por meio da fotogrametria computadorizada. Para isto 21 indivíduos, com idade 24,2 ± 1,3 anos de idade, foram fotografados em posição anterior, posterior, perfil e face. Para realização destas fotografias foram demarcados sobre a pele pontos anatômicos que são normalmente utilizados na avaliação postural tradicional. A partir destes pontos foram analisados diferentes ângulos através do aplicativo ALCimagem-2000. Para a análise interexaminador as fotos foram avaliadas por três examinadores diferentes e os resultados comparados. Para a análise intraexaminador as mesmas fotos foram avaliadas pelo mesmo examinador em duas ocasiões diferentes com um mês de intervalo. Para a análise da repetibilidade do método os voluntários foram fotografados duas vezes com intervalo de uma semana e as fotos avaliadas pelo mesmo examinador. Para comparação dos resultados intra e interexaminadores foram aplicados o coeficiente de correlação intraclasse. Os resultados revelaram que o método proposto apresenta significativa confiabilidade interexaminadores. Dos ângulos estatisticamente confiáveis, alguns tiveram menor coeficiente de confiabilidade, principalmente os ângulos do plano sagital referentes às curvaturas vertebrais, como lordose cervical, cifose torácica e lordose lombar. Na avaliação intra-examinador só não apresentou confiabilidade o ângulo da cifose torácica. Na repetibilidade do método somente o ângulo inferior da escápula não apresentou confiabilidade. Portanto, a fotogrametria computadorizada sugere ser um método confiável para avaliação postural no plano frontal anterior e posterior. Porém, para a análise no plano sagital necessita de mais estudos para definir parâmetros de normalidade das curvaturas vertebrais. / The purpose of this work was to verify the reproducibility, as well as the method repeatibility for postural evaluation through photogrammetry. For that, 21 individuals being 24,2 ??1,3 years old were photographed in anterior, posterior, profile and face positions. To perform these photos, several anatomic sites, which are often used in the traditional postural evaluation, were marked on the skin. Different angles from these sites were examined through the program ALCimagem-2000. For the inter-examiner analysis, the photos were evaluated by three different examiners whose results were compared. For the intra-examiner analysis, the same photos were evaluated by the same examiner in two different occasions. For the analysis of the repeatibility of the method, the volunteers were photographed twice with a period of a week interval, and the photos were evaluated by the same examiner. For comparing inter and intraexaminer results, the intra-class correlation coefficient was applied. The results revealed that the proposed method presented good inter-examiner reliability. From the statistically reliable angles, some had a lesser reliability coefficient, mainly the sagital plane angles referring to vertebral flexures such as the cervical lordosis, thoracic kyphosis, and lumbar lordosis. In the intra-examiner evaluation, just the thoracic kyphosis angle hasn\'t presented reliability. As for the repeatibility of the method just the inferior scapular angle haven\'t presented reliability. Thus, computerized photogrammetry seem be a reliable method for postural evaluation on the frontal, anterior and posterior planes. However, the sagital plane needs more studies to define normality parameters for the vertebral flexures.

Orientador: Maurício Etchebehere / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-23T08:02:41Z (GMT). No. of bitstreams: 1 Marcondes_FreddyBeretta_M.pdf: 34583892 bytes, checksum: 2793e847092565a4fd1459916551ede7 (MD5) Previous issue date: 2013 / Resumo: Introdução: existem diversos questionários de função traduzidos e adaptados à cultura brasileira para a avaliação da articulação do ombro. Entretanto, até o momento, nenhum destes questionários é específico para analisar a função em pacientes com lesões cápsulo-labrais, como a lesão de Bankart e lesões SLAP. Objetivo: traduzir e adaptar culturalmente os questionários Rowe para sujeitos com lesão de Bankart e Rowe modificado para atletas arremessadores, para que possam ser utilizados no Brasil. Métodos: o processo de tradução e adaptação cultural envolveu inicialmente as etapas de tradução, síntese, retro-tradução e revisão pelo Grupo de Tradução. Foi então criada uma versão pré-final do questionário que foram aplicados a 20 pacientes que sofreram luxação anterior do ombro (questionário Rowe) e a 20 atletas que fazem movimentos de arremesso com diagnóstico de lesões do tipo SLAP (Rowe modificado). Também foram aplicados a 12 profissionais da saúde, devido às questões dos questionários que são referentes ao exame clínico. Além disso, analisamos a Consistência Interna (CI) pelo alfa de Cronbach e a confiabilidade pelo Coeficiente de Correlação Intraclasse (CCI). Resultados: foi observada pouca dificuldade no entendimento de algumas expressões dos questionários por parte dos pacientes, as quais foram substituídas por termos mais compreensíveis. Observamos valor de alfa de 0,88 para o questionário Rowe e 0,85 para o Rowe modificado. Também observamos valores de CCI de 0,85 (IC95%; 0,71-0,92) e 0,83 (IC95%; 0,62-0,93) na confiabilidade inter e intraobservadores, respectivamente, do questionário Rowe. Também analisamos o CCI de 0,77 (IC95%; 0,41-0,90) e 0,88 (IC95%, 0,66-0,95) na confiabilidade inter e intraobservadores, respectivamente, do questionário Rowe modificado. Conclusão: após um processo criterioso de tradução e adaptação cultural, foi possível obter a versão brasileira dos questionários Rowe e Rowe modificado, o que demonstra a confiabilidade de ambas às ferramentas de avaliação funcional para pacientes com instabilidade anterior (Rowe) e lesões do tipo SLAP em atletas arremessadores (Rowe modificado) / Abstract: Introduction: There are several functional questionnaires translated and adapted to Brazilian culture for the assessment of the shoulder joint. However, to date, none of these questionnaires was specific to analyze the function in patients with capsularlabral lesions, like Bankart lesion and SLAP lesions. Objective: translate and culturally adapt the Rowe score for subjects with Bankart lesion and the modified Rowe score for overhead throwing athletes, so these tools can be used in Brazil. Methods: the translation and cultural adaptation firstly involved the steps of translation, synthesis, back-translation and revision by the Translation Group. Then a pre-final version of the questionnaire was created and was applied to 20 patients who underwent anterior dislocation (Rowe score) and applied to 20 overhead throwing athletes who had diagnoses of SLAP lesion of the shoulder (modified Rowe score). It was also applied to 12 health professionals because of the questions that are related to the clinical examination. Furthermore, the internal consistency (IC) was analyzed by the Cronbach alpha and reliability by the intraclass correlation coefficient (ICC). Results: it was observed little difficulty in understanding some expressions of the questionnaires by the patients, which were replaced by terms that were easily understood. An alpha value of 0,88 for Rowe and 0,85 for modified Rowe were observed. We also observed ICC values of 0,85 (CI95%; 0,71-0,92) and 0,83 (CI95%; 0,62-0,93) in interrater and test-retest reliability, respectively, of Rowe score. We analyzed the ICC value of 0,77 (CI95%; 0,41-0,90) and 0,88 (CI95%, 0,66-0,95) in interrater and test-retest reliability, respectively, in modified Rowe score. Conclusion: after a careful process of translation and cultural adaptation was achieved for the Brazilian version of the Rowe score and modified Rowe score, demonstrating the reliability of both functional assessment tools for patients with anterior instability (Rowe) and SLAP type injuries in athletes pitchers (modified Rowe) / Mestrado / Fisiopatologia Cirúrgica / Mestre em Ciências

Language areas of the brain can be mapped in individual participants with functional MRI. We investigated the validity and reliability of four language mapping paradigms that may be appropriate for individuals with acquired aphasia: sentence completion, picture naming, naturalistic comprehension, and narrative comprehension. Five neurologically normal older adults were scanned on each of the four paradigms on four separate occasions. Validity was assessed in terms of whether activation patterns reflected the known typical organization of language regions, that is, lateralization to the left hemisphere, and involvement of the left inferior frontal gyrus and the left middle and/or superior temporal gyri. Reliability (test-retest reproducibility) was quantified in terms of the Dice coefficient of similarity, which measures overlap of activations across time points. We explored the impact of different absolute and relative voxelwise thresholds, a range of cluster size cutoffs, and limitation of analyses to a priori potential language regions. We found that the narrative comprehension and sentence completion paradigms offered the best balance of validity and reliability. However, even with optimal combinations of analysis parameters, there were many scans on which known features of typical language organization were not demonstrated, and test-retest reproducibility was only moderate for realistic parameter choices. These limitations in terms of validity and reliability may constitute significant limitations for many clinical or research applications that depend on identifying language regions in individual participants. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-06-18T21:35:52Z No. of bitstreams: 1 Bruno Roberto Borges Barbosa.pdf: 2216860 bytes, checksum: 0f76840e9c877a9697af40f1a2580480 (MD5) / Made available in DSpace on 2018-06-18T21:35:52Z (GMT). No. of bitstreams: 1 Bruno Roberto Borges Barbosa.pdf: 2216860 bytes, checksum: 0f76840e9c877a9697af40f1a2580480 (MD5) Previous issue date: 2015-12-04 / Introduction: Temporomandibular joint (TMJ) is part of the stomatognathic system (SE) and is responsible for sucking, chewing, talking, swallowing. The kinematics is a reliable tool for quantitative evaluation of the movement, which records the trajectories of markers fixed in the body segments and assesses more accurately the human movement. Objective: To a systematic review of the use of kinematics and its application in the TMJ and analyze the kinematic reproducibility of the jaw by means of a three-dimensional tool for functional activity. Material and Methods: The following databases were consulted: BIREME, Capes, PubMed, Science Direct, Scielo and Peter. The search terms used were: "Kinematics", "Temporomandibular Joint", "CentricRelation", "Movements", "Patient-SpecificModeling", "MovementDisorders" in English and Portuguese. After two reviewers independently search, 40 articles were found and after the application of the exclusion criteria, 17 articles were selected for analysis. Participants included in the study underwent four stages of evaluation. As early 2 and 2 after one week. All participants were assessed with RDC / TMD and to exclude any sign or symptom of TMD and clinical condition. They evaluated the movements of opening; Obliquity, rotation, Translation / Antero-posterior, lateral-lateral and vertical movement. Results: 17 articles evaluated and studied three-dimensional dispisitivos demonstrated methodological differences regarding the types of models and variables to be studied. In the opening movement of the present results are promising because it presented ICC considered excellent (0.48 to 1.32). However for the laterality movements it needs a certain amount of caution because the results ranged from "poor" good "reproducibility (0.30 to 0.57). Conclusion: There is no scientific evidence of the clinical application of any of the models of kinematics evaluation of the jaw. The three-dimensional model is reproducible to be opening Intra / Inter days and Intra / Inter evaluators and less reproducible lateral excursions for intra / inter-day and inter evaluators. / Introdução: A Articulação temporomandibular (ATM) faz parte do sistema estomatognático (SE) e é responsável pela sucção, mastigação, fala, deglutição. A cinemática é uma ferramenta confiável para avaliação quantitativa do movimento,que registra as trajetórias de marcadores fixados nos segmentos corpóreos e avalia mais precisamente o movimento humano. Objetivo: Realizar uma revisão sistemática do uso da avaliação cinemática na ATM e sua aplicabilidade e propor a análise da reprodutibilidade cinemática da mandíbula por meio de um instrumento tridimensional durante atividades funcionais. Material e Métodos: Foram consultadas as seguintes bases de dados: BIREME, Periódicos Capes, PubMed, Science Direct, Scielo e Pedro. Os termos de busca utilizados foram:” Kinematics”, “Temporomandibular Joint”, “CentricRelation”, “Movements”, “Patient-SpecificModeling”, “MovementDisorders” em inglês e português. Após a busca independente de dois revisores, foram encontrados 40 artigos e, após a aplicação dos critérios de exclusão, 17 artigos foram selecionados para a análise. Os participantes incluídos no estudo foram submetidos a 4 fases de avaliação. Sendo 2 iniciais e 2 após uma semana. Todos os participantes foram avaliados com RDC/TMD para excluir qualquer sinal e ou sintoma de DTM e a condição clínica. Foram avaliados os movimentos de Abertura; Obliquidade, Rotação, Translação/Antero-posterior, Látero-lateral e Movimento Vertical. Resultados: Os 17 artigos avaliados estudaram dispisitivos tridimensionais e demonstraram diferenças metodológicas a respeito dos tipos de modelos e variáveis a serem estudadas. No movimento de abertura os resultados do modelo tridimensional são promissores, pois apresentaram ICC considerado excelente (0,48 a 1,32). No entanto para os movimentos de Lateralidade é necessário ter uma certa cautela pois os resultados variaram de “pobre a “boa” reprodutibilidade (0,30 a 0,57). Conclusão: Não há evidencia cientifica da aplicação clínica de nenhum dos modelos de avaliação cinemática da mandibula. O modelo tridimensional é reprodutível para Abertura seja Intra/Inter dias e Intra/Inter avaliadores e menos reprodutível para as Lateralidades intra/inter dias e inter avaliadores.

No description available.

Noninvasive brain-computer interfaces (BCIs) use scalp-recorded electrical activity from the brain to control an application. Over the past 20 years, research demonstrating that BCIs can provide communication and control to individuals with severe motor impairment has increased almost exponentially. Although considerable effort has been dedicated to offline analysis for improving signal detection and translation, far less effort has been made to conduct online studies with target populations. Thus, there remains a great need for both long-term and translational BCI studies that include individuals with disabilities in their own homes. Completing these studies is the only sure means to answer questions about BCI utility and reliability. Here we suggest an algorithm for candidate selection for electroencephalographic (EEG)-based BCI home studies. This algorithm takes into account BCI end-users and their environment and should assist in study design and substantially improve subject retention rates, thereby improving the overall efficacy of BCI home studies. It is the result of a workshop at the Fifth International BCI Meeting that allowed us to leverage the expertise of multiple research laboratories and people from multiple backgrounds in BCI research.

Purpose: It aimed at testing the applicability of a validated team-based learning student assessment instrument (TBL-SAI) to assess United Kingdom (UK) pharmacy students’ attitude toward team-based learning. Methods: TBL-SAI, consisting of 33 items, was administered to undergraduate pharmacy students from two schools of pharmacy each at University of Wolverhampton and University of Bradford that utilized TBL as a primary instructional method across credit bearing modules. Validity and reliability tests were conducted on the data, along with comparisons between the two schools. Results: Students’ response rate was 80.0% (138/173) in completion of the instrument. Overall, the instrument demonstrated validity and reliability when used with pharmacy students. Sub-analysis between schools of pharmacy did, however, show that four items from Wolverhampton data, had factor loadings of less than 0.40. No item in the Bradford data had factor loadings less than 0.40. Cronbach’s alpha score was reliable at 0.897 for the total instrument: Wolverhampton, 0.793 and Bradford, 0.902. Students showed preference to TBL, with Bradford’s scores being statistically higher (P < 0.005). Conclusion: This validated instrument has demonstrated reliability and validity when used with pharmacy students. Furthermore students at both schools preferred TBL compared to traditional teaching.