There is an arguable lack of activity and interest in the analysis of electroacoustic music when compared to its composition and performance. The absence of a strong and active analytical community is very concerning, as it should be a fundamental part of any larger musical community that wishes for works to be performed and discussed in later years. The problems that face electroacoustic music analysis are that there is no consensus or single analytical tool/methodology that dictates how such an activity should be undertaken. Rather than attempting to appropriate existing tools meant for traditional musics or create a new universal one this thesis will argue that a new culture should be adopted that promotes different opinions on the subject of electroacoustic music analysis, as opposed to defining a consensus as to how it should be conducted. To achieve this the thesis will: evaluate and critique what constitutes and defines electroacoustic music analysis; provide a general and flexible procedure to conduct an analysis of an electroacoustic work; develop a set of criteria and terms to cross-examine the current analytical tools for electroacoustic music in order to define the gaps in the field and to identify pertinent elements within electroacoustic works; analyse a number of electroacoustic works to test and implement the ideas raised within this thesis; and finally the concept of an analytical community (in which such a culture could exist) is outlined and implemented with the creation of the OREMA (Online Repository for Electroacoustic Music Analysis) project. This universal approach will cover both epistemological and ontological levels of electroacoustic music analysis. All of the concepts raised above are interlinked and follow the main hypothesis of this thesis: • There is no one single analysis that can fully investigate a work; • Analyses are a perspective on a work, ultimately formed through the subjective perception of the analyst; • These perspectives should be shared with other practitioners to help develop a better understanding of the art form. This PhD study was part of the New Multimedia Tools for Electroacoustic Music Analysis project (2010-2013) funded by the Arts and Humanities Research Council (UK). Other outcomes of that project included the various analysis symposiums held at De Montfort University in Leicester and the electroacoustic analysis software EAnalysis created by Pierre Couprie.

Les neurones exprimant l'hormone de mélano-concentration (MCH) sont observés dans l'hypothalamus postérieur de tous les vertébrés, de la lamproie à l'Homme. Ces neurones sont impliqués dans diverses fonctions comme le cycle veille/sommeil ou la prise alimentaire. Ils forment une population non homogène et au moins deux sous-populations sont reconnues, chez le rat. La première sous-population est composée de neurones nés au 11ème jour de vie embryonnaire (E11) qui projettent massivement sur les régions les plus postérieures du système nerveux central. La seconde est générée à E12/E13 et les neurones la caractérisant projettent sur les régions les plus antérieures du cerveau et expriment le peptide CART (cocaine and amphetamine regulated transcript) et le récepteur NK3 (neurokinine). L'objectif de notre travail était de comprendre l'origine de ces deux sous-populations. Pour cela, nous avons utilisé des approches histologiques, moléculaires et in vitro. Les neurones à MCH sont parmi les premiers neurones à naître et à différencier leur phénotype chimique le long d'une région longitudinale définie par une prolifération intense, appelée " cell cords " par Keyser en 1972. Cette bande longitudinale est caractérisée par l'expression de gènes comme Sonic Hedgehog (Shh), Nkx2.1, Nkx2.2 et a été récemment renommée " diagonale intrahypothalamica " ou ID. La différenciation des neurones à MCH dépend de l'expression du facteur morphogène Shh et ces neurones expriment Nkx2.1 et Nkx2.2, facteurs de transcription régulés positivement par Shh. Les neurones de la première sous-population envoient des projections le long du premier tractus longitudinal à se mettre en place, le tractus postopticus (tpoc). Ceux issus de la deuxième sous-population se différencient concomitamment au développement des régions télencéphaliques et leurs projections changent de direction pour innerver les régions antérieures du cerveau sous la dépendance de protéines de guidage axonal, Nétrine1 et Slit2. Nétrine1 permet d'attirer les axones MCH exprimant le récepteur DCC précocement vers la moelle épinière et plus tardivement vers le télencéphale alors que Slit2 contraint les axones MCH exprimant Robo2 à sortir de l'hypothalamus. L'étude du modèle " MCH " permet de mettre en lumière un changement d'organisation précocement au cours du développement dans l'axe longitudinal du prosencéphale. La bande longitudinale d'expression des facteurs de transcription Shh, Nkx2.2 peut être perçue comme une extension rostrale de la colonne neurogénique médiane déjà décrite chez des espèces d'invertébrés possédant une symétrie bilatérale. Les neurones générés le long de cette colonne le sont très tôt au cours du développement. / Neurons expressing melanin-concentrating hormone (MCH) are observed in the vertebrate posterior hypothalamus, from lampreys to humans. These neurons are involved in various functions such as sleep/wake cycle or food intake. They form a non-homogeneous population and at least two sub-populations are indentified in the rat. The first sub-population is composed of neurons born on the 11th embryonic day (E11) that project heavily on posterior regions of the central nervous system. The second is characterized by neurons born at E12/E13, projecting in anterior regions of the brain and expressing the peptide CART (cocaine and amphetamine Regulated Transcript) and the NK 3 receptor (neurokinin). The aim of this study was to understand the origin of these two sub-populations. For this, we used histological, molecular and in vitro approaches. MCH neurons are among the first neurons to be born and to differentiate their chemical phenotype along a longitudinal region defined by intense proliferation and called " cell cord " by Keyser in 1972. This longitudinal band is characterized by the expression of genes such as Sonic Hedgehog (Shh), Nkx2.1, Nkx2.2 and was recently named " diagonal intrahypothalamica " or ID. Differenciation of MCH neurons depends on expression of the morphogenetic factor Shh and these neurons express Nkx2.1 and Nkx2.2, transcription factors upregulated by Shh. The neurons of the first sub-population send projections along the tractus postopticus (tpoc), which is the first longitudinal tract to develop. Neurons of the second sub-population differentiate concomitantly to the development of the basal forebrain and their projections innervate anterior brain regions. Our results obtained in vitro showed that Netrin1 attracts MCH axons and that this reponse is mediated by DCC. Slit2 repulses MCH axons and this reponse is mediated by the Robo2 receptor. Overall, our study of the development of the MCH system shed light on an organizational change in the longitudinal axis of the forebrain during early development : a primary longitudinal organization characterized by the longitudinal expression of Shh and Nkx2.2 and the path of the tractus postopticus in the diencephalon and mesencephalon. MCH neurons of the first sub-population develop during this stage. Then, as the basal telencephalon extends and expresses Netrin1, the medial forebrain bundle differentiates, inducing a change in the main axis of the forebrain ; meanwhile MCH neurons of the second sub-population appear. MCH sub-populations reflect distinct developmental stages of the forebrain.

Master of Science / Department of Mechanical and Nuclear Engineering / Steven Eckels / Both cavitating and flashing flows are important phenomena in fluid flow. Cavitating flow, a common consideration in valves, orifices, and metering devices, is also a concern in loss of coolant accidents for liquid water in power plants when saturation pressures are below atmospheric pressure. Flashing flow is a common consideration for devices such as relief and expansion valves and fluid injectors as well as for loss of coolant accidents in which the coolant’s saturation pressure is above atmospheric. Of the two phenomena, flashing flow has received greater interest due to its applicability to safety concerns, though cavitating flow is perhaps of greater interest in terms of energy efficiency. It is possible for cavitating and flashing flow to actually become sonic. That is, the local velocity of a fluid can exceed the local speed of sound due to the unique properties of two-phase mixtures. When a flow becomes sonic, it is possible for the flow to accelerate and impose additional energy losses that would not otherwise occur. Models of this aspect of two-phase flow are not well developed, typically only being presented for the case of constant area ducts. In this paper two models for cavitating sonic flow are developed and described by applying the integral forms of the mass, momentum, and energy equations to a control volume of variable cross-sectional area. These models, based on the homogeneous equilibrium model (HEM) and separated flow model, are then applied to experimental data taken by the author with R-134a as the fluid of interest. Experimental data were taken with four instrumented converging-diverging nozzles of various geometries using a custom testing rig that allowed for precise control and measurement of flow parameters such as mass flow, temperature, and pressure. The resultant data from the models are then examined, focusing on the resultant velocities, Mach numbers, quality, and shear stresses.

This study brings forward the field of non-musical sound branding, concerning the use of sound in practical marketing and brand development. This interpretive, qualitative study has been conducted with the purpose of examining and explaining what aspects within non-musical sound branding that advocates and inhibits its use, ase well as exhibit how it can be created and developed. Interview data from advertising agencies and sound producers with extensive experience and knowledge in the field, is interpreted and analysed through theories within the fields of sensory marketing, brand theory, sound theory and non-musical sound branding. The results confirm that the intimate, subliminal qualities of sound, as well as the context in which it is mediated, are fundamental parameters for its reception and interpretation. The results also show that non-musical sound branding possess a number of aspects that both advocates and inhibits its use. The study also exhibit how it can be created and developed in regard to a number of fundamental and contributing perspectives.

Um método original para a fabricação de microbocais de diamante com perfil convergente-divergente foi desenvolvido neste trabalho. O método de fabricação desenvolvido utiliza deposição de diamante policristalino sobre moldes que posteriormente são removidos. Os moldes utilizados são fios de tungstênio submetidos a um processo de corrosão eletrolítica para gerar o perfil convergente-divergente de bocal. O microbocal de diamante foi fabricado para ser utilizado como controlador e medidor passivo de vazão de fluidos, quando operando em condições críticas de escoamento. Testes de vazão de gás foram realizados, utilizando os microdispositivos fabricados, para determinar os parâmetros de escoamento necessários para a utilização dos microdispositivos como controladores e medidores de vazão de gás. Os parâmetros críticos de escoamento, a saber, a vazão mássica crítica, a razão crítica de pressão e a vazão volumétrica crítica, bem cmo a faixa do número de Reynolds do escoamento e o coeficiente de descarga, foram determinados para todos os microdispositivos. A faixa de variação do número de Reynolds dos escoamentos obtidos foi de 1x10 POT.3-7x10 POT.4. Por exemplo, o microbocal de diamante com o menor diâmetro de garganta (16+/-1)x10mum apresentou vazão mássica crítica de (0,344+006)g/min, vazão volumétrica crítica de (314+/-5)cm POT.3/min e coeficiente de descarga de (1,27+/-0,19). Assim, foram fabricados com sucesso microbobais de diamante com perfil convergente-divergente e foram determinados os parâmetros críticos de escoamento que possibilitam a estes microbocais atuarem como controladores e medidores passsivos de baixo vazão de gás. / In this work an original method for the fabrication of diamond micronozzles with converget-divergent profile is presented. The method uses the deposition of polycrystalline diamond over a mold, which is subsequently removed. The referred molds are tungsten wires patterned by means of an electrolytic etching procedure in a way that the divergent-convergent profile is generated. The main motivation for producing such micronozzles is its application as passive flow controllers and flow meters elements when operating under critical flow conditions. The micronozzles produced here were tested in order to determine the critical flow parameters that are necessary for its operation, as passive flow controllers and flow meters elements. The critical flow parameters (critical mass flow rate, critical pressure ratio and critical volumetric flow rate), the Reynolds number range and the discharge coefficient were determined for all the microdevices produced. The Reynolds number for the microdevices was found to be in the range of 1x10 POT.3-7x10 POT.4. For instance, the diamond micronozzle with smaller throat diameter, (16+/-1)x10mum, presented critical mass flow rate of (0,344+0,006)g/min, critical volumetric flow rate of (314+/-5)cm POT.3/min and discharge coefficient of (1,27+/-0,19). Therefore, diamond micronozzles were successfully fabricated with convergent-divergent profile and the critical flow parameters necessary for its operation, as passive flow controllers and flow meters elements, were determined.

Os cacerolazos surgidos em meados de 1971 no Chile, que se espalharam posteriormente pela América do Sul, se configuram como ações coletivas que agenciam múltiplas formas de expressão sonoras a favor das lutas de um povo. Em sua maioria, os participantes de tais ações se utilizam de diversos tipos de panelas e/ou utensílios domésticos para produzir um território rico e de alta intensidade e complexidade sonora. A pesquisa: Memórias dos Cacerolazos: cartografia de forças não sonoras se tornando sonoras tem como propósito tecer uma cartografia a partir de relatos, depoimentos e vivências acerca dos cacerolazos que aconteceram em Buenos Aires (2001) e Santiago do Chile (2011). Pretende-se fazer um caminhar nômade, de uma análise fluída que escuta a vida; isto é, compreender através da escuta os sentidos produzidos por aqueles que participaram destas ações. Tais encontros permitem colocar corpos em movimentos e assim criar e possibilitar a efetuação de novos territórios que se dão nos deslocamentos destas forças e fluxos. São memórias como acontecimento, que emergem e se desdobram a partir de forças não sonoras e que permitem pensar numa memória a partir de uma escuta da diferença. A pesquisa lança mão de conceitos fundamentais para se pensar o tempo do acontecimento; do tempo Aíon. Um tempo que não é o tempo das medidas e dos relógios, mas um tempo incorpóreo que permite que cada indivíduo entre neste constante produzir-se e assim permita que os hábitos e as memórias se articulem num devir inventivo: produtor de novos tempos e de novos modos de se viver a cada instante. Deste modo pode-se vislumbrar novas maneiras de se fazer política a partir de memórias que não são estanques, mais inventivas e produtoras de novas realidades / The cacerolazos, originated in mid-1971 in Chile, which later spread throughout South America, are collective actions promoting multiple forms of sonic expression in favor of a peoples fight. Mostly, the participants of such actions use various types of cookware and/or household itens to produce a rich territory of high intensity and complexity sounding. The research Memories of Cacerolazos: cartography of non sonic forces becoming sonic aims to weave a mapping through reports, statements and experiences about cacerolazos that happened in Buenos Aires and Chile in 2011. It seeks to wander, from a fluid analysis that listens life; i.e., to comprehend through hearing the meanings produced for those who participate in these actions. Such meetings allow bodies to be put in movement, creating and enabling the effectuation of new territories that occurs at offsets of these forces and flows. Those meetings are memories as events, emerging and unfolding from non sonic forces, that enable considering a memory from a listening of difference. This research makes use of fundamental concepts to ponder the time of the event; the Aíon time. A time that is not the time from measurements and watches, but an incorporeal time that allows each individual to enter this constant becoming and thus allow the habits and memories being articulated in a inventive becoming: producer of new times and new ways of living every moment. Therefore one can envision new ways of doing politics from memories that are not watertight, but more inventive and producer of new realities

Os cacerolazos surgidos em meados de 1971 no Chile, que se espalharam posteriormente pela América do Sul, se configuram como ações coletivas que agenciam múltiplas formas de expressão sonoras a favor das lutas de um povo. Em sua maioria, os participantes de tais ações se utilizam de diversos tipos de panelas e/ou utensílios domésticos para produzir um território rico e de alta intensidade e complexidade sonora. A pesquisa: Memórias dos Cacerolazos: cartografia de forças não sonoras se tornando sonoras tem como propósito tecer uma cartografia a partir de relatos, depoimentos e vivências acerca dos cacerolazos que aconteceram em Buenos Aires (2001) e Santiago do Chile (2011). Pretende-se fazer um caminhar nômade, de uma análise fluída que escuta a vida; isto é, compreender através da escuta os sentidos produzidos por aqueles que participaram destas ações. Tais encontros permitem colocar corpos em movimentos e assim criar e possibilitar a efetuação de novos territórios que se dão nos deslocamentos destas forças e fluxos. São memórias como acontecimento, que emergem e se desdobram a partir de forças não sonoras e que permitem pensar numa memória a partir de uma escuta da diferença. A pesquisa lança mão de conceitos fundamentais para se pensar o tempo do acontecimento; do tempo Aíon. Um tempo que não é o tempo das medidas e dos relógios, mas um tempo incorpóreo que permite que cada indivíduo entre neste constante produzir-se e assim permita que os hábitos e as memórias se articulem num devir inventivo: produtor de novos tempos e de novos modos de se viver a cada instante. Deste modo pode-se vislumbrar novas maneiras de se fazer política a partir de memórias que não são estanques, mais inventivas e produtoras de novas realidades / The cacerolazos, originated in mid-1971 in Chile, which later spread throughout South America, are collective actions promoting multiple forms of sonic expression in favor of a peoples fight. Mostly, the participants of such actions use various types of cookware and/or household itens to produce a rich territory of high intensity and complexity sounding. The research Memories of Cacerolazos: cartography of non sonic forces becoming sonic aims to weave a mapping through reports, statements and experiences about cacerolazos that happened in Buenos Aires and Chile in 2011. It seeks to wander, from a fluid analysis that listens life; i.e., to comprehend through hearing the meanings produced for those who participate in these actions. Such meetings allow bodies to be put in movement, creating and enabling the effectuation of new territories that occurs at offsets of these forces and flows. Those meetings are memories as events, emerging and unfolding from non sonic forces, that enable considering a memory from a listening of difference. This research makes use of fundamental concepts to ponder the time of the event; the Aíon time. A time that is not the time from measurements and watches, but an incorporeal time that allows each individual to enter this constant becoming and thus allow the habits and memories being articulated in a inventive becoming: producer of new times and new ways of living every moment. Therefore one can envision new ways of doing politics from memories that are not watertight, but more inventive and producer of new realities

A Anfotericina B (AB) é um antibiótico antifúngico natural, do grupo dos polienos, produzido por cultura de bactérias Streptomyces nodosus. A AB foi isolada pela primeira vez em 1953, e desde então tem sido utilizada extensivamente no tratamento clínico de infecções sistêmicas. Como a AB é altamente insolúvel em meio aquoso, a formulação de escolha tem sido dispersões aquosas de micelas mistas de AB e desoxicolato de sódio (Fungizon). Entretanto, a alta toxicidade deste fármaco tem estimulado a proposição de várias outras formulações. O presente trabalho estuda uma dessas formulações alternativas propostas: agregados de AB e Brometo de dioctadecildimetilamônio (DODAB). O objetivo principal deste trabalho foi tentar avaliar, numa visão estrutural, as propriedades e peculiaridades envolvidas na interação da AB com as dispersões de DODAB. Neste trabalho, centrou-se no estudo de dispersões de DODAB, sonicadas (DODABS) e não sonicadas (DODABNS), onde o antibiótico estivesse, principalmente, na forma monomérica, tendo em vista a proposta baixa toxicidade da AB enquanto monômero. Para avaliar estes sistemas utilizaram-se as técnicas de absorção óptica, calorimetria diferencial de varredura (DSC) e a Ressonância Paramagnética Eletrônica (RPE) de marcadores de spin incorporados nos agregados lipídicos. Mostrou-se que a AB monomérica incorpora-se tanto em vesículas de DODABNS, como nos pequenos agregados de DODABS, sendo maior sua incorporação nestes últimos. Foi possível mostrar que até a fração molar (AB/DODAB) de 1,2 mol% a AB está totalmente monomérica, incorporada em agregados de DODABS, mas somente parcialmente em vesículas de DODABNS. Nas bicamadas de DODABNS, a preferência da AB monomérica é pela fase gel, 40 % incorporada, comparada com 23 % na fase fluida. As várias técnicas indicam que a AB encontra-se na superfície da bicamada, com seu cromóforo hidrofóbico enxergando um meio de polarizabilidade maior do que a da água, tanto em DODABS como em DODABNS. Marcadores de spin mostram a coexistência de domínios lipídicos em fases diferentes, gel e fluida, a baixas temperaturas, em DODABS. Curiosamente, indicam que a AB monomérica interage, preferencialmente, com os domínios mais fluidos, em desacordo com a observada maior afinidade da AB pela fase gel de bicamadas lipídicas de DODABNS. O estudo termo-estrutural de dispersões de DODABNS e DODABS aqui apresentado, na presença e ausência de AB, pode ser relevante na proposta de novas formulações farmacológicas. / Amphotericin B (AB) is a natural antibiotic, produced by Streptomyces nodosus, with a very potent antifungal activity. It is a polyene macrolide molecule, isolated in 1953. Since then, it has been extensively used in the treatment of systemic mycotic infections. Considering AB very low solubility in aqueous medium, it has been largely used as an aqueous dispersion of sodium deoxycholate-AB mixed micelles (Fungizon). However, the high toxicity of this preparation has led to the proposition of different other formulations. The present work focuses on one of the proposed preparations, namely aggregates formed by AB and the cationic lipid dioctadecyldimethylammonium (DODAB). Considering the proposed low toxicity of monomeric AB, the present work studies DODAB dispersions, sonicated (DODABS) and non-sonicated (DODABNS), where AB is mostly monomeric. To the structural analysis, optical absorption, differential scanning calorimetry (DSC) and electron spin resonance of spin labels incorporated in the aggregates were used. It was found that AB as a monomer incorporates in aggregates present in both dispersions, DODABS and DODABNS, but the incorporation of monomeric AB in the small fragments present in DODABS is much larger. It was shown that AB incorporates in DODABS aggregates, as a monomer, up to AB/DODAB concentration of 1.2 mol%. At this concentration, only 40 % and 23 % of AB molecules are in the monomeric state in the gel and fluid phases of DODABNS bilayers, respectively. Hence, the gel phase of DODABNS bilayers favors the monomerization of AB, as compared to the bilayer fluid phase. All the applied techniques point to a superficial interaction of monomeric AB with DODAB aggregates, with the hydrophobic polyene chromophor positioned relatively inside the bilayer, in a region of polarizability higher than that of water, in both dispersions, DODABS and DODABNS. Spin labels indicate the coexistence of gel and fluid domains in DODABS aggregates, at low temperatures, supporting the proposed hypothesis of the presence of bilayer fragments in the dispersion. Contrarily to the higher detected affinity of monomeric AB for the gel phase, as compared to the fluid phase of DADABNS bilayers, spin labels indicate that monomeric AB is mostly adsorbed at the fluid domain of the fragments, possibly corresponding to the periphery of the fragments. The thermal-structural study presented here of DODABNS and DODABS, in the presence and absence of AB, can be relevant in the design of new pharmaceutical formulations.

This dissertation examines the relationship between phonetic sound and content in Latin poetry, with a focus on Books 1-3 of Horace's Odes. The central argument is that a relationship exists between sound and content in poetry, that this can be analysed and described more thoroughly and systematically than is usually the case, and that the appreciation of poetry can be enhanced by doing so. Part 1 presents a scheme for describing the sound-content relationship, and argues that this accurately reflects the perceptions of poetic audiences and is psychologically valid. The scheme begins with the concept of the 'sonance', defined as any set of sounds that renders a passage sonically noteworthy. Sonances that relate to content are classified either as 'harmonic sonances', which relate to content due to the properties of the relevant sounds, or 'repetitive sonances', which relate to content purely due to the repetition (including patterning or contrasting) of sounds, regardless of their properties. Harmonic sonances, it is argued, may relate to content through four 'harmonies', depending on whether acoustic or articulatory properties are involved and whether the relationship is one of similarity between property and content or a more distant 'metaphor'. Repetitive sonances may relate to content by several different means, or 'modes of repetition'. Part 2 presents a simple method of numerical analysis which may be applied to the text by computer to extract passages that are relatively likely to contain a sonance, and briefly discusses the process of assessing these results, identifying further sonances by more natural means, and relating each sonance to the relevant content. As an essential preliminary to such matters, Latin phonetics and phonology are also discussed in detail. Parts 3 and 4 present the results of applying these resources of assessment and description to the text, to demonstrate the type of poetic appreciation which may thus be gained. Part 3 consists of two catalogues of harmonic and repetitive sonances taken from the whole of Odes 1-3. Part 4 is a specific examination of two entire odes in much greater detail. / Thesis (Ph.D.)--Humanities, 2004.

<p>Despite its lack of septation, the tissue patterning of the arterial pole of the zebrafish is remarkably similar to the patterning of pulmonary and aortic arterial poles observed in mouse and chick. The secondary heart field (SHF) is a conserved developmental domain in avian and mammalian embryos that contributes myocardium and smooth muscle to the cardiac arterial pole. This field is part of the overall heart field, and its myocardial component has been fate mapped from the mesoderm to the heart in both mammals and birds. In this study I demonstrate that the population that gives rise to the arterial pole of the zebrafish can be traced from the epiblast, is a discrete part of the mesodermal heart field. This zebrafish SHF contributes myocardium after initial heart tube formation, giving rise to both smooth muscle and myocardium. I show that this field expresses Isl1, a transcription factor associated with the SHF in other species. I further show that differentiation, induced by Bmp signaling, occurs in this progenitor population as cells are added to the heart tube. Some molecular pathways required for SHF development in birds and mammals are conserved in teleosts, as Nkx2.5 and Nkx2.7 as well as Fgf8 regulate Bmp signaling in the zebrafish heart fields. Additionally, the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole.</p> / Dissertation