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Desenvolvimento e avaliação de uma intervenção para tabagismo mediada por internetGomide, Henrique Pinto 10 February 2014 (has links)
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Previous issue date: 2014-02-10 / Intervenções para tabagismo mediadas por internet disponíveis em língua portuguesa não cobrem
todos os conteúdos das diretrizes de tratamento do tabagismo. Não existem intervenções
de código-aberto na internet, isto é, que divulgam todo o código-fonte para sua adaptação e replicação
para outros contextos e populações. O objetivo do estudo foi descrever uma metologia de
desenvolvimento e avaliar a intervenção para tabagismo mediada por internet de código-aberto
- “Viva sem Tabaco”. O desenvolvimento aconteceu nas seguintes etapas:(1) desenvolvimento
do protótipo, (2) realização de um grupo focal fumantes e correção do protótipo e (3) avaliação
da cobertura, precisão e interatividade do conteúdo com base nos 12 componentes das diretrizes
de tratamento para tabagismo, e (4) revisão do conteúdo. Com os resultados do grupo focal
e na revisão teórica das diretrizes, o protótipo foi desenvolvido e corrigido. Após as correções,
o protótipo foi avaliado pelos especialistas e corrigido. O conteúdo da intervenção foi avaliado
por dois pesquisadores de forma independente, 9 dos 12 tópicos apresentaram cobertura considerada
adequada e 3 com cobertura mínima. Quanto à precisão, 8 tópicos foram avaliados como
corretos e 4 como maior parte correto. Dois dos 12 tópicos apresentaram interatividade. Após
a avaliação, a intervenção foi corrigida. A versão final da intervenção desenvolvida apresentou
convergência com as diretrizes de tratamento. Estudos devem ser conduzidos para avaliar a
eficácia da intervenção. / Web-assisted tobacco interventions (WATI) in Portuguese do not cover the standard guidelines
for smoking treament and lack content quality. Current web-assisted tobacco interventions are
not open-source, which reduce the development speed in developing countries. The objective
of this study was to describe a development methodology of a open-source WATI and evaluate
its quality. The development comprised the following stages: (1) prototype development, (2)
assessment of the prototype using focus groups, and (3) content coverage, accuracy and interactivity
evaluation using as reference the guideline “Treating tobacco use and depedence - 2008
update”, and (4) final review. Based on the data from focus groups and content review, the
initial prototype was redesigned. The content evaluation, performed independently by two specialists,
showed that 9 of 12 components were well covered and 3 minimally covered. Eight of 12
components were classified as correct and 4 as mostly correct. Just two topics were considered
interactive. Based on the evaluation, a final review was conducted in the intervention content.
The developed intervention was compliant with tobacco treatment guidelines, providing an evidence
based guide for smokers who seek help over the internet. Future studies should address
the clinical efficacy of the developed intervention.
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How to merge virtual project room with a project management modelKarlsson, Marine, Richardsson, Anna January 2001 (has links)
Managing a project is multitasking. For making this easier, a project mangaer has a lot of tools. Two of the tools that are often used are a project management model and a virtual project room. These two can be of different types in different compaies and in different culutres. In this thesis, we investigate it there is any neeed for these two tools to be combined. If there is a need, how should the combination be done?
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A P2P middleware design for digital access nodes in marginalised rural areasWertlen, Ronald January 2010 (has links)
This thesis addresses software design within the field of Information and Communications Technology for Development (ICTD). Specifically, it makes a case for the design and development of software which is custom-made for the context of marginalised rural areas (MRAs). One of the main aims of any ICTD project is sustainability and such sustainability is particularly difficult in MRAs because of the high costs of projects located there. Most literature on ICTD projects focuses on other factors, such as management, regulations, social and community issues when discussing this issue. Technical matters are often down-played or ignored entirely. This thesis argues that MRAs exhibit unique technical characteristics and that by understanding these characteristics, one can possibly design more cost-effective software. One specific characteristic is described and addressed in this thesis – a characteristic we describe here for the first time and call a network island. Further analysis of the literature generates a picture of a distributed network of access nodes (DANs) within such network islands, which are connected by high speed networks and are able to share resources and stimulate usage of technology by offering a wide range of services. This thesis attempts to design a fitting middleware platform for such a context, which would achieve the following aims: i) allow software developers to create solutions for the context more efficiently (correctly, rapidly); ii) stimulate product managers and business owners to create innovative software products more easily (cost-effectively). A given in the context of this thesis is that the software should use free/libre open source software (FLOSS) – good arguments do also exist for the use of FLOSS. A review of useful FLOSS frameworks is undertaken and several of these are examined in an applied part of the thesis, to see how useful they may be. They form the basis for a walking skeleton implementation of the proposed middleware. The Spring framework is the basis for experiments, along with Spring-Webservices, JMX and PHP 5’s web service capabilities. This thesis builds on three years of work at the Siyakhula Living Lab (SLL), an experimental testbed in a MRA in the Mbashe district of the Eastern Cape of South Africa. Several existing products are deployed at the SLL in the fields of eCommerce, eGovernment and eLearning. Requirements specifications are engineered from a variety of sources, including interviews, mailing lists, the author’s experience as a supervisor at the SLL, and a review of the existing SLL products. Future products are also investigated, as the thesis considers current trends in ICTD. Use cases are also derived and listed. Most of the use cases are concerned with management functions of DANs that can be automated, so that operators of DANs can focus on their core business and not on technology. Using the UML Components methodology, the thesis then proceeds to design a middleware component architecture that is derived from the requirements specification. The process proceeds step-by-step, so that the reader can follow how business rules, operations and interfaces are derived from the use cases. Ultimately, the business rules, interfaces and operations are related to business logic, system interfaces and operations that are situated in specific components. The components in turn are derived from the business information model, that is derived from the business concepts that were initially used to describe the context for the requirements engineering. In this way, a logical method for software design is applied to the problem domain to methodically derive a software design for a middleware solution. The thesis tests the design by considering possible weaknesses in the design. The network aspect is tested by interpolating from formal assumptions about the nature of the context. The data access layer is also identified as a possible bottleneck. We suggest the use of fast indexing methods instead of relational databases to maintain flexibility and efficiency of the data layer. Lessons learned from the exercise are discussed, within the context of the author’s experience in software development teams, as well as in ICTD projects. This synthesis of information leads to warnings about the psychology of middleware development. We note that the ICTD domain is a particularly difficult one with regards to software development as business requirements are not usually clearly formulated and developers do not have the requisite domain knowledge. In conclusion, the core arguments of the thesis are recounted in a bullet form, to lay bare the reasoning behind this work. Novel aspects of the work are also highlighted. They include the description of a network island, and aspects of the DAN middleware requirements engineering and design. Future steps for work based on this thesis are mapped out and open problems relating to this research are touched upon.
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Influência da qualidade do trabalho em equipe no sucesso de projetos de software / Teamwork quality influence in software projects successPires, Daniel de Lima 15 February 2017 (has links)
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Previous issue date: 2017-02-15 / Software projects are increasingly prominent in today's organizational environment. Its use refers to increased efficiency, improvements in products and services, and also the technological strategy of organizations. They are technically complex, do not have physical limitations and are intangible, nevertheless they are very ambitious and surrounded by uncertainties. Software projects teams must deal with a large amount of information, in addition to making intensive use of knowledge of several areas simultaneously, and also must be skilled in communicating and coordinating their actions. In this dissertation, a quantitative approach research using Structural Equation Modeling with Partial Least Squares (PLS-SEM) was carried out to evaluate the relationship between Teamwork quality and software projects success. The Teamwork quality is a construct that allows measuring the internal collaboration of the team within six dimensions: mutual support, contribution balancing, cohesion, communication, coordination and effort. Software projects success is a widely studied construct in the scientific literature, and in this dissertation was considered as composed of efficiency, impact on the consumer and impact on the team. The result obtained showed that the Teamwork quality exerts considerable influence on the software projects success, corroborating the results of previous academic research, and generating the knowledge that the collaboration should be fostered by the organizations in software development teams. In addition, as a contribution to practice, a model was proposed to evaluate the software project teams teamwork quality, aiming to increase the internal collaboration of the project team and, consequently, the success of the software project. / Projetos de software são cada vez mais expoentes no atual ambiente organizacional. Seu uso remete ao aumento da eficiência, melhorias em produtos e serviços, e também a estratégia tecnológica das organizações. São tecnicamente complexos, sem limitações físicas e intangíveis, não obstante são muito ambiciosos e cercados de incertezas. Assim, as equipes de projetos de software devem lidar com uma grande quantidade de informações, além de fazerem uso intensivo do conhecimento de várias áreas simultaneamente, e por isso devem ser hábeis na comunicação e coordenação de suas ações. Nesta dissertação foi realizada uma pesquisa com abordagem quantitativa utilizando Modelagem de Equações Estruturais com Mínimos Quadrados Parciais (PLS-SEM) para testar a relação da Qualidade do trabalho em equipe com o Sucesso dos projetos de software. A Qualidade do trabalho em equipe é um construto que permite mensurar a colaboração interna da equipe a partir de seis dimensões: apoio mútuo, balanceamento de contribuições, coesão, comunicação, coordenação e esforço. O Sucesso em projetos de software é um construto amplamente estudado na literatura científica, e nesta dissertação foram consideradas as dimensões: eficiência, impacto no consumidor e impacto na equipe do projeto. O resultado obtido mostrou que a Qualidade do trabalho em equipe exerce influência considerável no Sucesso dos projetos de software, corroborando os resultados de pesquisas acadêmicas anteriores, e gerando o conhecimento de que a colaboração deve ser fomentada pelas organizações nas equipes de desenvolvimento de software. Adicionalmente foi proposto, como contribuição para prática, um modelo para avaliação da Qualidade do trabalho em equipe para equipes de Projetos de software, visando o aumento da colaboração interna da equipe do projeto e, consequentemente do Sucesso dos projetos de software.
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Vizuální detekce elektronických součástek / Visual detection of electronic devicesJuhas, Miroslav January 2010 (has links)
This thesis describes application of image processing for precise distance measurement in self acting production of a tip for AFM microscopes. The main goal is to measure distances between assembly parts during fabrication process. The purpose is to acquire a data for self acting assembly line which have to substitute inaccurate and nonrecurring manual assembly process. The assembly process consists of three technological steps. In first two steps the tungsten wire is glued to the cantilever. Distance measurement is necessary in all axes for proper alignment of parts. In third step the sharp tip is etched by KOH solution. The right distance between liquid level and the cantilever must be kept. A camera with high resolution and macro objective is used to acquire an image. Camera image is then calibrated to suppress distortions and scene position with respect to camera position. Length conversion coefficient is also computed. Object recognition and distance measurement is based on standard computer vision methods, mainly: adaptive thresholding, moments, image statistics, canny edge detector, Hough transform… Proposed algorithms have been implemented in C++ using Intel OpenCV library. The final achieved distance resolution is about 10µm per pixel. Algorithm output was successfully used to assembly few test tips.
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Requirements fixation: the effect of specification formality on design creativityMohanani, R. P. (Rahul Prem) 29 November 2019 (has links)
Abstract
There is a broad consensus in the software engineering (SE) research community that understanding system desiderata and design creativity is critical for the success of software projects. This has motivated a plethora of research in SE to improve requirements engineering (RE) processes. However, little research has investigated the relationship between the way desiderata are presented (i.e., framed) and creative design performance. This dissertation, therefore, examines the effects of more formal presentations of desiderata on design creativity.
The research was conducted in three phases. The first consisted of summarizing the available literature on cognitive biases in SE to build a comprehensive body of knowledge, understand the current state of research, and identify the relevant literature to position and delineate subsequent investigations involving the framing effect and fixation. This research phase also investigated how creativity is conceptualized (i.e., understood, assessed and improved) in SE by exploring the perceptual differences and similarities between SE researchers and practitioners. In the second phase, two controlled experiments were conducted to investigate the impact of framing desiderata first as requirements (in general) and then as prioritized requirements on design creativity (i.e., the originality and practicality of a design). The third phase involved a protocol study to explore the underlying cognitive mechanisms that may explain why framing desiderata as formal requirements affects creativity. The empirical evidence from the second and third phases was interpreted together to propose a theoretical framework that explains the effect of specification formality on design creativity.
While the results of the experiments show that specification formality is negatively related to design creativity (i.e., desiderata framed as requirements or prioritized requirements result in designs that are less creative), the findings from the protocol study indicate that the negative relationship between specification formality and design creativity is mediated by fixation (i.e., more formal presentation of desiderata induces fixation and hinders critical thinking). Overall, the results of this dissertation suggest that more formal and structured presentations of desiderata cause requirements fixation—the tendency to attribute undue confidence and importance to desiderata presented as formal requirements statements—that affects design creativity, and thus undermines software engineering success. / Tiivistelmä
Ohjelmistotuotannon tutkijoiden keskuudessa on laaja yksimielisyys järjestelmän tarpeiden ja suunnittelun luovuuden ymmärtämisen kriittisyydestä ohjelmistoprojektien menestyksessä. Tämä on motivoinut monia ohjelmistotuotannon vaatimusmäärittelyprosessien parantamiseen liittyviä tutkimuksia. Harvassa on tarkasteltu tarpeiden esitystavan (eli muotoilun) ja luovan suunnittelun lopputuloksen välistä yhteyttä. Tässä väitöskirjassa tarkastellaan tarpeiden muodollisempien esitystapojen vaikutuksia suunnittelun luovuuteen.
Tutkimus oli kolmivaiheinen. Ensin referoitiin ohjelmistotuotannossa kognitiivisiin harhoihin liittyvä kirjallisuus kartoittamaan nykytutkimuksen tila ja merkityksellinen kirjallisuus myöhempien, kehysvaikutuksen ja fiksaation sisältävien tutkimusten sijoittamiseen ja rajaamiseen. Lisäksi tarkasteltiin luovuuden käsitteellistämistä (eli ymmärrettävyyttä, arviointia ja parantamista) tutkimalla katsannollisia eroja ja yhtäläisyyksiä tutkijoiden ja ammattilaisten välillä. Toisessa vaiheessa tehtiin kaksi kontrolloitua koetta tarpeiden muotoilun vaikutuksien tutkimiseksi, ensin vaatimuksina (yleisesti) ja sitten tärkeysjärjestykseen laitettuina vaatimuksina suhteessa suunnittelun luovuuteen (eli omaperäisyyteen ja käytännöllisyyteen). Lopuksi, protokollatutkimuksella selvitettiin taustalla olevia kognitiivisia mekanismeja selittämään syitä muodollisina vaatimuksina esitettyjen tarpeiden vaikutuksista luovuuteen. Toisesta ja kolmannesta vaiheesta saatujen empiiristen aineistojen tulkittiin yhdessä muodostavan teoreettisen viitekehyksen, joka selittää määrittelyn muodollisuuden vaikutusta suunnittelun luovuuteen.
Vaikka kokeiden tulokset osoittavat määrittelyjen muodollisuuden vaikuttavan negatiivisesti suunnittelun luovuuteen (eli tarpeiden muotoilu vaatimuksina tai priorisoituina vaatimuksina vähentää suunnitelmien luovuutta), protokollatutkimuksen tulokset viittaavat fiksaation vaikuttavan negatiiviseen yhteyteen määrittelyjen muodollisuuden ja suunnittelun luovuuden välillä (eli tarpeiden muodollisempi esitystapa aiheuttaa fiksaatiota ja vaikeuttaa kriittistä ajattelua). Kaiken kaikkiaan, väitöskirjan tulokset esittävät muodollisempien ja strukturoidumpien tarpeiden esitystapojen aiheuttavan vaatimusten fiksaatiota, taipumusta pitää luottamusta ja tärkeyttä tarpeiden muodollisten vaatimusten ilmaisun ansioina, joka vaikuttaa suunnittelun luovuuteen heikentäen ohjelmistotuotannon menestymisen mahdollisuutta.
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Dresdner Arbeitstagung Schaltungs- und Systementwurf: 8.-9. Mai 2007Hardt, Wolfram 11 June 2007 (has links)
Die jedes Frühjahr stattfindende »Dresdner Arbeitstagung Schaltungs- und Systementwurf« wird traditionell vom Fraunhofer-Institut für Integrierte Schaltungen, Institutsteil Entwurfsautomatisierung (EAS) und vom Sächsischen Arbeitskreis Informationstechnik des VDE Bezirksvereins Dresden ausgerichtet.
Die Arbeitstagung hat bereits eine über 30-jährige Tradition und wird von Wissenschaftlern aus Forschungsinstituten und Ingenieuren aus der Industrie für einen regen fachlichen Austausch genutzt. Gegenstand der Tagung sind aktuelle Ergebnisse und neue Erkenntnisse aus Forschung und Entwicklung sowie Erfahrungsberichte und Problemdiskussionen auf dem Gebiet des Entwurfs analoger, digitaler und hybrider Systeme. Das Tagungsprogramm bietet den Teilnehmern wieder interessante Beiträge über neue Lösungen zum Entwurf komplexer Schaltungen und Systeme, die auch Themen wie Rekonfigurierbarkeit, Architekturen, Performance,
Hardware-Software, Test und Optimierung behandeln.
Begleitend zur Tagung wird von der Firma Mentor Graphics ein Workshop zum Thema »Advanced Verification Methodology« angeboten. Hier werden an einem Beispiel die Vorteile der zukünftigen Design Verifikation mit System Verilog und Assertions erläutert.
Der vorliegende Tagungsband enthält die Langfassungen der Beiträge, für deren Form und Inhalt die Autoren verantwortlich sind. Als Veranstalter bedanken wir uns bei den Autoren für die Bereitstellung dieser Beiträge, die als Grundlage für die fachlichen Diskussionen dienen, und bei den Teilnehmern für ihr Interesse an unserer Arbeitstagung.
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Software Design Ethics for BiomedicineGotterbarn, Don, Rogerson, Simon 16 May 2006 (has links)
No description available.
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Plant Level IIoT Based Energy Management FrameworkKoshy, Liya Elizabeth 05 1900 (has links)
Indiana University-Purdue University Indianapolis (IUPUI) / The Energy Monitoring Framework, designed and developed by IAC, IUPUI, aims to
provide a cloud-based solution that combines business analytics with sensors for real-time
energy management at the plant level using wireless sensor network technology.
The project provides a platform where users can analyze the functioning of a plant using
sensor data. The data would also help users to explore the energy usage trends and identify
any energy leaks due to malfunctions or other environmental factors in their plant. Additionally,
the users could check the machinery status in their plant and have the capability
to control the equipment remotely.
The main objectives of the project include the following:
• Set up a wireless network using sensors and smart implants with a base station/ controller.
• Deploy and connect the smart implants and sensors with the equipment in the plant
that needs to be analyzed or controlled to improve their energy efficiency.
• Set up a generalized interface to collect and process the sensor data values and store
the data in a database.
• Design and develop a generic database compatible with various companies irrespective
of the type and size.
• Design and develop a web application with a generalized structure. Hence the database
can be deployed at multiple companies with minimum customization. The web app
should provide the users with a platform to interact with the data to analyze the sensor
data and initiate commands to control the equipment.
The General Structure of the project constitutes the following components:
• A wireless sensor network with a base station.
• An Edge PC, that interfaces with the sensor network to collect the sensor data and
sends it out to the cloud server. The system also interfaces with the sensor network to
send out command signals to control the switches/ actuators.
• A cloud that hosts a database and an API to collect and store information.
• A web application hosted in the cloud to provide an interactive platform for users to
analyze the data.
The project was demonstrated in:
• Lecture Hall (https://iac-lecture-hall.engr.iupui.edu/LectureHallFlask/).
• Test Bed (https://iac-testbed.engr.iupui.edu/testbedflask/).
• A company in Indiana.
The above examples used sensors such as current sensors, temperature sensors, carbon
dioxide sensors, and pressure sensors to set up the sensor network. The equipment was
controlled using compactable switch nodes with the chosen sensor network protocol. The
energy consumption details of each piece of equipment were measured over a few days. The
data was validated, and the system worked as expected and helped the user to monitor,
analyze and control the connected equipment remotely.
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Imagens de ressonância magnética funcional em pacientes com doença de Parkinson submetidos à estimulação cerebral profunda / Functional Magnetic Resonance Imaging in patients with Parkinson\'s disease with deep brain stimulationArantes, Paula Ricci 22 March 2005 (has links)
INTRODUÇÃO: A estimulação cerebral profunda (ECP) é usada para tratar a doença de Parkinson (DP) avançada. A estimulação do núcleo subtalâmico (NST) melhora os sintomas de parkinsonismo, mas seu mecanismo de ação permanece pouco compreendido. A ressonância magnética functional (RMf) pode auxiliar no estudo de áreas cerebrais motoras de forma a melhorar o entendimento dos mecanismos de ação da ECP. O objetivo desta tese foi de desenvolver e testar técnicas de RMf para estudo de pacientes com DP tratados com ECP. MÉTODOS: Foram realizados testes para verificar interferência do sistema de ECP nas imagens de RMf e realizadas adaptações de modo a diminuir os artefatos na imagem. A seguir foram examinados pacientes com DP em quatro condições: durante a movimentação da mão direita (antes do implante dos eletrodos para ECP, depois da cirurgia sem estímulo elétrico e depois da cirurgia com estímulo elétrico no NST) e durante o repouso com a estimulação elétrica ligada e desligada. No total foram examinados dez pacientes, dos quais oito foram comparados a voluntários normais. Foram realizadas três sessões de RMf em cada condição, utilizando dois tipos de seqüências: em bloco (BL) e relacionada a eventos (RE). As imagens foram analisadas calculando-se a freqüência de atividade cerebral detectada em 19 áreas sensitivo-motoras. Dados comportamentais durante o exame e a evolução clínica foram analisados. RESULTADOS: Os pacientes não apresentaram complicações decorrentes dos exames de RMf. Após modificações na técnica de implante do eletrodo e ajustes do intervalo pós-cirúrgico para o exame, os artefatos nas imagens foram reduzidos. Nos controles, as sequencias RE mostraram mais atividade que BL nas áreas: área suplementar motora, área pré-motora (pM) direita, cíngulo anterior (Cga), cíngulo posterior (Cgp), tálamo bilateral e putamen direito. Durante a movimentação da mão dominante, comparando as seqüências BL e RE dos pacientes com DP, não houve diferença significativa considerando todos experimentos pré-operatórios e pósoperat órios sem o estímulo elétrico. Com o estímulo elétrico ligado, nas seqüências BL houve maior atividade em relação às RE, na área sensitivomotora primária (SM1) esquerda. Durante o repouso, quando a estimulação elétrica foi ligada houve maior atividade das seguintes áreas: cerebelo direito, SM1 esquerda, Cgp, pM bilateral, mesencéfalo esquerdo e Cga. Houve melhora clínica dos pacientes e tanto a avaliação motora na primeira semana pós-operatória, na fase sem medicação, bem como a avaliação global em seis meses estiveram correlacionadas com os parâmetros motores aferidos durante os exames de RMf. CONCLUSÕES: Foi desenvolvido método para a aplicação da RMf em pacientes com DP submetidos à ECP que permitiu as seguintes observações: as seqüências BL mostraram maior freqüência de atividade na SM1 nos pacientes com DP e ECP ligada, enquanto as seqüências RE mostraram maior freqüência de atividade nos voluntários normais nas áreas motoras primárias e secundárias; e o estímulo elétrico no repouso produziu atividade detectada no cerebelo e nas regiões motoras primárias e secundárias / INTRODUCTION: Deep brain stimulation (DBS) is used to treat advanced Parkinson\'s disease (PD). Stimulation of the subthalamic nucleus (STN) is effective to improve the symptoms related to parkinsonism, but its mechanism of action remains poorly understood. Functional magnetic resonance imaging (fMRI) can be applied to study brain areas involved in motor activity, as a mean to better understand the effects of DBS. In this work we aimed to develop and test fMRI techniques to study DP patients treated with DBS. METHODS: We have initially performed tests to check the interference of the DBS in image quality and made adaptations that minimized the artifacts. After this initial phase PD patients were examined by fMRI in four different phases: during right hand movement (before surgery to implant DBS electrodes, after the surgery with the electrical stimulation turned off, and after the surgery with the electrical stimulation turned on the STN) and at rest with electrical stimulation turned on. In total, ten patients were examined, eight of them paired to matched normal volunteers. All tasks were performed in three independent sessions for each condition, using two types of runs: blocked (BK) and event-related (ER). The images were analyzed calculating the frequency of activation detected in 19 sensory-motor areas. Behavioral data during fMRI exams and clinical data were also recorded. RESULTS: There were no clinical complications due to fMRI exams. The modifications in the DBS procedure and post-surgical time to fMRI examination resulted in a reduction of the image artifacts. In the controls the ER runs showed more activity than BK in: supplementary motor area, right pre-motor area (pM), anterior cingulated gyrus (aCg), posterior cingulated gyrus (pCg), bilateral thalamus, and right putamen. During the dominant hand movements, when comparing ER and BK runs in PD patients there was no significant difference considering pre and post operative phases without electrical stimulation. When the electrical stimulation was turned on, BK runs showed more activation in the left primary sensory-motor cortex (SM1) compared to ER runs. In the rest state, when the electrical stimulation was turned on, there was more activation in the following areas: right cerebellum, left SM1, pCg, bilateral pM, left mesencephalus and aCg. There was clinical improvement in the patients, and the motor performance in the first post operative week, in the drug withdrawn phase as well as in the global evaluation after six months were correlated with the motor parameters recorded during the fMRI exams. CONCLUSIONS: we have developed a method for fMRI in PD patients with DBS, which enabled the following observations: BK runs showed increased frequency of activity in SM1 in PD patients with electrical stimulation turned on, while the ER runs showed more frequency of activation in normal volunteers in primary and secondary motor regions; the electrical stimulations in rest state produced activity detected in cerebellum, primary and secondary motor regions
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