Orientador: Odilon Helou Fleury Curado / Resumo: A presente pesquisa tem como tema central a questão da linguagem em seu eixo dialógico, em particular os postulados sociointeracionistas. Nosso estudo adota como ponto inicial o trabalho desenvolvido em sala de aula focalizando justamente as práticas de leitura realizadas num contexto cuja caracterização, definida por orientações monologizantes, tende a promover a fragilização da relação entre sujeito e linguagem, com repercussões decisivas no antagonismo que se cria entre o sujeito discursivo/leitor e o estudante, mantendo-os isolados. Privilegiam-se ações e atitudes do estudante por intermédio de sua relação com a disciplina de língua portuguesa, com perdas importantes para a formação do sujeito discursivo da língua materna, na medida da desconfiguração desta, como mecanismo cultural de interação sociocomunicativa. Os parâmetros monológicos de ensino, burocratizantes e confinados à escola, abrem mão do contexto sócio-histórico-cultural como basilares de toda e qualquer possível e efetiva compreensão, a partir da construção de modelos de representação funcional da língua, limitando ao indivíduo percepções formadoras de sua identidade de sujeito leitor. A pesquisa pretende investigar o instrumento pedagógico utilizado em sala de aula, pressuposto nas práticas de leitura realizadas, como agenciadores destas ações dicotômicas. Na tentativa de fortalecer a relação entre sujeito e linguagem, fundamental neste processo formativo do leitor, cabe ainda pensar em práticas que invista... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The current research has as its central theme the question of language in its dialogical axis, especially the socio-interactionist postulates. Our study adopts as a starting point the work developed in the classroom focusing precisely on the reading practices carried out in a context whose characterization, defined by monologistic orientations, tends to promote the weakening of the relation between subject and language, with decisive repercussions on the antagonism that is created between the discursive subject / reader and the student, keeping them isolated. Students' actions and attitudes are privileged through their relationship with the portuguese language subject, with important losses for the formation of the discursive subject of the mother tongue, in the measure of the deconfiguration of this, as a cultural mechanism of socio-communicative interaction. The monological parameters of teaching, bureaucratic and confined to the school, ignore the socio-historical-cultural context as the bases of any possible and effective understanding, from the construction of functional representation models of the language, limiting to the individual perceptions his identity as a reader. The research intends to investigate the pedagogical instrument used in the classroom, presupposed in the practices of reading carried out, as agents of these dichotomous actions. In an attempt to strengthen the relation between subject and language, crucial to this formative process of the reader, it i... (Complete abstract click electronic access below) / Mestre

Symbicort Turbuhaler is a medical device produced by the pharmaceutical company AstraZeneca for the treatment of asthma and symptoms of chronic obstructive pulmonary disease. The delivery reliability of the product is dependent on the performance of the whole supply chain and as part of the chain the results from the department, Quality Control (QC), are mandatory to release the produced batches to the market. The performance of QC is thus an important part of the supply chain. In order to reduce the risk of supply problems and market shortage, it is very important to investigate whether the performance of QC can be improved. The purpose of the thesis is to provide AstraZeneca with scientifically based data to identify sensitive parameters and readjust work procedures in order to improve the performance of QC. The goal of this thesis is to map out the flow of the QC Symbicort Turbuhaler operation and construct a model of it. The model is intended to be used to simulate and optimize different parameters, such as the inflow of batch samples, the utilization of the instrumentation and staff workload. QC is modelled in a simulation software. The model is used to simulate and optimize different scenarios following a discrete event simulation and an optimization technique based on evolution strategies. By reducing the number of analytical robots from 14 to 10, it is possible to maintain existing average lead time. Through a reduction, the utilization of the robots increases, simultaneously the workload decreases for some of the staff. However, it is not possible to extend the durability of the system suitability test (SST), and still achieve existing average lead time. From the investigation of different parameters, it is found that, an added laboratory engineer at the high-performance liquid chromatography (HPLC) station has the best outcome on lead time and overall equipment effectiveness. However, a reduced laboratory engineer at the Minispice robots has the worst outcome. With the resources available today the lead times cannot be maintained in the long run, if the inflow is of 35 batch samples a week or more. By adding a laboratory engineer at the HPLC station and by using a SST with durability of 48 hours, the best outcome in terms of average lead time and number of batch samples with a lead time less than 10 days is received. / Symbicort Turbuhaler är en medicinsk enhet som tillverkas av läkemedelsföretaget AstraZeneca för behandling av astma och symptomen för kronisk obstruktiv lungsjukdom. Leveranssäkerheten för produkten är beroende av hela försörjningskedjans prestanda och som en del utav kedjan är resultaten från kvalitetskontrollen (QC) obligatoriska för att släppa en batch av produkten till marknaden. QCs prestanda är därför en viktig del av försörjningskedjan. För att minska risken för leveransproblem och produktbrist på marknaden är det viktigt att undersöka huruvida prestandan hos QC kan förbättras. Syftet med arbetet är att ge AstraZeneca vetenskapligt baserat data för att identifiera känsliga parametrar och justera arbetssätt för att förbättra prestandan hos QC. Målet med detta arbete är att kartlägga flödet av QC Symbicort Turbuhaler och konstruera en modell utifrån det flödet. Modellen är avsedd för att simulera och optimera olika parametrar, såsom inflödet av batchprover, utnyttjande av instrumentering och arbetsbelastning av personal. Genom att minska antalet analytiska robotar från 14 till 10, är det möjligt att bibehålla befintlig genomsnittlig ledtid. Genom denna minskning ökar utnyttjandet av robotarna, samtidigt som arbetsbelastningen minskar för en del av bemanningen. Det är inte möjligt att förlänga hållbarheterna på robotarnas systemtest (SST) och fortfarande uppnå befintlig genomsnittlig ledtid. Vid undersökning av olika parametrar indikerar resultatet att en ytterligare laboratorieingenjör vid högpresterande vätskekromatografi-stationen (HPLC) har den bästa effekten på ledtid och produktionseffektivitet. En laboratorieingenjör som reduceras från Minispice-robotarna har däremot den värsta effekten. Med de resurser som finns tillgängliga idag kan ledtiderna inte bibehållas långsiktigt om inflödet är 35 batchprover per vecka eller mer. Genom att addera en laboratorieingenjör vid HPLC-stationen och användaen SST med en hållbarhet på 48 timmar, erhålls det bästa resultatet i termer av genomsnittlig ledtid och antal batchprover som har en individuell ledtid på mindre än 10 dagar.

As more services and workflows are moved into computerized systems the number of accounts a person has to be aware of is on steady increase. Today the average user is likely to have more than 25 accounts for different services used on a daily basis that all need authentication. The dominant authentication mechanism used today is still password authentication. In an attempt to satisfy the requirements of different password creation policies and to recall all passwords when needed users tend to rely on different strategies for password creation. These strategies may all seem to provide adequate security, and they may do, but the reality is that they differ tremendously in terms of how time consuming it is to crack passwords generated with the different strategies. By conducting interviews with domain experts different password creation strategies are discussed and pseudo algorithms for cracking passwords are constructed. Based on mutual definitions of the classes and a predefined word list the cost for cracking passwords generated by different strategies are explored. Major findings indicate that strategies based on phrases are at the top of the list. Using a strategy to create a seemingly random password based on a logical phrase, where only the first letter from each word is used, tends in some cases to be the best of choice. An example is to turn the phrase “this password is the greatest of them all” into “tpitgota” instead of using the phrase “goodword” to create an 8 character long password. However, if the phrase contains words not usually found in common dictionaries the best strategy seems instead to be utilizing character substitution as in turning the phrase “my dog Krillex is cool” into “myDoGkriLLExiscooL”.

Introdução: A craniossinostose é causada pela fusão prematura de uma ou mais suturas cranianas, levando à deformidade do crânio. Formas sindrômicas ocorrem quando a craniossinostose é associada a características dismorfológicas adicionais. A fusão precoce das suturas pode ser causada por fatores ambientais e genéticos. No presente trabalho, pretende-se reconhecer os diagnósticos clínicos e características fenotípicas da craniossinostose em pacientes atendidos nos ambulatórios de Genética Médica do Hospital de Clinicas de Porto Alegre no período de 2006 a 2016. O protocolo de investigação incluiu anamnese, exame dismorfológico e revisão de prontuário, incluindo exames de investigação realizados. Resultados: Entre 2006 e 2016, foram avaliados 133 indivíduos com craniossinostose, sendo que 121 reuniram critérios para inclusão neste estudo. A idade média de diagnóstico da craniossinostose foi de 38,4 meses. A sutura mais frequentemente acometida foi a sutura metópica. Houve maior proporção de casos sindrômicos (69,4%). Em 25 desses pacientes, foram identificadas as síndromes de Apert, Crouzon, Pfeiffer, Muenke, Craniofrontonasal ou Saethre-Chotzen. Síndromes não tipicamente relacionadas a craniossinostose foram também identificadas, como distrofia miotônica tipo 1 (n=2), síndrome de Gorlin, síndrome de Beckwith-Wiedemann e galactosemia. Os sinais clínicos não eram típicos de qualquer síndrome particular em 32 indivíduos (38,1% dos casos sindrômicos). Características fenotípicas frequentes incluíram malformações de extremidades (35,5%), do sistema nervoso central (32,1%), cardiovasculares (21,4%) e genito-urinárias (16,6%). Foram observadas malformações raras como espinha bífida (n=3), hérnia diafragmática congênita (n=3) e hipoplasia congênita de parede abdominal (n=2). Anormalidades citogenéticas ou moleculares foram identificadas em 18 indivíduos sindrômicos, sendo a síndrome de Muenke o diagnóstico mais frequente (n=7). Discussão: A maior proporção de casos sindrômicos em relação a outras séries é possivelmente relacionada ao fato de tratar-se de casos atendidos em um serviço de Genética clínica. Observou-se diagnóstico significativamente tardio na presente casuística, reforçando a necessidade de estratégias de saúde pública envolvendo treinamento de recursos humanos e otimização da referência aos centros terciários. O acometimento multissistêmico reforça a importância do acompanhamento multidisciplinar. Conclusão: O estudo demonstra uma amostra amplamente heterogênea em termos clínicos, genéticos e terapêuticos. É fundamental o desenvolvimento de estratégias de educação contínua não apenas dentro da equipe, mas também ao acessar pacientes e familiares, através do aconselhamento genético e de ferramentas de comunicação. Para isso, propõe-se uma cartilha informativa sobre craniossinostoses para pacientes e familiares. Faltam estudos em países em desenvolvimento para análise comparativa dos dados em contextos sociais semelhantes. / Introduction: Craniosynostosis is caused by premature fusion of one or more cranial sutures, leading to deformity of the skull. Syndromic forms occur when craniosynostosis is associated with additional dysmorphological features. Early suture fusion can be caused by environmental and genetic factors. In this study, it is intended to recognize the clinical diagnosis and phenotypic characteristics of craniosynostosis in patients attending Medical Genetics outpatient clinics of Hospital de Clínicas de Porto Alegre from 2006 to 2016. The research protocol included anamnesis, dysmorphological examination, review of medical records and investigations carried out. Results: Between 2006 and 2016, 133 individuals with craniosynostosis were evaluated, and 121 met inclusion criteria for this study. The mean age at diagnosis of craniosynostosis was 38.4 months. Metopic suture was the most commonly involved. There was a higher proportion of syndromic cases (69.4%). In 25 of these patients, Apert, Crouzon, Pfeiffer, Muenke, Craniofrontonasal or Saethre-Chotzen syndromes were identified. Syndromes not typically associated to craniosynostosis were also identified, such as myotonic dystrophy type 1 (n = 2), Gorlin syndrome, Beckwith-Wiedemann syndrome and galactosemia. Clinical signs were not typical of any particular syndrome in 32 individuals (38.1% of syndromic cases). Frequent phenotypic features included extremities (35.5%), central nervous system (32.1%), cardiovascular (21.4%) and genitourinary malformations (16.6%). Rare malformations such as spina bifida (n = 3), diaphragmatic hernia (n = 3) and congenital abdominal wall hypoplasia (n = 2) were observed. Cytogenetic or molecular abnormalities were identified in 18 syndromic patients, and Muenke syndrome was the most frequent diagnosis (n = 7). Discussion: The higher proportion of syndromic cases than in other series is possibly due to the fact that these cases are treated in a clinical genetics service. Significantly late diagnosis was observed in the present series, reinforcing the need for public health strategies involving training of human resources, optimization of referral to tertiary centers and active search strategies. Multisystemic involvement reinforces the importance of multidisciplinary follow-up. Conclusion: This study demonstrates a widely heterogeneous clinical, genetic and therapeutic sample. Strategies for continuous education within the team, patients and family members, through genetic counseling and communication tools are important, so it is proposed an information booklet for patients and families. There is a scarcity of case series from developing countries for comparative analysis in similar social contexts.

Em todo mundo, muitas instalações nucleares foram construídas e necessitarão serem desligadas em um determinado momento por estarem próximas do seu tempo recomendado de utilização que é de aproximadamente 40 anos. A AIEA (Agência Internacional de Energia Atômica) busca orientar e recomendar uma série de diretrizes para a realização de atividades de descomissionamento de instalações nucleares, com atenção especial aos países que não possuem um quadro regulatório legal que ampare as atividades de descomissionamento. O Brasil, até o momento, não possui uma norma específica que oriente as etapas de descomissionamento de reatores de pesquisa. Entretanto, em março de 2011 foi constituída uma comissão de estudo com a atribuição principal voltada às questões de descomissionamento das instalações nucleares brasileiras, culminando na resolução 133, de 8 de novembro de 2012, um projeto de norma que dispõe sobre o Descomissionamento de Usinas Nucleoelétricas. O Instituto de Pesquisas Energéticas e Nucleares (IPEN) possui dois reatores de pesquisa sendo um deles o reator IPEN/MB-01. O objetivo dessa dissertação de mestrado é elaborar um plano preliminar de descomissionamento desse reator de pesquisa, considerando a documentação técnica da instalação (RAS-Relatório de Análise de Segurança), as normas existentes da CNEN (Comissão Nacional de Energia Nuclear), assim como as recomendações da AIEA. Em termos de procedimentos de descomissionamento para reatores de pesquisa, este trabalho se baseou no que existe de mais moderno em experiências, estratégias e lições aprendidas realizadas e documentadas nas publicações da AIEA que abrangem técnicas e tecnologias de descomissionamento. Considerando estes conhecimentos técnicos e às peculiaridades da instalação, foi selecionada a estratégia de desmantelamento imediato, que corresponde ao inicio das atividades de descomissionamento assim que a instalação for desligada, dividindo-a em setores de trabalho. Como recurso de gerenciamento e acompanhamento do projeto de descomissionamento do reator e manutenção de registros, foi desenvolvido um banco de dados utilizando o programa Microsoft Access 2007, no qual contêm todos os itens e informações referentes ao plano preliminar de descomissionamento. O trabalho aqui descrito busca atender os requisitos, critérios técnicos e institucionais, incorporando o que se tem de mais atual em procedimentos de descomissionamento, podendo servir como guia para as demais instalações brasileiras. / Around the world, many nuclear plants were built and need to be turned off at a certain time because they are close to their recommended time of use is approximately 50 years. So the IAEA (International Atomic Energy Agency), seeks to guide and recommend a set of guidelines for the conduct of activities of nuclear facilities, with special attention to countries that do not have a framework regulatory Legal that sustain the activities of decommissioning. Brazil, so far, does not have a specific standard to guide the steps of the guidelines regarding decommissioning research reactors. However, in March 2011 a study committee was formed with the main task facing the issues of decommissioning of nuclear installations in Brazil, culminating in Resolution 133 of November 8, 2012, a standard project that treat about the Decommissioning of nucleoelectric plants. O Instituto de Pesquisas Energéticas e Nucleares (IPEN) has two research reactors one being the reactor IPEN/MB-01. The purpose of this master dissertation is to develop a preliminary plan for decommissioning this research reactor, considering the technical documentation of the facility (RAS-Safety Analysis Report), the existing standards of CNEN (National Nuclear Energy Commission), as well as IAEA recommendations. In terms of procedures for decommissioning research reactors, this work was based on what is most modern in experiences, strategies and lessons learned performed and documented in IAEA publications covering techniques and technologies for decommissioning. Considering these technical knowledges and due to the peculiarities of the facility, was selected to immediate dismantling strategy, which corresponds to the start of decommissioning activities once the installation is switched off, dividing it into work sectors. As a resource for monitoring and project management of reactor decommissioning and maintenance of records, we developed a database using Microsoft Access 2007, which contain all the items and information for the preliminary decommissioning plan. The work described here aims to meet the requirements, technical and institutional criteria, incorporating what is most current procedures and lessons learned of decommissioning, may serve as a guideline for the other brazilian facilities.

Chronic infection with the hepatitis C virus infection (HCV) affects over 170 million individuals worldwide. In this thesis the natural history and management of hepatitis C in North- East London was investigated. The prevalence of cirrhosis in patients with chronic hepatitis C rises with increasing duration of infection. In Asian patients infected at birth, infection over 60 years causes cirrhosis in 71 % of infected individuals. Since the rate of fibrosis progression in Asian patients is the same as that seen in Caucasian patients, it is likely that similar rates of cirrhosis will be seen in all patients who are infected with HCV for over 60 years. Factors found to be associated with fibrosis progression were:- age and alcohol excess. Insulin resistance was associated with fibrosis progression. However, elevated serum ferritin or hepatiC iron were not. Knowledge of hepatitis C in the East of London was examined and found to be poor despite the Department of Health information campaign. Educational meetings and postal surveys improved the level of knowledge of HCV. However as our group only assessed knowledge immediately after completion of the sessions, such a testing regime does not address long-term knowledge retention. We examined current and novel management strategies for patients with chronic HCV. Current therapy involves pegylated interferon and ribavirin. We found that insulin resistance was a poor predictor of sustained virological response. Chinese herbal treatments for hepatitis C are widely used but poorly studied. Our group designed a randomised controlled double blind study to assess whether Chinese herbal treatment is effective and results from this study show that recruitment and retention in trials of alternative therapies are problematic and that the herbal remedy had little effect on viraemia and quality of life, although liver function tests did improve a little.

This research discusses how to motive and retain employees in China based on analyzing factors influencing employee enthusiasm and strategies to motivate employees under the framework of Herzberg’s two-factor theory. With the proposition that hygiene factors and motivators both influence the work enthusiasm, 15 interviews were arranged to collect the needed data for further analysis. According to the information obtained from the 15 interviewees from P&G, hygiene factors and motivators all exert influences over their work behaviors and the impact of the factors differs according to the different conditions of the employees. The findings of this research generally agree with the two-factor theory. Based on how the work enthusiasm of P&G’s employees are influenced by each of the factors, strategies are correspondingly formulated to motivate employees at work. Generally speaking, this research is significant for being conducted from a microscopic perspective to the macroscopic perspective. In other words, a specific organization is studied to figure out the answers to the research questions and the findings can be used for future studies as well for practical purposes. More specifically, when conducting this study, such factors as unsatisfying wages and benefits, heavy workload, task conflicts, ambiguous duties, interpersonal conflicts and ineffective management system, etc., all discourage the enthusiasm of employees. In response to that, a reasonable management system and sound motivational mechanism should be established to keep employees active at work or retain those who want to resign.

This thesis investigates the profitability of the Momentum and Contrarian strategies in international equity markets. In particular, I introduce for the first time the use of countries' indices performance to momentum and contrarian portfolio selection. I show that investors can switch back and forth from one country to the other in designing worldwide strategies. The global momentum strategy is consistently profitable between 1969 and 2014. The most successful momentum strategy selects stocks based on their previous performances over 9 months and then holds the portfolio for the next 3 months. This strategy yields 3% per month (42.57% per year). Interestingly, countries' indices' portfolios formed based on prior 48 months; prior losers outperform prior winners by 0.83% per month (10.40% per year) during the subsequent 60 months. The reversal effect is substantially stronger for emerging countries where it yields 1.37% per month (17.70% per year). It remains profitable in the period post-globalization. In addition, I examine for the first time the role of world risks factors in explaining the global momentum and contrarian profits and find that the global momentum strategies obtain significant abnormal returns after adjusting consecutively for world Fama and French risks (0.9% per month or 11.35% per year), and world market states risks (1.31% per month or 16.76% year). Of particular interest, I find a strong relation between world macroeconomic risks factors, notably world industrial production and the momentum return. Second, I find no substantial relation between world risks factors and the contrarian profit. These results suggest that excess return can be earned in the long run by using global investment strategies based on historical prices, challenging the weak form of the Efficient Market Hypothesis. In Chapter 1, I explain the momentum and the contrarian strategies, motivate the importance of what I propose as global momentum and contrarian strategies, and present the results obtained. In chapter 2, I review the Efficient Market Hypothesis' literatures in conformity with the Standard Finance theory. Additionally, I review the Behavioural Finance literatures with a focus on the psychology of investor decision, and the stock market under-reaction and overreaction approach of explaining the momentum and contrarian profitability. In chapter 3, I explain in details the main methodologies used to examine the global momentum and contrarian strategies profitability, and motivate the dataset used. In Chapter 4, I examine the new global momentum strategy profitability internationally. In Chapter 5, I examine the new contrarian strategy profitability internationally. In Chapter 6 I examine the role of global risks factors in explaining the momentum and contrarian profits. Finally, in Chapter 7 I conclude and highlights the limitations of the thesis.

A administração estratégica (AE) é um fator relevante para a competitividade das empresas. O gerenciamento isolado, porém, não se apresenta como uma alternativa completa para enfrentar os desafios dos mercados. É necessário alterar a abordagem individual, onde cada unidade da cadeia de suprimentos (CS) toma decisões sem considerar o impacto para os membros participantes, por estratégias integradas que geram um ambiente globalmente otimizado. Nesse contexto, uma questão importante é evidenciada: que elementos são importantes para a realização da integração das estratégias entre uma empresa focal (EF) e sua cadeia de suprimentos, considerando a relação com fornecedores diretos? Na busca de uma resposta ao questionamento, o presente trabalho desenvolve um estudo de caso em uma empresa fabricante de equipamentos agrícolas do RS e seus fornecedores. Como limite de pesquisa, são consideradas especificamente as estratégias de manufatura na CS direta. Os resultados obtidos sugerem que o tipo e o nível de importância dos elementos de integração mudam na visão da EF e dos fornecedores. Para a EF, por exemplo, é notável a centralidade do lean manufacturing (LM) na definição e execução das estratégias e também a necessidade de alinhamento interno entre departamentos. Já para os fornecedores são salientados aspectos como a confiança para troca de informações entre os membros da CS e uma comunicação adequada. / Strategic management is a relevant factor for a company’s competitiveness. However, management alone is not a complete alternative to overcome the challenges imposed by the market. It is necessary to change from individual approaches, where each component of the supply chain (SC) makes decisions without considering the impact for other participating members, to integrated strategies, that generate a globally optimized environment. In this context, an important issue outstands: what are the important elements to integrate the strategies of a focal company (FC) and its supply chain, considering the relationship with suppliers? In the search for an answer to this question, this paper develops a case study in an agricultural equipment manufacturing company based on Rio Grande do Sul and the company’s direct suppliers. As a research limit, manufacturing strategies considered specifically the direct supply chain. The results show that the integration elements type and level of importance are different for the FC and the suppliers. The FC, for example, remarkably centers the strategy definition and execution on lean manufacturing (LM) and internal alignment by departments as an requirement. On the other hand, suppliers emphasize aspects such as the trust to exchange information between SC members and a proper communication.

Background. The prevalence of alcohol dependence, defined as being physically and psychologically dependent on alcohol, among homeless people is 8%-58% compared to 4%-16% of alcohol dependence prevalence in the general population. Homelessness also contributes to alcohol dependence, and alcohol dependence is more difficult to treat and manage when combined with homelessness and alcohol-related harms. Alcohol harm reduction strategies for those with severe alcohol dependence and experiencing homelessness are gaining traction. There are 22 Managed Alcohol Programs (MAPs) in several cities across Canada. MAPs can reduce harms for people with severe alcohol dependence who live with acute, chronic, and social harms. In this research, I report on MAP participants views in the first six months of being in a MAP to provide insights into implementation of MAPs. Research Question. My central research question was: What are MAP participants perspectives of MAP during the early period of transition into MAP? With an objective to understand implementation from participants perspectives, I specifically asked: How are MAP participants situated in the world, what are their experiences, and what are the relational shifts that occur during early transition into MAP? Methodology and Theoretical Perspective. In my research, I used interpretive description informed by constructivism. I drew on relational theory to interpret my findings. The use of interpretive description, informed by constructivism and relational theory, brought forth greater insight into MAP participants views of and subsequent shifts in their relationships with the environment, alcohol, themselves, and others before and during MAP. Results/Findings. Participants perspectives focused on four key findings: (a) participants shifting perspectives of non-beverage alcohol when beverage alcohol was available in MAP, (b) participants motivation to change and insights into their own drinking, (c) reasons for drinking outside of MAP, and (d) relational insights and shifts in their connections with others. Conclusions. For individuals experiencing homelessness and severe alcohol dependence and its inherent associated harms, MAPs help to support relational shifts that support safer drinking patterns and/or meaningfully interrupt cycles of uncontrolled drinking as well as help to re-establish new relationships with alcohol, themselves, family, and friends. / Graduate